Loren E. Wold, Ph.D.

Research Center:

• Center for Cardiovascular and Pulmonary Research

Areas of Interest:

• My research is based on how cardiovascular function is affected by different disease states, including diabetes, obesity and hypertension. My laboratory uses isolated heart and isolated myocyte preparations to study the organ at the tissue and cell level, with endpoints including real-time function, intracellular calcium concentration and intracellular reactive oxygen species (ROS) signaling. I have also recently become interested in how the heart responds to environmental stressors, including smog.

Undergraduate School

• Boston University
  Date Completed: 06/30/1997

Medical School

• University of North Dakota School of Medicine and Health Sciences
  Date Completed: 06/30/2000

Post Doctoral

• University of North Dakota School of Medicine and Health Sciences
  Date Completed: 06/30/2003

2012–present

• Associate Professor (tenured) – Department of Pediatrics, The Ohio State University, Columbus, OH

2012–present

• Adjunct Associate Professor – Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH

2009–present

• Participating Faculty, Medical Scientist Program, The Ohio State University College of Medicine, Columbus, OH

2009–present

• Fellow, The American Heart Association

2008–present

• Investigator - The Dorothy M. Davis Heart and Lung Research Institute, Myocyte Biology Program, The Ohio State University College of Medicine, Columbus, OH

2007–present

• Faculty – Integrated Biomedical Graduate Program, The Ohio State University, Columbus, OH

2006–present

• Faculty, Integrated Biomedical Graduate Program, The Ohio State University College of Medicine, Columbus OH

2006–present

• Principal Investigator – Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Columbus, OH

2009–2012

• Assistant Professor (tenure track) – Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH

2008–2012

• Adjunct Assistant Professor, Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH

2006–2012

• Assistant Professor, Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus OH

2006–2009

• Research Assistant Professor - Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH

2005–2006

• Instructor – Department of Pharmacology, University of New England, Biddeford, ME

2005–2006

• Instructor, Department of Biochemistry, University of New England College of Osteopathic Medicine, Biddeford, ME

2005–2006

• Senior Research Associate, Department of Pharmacology, University of New England College of Osteophathic Medicine, Biddeford, ME

2003–2005

• Cardiology Research Fellow, The Heart Institute, Good Samaritan Hospital and Keck School of Medicine, University of Southern California, Los Angeles, CA

1998–2003

• Graduate Research Assistant – Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, Grand Forks, ND

