The Center for Perinatal Research at Nationwide Children’s has a unique, integrative approach to prematurity research that extends before and after birth. In close collaboration with the Section of Neonatology, the mission of faculty in the Center for Perinatal Research is to conduct innovative basic, translational and clinical research focused on prevention of preterm birth and improvement of prematurity-related outcomes.
Principal investigators in the Center for Perinatal Research focus on research aimed at prevention of prematurity and prematurity complications that together achieve the best possible outcomes. Their laboratories use state-of-the-art molecular, basic science and translational approaches to understand the causes, mechanisms and consequences of being born too soon. Several investigators study pregnancy conditions that cause preterm birth such as intrauterine infection; shortened cervix; preterm, premature rupture of the membranes; placental abruption (bleeding); and preeclampsia (a complication of pregnancy characterized by high blood pressure, proteins in urine and other symptoms and problems). Other laboratories focus on prevention and reduction of complications of prematurity including infections, necrotizing enterocolitis, bronchopulmonary dysplasia, pulmonary hypertension, neuro-developmental delay and cerebral palsy.
The Ohio Perinatal Research Network (OPRN) is a collaborative among clinicians and scientists from medical and research institutions with the goal of examining risk factors, associated complications and ultimately the prevention of preterm births.
The Neonatal Research Network (NRN) was founded in 1986 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health. The Research Institute at Nationwide Children’s Hospital has joined seventeen other premier research centers across the country that comprise the network. By conducting multi-center clinical studies in neonatal medicine, the NRN is focused on improving care and outcomes for premature infants.
Prematurity is a significant health challenge facing Ohio and part of The Research Institute’s strategic plan because of the following:
Alpha MED Scientific, Inc. announced Mark Hester, PhD, principal investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children's Hospital, as the first prize recipient of the Travel Award for the 2016 Society of Neuroscience Annual Meeting.[read more...]
Dr. Hester uses the MED64 micro-electrode array (MEA) system to measure electrical activity from human cerebral brain organoids, brain-like structures which are derived from induced pluripotent stem cells (iPSC). The title of his poster is "Utilization of Multi-Electrode Array Technology to Investigate Electrophysiological Properties within Human Cerebral Organoids."
As Dr. Hester describes, "Human cerebral organoids represent a powerful in vitro tool to model human cortical development and can be utilized to gain mechanistic insight into brain disorders." His experiments are the first documented case of MEAs being used to make a functional read-out of multiple different brain regions, all recorded simultaneously. Additionally, Dr. Hester was able to stimulate different regions of the brain organoids and to record elicited signals in neighboring regions.[hide]
Infants presenting with apparent life threatening events (ALTE) are frequently treated for gastroesophageal reflux (GER). Through utilization of pharyngo-esophageal manometry, respiratory inductance plethysmography, and nasal airflow thermistor methods we were able to observe swallow-respiratory junction interactions in infants presenting with ALTE compared to controls. Findings were that ALTE infants have more frequent and prolonged spontaneous respiratory events most frequently associated with dysfunctional swallow-respiratory junction interactions, not GER. Therefore, treatment of ALTE infants should target the proximal aero-digestive tract, unless objective evidence has proven GER.[read more...]
Until recently, predicting the severity of cognitive, motor and behavioral deficits in infants born prematurely was almost impossible. But physicians may now be able to use a highly reliable 3-D MRI imaging technique—developed by a team led by Nehal Parikh, DO, principal investigator in the Center for Perinatal Research—to identify which infants are most at risk.[read more...]
“Developing a reliable and reproducible methodology for studying the premature brain was crucial in order for us to get to the next step: assessing neuroprotective therapies,” said Nehal A. Parikh, DO, senior author on the paper. “Now that we have this protocol, we can improve the standard of care and evaluate efforts to promote brain health within 8 to 12 weeks of beginning the interventions. That way, we can quickly see what really works.” Read press release.[hide]
Preeclampsia is one of the most common hypertensive disorders in pregnancy. And one of the leading causes of maternal and perinatal mortality worldwide. The severe complications from preeclampsia are avoidable through prevention and timely treatment. But the disease is only partially understood. An exact cause is unknown. Its diagnosis made difficult because, often, women do not feel sick. Many signs and symptoms of preeclampsia are also typical of a normal pregnancy: headache, nausea, swelling.
