Chang-Yong Tsao, MD

Chang-Yong Tsao, MD, FAAN, FAAP, is an attending pediatric neurologist at Nationwide Children’s and a Professor of Clinical Pediatrics and Neurology at The Ohio State University. Dr. Tsao’s clinical and research interests include mitochondrial and neuromuscular diseases. Dr. Tsao is an active member of the Muscular Dystrophy Association Clinic. In 2006, Dr. Tsao was named Nationwide Children’s Hospital Physician of the Year. He is named among the “Best Doctors in America.”

Gender:

• Male

Languages Spoken:

• English
• Chinese

Internship

• Mackay Memorial Hospital/Taipei Medical College
  Date Completed: 06/30/1977

Medical School

• Taipei Medical College
  Date Completed: 06/30/1977

Residency

• Delaware County Memorial Hospital (Philadelphia)
  Date Completed: 06/30/1981

Residency

• Albert Einstein Medical Center (Temple University)
  Date Completed: 06/30/1983

Residency

• University Hospital
  Date Completed: 06/30/1984

Fellowship

• University of Cincinnati
  Date Completed: 06/30/1986

Department:

• Pediatrics

Section:

• Neurology

Speciality:

• Child Neurology
  
• Neurology
  

Date of Appointment at Nationwide Children’s Hospital:

