Chack-Yung Yu, D.Phil.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Molecular and Human Genetics

Areas of Interest:

• Currently we are investigating the details of gene copy number variations in human autoimmune, neurological and infectious diseases. We are funded by the NIH to study the genetic and clinical risk factors of human systemic lupus erythematosus (SLE). We are a member of the Ohio SLE Study Group that consists of four research teams headed by Dr. Lee Hebert, Dr. Brad Rovin, Dr. Dan Birmingham and Dr. Chack-Yung Yu. Our laboratory is specialized in molecular genetic analyses of human complex diseases. Our lab is recognized for the characterization of the RCCX modules and gene copy number variations of human complement components C4A and C4B. We apply a variety of genotyping and phenotyping techniques in our research projects, which include real-time PCR, genomic restriction fragment length polymorphism, DNA sequencing, pulsed field gel electrophoresis, immunofixation, immunodiffusion and flow cytometry.

Undergraduate

• The Chinese University of Hong Kong
  Date Completed: 06/30/1981

Masters

• The Chinese University of Hong Kong
  Date Completed: 06/30/1983

Doctorate

• Trinity College, Oxford University
  Date Completed: 01/31/1987

Fellowship

• MRC Laboratory of Molecular Biology
  Date Completed: 01/31/1989

2006–present

• Proessor, Department of Pediatrics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University

1991–present

• Faculty Member, Molecular, Cellular and Development Biology Program, The Ohio State University

1990–present

• Principal Investigator, The Research Institute at Nationwide Children's Hospital 

1996–2006

• Associate Professor, Department of Pediatrics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University

1990–1996

• Assistant Professor, Pediatrics, Medical Microbiology and Immunology, The Ohio State University

1987–1990

• Research Fellow and Non-Clinical Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge,U.K. (with Dr. Cesar Milstein, Nobel laureate, C.H., F.R.S.)

1983–1987

• Research Student, Medical Research Council (MRC) Immunochemistry Unit, Oxford University (with the late Prof. Rodney R. Porter, Nobel laureate, C.H., F.R.S. and Dr. R. Duncan Campbell)