The global health community has called for targeted research of preeclampsia diagnostic screening tools that would allow for appropriate and timely care. A team led by Dr.. Irina Buhimschi, director of the Center for Perinatal Research at Nationwide Children’s Hospital, answered the call. And the answer will lead to best outcomes here and around the world.
“We developed a method of diagnosing and predicting preeclampsia that is innovative, low cost, sustainable and scalable,” said Dr. Buhimschi. The paper-based urine test her team developed enables early diagnosis of preeclampsia, which is characterized by protein in the urine (proteinuria). The test reveals misfolded proteins in the urine through Congo Red—a readily available dye used worldwide in textiles, wood pulp and paper.
The team’s innovative test earned them a grant from the Saving Lives at Birth partnership, which includes the US Agency for International Development (USAID), the Government of Norway, the Bill & Melinda Gates Foundation, Grand Challenges Canada, and the UK’s Department for International Development.
The partnership received more than 400 entries in response to their Grand Challenge for Development. Fifty three were shortlisted. Twenty two were awarded grants. Dr. Buhimschi’s team was one of four to receive a transition-to-scale grant (up to $2 million for four years) aimed to grow bold new ideas to save the lives of mothers and newborns in developing countries.
Team collaborators included Dr. Catalin Buhimschi (Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center), Dr. Hemant Tagare and Dr. Michael Choma (Yale University School of Medicine), Dr. Robert Pattinson and Dr. Pedro Mulder (University of Pretoria, South Africa), Dr. Thomas Easterling (University of Washington, Seattle), Dr. Hillary Bracken and Dr. Beverly Winikoff (Gynuity Health Projects).[hide]
Dr. Sudarshan Jadcherla, principal investigator at the Center for Perinatal Research at Nationwide Children’s Hospital, was one of 20 presenters—the only neonatologist—at this year’s Digestive Diseases Week (DDW) selected to highlight his research in a video interview featured on YouTube.[read more...]
In the video above, Dr. Jadcherla discusses his research and the Neonatal and Infant Feeding Disorders Program he leads at Nationwide Children’s Hospital Feeding Enhancement Program.
Dr. Jadcherla's program presented seven abstracts, two at research forums and five at poster sessions. The video interview features one of the abstracts: Innovative Neonatal Feeding Quality Initiative Optimizes Consumption of Drug-Use in the Neonatal Intensive Unit. Abstract authors: Ish K. Gulati, Manish B. Malkar, Shawn M. Pierson, James Dail, Sudarshan R. Jadcherla.[hide]
Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor "heparin-binding EGF-like growth factor" (HB-EGF). Dr. Besner works to understand HB-EGF’s ability to protect the intestine from injury.[read more...]
The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates.
Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and the disease necrotizing enterocolitis. Necrotizing enterocolitis results in the destruction of the intestine in newborn babies, especially those born prematurely. Clinical studies are on the horizon to further test HB-EGF as a treatment option.[hide]
Dr. Sudarshan Jadcherla’s research focuses on neonatal feeding disorders. His clinical research works to define the mechanisms of feeding failure and airway compromise in developing infants and to pave the way for evidence-based diagnosis and therapeutic intervention particularly in neonatal dysphagia, gastroesophageal reflux disease and chronic lung disease of infancy.[read more...]
The Small Baby Guidelines (SBGs), developed by the neonatology team at Nationwide Children’s, provide a uniform, interdisciplinary approach to the family-centered care of extremely premature babies.[read more...]
The guidelines outline care regarding development, nutrition, cardiovascular functioning, infection and other potential health concerns during the first week of these infants’ lives. Guidelines included the following sub-headings.
Evaluation of the SBGs can improve patient outcomes and decrease the length of hospitalization. Infants who were treated using SBGs were discharged an average 13 days earlier than infants who were not treated using a unified approach. The research was published in Acta Paediatrica (2009) and was the first published study that examined this particular patient population while covering all aspects of their care. Learn more about the Small Baby Guidelines.[hide]
Center for Perinatal Research Faculty
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