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Laboratory Test Directory

Aneuploidy Screen by FISH, Neonatal / Postnatal


Name Method Department Units
Aneuploidy by FISH (Neonatal) Fluorescence in situ hybridization (FISH)

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume

Green tube (Sodium heparin), No Gel

3 mL 3 mL

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not centrifuge
  • Do not freeze
  • Transport to laboratory as soon as possible
  • Keep at room temperature

Reasons for Rejection

  • Wrong collection tube
  • Frozen specimen
  • Centrifuged specimen
  • Clotted specimen
  • Serum sample


Submission of a completed Genetic Test Requisition Form is required. Please call Cytogenetics Lab at (614) 722-5321 to obtain the form. Physician MUST call the Cytogenetics Lab prior to sending specimen. Testing not performed on weekends; if weekend reporting is required, please call the lab before sending a specimen to discuss weekend reporting option.

This test evaluates uncultured interphase cells for numerical abnormalities of chromosomes 13,18, X, and Y and is used to screen for common numerical chromosome abnormalities such as trisomy 13, trisomy 18, monosomy X (Turner syndrome), triploidy and tetraploidy. This test is performed only in conjunction with chromosome analysis.

Please Note: this test does not screen for aneuploidy of chromosome 21 (e.g. Trisomy 21 / Down syndrome). If the patient is suspected to have trisomy 21, please consider the alternate test called "STAT Chromosome Analysis (test code: STATPB)," which is performed on peripheral blood specimen, has the same result turn-around-time (2 days) as this test, and can evaluate for numerical abnormalities for all chromosomes including chromosome 21.

CPT Code

  • 88275
  • 88271 (x4)