• Fu Q; Zhao J; Qian X; Wong JL; Kaufman KM; Yu CY; Mok MY; Harley JB; Guthridge JM; Song YW; Cho SK; Bae SC; Grossman JM; Hahn BH; Arnett FC; Shen N; Tsao BP. 2011. Association of a functional IRF7 variant with systemic lupus erythematosus.  Arthritis And Rheumatism. Vol. 63, no. 3. (March 1): 749.
• Lessard CJ; Adrianto I; Kelly JA; Kaufman KM; Grundahl KM; Adler A; Williams AH; Gallant CJ; Anaya JM; Bae SC; Boackle SA; Brown EE; Chang DM; Criswell LA; Edberg JC; Freedman BI; Gregersen PK; Gilkeson GS; Jacob CO; James JA; Kamen DL; Kimberly RP; Martin J; Merrill JT; Niewold TB; Park SY; Petri MA; Pons-Estel BA; Ramsey-Goldman R; Reveille JD; Song YW; Stevens AM; Tsao BP; Vila LM; Vyse TJ; Yu CY; Guthridge JM; Bruner GR; Langefeld CD; Montgomery C; Harley JB; Scofield RH; Gaffney PM; Moser KL. 2011. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.  American Journal Of Human Genetics. Vol. 88, no. 1. (January 7): 83.
• Atkinson, J.P. and Yu, C.Y. 2011. Genetic Susceptibility and Class III complement Genes. In Systemic Lupus Erythematosus. Fifth ed. Edited by Lahita,R.G., Tsokos,G., Buyon,J., Koike,T. Amsterdam: Academic Press at Elsevier. 21-45.
• Birmingham DJ; Irshaid F; Nagaraja HN; Zou X; Tsao BP; Wu H; Yu CY; Hebert LA; Rovin BH. 2010. The complex nature of serum C3 and C4 as biomarkers of lupus renal flare.  Lupus. Vol. 19, no. 11. (October 1): 1272.
• Soto K; Wu YL; Ortiz A; Aparício SR; Yu CY. 2010. Familial C4B deficiency and immune complex glomerulonephritis.  Clinical Immunology (Orlando, Fla.). Vol. 137, no. 1. (October 1): 166.
• Shen N; Fu Q; Deng Y; Qian X; Zhao J; Kaufman KM; Wu YL; Yu CY; Tang Y; Chen JY; Yang W; Wong M; Kawasaki A; Tsuchiya N; Sumida T; Kawaguchi Y; Howe HS; Mok MY; Bang SY; Liu FL; Chang DM; Takasaki Y; Hashimoto H; Harley JB; Guthridge JM; Grossman JM; Cantor RM; Song YW; Bae SC; Chen S; Hahn BH; Lau YL; Tsao BP. 2010. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 107, no. 36. (September 7): 15838.
• Fernando MM; Boteva L; Morris DL; Zhou B; Wu YL; Lokki ML; Yu CY; Rioux JD; Hollox EJ; Vyse TJ. 2010. Assessment of complement C4 gene copy number using the paralog ratio test.  Human Mutation. Vol. 31, no. 7. (July 1): 866.
• Wu YL; Hauptmann G; Viguier M; Yu CY. 2009. Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosus.  Genes And Immunity. Vol. 10, no. 5. (July 1): 433.
• Saxena K; Kitzmiller KJ; Wu YL; Zhou B; Esack N; Hiremath L; Chung EK; Yang Y; Yu CY. 2009. Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: a comparison of Asian-Indian and European American populations.  Molecular Immunology. Vol. 46, no. 7. (April 1): 1289.
• Hebert LA; Birmingham DJ; Shidham G; Rovin B; Nagaraja HN; Yu CY. 2009. Random spot urine protein/creatinine ratio is unreliable for estimating 24-hour proteinuria in individual systemic lupus erythematosus nephritis patients.  Nephron. Clinical Practice. Vol. 113, no. 3. (January 1): c177.
• Santos PS; Füst G; Prohászka Z; Volz A; Horton R; Miretti M; Yu CY; Beck S; Uchanska-Ziegler B; Ziegler A. 2008. Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex.  Genetic Testing. Vol. 12, no. 4. (December 1): 481.
• Wu H; Birmingham DJ; Rovin B; Hackshaw KV; Haddad N; Haden D; Yu CY; Hebert LA. 2008. D-dimer level and the risk for thrombosis in systemic lupus erythematosus.  Clinical Journal Of The American Society Of Nephrology: CJASN. Vol. 3, no. 6. (November 1): 1628.
