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Laboratory Test Directory

Aneuploidy Screen by FISH, Neonatal / Postnatal (Updated)


Name Method Department Units
Aneuploidy by FISH (Neonatal) Fluorescence in situ hybridization (FISH)

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume

Green tube (Sodium heparin), No Gel

3 mL 3 mL

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not centrifuge
  • Do not freeze
  • Transport to laboratory as soon as possible
  • Keep at room temperature

Reasons for Rejection

  • Wrong collection tube
  • Frozen specimen
  • Centrifuged specimen
  • Clotted specimen
  • Serum sample


Submission of a completed Genetic Test Requisition Form is required. Please call Cytogenetics Lab at (614) 722-5321 to obtain the form. Physician MUST call the Cytogenetics Lab prior to sending specimen. Testing not performed on weekends; if weekend reporting is required, please call the lab before sending a specimen to discuss weekend reporting option.

This test evaluates uncultured interphase cells for numerical abnormalities of chromosomes 13,18, X, and Y and is used to screen for common numerical chromosome abnormalities such as trisomy 13, trisomy 18, monosomy X (Turner syndrome), triploidy and tetraploidy. This test is performed only in conjunction with chromosome analysis.

Please Note: this test does not screen for aneuploidy of chromosome 21 (e.g. Trisomy 21 / Down syndrome). If the patient is suspected to have trisomy 21, please consider the alternate test called "STAT Chromosome Analysis (test code: STATPB)," which is performed on peripheral blood specimen, has the same result turn-around-time (2 days) as this test, and can evaluate for numerical abnormalities for all chromosomes including chromosome 21.

CPT Code

  • 88275
  • 88271 (x4)