Biopathology Center

Positively Impacting Patient Care Through Management of High Quality Annotated Biospecimens

Biopathology Center

The Biopathology Center (BPC) is part of the Abigail Wexner Research Institute at Nationwide Children’s Hospital (AWRI) and provides a full range of services related to biospecimen procurement, processing banking, and distribution. The BPC is accredited by the College of American Pathologists Laboratory and Biorepository Accreditation Programs (CAP LAP, CAP BAP).

Our Mission

The mission of the Biopathology Center is to support cutting-edge research and positively impact patient care through the procurement, processing, banking, and distribution of high-quality clinically-annotated biospecimens.

In 2021, Nationwide Children’s Hospital announced their new strategic plan: Leading the Journey to Best Outcomes for Children Everywhere, focusing on integrated care and research.  

The Biopathology’s strategic plan is focused on Operational Excellence, Quality and Safety, Culture and Talent, Partnerships, and Technology.

Learn more about the Biopathology Center at Nationwide Children's

Our Facility

The BPC facility includes space for biospecimen accessioning, processing, and testing laboratories and biorepository space for biospecimen distribution and storage.

Meet the Biopathology Center Team

Nationwide Children's Hospital Medical Professional

Nilsa Del Carmen Ramirez Milan

Nilsa C. Ramirez, MD, is a board-certified anatomic pathologist with subspecialty training in gynecologic pathology and expertise in perinatal and obstetrical pathology, as well as in biobanking in the context of adult and pediatric cancer clinical trials. She is a member of the Department of Pathology and Laboratory Medicine at Nationwide Children’s and Director of the Biopathology Center, housed at the Abigail Wexner Research Institute at Nationwide Children's.

Nationwide Children's Hospital Medical Professional

Diana L. Thomas

Diana Thomas, MD, PhD, is an attending neuropathologist in the Department of Pathology and Lab Medicine at Nationwide Children’s Hospital and the director of Digital Pathology where she leads the Nationwide Children's Enterprise Digital Pathology Program. She also serves as the Pathology operations director of the Biopathology Center and the medical director of the Abigail Wexner Research Institute Histopathology Core.

Services We Offer

The Biopathology Center offers a wide range of services related to the procurement, processing, banking, and distribution of biospecimens in support of research, including access to specialized BPC-based services (e.g., biomedical imaging [virtual microscopy/digital pathology], informatics, and kit management) and centralized shared Nationwide Children's Hospital based research resources.

Laboratory Services

Standard operating procedures and best practices, biospecimen processing and pathology review and laboratory services

Biorepository

Biospecimen storage and biospecimen distribution

Other Services

Protocol development, biospecimen kits and informatics

Affiliations and Collaborations

The Biopathology Center (BPC) aims to excel in the long-term acquisition and storage of cancer-related tissue specimens and associated data to support cutting-edge research. Primarily government-funded, the BPC partners with various research organizations to establish a robust infrastructure to support excellence in tissue banking, testing and distribution. Partnering investigators include those from the Abigail Wexner Research Institute at Nationwide Children’s Hospital and national cooperative cancer groups and research organizations.

The BPC houses several National Cancer Institute (NCI) funded biospecimen collection efforts, including:

  • Children’s Oncology Group (COG)
  • NRG Oncology Biospecimen Bank-Columbus (formerly the Gynecologic Oncology Group Tissue Bank)
  • SWOG (formally known as the Southwest Oncology Group)
  • Early-Phase and Experimental Clinical Trials (EET) Biobank
  • Pediatric Division of the Cooperative Human Tissue Network (CHTN) For more details click here (go to document)
  • Biospecimen Core Resource (BCR) of the NCI Center for Cancer Genomics

The BPC stores numerous biospecimen collections supported by other sponsors including:

  • Nationwide Children’s Hospital Funded Investigators
  • Sarcoma Alliance for Research through Collaboration (SARC) Foundation
  • Gynecologic Oncology Group (GOG) Foundation
  • Childhood Cancer Survivor Study (CCSS)
  • Leukemia and Lymphoma Society (LLS)
  • Dilated Cardiomyopathy (DCM) Consortium

Request Specimens

The BPC works with several cooperative groups which all require specific applications and paperwork to be submitted during the approval process. In order to access specimens from the Biopathology Center, an application will need to be completed for the cooperative group from which you wish to receive specimens. The application will provide the cooperative group your contact information and the specific specimens being requested.

To access specimens from the Biopathology Center, the following steps are needed:

  1. An application will need to be completed for the cooperative group from which you wish to receive specimens.
  2. The application will provide the cooperative group your contact information and the specific specimens being requested.
  3. The following links give additional information about the approval processes and paperwork for each cooperative group:
  4. *Requests routed through National Clinical Trials Network (NCTN) Navigator

    To request specimens from cooperative groups not listed above or for questions regarding the application process please contact us at BPC@NationwideChildrens.org.

    Additional Research Groups to Explore

Join the Biopathology Center Team

The team at the Biopathology Center is growing. Click the links below to view current job listings and to learn more about careers at Nationwide Children’s Hospital.

View Open Job Listings

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