• Wu H, Birmingham DJ, Rovin B, Hackshaw KV, Haddad N, Haden D, Yu CY, Hebert LA. 2008. D-dimer level and the risk for thrombosis in systemic lupus erythematosus. Clin J Am Soc Nephrol. Vol. 3, no. 6. (November): 1628-1636. (IF: 2.236)
• Zhang X; Jin M; Wu H; Nadasdy T; Nadasdy G; Harris N; Green-Church K; Nagaraja H; Birmingham DJ; Yu CY; Hebert LA; Rovin BH. 2008. Biomarkers of lupus nephritis determined by serial urine proteomics.  Kidney International. Vol. 74, no. 6. (September 1): 799.
• Cohen RA; Bayliss G; Crispin JC; Kane-Wanger GF; Van Beek CA; Kyttaris VC; Avalos I; Yu CY; Tsokos GC; Stillman IE. 2008. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis.  Clinical Immunology (Orlando, Fla.). Vol. 128, no. 1. (July 1): 1.
• Shontz KM; Zhou B; Yu CY; Su BY. 2008. Cloning and functional analysis of the swine eNOS promoter.  DNA Sequence: The Journal Of DNA Sequencing And Mapping. Vol. 19, no. 1. (February 1): 62.
• Wu YL; Yang Y; Chung EK; Zhou B; Kitzmiller KJ; Savelli SL; Nagaraja HN; Birmingham DJ; Tsao BP; Rovin BH; Hebert LA; Yu CY. 2008. Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus.  Cytogenetic And Genome Research. Vol. 123, no. 1-4. (January 1): 131.
• Birmingham DJ; Rovin BH; Shidham G; Nagaraja HN; Zou X; Bissell M; Yu CY; Hebert LA. 2007. Spot urine protein/creatinine ratios are unreliable estimates of 24 h proteinuria in most systemic lupus erythematosus nephritis flares.  Kidney International. Vol. 72, no. 7. (October 1): 865.
• Wu YL; Savelli SL; Yang Y; Zhou B; Rovin BH; Birmingham DJ; Nagaraja HN; Hebert LA; Yu CY. 2007. Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short, and RCCX modules: elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA genotypes.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 179, no. 5. (September 1): 3012.
• Birmingham DJ; Irshaid F; Gavit KF; Nagaraja HN; Yu CY; Rovin BH; Hebert LA. 2007. A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding.  Molecular Immunology. Vol. 44, no. 14. (July 1): 3510.
• Yang Y; Chung EK; Wu YL; Savelli SL; Nagaraja HN; Zhou B; Hebert M; Jones KN; Shu Y; Kitzmiller K; Blanchong CA; McBride KL; Higgins GC; Rennebohm RM; Rice RR; Hackshaw KV; Roubey RA; Grossman JM; Tsao BP; Birmingham DJ; Rovin BH; Hebert LA; Yu CY. 2007. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.  American Journal Of Human Genetics. Vol. 80, no. 6. (June 1): 1037.
• Auer H; Newsom DL; Nowak NJ; McHugh KM; Singh S; Yu CY; Yang Y; Wenger GD; Gastier-Foster JM; Kornacker K. 2007. Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays.  BMC Genomics. Vol. 8. (April 30): 111.
• Wang L; Lin S; Rammohan KW; Liu Z; Liu JQ; Liu RH; Guinther N; Lima J; Zhou Q; Wang T; Zheng X; Birmingham DJ; Rovin BH; Hebert LA; Wu Y; Lynn DJ; Cooke G; Yu CY; Zheng P; Liu Y. 2007. A dinucleotide deletion in CD24 confers protection against autoimmune diseases.  Plos Genetics. Vol. 3, no. 4. (April 6): e49.
• Wu H; Boackle SA; Hanvivadhanakul P; Ulgiati D; Grossman JM; Lee Y; Shen N; Abraham LJ; Mercer TR; Park E; Hebert LA; Rovin BH; Birmingham DJ; Chang DM; Chen CJ; McCurdy D; Badsha HM; Thong BY; Chng HH; Arnett FC; Wallace DJ; Yu CY; Hahn BH; Cantor RM; Tsao BP. 2007. Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 104, no. 10. (March 6): 3961.
• Birmingham DJ, Irshaid F, Gavit KF, Nagaraja HN, Yu CY, Rovin BH and Hebert LA. 2007. (2007) A polymorphism in the type one complement receptor (CR1) adds a cysteine in the C3b/C4b binding domain that inhibits ligand binding. Molecular Immunology. Vol. 44: 3510-3516.