• Gardner,J,D; Murray,D,B; Wold,L,E. 2013. Cardiac dysfunction in diabetes.  Life sciences. Vol. 92, no. 11. (March): 599-600.
• Backes,Carl,H; Nelin,Timothy; Gorr,Matthew,W; Wold,Loren,E. 2013. Early life exposure to air pollution: How bad is it?.  TOXICOLOGY LETTERS. Vol. 216, no. 1. (January): 47-53.
• Lucchesi P.A., Hutchinson K.R., Martins L. and L.E. Wold. 2012. Development of myocardial structure and function. In Moss and Adams Pediatric Cardiology. 8 ed. Edited by Allen H., Driscoll D.J., Shaddy R and Feltes T.. Philadelphia, PA: Lippincott Williams & Wilkins.
• Wold,Loren,E; Lucchesi,Pamela,A; Schaffer,Stephen,W. 2012. Vascular dysfunction in diabetes.  VASCULAR PHARMACOLOGY. Vol. 57, no. 5-6. (November): 131-132.
• Wold L.E., Ying Z., Hutchinson K.R., Velten M., Gorr M.W., Velten C., Youtz D.J., Wang A., Lucchesi P.A., Sun Q. and S. Rajagopalan. 2012. Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution.  Circulation: Heart Failure. Vol. 5, no. 4. (July): 452-461.
• Gorr,Matthew,W; Stevens,Sarah,CW; Wold,Loren,E. 2012. Ataxia telangiectasia mutated kinase in the heart: currency for myocyte apoptosis.  EXPERIMENTAL PHYSIOLOGY. Vol. 97, no. 4. (April): 476-476.
• Nelin TD; Joseph AM; Gorr MW; Wold LE. 2012. Direct and indirect effects of particulate matter on the cardiovascular system.  Toxicology Letters. Vol. 208, no. 3. (February): 293-299.
• Velten M; Hutchinson KR; Gorr MW; Wold LE; Lucchesi PA; Rogers LK. 2011. Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice.  PLoS ONE. Vol. 9, no. 6. (September): ee24544.
• Hua Y; Zhang Y; Ceylan-Isik AF; Wold LE; Nunn JM; Ren J. 2011. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy.  Basic Research in Cardiology.
• Murray DB; Gardner JD; Wold LE. 2011. Call for papers: special issue on cardiac dysfunction in diabetes.  Life Sciences. Vol. 11-12, no. 89. (August): e415.
• Zuo L; Youtz DJ; Wold LE. 2011. Particulate matter exposure exacerbates high glucose-induced cardiomyocyte dysfunction through ROS generation.  PLoS ONE. Vol. 8, no. 6. (August): ee23116.
• Mishra R; Vijayan K; Colletti EJ; Harrington DA; Matthiesen TS; Simpson D; Goh SK; Walker BL; Almeida-Porada G; Wang D; Backer CL; Dudley SC Jr; Wold LE; Kaushal S. 2011. Characterization and functionality of cardiac progenitor cells in congenital heart patients.  Circulation. Vol. 123, no. 4. (February): 364-373.
• Xu H; Crawford D; Hutchinson KR; Youtz DJ; Lucchesi PA; Velten M; McCarthy DO; Wold LE. 2011. Myocardial dysfunction in an animal model of cancer cachexia.  Life Sciences. Vol. 88, no. 9-10. (February): 406-410.
• Monreal G; Youtz DJ; Phillips AB; Eyman ME; Gorr MW; Velten C; Lucchesi PA; Wold LE; Gerhardt MA. 2010. Right ventricular remodeling in restrictive ventricular septal defect.  Journal Of Molecular And Cellular Cardiology. Vol. 49, no. 4. (October): 699-706.
• Ren J, Dong F, Zhao P, Wold LE, Pei J. 2010. Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling.  PLoS ONE. Vol. 5, no. 4. (April): ee10085.
• Kaushal S, Wold LE. 2010. Invited Commentary on: Marrow stromal cells for cell-based therapy: the role of antiinflammatory cytokines in cellular cardiomyoplasty.  Annals of Thoracic Surgery. Vol. 90, no. January: 197-198.
• Sun Q, Hong X, Wold LE. 2010. Cardiovascular effects of ambient particulate air pollution exposure.  Circulation. Vol. 121, no. 25. (January): 2755-2765.
• Xu X, Kherada N, Hong X, Quan C, Zheng L, Wang A, Wold LE, Lippmann M, Chen LC, Rajagopalan S, Sun Q. 2009. Diesel exhaust exposure induces angiogenesis.  Toxicological Letters. Vol. 191, no. 1. (January): 57-68.
• Youtz DJ, Wold LE. 2009. The role of aldehyde dehydrogenase-2 in alcoholic liver disease.  Clinical and Experimental Pharmacology and Physiology. Vol. 36, no. January: e462.
• Kaushal S, Bouchard CP, Wold LE. 2009. Myocardial oxygenation is critical for improving regeneration capacity.  American Journal of Physiology - Heart and Circulatory Physiology. Vol. 296, no. January: H1215-H1216.