• 09/11/1990

• Dr. Chang-yong Tsao. 2012. Congenital Muscular Dystrophy. In The 5 Minute Neurology Consult. 2 ed. Edited by D. Joanne Lynn, Herbert B. Newton, Alexander D. Rae-Grant.. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Dr Chang-yong Tsao. 2012. Mitochondrial disorders. In The 5 Minute Neurology Consult. 2 ed. Edited by D. Joanne Lynn, Herbert B. Newton, Alexander D. Rae-Grant.. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Tsao CY. 2012. Myasthenia gravis. In Manual of pediatric neurology. Edited by Weisleder P. Hackensack, NJ: World Scientific Inc.
• Tsao CY. 2012. Duchenne muscular dystrophy. In Manual of pediatric neurology. Edited by Weisleder P. Hackensack, NJ: World Scientific Inc..
• Tsao CY. 2012. Spinal muscular atrophy. In Manual of pediatric neurology. Edited by Weisleder P. Hackensack, NJ: World Scientific.
• Dr. Chang-yong Tsao. 2012. Hypotonic Infant Syndrome. In The 5 Minute Neurology Consult. 2 ed. Edited by D. Joanne Lynn, Herbert B. Newton, Alexander D. Rae-Grant.. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Dr. Chang-yong Tsao. 2012. Gangliosidoses. In The 5 Minute Neurology Consult. 2 ed. Edited by D. Joanne Lynn, Herbert B. Newton, Alexander D. Rae-Grant.. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Rosales,Xiomara,Q; Tsao,Chang-Yong. 2012. Childhood Onset of Limb-Girdle Muscular Dystrophy.  PEDIATRIC NEUROLOGY. Vol. 46, no. 1. (January): 13-23.
• Tsao,Chang,Y. 2011. Intractable Epilepsy, Audio-Visual Hallucinations and Charcot-Marie-Tooth Disease 1A in an African-American Boy.  CLINICAL EEG AND NEUROSCIENCE. Vol. 42, no. 3. (July): 206-208.
• Dr Chang-yong Tsao. 2011. Intractable epilepsy, audio-visual hallucinations and Charcot-Marie-Tooth disease 1A in an African-American boy.  Clin EEG Neuroscience. Vol. 42, no. 3. (July): 206-208.
• Cottrell CE, Prior TW, Pyatt R, Astbury C, Reshmi S, Bartholomew D, Atkin J, Thrush DL, Pastore M, Mendell JR, Tsao CY, al-Dahhak R, Newmeyer A, Gastier-Foster J. 2010. The unexpected detection of dystrophin gene deletions by array comparative genomic hybridization.  Am J Med Genet A. Vol. 152A, no. 9. (September): 2301-2307.
• Tsao CY. 2010. Vagus nerve stimulation is effective in the treatment of intractable epilepsy associated with nonketotic hyperglycinemia in two children.  J Child Neurol. Vol. 25, no. 3. (March): 375-378.
• Tsao CY. 2009. Current trends in the treatment of infantile spasms.  Neuropsychiatric Disease and Treatment. Vol. 5, no. May: 289-299.
• Tsao CY, Mendell JR. 2009. Partial epilepsy in an adolescent male with limb girdle muscular dystrophy 1B.  J Child Neurol. Vol. 24, no. 3. (March): 346-348.
• Tsao CY, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  Semin Pediatr Neurol. Vol. 15, no. 4. (December): 151-153.
• Guenther UP, Handoko L, Varon R, Stephani U, Tsao CY, Mendell JR, Lützkendorf S, Hübner C, von Au K, Jablonka S, Dittmar G, Heinemann U, Schuetz A, Schuelke M. 2008. Clinical variability in distal spinal muscular atrophy type 1 (DSMA1): determination of steady-state IGHMBP2 protein levels in five patients with infantile and juvenile disease.  J Mol Med. Vol. 87, no. 1. (January): 31-41.
• Tsao, Chang-Yong; Lo, Warren, D; Rusin, Jerome, A; Henwood, Maria, J; Boue, Daniel R. 2007. Isolated neurosarcoidosis presenting as headache and multiple brain and spinal cord lesions mimicking central nervous system metastases.  Brain & development. Vol. 29, no. 8. (January).
• Tsao, Chang-Yong; Mendell, Jerry R. 2007. Autistic disorder in 2 children with mitochondrial disorders.  Journal of child neurology. Vol. 22, no. 9. (January).
• Tsao CY, Mendell JR. 2006. Coexisting muscular dystrophies and epilepsy in children.  J Child Neurol. Vol. 21, no. 2. (February): 148-150.
• Tsao CY, Paulson G. 2005. Type 1 ataxia with oculomotor apraxia with aprataxin gene mutations in two American children.  J Child Neurol. Vol. 20, no. 7. (July): 619-620.
• Tsao CY, Wenger GD, Bartholomew DW. 2005. Cri du chat syndrome and complex karyotype in a patient with infantile spasms, hypsarrhythmia, nonketotic hyperglycinemia, and heterotopia.  Am J Med Genet A. Vol. 134A, no. 2. (April): 198-201.