• Wang L, Lin S, Rammohan KW, Liu Z, Liu J-Q, Liu R-H, Guinther N, Lima J, Shou Q, Wang T, Zheng X, Birmingham DJ, Rovin BH, Hebert LA, Wu Y, Lynn DJ, Cooke G, Yu CY, Zheng P, Liu Y. 2007. (2007) A di-nucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genetics. Vol. 3: 49e1-49e10.
• Yu CY, Hauptmann G, Yang Y, Wu L, Birmingham DJ, Rovin BH, Herbert LA. 2007. Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis. In Systemic Lupus Erythematosus: a Companion to Rheumatology. Edited by Tsokos GC, Gordon C, Smolen JS. Philadelphia, PA: Elsevier.
• Kiszel P, Kovacs M, Szalai C, Yang Y, Pozsonyi E, Blasko B, Laki J, Prohaszka Z, Fazakas A, Panczel P, Hosszufalusi N, Rajczy K, Wu YL, Chung EK, Zhou B, Blanchong CA, Vatay A, Yu CY, Fust G. 2007. Frequency of carriers of 8.1 ancestral haplotype and its fragments in two Caucasian populations. Immunological Investigations. Vol. 36: 307-319.
• Kiszel P; Kovács M; Szalai C; Yang Y; Pozsonyi E; Blaskó B; Laki J; Prohászka Z; Fazakas A; Pánczél P; Hosszúfalusi N; Rajczy K; Wu YL; Chung EK; Zhou B; Blanchong CA; Vatay A; Yu CY; Füst G. 2007. Frequency of carriers of 8.1 ancestral haplotype and its fragments in two Caucasian populations.  Immunological Investigations. Vol. 36, no. 3. (January 1): 307.
• Rovin, B.H., Birmingham, D.J., Nagaraja, H.N., Yu, C.Y., and Hebert, L.A. 2007. Biomarker discovery in human SLE nephritis.  Bull. NYU Hosp. Joint Dis.. Vol. 65. : 187-193.
• Shontz KM, Zhou B, Yu CY, Su BY. 2007. Cloning and functional analysis of the swine eNOS promoter.  DNA Sequence. Vol. 19. : 62-67.
• Rovin BH; Birmingham DJ; Nagaraja HN; Yu CY; Hebert LA. 2007. Biomarker discovery in human SLE nephritis.  Bulletin Of The NYU Hospital For Joint Diseases. Vol. 65, no. 3. (January 1): 187.
• Laki J; Kiszel P; Vatay A; Blaskó B; Kovács M; Körner A; Madácsy L; Blatniczky L; Almássy Z; Szalai C; Rajczy K; Pozsonyi E; Karádi I; Fazakas A; Hosszúfalusi N; Pánczél P; Arason GJ; Wu YL; Zhou B; Yang Y; Yu CY; Füst G. 2007. The HLA 8.1 ancestral haplotype is strongly linked to the C allele of -429T>C promoter polymorphism of receptor of the advanced glycation endproduct (RAGE) gene. Haplotype-independent association of the -429C allele with high hemoglobinA1C levels in diabetic patients.  Molecular Immunology. Vol. 44, no. 4. (January 1): 648.
• Birmingham DJ, Rovin BH, Shidham G, Nagaraja HN, Zou X, Bissell M, Yu CY, Hebert LA. 2007. Spot urine protein/creatinine ratio is an unreliable estimate of 24-hr proteinuria in most SLE nephritis flares. Kidney International. Vol. 72: 865-870.
• Chung, E.K., Wu, Y.L., Yang, Y., Zhou, B. and Yu, C.Y. 2005. Human complement components C4A and C4B: complex genotypes and phenotypes. In Current Protocols in Immunology. Edited by Coligan, J.E., Bierer, B.E., Margulis, D.H., Shevach, E.M. and Strober, W. Edison, NJ: John Wiley & Sons, Inc. 13.8.1-13.8.36.
• Yang, Y., Chung, E.K., Lhotta, K., Wu, Y.L., Higgins, G.C., Rennebohm, R.M., Hebert, L.A., Birmingham, D.J., Rovin, B.H., and Yu, C.Y. 2005. Complement components C4A and C4B in human lupus. In Molecular Autoimmunity. Edited by Zouali, M. New York, USA: Springer. 85-99.
• Yu CY; Whitacre CC. 2004. Sex, MHC and complement C4 in autoimmune diseases.  Trends In Immunology. Vol. 25, no. 12. (December 1): 694.