• Kaushal S, Jacobs JP, Gossett JG, Steele A, Steele P, Davis CR, Pahl E, Vijayan K, Asante-Korang A, Boucek RJ, Backer CL, Wold LE. 2009. Innovation in basic science: stem cells and their role in the treatment of paediatric cardiac failure - opportunities and challenges.  Cardiology in the Young. Vol. 19, no. Suppl 2. (January): 74-84.
• Dhanasekaran M, Karuppagounder SS, Uthayathas S, Wold LE, Parameshwaran K, Babu RJ, Suppiramaniam V, Brown-Borg HM. 2008. Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content.  Life Sciences. Vol. 83, no. January: 92-95.
• Ceylan-Isik AF, Fliethman RM, Wold LE, Ren J. 2008. Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus.  Curr Diabetes Reviews. Vol. 4, no. January: 320-328.
• Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. 2008. Necrotizing enterocolitis in neonates with congenital heart disease.  Life Sciences. Vol. 82, no. January: 341-347.
• Wold LE, Dai W, Dow JS, Kloner RA. 2008. Stem cell therapy in the heart and vasculature. In Methods in Molecular Medicine. Edited by Sreejayan N, Ren J. Totowa, NJ: Humana Press.
• Monreal G, Nicholson LM, Han B, Joshi MS, Phillips AB, Wold LE, Bauer JA, Gerhardt MA. 2008. Cytoskeletal remodelling of desmin is a more accurate measure of cardiac dysfunction than fibrosis or myocyte hypertrophy.  Life Sciences. Vol. 83, no. January: 786-794.
• Wold LE, Ren J. 2008. Mechanical measurement of contractile function of theisolated ventricular myocyte. In Methods in Molecular Medicine. Edited by Sreejayan N. and Ren J. Totawa, NJ: Humana Press.
• Ren J, Wold LE. 2008. Mechanisms of alcoholic heart disease.  Therapeutic Advances in Cardiovascular Disease. Vol. 2, no. 6. (January): 497-506.
• Saari JT, Wold LE, Duan J, Ren J, Carlson HL, Bode AM, Lentsch AB, Zeng H, Schuschke DA. 2007. Cardiac nitric oxide synthases are elevated in dietary copper deficiency.  Journal of Nutritional Biochemistry. Vol. 18, no. 7. (January): 443-448.
• Wold LE, Ceylan-Isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J. 2006. Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of Ca(2+) cycling proteins, NADPH oxidase, Poly(ADP-Ribose) polymerase and myosin heavy chain isozyme.  Free Radical Biology and Medicine. Vol. 40, no. 8. (January): 1419-1429.
• Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. 2006. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias.  Cardiovascular Toxicology. Vol. 6, no. 1. (January): 69-78.
• Nordlie MA, Wold LE, Simkhovich BZ, Sesti C, Kloner RA. 2006. Molecular aspects of ischemic heart disease: Ischemia/reperfusion-induced genetic changes and potential applications of gene and RNAi therapy.  Journal of Cardiovascular Pharmacology and Therapeutics. Vol. 11, no. 1. (January): 17-30.
• Dai W, Hale SL, Martin BJ, Kuang J-Q, Dow JS, Wold LE, Kloner RA. 2005. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects.  Circulation. Vol. 112, no. 2. (January): 214-223.
• Dai W, Wold LE, Dow JS, Kloner RA. 2005. Thickening of the infarcted wall by collagen injection improves left ventricular function in rats: a novel approach to preserve cardiac function after myocardial infarction.  Journal of the American College of Cardiology. Vol. 46, no. 4. (January): 714-719.
• Wold LE, Aberle NA II, Ren J. 2005. Doxorubicin induces cardiomyocyte dysfunction via an oxidative stress mechanism.  Cancer Detectection and Prevention. Vol. 29, no. 3. (January): 294-299.
• Dong F, Zhang X, Wold LE, Ren Q, Zhang Z, Ren J. 2005. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: Role of ETB receptor, NADPH oxidase and caveolin-1.  British Journal of Pharmacology. Vol. 145, no. 3. (January): 323-333.
• Nordlie MA, Wold LE, Kloner RA. 2005. Genetic contributors toward increased risk for ischemic heart disease.  Journal of Molecular and Cellular Cardiology. Vol. 39, no. 4. (January): 667-679.
• Wold LE, Ceylan-Isik AF, Ren J. 2005. Oxidative stress and stress signalling: menace of diabetic cardiomyopathy.  Acta Pharmacologica Sinica. Vol. 26, no. 8. (January): 908-917.
• Wold LE, Dutta K, Mason MM, Ren J, Cala SE, Schwanke ML, Davidoff AJ. 2005. Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats.  Journal of Molecular and Cellular Cardiology. Vol. 39, no. 2. (January): 297-307.
