Joy Lincoln :: Nationwide Children's Hospital, Columbus, Ohio

Joy Lincoln, PhD

Joy  Lincoln, PhD

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus , OH 43205 [ map ]
Assistant: (614) 722-5152

Biography

Joy Lincoln, PhD, is a Principal Investigator in The Center for Cardiovascular and Pulmonary Research at Nationwide Children's Hospital and Associate Professor in the Department of Pediatrics at The Ohio State University. Dr. Lincoln's funded research is focused on understanding mechanisms of embryonic heart development and congenital heart disease.

View CV »

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • My laboratory focuses on understanding the molecular mechanisms that regulate normal heart formation in the embryo and identifying developmental origins of adult cardiovascular disease. Development of the heart is a complex process involving multiple molecular pathways that modulate cardiac morphogenesis. Alterations in these genetic networks during embryogenesis frequently lead to structural cardiac defects, malfunction and congenital heart disease (CHD) in approximately 1% of all live births. Despite the clinical significance, the regulatory pathways required for heart formation, and the genetic contributions of CHD are largely unknown. Understanding the structure-function relationship of genes important during embryonic cardiogenesis will provide insights into genetic causes of CHD associated with structural defects and dysfunction.
    To understand this, my laboratory has established sophisticated in vivo tools to manipulate target gene function during cardiogenesis and examine heart structure and function in adult mutant mice. In addition, we have developed elegant in vitro tools that allow us to manipulate signaling pathways in primary cardiac cells.

Research Funding*:

  • 08/01/2008-05/31/2013 NIH R01 (R01HL091878), PI-Lincoln Annual Direct costs: $250,000; Indirect costs $132,500; Total costs $382,500 40% effort “Molecular regulation of heart valve development and disease” Scleraxis regulation and function during heart valve development
  • 08/01/2009-07/31/2011 NIH ARRA (R01HL091878S1), PI-Lincoln Annual Direct costs: $52,000; Indirect costs $27,560; Total costs $79,560 Scleraxis regulation by microRNAs
  • 07/01/2010-06/30/2012 American Heart Association, Predoctoral fellowship (10PRE4360052) Sponsor-Lincoln, PI-Ge Tao Total annual costs: $21,770 “The role of Snail in heart valve development” Understanding the regulatory mechanisms of Snail function in embryonic and adult heart valve connective tissue

Education and Training

Undergraduate

  • University of Durham, UK
    Date Completed: 06/01/1998

Certificate Program

  • University of Durham, UK
    Date Completed: 06/01/1999

Doctorate

  • University of Durham, UK
    Date Completed: 06/01/2002

Professional Experience

2011–present

  • Principal Investigator, Associate Professor, Center of Cardiovascular and Pulmonary Research The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University

2006–2011

  • Tenure Track Assistant Professor, Department of Molecular and Cellular Pharmacology, Department of Medicine, University of Miami, Leonard M. Miller School of Medicine

2002–2006

  • Postdoctoral Research Fellow Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, Mentor: Katherine E. Yutzey, PhD

Publications

  • Marco Ricci, MD, Yanji Xu, PhD, Harriet L. Hammond, MS, David A. Willoughby, PhD, Lubov Nathanson, PhD, Maria M. Rodriguez, MD, Matteo Vatta, PhD, Steven E. Lipshultz, MD and Joy Lincoln, PhD. Alternative RNA splicing and gene expression profiles in early stage Hypoplastic Left Heart Syndrome. PLoS ONE, 7(1):e29784 Epub 2012
  • Peacock, J.D., Huk, D.J. Ediriweera, H. and Lincoln, J. Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS ONE, 6(10):e26769 Epub 2011
  • Tao, G., Levay, AK., Gridley, T., Lincoln, J. Snai1 is required for mmp15 expression to promote endothelial to mesenchymal transformation during endocardial cushion development. Developmental Biology 359(2):209-21, 2011
  • Faul C*, Amaral AP*, Oskouei B*, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St. John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M. Fibroblast Growth Factor 23 Induces Left Ventricular Hypertrophy. Journal of Clinical Investigation, 121(11):4393-408, 2011
  • Lincoln, J. and Yutzey, K.E. Molecular and developmental mechanisms of congenital heart valve disease. Invited review: Birth Defects Research Part A Clin Mol Teratol. 91(6):526-34, 2011
  • Ricci M, Panos AL, Lincoln J, Salerno TA, Warshauer L. Is aviation a good model to study human errors in health care? American Journal of Surgery, 2011 Sep 2
  • Marco Ricci, MD and Joy Lincoln, PhD. Molecular markers of cardiomyopathy in cyanotic pediatric congenital heart disease. Progress in Pediatric Cardiology 32(1):19-19-23, 2011
  • Ge Tao, James D. Kotick and Joy Lincoln.Heart Valve Development, Maintenance and Disease: The Role of Endothelial Cells. Current Topics In Developmental Biology, 2011. Invited Review. Accepted
  • Peacock, JD., Levay, AK., Gillaspie, D., Tao, G., Lincoln, J. Reduced sox9 function leads to calcific heart valve phenotypes in vivo. Circulation Research 106(4):712-9, 2010
  • Ricci, M., Mohapatra, B., Urbiatondo, A., Birgusingh, R.J., Morgado, M., Rodriguez, M.M., Lincoln, J., Vatta, M. Differential changes in TGF-beta/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome. Journal of Cardiac Failure 16(8):628-34, 2010
  • Levay, A.K., Peacock, J.D., Lu, Y., Hinton, Jr., Koch, M., Hinton, R.B., Kadler, K.E., Lincoln, J. Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circulation Research 103(9): 948-56, 2008
  • Peacock, J.D., Lu, Y., Koch, M., Kadler, K.E., and Lincoln, J. Temporal and Spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Developmental Dynamics (237)10;3051-8, 2008
  • Lincoln, J., Kist, R., Scherer, G. Yutzey, K.E. Sox9 is required for valve precursor cell expansion and extracellular matrix organization during mouseheart valve development. Developmental Biology 305(1):120-32, 2007
  • Lincoln, J., Lange, A.L., Yutzey, K.E. “Hearts and Bones”: Shared regulatory mechanisms in heart valve, cartilage, tendon and bone. Review article. Developmental Biology 294; 292-302, 2006
  • Lincoln, J., Florer, J.B., Deutsch, G.H., Wenstrup, R.J., Yutzey, K.E. ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. Developmental Dynamics 235(12);3295-3305, 2006
  • Hinton, Jr., R.B*., Lincoln, J*., Deutsch, G., Osinska, H., Benson, W., Yutzey, K.E. Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circulation Research 98(11):1431-8, 2006 . *Both authors contributed equally. Front cover article.
  • Lincoln, J., Alfieri, C.M., Yutzey, K.E. BMP and FGF regulatory pathways control cartilage- and tendon-like cell lineage differentiation ofheart valve precursor cells. Developmental Biology 292;290-302, 2006
  • Lincoln, J., Alfieri, C.M., Yutzey K.E. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Developmental Dynamics 229 (4), 2004. Front cover article.
  • Lako, M., Lindsay, S., Lincoln, J., Cairns, P.M., Armstrong, L., Hole, N. Charaterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation. Mechanisms of Development 103, 49-59 2001
  • Armstrong, L., Lako, M., Lincoln, J., Cairns, P.M., Hole, N. mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. Mechanisms of Development 97, 109-116, 2000