• Tallian KB, Nahata MC, Lo W, Tsao CY. 2004. Pharmacokinetics of gabapentin in paediatric patients with uncontrolled seizures.  J Clin Pharm Ther. Vol. 29, no. 6. (December): 511-515.
• Dr Chang-yong Tsao. 2004. Effective treatment with oxcarbazepine in paroxysmal kinesigenic choreoathetosis.  J Child Neurol.. Vol. 19, no. 4. (April): 300-301.
• Tsao CY. 2004. Congenital Myopathy. In The 5 Minute Neurology Consult. 1 ed. Edited by Lynn J, Kissel J, Newton H. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Tsao CY. 2004. Gangliosidoses. In The 5 Minute Neurology Consult, Lippincott Williams & Wilkins Inc, Philadelphia. I ed. Edited by Lynn J, Newton H, Rae-Grant AD. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Tsao CY. 2004. Mitochondrial Diseases. In The 5 Minute Neurology Consult. 1 ed. Edited by Lippincott Williams & Wilkins Inc. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• Tsao CY. 2004. Congenital Muscular Dystrophy. In The 5 Minute Neurology Consult. 1 ed. Edited by Lynn J, Kissel J, Newton H. Philadelphia, PA: Lippincott Williams & Wilkins Inc.
• 39. Tsao CY. 2004. Hypotonic Infant Syndrome. In The 5 Minute Neurology Consult. 1 ed. Edited by Lynn J,Newton H, Rae-Grant AD. Philadelphia, PA: Lippincott, Williams & Wilkins Inc.
• Tsao, Chang-Yong; Herman, Gail; Boue, Daniel, R; Prior, Thomas, W; Lo, Warren, D; Atkin, Joan, F; Rusin, Jerome. 2003. Leigh disease with mitochondrial DNA A8344G mutation: case report and brief review.  Journal of child neurology. Vol. 18, no. 1. (January).
• Joseph SA, Tsao CY. 2002. Guillain-Barré syndrome.  Adolesc Med. Vol. 13, no. 3. (October): 487-494.
• Tsao CY, Mendell JR, Kissel JT. 2002. Dermatomyositis in two siblings and a brief review of familial dermatomyositis.  J Child Neurol.. Vol. 17, no. 7. (July): 540-542.
• Tsao CY, Mendell JR. 2002. Combined partial deficiencies of carnitine palmitoyltransferase II and mitochondrial complex I presenting as increased serum creatine kinase level.  J Child Neurol.. Vol. 17, no. 4. (April): 304-306.
• Tsao CY, Kien CL. 2002. Complete biotinidase deficiency presenting as reversible progressive ataxia and sensorineural deafness.  J Child Neurol.. Vol. 17, no. 2. (February): 146-146.
• Tsao CY, Mendell JR, Friemer ML, Kissel JT. 2002. Lambert-Eaton myasthenic syndrome in children.  J Child Neurol.. Vol. 17, no. 1. (January): 74-76.
• Tsao CY, Mendell JR, Bartholomew D. 2001. High mitochondrial DNA T8993G mutation (<90%) without typical features of Leigh's and NARP syndromes.  J Child Neurol.. Vol. 16, no. 7. (July): 533-535.
• Musumeci O, Naini A, Slonim AE, Skavin N, Hadjigeorgiou GL, Krawiecki N, Weissman BM, Tsao CY, Mendell JR, Shanske S, De Vivo DC, Hirano M, DiMauro S. 2001. Familial cerebellar ataxia with muscle coenzyme Q10 deficiency.  Neurology.. Vol. 56, no. 7. (April): 849-855.
• Tsao CY, Mendell JR, Luquette M, Dixon B, Morrow G 3rd. 2000. Mitochondrial DNA depletion in children.  J Child Neurol. Vol. 15, no. 12. (December): 822-824.
• Tsao CY, Mendell JR, Lo WD, Luquette M, Rennebohm R. 2000. Myasthenia gravis and associated autoimmune diseases in children.  J Child Neurol. Vol. 15, no. 11. (November): 767-769.
• Tsao CY, Mendell JR, Lo WD, Luquette M, Rusin J. 2000. Mitochondrial respiratory-chain defects presenting as nonspecific features in children.  J Child Neurol.. Vol. 15, no. 7. (July): 445-448.
• Sue CM, Bruno C, Andreu AL, Cargan A, Mendell JR, Tsao CY, Luquette M, Paolicchi J, Shanske S, DiMauro S, De Vivo DC. 1999. Infantile encephalopathy associated with the MELAS A3243G mutation.  J Pediatr.. Vol. 134, no. 6. (June): 696-700.
• Tsao CY, Mendell JR. 1999. The childhood muscular dystrophies: making order out of chaos.  Semin Neurol.. Vol. 19, no. 1. (January): 9-23.
• 25. Tsao CY, Mendell JR. 1999. Childhood Muscular Dystrophies Sharing a Common Pathogenesis of Membrane Instability. In Motor Disorders. 1 ed. Edited by Younger DS. Philadelphia, PA: Lippincott Williams & Wilkins.
