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Laboratory Test Directory

Methylmalonic Acid, Serum or Plasma (Vitamin B12 Status)

Components

Name Method Department Units
Methylmalonic Acid, B12 Status Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Send Out umol/L

Specimen Requirements

Serum Spun, Plasma Spun

Container Type Container Size Specimen Volume
Preferred

Red tube, (no anticoagulant), No Gel

6 mL 2 mL
Alternate

Gold tube, (SST) with Gel

3.5 mL 2 mL
Alternate

Purple tube (EDTA)

4 mL 2 mL
Alternate

Green tube (Sodium heparin), No Gel

6 mL 2 mL
Alternate

Red Tube (no anticoagulant) with Gel

3 mL 2 mL
Alternate

Green tube (Lithium heparin), No Gel

6 mL 2 mL
Alternate

Green tube (Lithium heparin), with Gel

3 mL 2 mL
Stability

Frozen - 1 month(s)
Refrigerated - 1 week(s)

Specimen Preparation

  • Centrifuge within 2 hours, separate supernatant and freeze

Reasons for Rejection

  • Room temperature receipt
  • Gross hemolysis
  • Lipemic specimen

Comments

This test is specific for the evaluation of Vitamin B-12 deficiency. Metabolic disorder testing associated with Methylmalonic acid should be tested by the in house test PMMA.

CPT Code

  • 83921