• Yang, Y., Chung, E.K., Zhou, B., Lhotta, K., Hebert, L.A., Birmingham, D.J., Rovin, B.H. and Yu, C.Y. 2004. The intricate role of complement component C4 in human SLE. In Current Directions in Autoimmunity. Vol. 7. Edited by Tsokos, G.C. Basel: Karger. 98-132.
• Yu, C.Y. and Whitacre, C.C. 2004. Sex, MHC and complement C4 in autoimmune diseases.  Trends Immunol.. Vol. 25. : 694-699.
• Yu CY; Chung EK; Yang Y; Blanchong CA; Jacobsen N; Saxena K; Yang Z; Miller W; Varga L; Fust G. 2003. Dancing with complement C4 and the RP-C4-CYP21-TNX (RCCX) modules of the major histocompatibility complex.  Progress In Nucleic Acid Research And Molecular Biology. Vol. 75. (January 1): 217.
• Yu, C.Y., Blanchong, C.A., Chung, E.K., Rupert, K.L., Yang, Y., Yang, Z., Zhou, B. and Moulds, J.M. 2002. Molecular genetic analyses of human complement components C4A and C4B. In Manual of Clinical Laboratory Immunology. Sixth ed. Edited by Rose, N.R., Hamilton,R.G., Detrick,B. Washington,D.C.: American Society for Microbiology Press. 117-131.
• Martinez OP; Longman-Jacobsen N; Davies R; Chung EK; Yang Y; Gaudieri S; Dawkins RL; Yu CY. 2001. Genetics of human complement component C4 and evolution the central MHC.  Frontiers In Bioscience: A Journal And Virtual Library. Vol. 6. (August 1): D904.
• Yang Z; Qu X; Yu CY. 2001. Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region.  Frontiers In Bioscience: A Journal And Virtual Library. Vol. 6. (August 1): D927.
• Blanchong CA; Chung EK; Rupert KL; Yang Y; Yang Z; Zhou B; Moulds JM; Yu CY. 2001. Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.  International Immunopharmacology. Vol. 1, no. 3. (March 1): 365.
• Birmingham DJ; Rovin BH; Yu CY; Hebert LA. 2001. Of mice and men: the relevance of the mouse to the study of human SLE.  Immunologic Research. Vol. 24, no. 2. (January 1): 211.
• Blanchong, C.A., Chung, E.,Yang, Y. and Yang, Z., Moulds, J.M., and Yu, C.Y. 2001. Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.  Int. Immunopharmacol.. Vol. 1. : 365-392.
• Yang, Z., Qu, X. and Yu, C.Y. 2001. Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region.  Front. Bioscience. Vol. 6. : d927-d935.
• Yung Yu C; Yang Z; Blanchong CA; Miller W. 2000. The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment.  Immunology Today. Vol. 21, no. 7. (July 1): 320.
• Yu CY. 1998. Molecular genetics of the human MHC complement gene cluster.  Experimental And Clinical Immunogenetics. Vol. 15, no. 4. (January 1): 213.
• Yu, C.Y. 1998. Molecular genetics of the MHC complement gene cluster.  Exp. Clin. Immunogenet.. Vol. 15. : 213-230.
• Calabi, F., Yu, C.Y., Bilsland, C.A. and Milstein, C. 1991. CD1: From structure to function. In Current Concepts in Immunogenetics. Edited by Srivastava, R., Ram, B.P. and Tyle, P. New York: VCH Publishers Inc. 215-243.
• Yu CY; Milstein C. 1989. A physical map linking the five CD1 human thymocyte differentiation antigen genes.  The EMBO Journal. Vol. 8, no. 12. (December 1): 3727.
• Calabi, F; Belt, K, T; Yu, C, Y; Bradbury, A; Mandy, W, J; Milstein, C. 1989. The rabbit CD1 and the evolutionary conservation of the CD1 gene family.  Immunogenetics. Vol. 30, no. 5. : 370-7.
• Yu, C.Y. and Milstein, C. 1989. A physical map linking the five CD1 human thymocyte differentiation antigen genes.  EMBO J.. Vol. 8. : 3727-3782.
• Calabi F; Belt KT; Yu CY; Bradbury A; Mandy WJ; Milstein C. 1989. The rabbit CD1 and the evolutionary conservation of the CD1 gene family.  Immunogenetics. Vol. 30, no. 5. (January 1): 370.
