The BCR is a CAP-accredited laboratory and biorepository within the Biopathology Center (BPC) at Nationwide Children's Hospital.
The Biospecimen Core Resource (BCR) is a CAP-accredited laboratory and biorepository within the Biopathology Center (BPC) at Nationwide Children’s Hospital. The BCR supports multiple cancer genomics projects such as The Cancer Genome Atlas (TCGA), Cancer Driver Discovery Project (CDDP), HIV+ Tumor Molecular Characterization Project (HTMCP) and Burkitt Lymphoma Genome Sequencing Project (BLGSP), Therapeutically Applicable Research to Generate Effective Treatments (TARGET), Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials (ALCHEMIST) and Exceptional Responders (ER) Initiative.
Nationwide Children’s Hospital was selected to serve as the BCR for The Cancer Genome Atlas (TCGA) because of the Biopathology Center's reputation for quality biobanking and tissue processing. Due to the modularity of the BCR’s system and high quality output, the BCR expanded into projects such as HTMCP and BLGSP, and newer projects for the Center for Cancer Genomics. More than 20 years ago, pediatric cancer pathologist Stephen J. Qualman, MD, was ahead of his time in realizing the importance of developing biobanking as a scientific discipline. A sophisticated, high-quality biobanking effort has existed at Nationwide Children’s since the late 1980s, and now serves as the biorepository for three of the National Cancer Institute’s (NCI) Cooperative Cancer Groups: Children’s Oncology Group (COG), NRG Oncology (NRG)*, and SWOG (formerly Southwest Oncology Group). The BPC also serves as a centralized clinical reference laboratory for COG, performing testing to assign patients to risk-based therapies.
*NRG Oncology is a collaborative group of the National Surgical Adjuvant Breast and Bowell Project (NSABP), Radiation Therapy Oncology Group (RTOG) and Gynecologic Oncology Group (GOG).