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Laboratory Test Directory

Maternal Cell Contamination (MCC) Study


Name Method Department Units
Maternal Cell Contamination (MCC) Study Capillary electrophoresis
Polymerase chain reaction (PCR)
Microsatellite analysis
DNA extraction
Molecular Genetics

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume

Purple tube (EDTA)

6 mL 3 mL-6 mL

Room temperature - 24 hour(s)
Refrigerated - 72 hour(s)

Specimen Preparation

  • Do not freeze
  • Do not centrifuge

Reasons for Rejection

  • Clotted specimen
  • Frozen specimen
  • Wrong collection tube
  • Delayed or improper handling


Submission of a completed Genetic Test Requisition Form is required - please complete Prenatal Genetic Test Requisition Form if submitting amniotic fluid sample from on-going pregnancy, and please complete Products of Conception Test Requisition Form if submitting amniotic fluid or placental/fetal tissue specimen from a pregnancy loss. Submission of informed consent form is recommended but not required. For further questions, please call (614) 722-5321 and ask to speak to a laboratory genetic counselor to make arrangements.

This test is primarily performed in conjunction with another molecular genetic testing performed on prenatal specimen (e.g. amniotic fluid) or on products of conception specimen (e.g. placental or fetal tissue). This test may also be used to evaluate for a potential molar pregnancy in products of conception specimen. In order to perform maternal cell contamination study, maternal blood sample in EDTA tube must be submitted in addition to the amniotic fluid specimen or products of conception specimen. 

PLEASE NOTE:  For Prenatal Microarray Analyses, maternal cell contamination is required and included in the Prenatal Microarray Analysis charge and no separate test order for maternal cell contamination is needed. 


Lab Form

CPT Code

  • 81265 (and 81266 if additional prenatal/POC tissue source tested)