• Tsao CY, Mendell JR, Rusin J, Luquette M. 1998. Congenital muscular dystrophy with complete laminin-alpha2-deficiency, cortical dysplasia, and cerebral white-matter changes in children.  J Child Neurol.. Vol. 13, no. 6. (June): 253-256.
• Tallian KB, Nahata MC, Tsao CY. 1998. Role of the ketogenic diet in children with intractable seizures.  Ann Pharmacother.. Vol. 32, no. 3. (March): 349-361.
• Mendell JT, Panicker SG, Tsao CY, Feng B, Sahenk Z, Marzluf GA, Mendell JR. 1998. Novel compound heterozygous laminina2-chain gene (LAMA2) mutations in congenital muscular dystrophy. Mutations in brief no. 159. Online.  Hum Mutat.. Vol. 12, no. 2. (February): 135-135.
• Tsao CY, Westman JA. 1997. Infantile spasms in two children with Williams syndrome.  Am J Med Genet.. Vol. 71, no. 1. (July): 54-56.
• Tsao CY, Luquette M, Rusin JA, Herr GM, Kien CL, Morrow G 3rd. 1997. Leigh syndrome, cytochrome C oxidase deficiency and hypsarrhythmia with infantile spasms.  Clin Electroencephalogr.. Vol. 28, no. 4. (April): 214-217.
• Dr Chang-yong Tsao. 1997. Dystrophin expression in a Duchenne muscular dystrophy patient with a frame shift deletion.  Neurology.. Vol. 48, no. 2. (February): 486-488.
• Tsao CY , Mendell JR. 1997. The Muscular Dystrophies. In Current Neurology, Vol 17.. Edited by Appel SH. Amsterdam: IOS Press.
• Dr Chang-yong Tsao. 1996. Gabapentin associated with aggressive behavior in pediatric patients with seizures.  Epilepsia. Vol. 37, no. 5. (May): 501-502.
• Dr Chang-yong Tsao. 1995. Critical illness polyneuropathy in a 2-year-old girl with hemorrhagic shock encephalopathy syndrome.  J Child Neurol.. Vol. 10, no. 6. (November): 486-488.
• Tsao CY, Wright FS, Boesel CP, Luquette M. 1994. Partial NADH dehydrogenase defect presenting as spastic cerebral palsy.  Brain Dev.. Vol. 16, no. 5. (September): 393-395.
• Tsao CY, Romshe CA, Lo WD, Wright FS, Sommer A. 1994. Familial adrenal insufficiency, achalasia, alacrima, peripheral neuropathy, microcephaly, normal plasma very long chain fatty acids, and normal muscle mitochondrial respiratory chain enzymes.  J Child Neurol.. Vol. 9, no. 2. (April): 135-138.
• Tsao CY, Boesel CP, Wright FS. 1994. A hypotonic infant with complete deficiencies of acid maltase and debrancher enzyme.  J Child Neurol. Vol. 9, no. 1. (January): 90-91.
• Tsao CY, Sommer A, Hamoudi AB. 1993. Aicardi syndrome, metastatic angiosarcoma of the leg, and scalp lipoma.  Am J Med Genet.. Vol. 45, no. 5. (March): 594-596.
• Tsao CY, Wright FS. 1993. Acute chemical pancreatitis associated with carbamazepine intoxication.  Epilepsia.. Vol. 34, no. 1. (January): 174-176.
• Tsao CY, Lo WD, Craenen J. 1992. Congestive heart failure and cardiac thrombus as first presentations of Friedreich ataxia.  Pediatr Neurol.. Vol. 8, no. 4. (July): 313-314.
• Tsao CY. 1992. Generalized tonic-clonic status epilepticus in a child with cat-scratch disease and encephalopathy.  Clin Electroencephalogr. Vol. 23, no. 2. (April): 65-67.
• Tsao CY, Ellingson RJ, Wright FS. 1991. Recovery of cognition from persistent vegetative state in a child with normal somatosensory evoked potentials.  Clin Electroencephalogr. Vol. 22, no. 3. (July): 141-143.
• Tsao CY, Ellingson RJ. 1990. Infantile spasms in two brothers with broad thumbs syndrome.  Clin Electroencephalogr. Vol. 21, no. 2. (April): 93-95.
• Tsao CY, McComb RD. 1990. Myalgia with partial defects of mitochondrial enzyme and myoadenylate deaminase.  Pediatr Neurol. Vol. 6, no. 1. (January): 65-65.
• Tsao CY, Ellingson RJ. 1989. Normal somatosensory evoked potentials in a child in persistent coma.  Pediatr Neurol.. Vol. 5, no. 4. (July): 257-258.
• Tsao CY. 1988. Low-dose Trihexyphenidyl in the Treatment of Dystonia.  Pediatric Neurology.
• Tsao CY. Muscle disease in children.  Pediatrics in review.

• Listed, "Best Doctors in America"
• Nationwide Children’s Hospital Physician of the Year Award, January 2007
• Notable Nationwide Children’s Hospital Employee for Asian Pacific American Heritage Month, May 2007
• Member, Child Neurology Society