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Laboratory Test Directory

Maternal Cell Contamination (MCC) Study


Name Method Department Units
Maternal Cell Contamination (MCC) Study Capillary electrophoresis
Polymerase chain reaction (PCR)
Microsatellite analysis
DNA extraction
Molecular Genetics

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume

Purple tube (EDTA)

4 mL 4 mL-8 mL

Room temperature - 24 hour(s)
Refrigerated - 72 hour(s)

Specimen Preparation

  • Do not freeze
  • Do not centrifuge

Reasons for Rejection

  • Clotted specimen
  • Frozen specimen
  • Wrong collection tube
  • Delayed or improper handling


Primarily used in conjunction with molecular genetic testing performed on prenatal specimen (e.g. amniotic fluid) or on products of conception specimen (e.g. placental or fetal tissue). Maternal cell contamination study can also be performed on products of conception specimen to evaluate for a potential molar pregnancy. In order to perform maternal cell contamination study, maternal blood sample in EDTA tube must be submitted in addition to the prenatal or products of conception specimen. Submission of completed Genetic Test Requisition Form is required, and submission of informed consent form is recommended. Please complete Prenatal Genetic Test Requisition Form if submitting amniotic fluid sample from on-going pregnancy, and please complete Products of Conception Test Requisition Form if submitting amniotic fluid or placental/fetal tissue specimen from pregnancy loss. For further questions, please call (614) 722-5321 and ask to speak to a laboratory genetic counselor to make arrangements.


Lab Form

CPT Code

  • 81265 (and 81266 if additional prenatal/POC tissue source tested)