• Davidoff AJ, Mason MM, Davidson MB, Carmody MW, Hintz KK, Wold LE, Podolin DA, Ren J. 2004. Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments.  American Journal of Physiology - Endocrinology and Metabolism. Vol. 286, no. 5. (January): E718-E724.
• Wold LE, Dai W, Sesti C, Hale SL, Dow JS, Martin BJ, Kloner RA. 2004. Stem cell therapy for the heart.  Congestive Heart Failure. Vol. 10, no. 6. (January): 293-301.
• Ren J, Porter JE, Wold LE, Aberle II NS, Muralikrishnan D, Haselton JR. 2004. Depressed contractile function and adrenergic responsiveness of cardiac myocytes in an experimental model of Parkinson disease, the MPTP-treated mouse.  Neurobiology of Aging. Vol. 25, no. 1. (January): 131-138.
• Wold LE, Ren J. 2004. Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism.  Biochemical and Biophysical Research Communications. Vol. 318, no. 4. (January): 1066-1071.
• Klein AL, Wold LE, Ren J. 2004. The cyclooxygenase-2 product prostaglandin E2 modulates cardiac contractile function in adult rat ventricular cardiomyocytes.  Pharmacological Research. Vol. 49, no. 2. (January): 99-103.
• Privratsky JR, Wold LE, Sowers JR, Quinn MT, Ren J. 2003. AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: Role of the AT1 receptor and NADPH oxidase.  Hypertension. Vol. 42, no. 2. (January): 206-212.
• Wold LE, Muralikrishnan D, Albano CB, Norby FL, Ebadi M, Ren J. 2003. Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q-9 and Q-10.  Acta Diabetologica. Vol. 40, no. 2. (January): 85-90.
• Ren J, Roughead ZK, Wold LE, Norby FL, Rakoczy S, Mabey RL, Brown-Borg HM. 2003. Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats.  Pharmacological Research. Vol. 47, no. 4. (January): 341-347.
• Norby FL, Wold LE, Duan J, Hintz KK, Ren J. 2002. IGF-1 attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes.  American Journal of Physiology - Endocrinology and Metabolism. Vol. 283, no. 4. (January): E658-E666.
• Wold LE, Relling DP, Duan J, Norby FL, Ren J. 2002. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: Role of Jak/STAT pathway.  Hypertension. Vol. 39, no. 1. (January): 69-74.
• Ren J, Wold LE, Natavio M, Ren BH, Hannigan JH, Brown RA. 2002. Influence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: Role of intracellular calcium and apoptosis.  Alcohol and Alcoholism. Vol. 37, no. 1. (January): 30-37.
• Hintz KK, Wold LE, Colligan PB, Scott GI, Lee KJ, Sowers JR, Ren J. 2001. Influence of ovariectomy on ventricular myocyte contraction in simulated diabetes.  Journal of Biomedical Science. Vol. 8, no. 4. (January): 307-313.
• Wold LE, Saari JT, Ren J. 2001. Isolated ventricular myocytes from copper-deficient rat hearts exhibit enhanced contractile function.  American Journal of Physiology - Heart and Circulatory Physiology. Vol. 281, no. 2. (January): H476-H481.
• Wold LE, Relling DP, Colligan PB, Scott GI, Hintz KK, Ren BH, Epstein PN, Ren J. 2001. Characterization of contractile function in diabetic hypertensive cardiomyopathy in adult rat ventricular myocytes.  Journal of Molecular and Cellular Cardiology. Vol. 33, no. 9. (January): 1719-1726.
• Ren J, Wold LE. 2001. Measurement of cardiac mechanical function in isolated ventricular myocytes from rats and mice by computerized video-based imaging.  Biological Procedures Online. Vol. 3, no. 1. (January): 43-53.
• Wold LE, Norby FL, Hintz KK, Colligan PB, Epstein PN, Ren J. 2001. Prenatal ethanol exposure alters ventricular myocyte contractile function in the offspring of rats: Influence of maternal Mg2+ supplementation.  Cardiovascular Toxicolology. Vol. 1, no. 3. (January): 215-224.
• Ren J, Wold LE, Epstein PN. 2000. Diabetes enhances acetaldehyde-induced depression of cardiac myocyte contraction.  Biochemical and Biophysical Research Communications. Vol. 269, no. 3. (January): 697-703.
• Nickola MW, Wold LE, Colligan PB, Wang GJ, Samson WK, Ren J. 2000. Leptin attenuates cardiac contraction in rat ventricular myocytes: Role of NO.  Hypertension. Vol. 36, no. 4. (January): 501-505.