Center for Perinatal Research Faculty
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In the Center for Perinatal Research, basic science programs focus on molecular mechanisms of lung development and injury, digestive diseases, infection and inflammation, as well as pulmonary hypertension; with a particular focus on bronchopulmonary dysplasia and necrotizing enterocolitis.
The Center's mission is to prevent premature delivery and to improve the outcomes of critically ill neonates and children through innovative interdisciplinary basic and translational research.
The Ohio Perinatal Research Network (OPRN) is a collaborative among clinicians and scientists from medical and research institutions with the goal of examining risk factors, associated complications and ultimately the prevention of preterm births.
The Neonatal Research Network (NRN) was founded in 1986 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health. The Research Institute at Nationwide Children’s Hospital has joined seventeen other premier research centers across the country that comprise the network. By conducting multi-center clinical studies in neonatal medicine, the NRN is focused on improving care and outcomes for premature infants.
Prematurity is a significant health challenge facing Ohio and part of The Research Institute’s strategic plan because of the following:
Dr. Sudarshan Jadcherla, principal investigator at the Center for Perinatal Research at Nationwide Children’s Hospital, was one of 20 presenters—the only neonatologist—at this year’s Digestive Diseases Week (DDW) selected to highlight his research in a video interview featured on YouTube.[read more...]
In the video above, Dr. Jadcherla discusses his research and the Neonatal and Infant Feeding Disorders Program he leads at Nationwide Children’s Hospital Feeding Enhancement Program.
Dr. Jadcherla's program presented seven abstracts, two at research forums and five at poster sessions. The video interview features one of the abstracts: Innovative Neonatal Feeding Quality Initiative Optimizes Consumption of Drug-Use in the Neonatal Intensive Unit. Abstract authors: Ish K. Gulati, Manish B. Malkar, Shawn M. Pierson, James Dail, Sudarshan R. Jadcherla.
Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor "heparin-binding EGF-like growth factor" (HB-EGF). Dr. Besner works to understand HB-EGF’s ability to protect the intestine from injury.[read more...]
The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates.
Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and the disease necrotizing enterocolitis. Necrotizing enterocolitis results in the destruction of the intestine in newborn babies, especially those born prematurely. Clinical studies are on the horizon to further test HB-EGF as a treatment option.[hide]
Dr. Sudarshan Jadcherla’s research focuses on neonatal feeding disorders. His clinical research works to define the mechanisms of feeding failure and airway compromise in developing infants and to pave the way for evidence-based diagnosis and therapeutic intervention particularly in neonatal dysphagia, gastroesophageal reflux disease and chronic lung disease of infancy.[read more...]
The Small Baby Guidelines (SBGs), developed by the neonatology team at Nationwide Children’s, provide a uniform, interdisciplinary approach to the family-centered care of extremely premature babies.[read more...]
The guidelines outline care regarding development, nutrition, cardiovascular functioning, infection and other potential health concerns during the first week of these infants’ lives. Guidelines included the following sub-headings.
Evaluation of the SBGs can improve patient outcomes and decrease the length of hospitalization. Infants who were treated using SBGs were discharged an average 13 days earlier than infants who were not treated using a unified approach. The research was published in Acta Paediatrica (2009) and was the first published study that examined this particular patient population while covering all aspects of their care. Learn more about the Small Baby Guidelines.[hide]