• Yu CY; Campbell RD; Porter RR. 1988. A structural model for the location of the Rodgers and the Chido antigenic determinants and their correlation with the human complement component C4A/C4B isotypes.  Immunogenetics. Vol. 27, no. 6. (January 1): 399.
• Rodrigues NR; Dunham I; Yu CY; Carroll MC; Porter RR; Campbell RD. 1987. Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia.  The EMBO Journal. Vol. 6, no. 6. (June 1): 1653.
• Rodrigues N; Dunham I; Yu CY; Carroll MC; Porter RR; Campbell RD. 1987. Structure of the HLA-linked steroid 21-hydroxylase genes.  Biochem Soc Trans. Vol. 5. : 656-657.
• Yu, C, Y; Campbell, R D. 1987. Definitive RFLPs to distinguish between the human complement C4A/C4B isotypes and the major Rodgers/Chido determinants: application to the study of C4 null alleles. Immunogenetics. Vol. 25, no. 6: 383-90.
• Yu CY; Campbell RD. 1987. Sau 3AI polymorphism of human complement C4 and C4d region.  Biochem Soc Trans. Vol. 5. : 654-655.
• Yu CY; Campbell RD. 1987. Definitive RFLPs to distinguish between the human complement C4A/C4B isotypes and the major Rodgers/Chido determinants: application to the study of C4 null alleles.  Immunogenetics. Vol. 25, no. 6. (January 1): 383.
• Rodrigues, N., Dunham, I., Yu, C.Y., Carroll, M.C., Porter, R.R. and Campbell, R.D. 1987. Structure of the HLA-linked steroid 21-hydroxylase Genes. Biochem. Soc. Trans.. Vol. 5: 656-657.
• Yu CY; Belt KT; Giles CM; Campbell RD; Porter RR. 1986. Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.  The EMBO Journal. Vol. 5, no. 11. (November 1): 2873.
• Carroll, M.C., Palsdottir, A., Belt, K.T., and Yu, C.Y. 1986. Molecular genetics of the fourth component of human complement.  Biochem. Soc. Symp.. Vol. 51. : 29-36.
• Carroll MC; Palsdottir A; Belt KT; Yu CY. 1986. Molecular genetics of the fourth component of human complement.  Biochemical Society Symposium. Vol. 51. (January 1): 29.
• Carroll MC; Belt KT; Palsdottir A; Yu Y. 1985. Molecular genetics of the fourth component of human complement and steroid 21-hydroxylase.  Immunological Reviews. Vol. 87. (October 1): 39.
• Yu CY; Mark KK. 1985. Expression of T4 early genes 62, 44, 45 and 46 in the lambda-T4 recombinant phage lambda 806-17.  The Journal Of General Virology. Vol. 66 ( Pt 6). (June 1): 1215.
• Belt KT; Yu CY; Carroll MC; Porter RR. 1985. Polymorphism of human complement component C4.  Immunogenetics. Vol. 21, no. 2. (January 1): 173.
• Belt, K, T; Yu, C, Y; Carroll, M, C; Porter, R R. 1985. Polymorphism of human complement component C4. Immunogenetics. Vol. 21, no. 2: 173-80.
• Dr Chack-Yung Yu. 2000. The Human and Mouse MHC class III region. Presented at OSU Immunology Seminar. Columbus, Ohio. (February 15)
• Dr Chack-Yung Yu. 1998. Genetics and evolution on the MHC-linked complement gene cluster: from C2 to TNX. Presented at VIIth Complement Genetics Workshop and Conference. Mainz, Germany. (May 15)
• Dr Chack-Yung Yu. 2001. Type I Diabetes. Presented at Guest Lecturer, Otterbein College. Columbus, Ohio. (February 15)
• Dr Chack-Yung Yu. 2004. . Presented at 1st International Congress in Clinical and Basic Immunogenomics. Budapest, Hungary. (October 3)
• Dr Chack-Yung Yu. 1999. C4, HERV-K(C4) and primate evolution. Presented at Centre for Molecular Immunology and Instrumentation Retreat. Perth, Australia. (July 15)