Joy Lincoln, PhD

Joy Lincoln, PhD, is a Principal Investigator in The Center for Cardiovascular and Pulmonary Research at Nationwide Children's Hospital and Associate Professor in the Department of Pediatrics at The Ohio State University. Dr. Lincoln's funded research is focused on understanding mechanisms of embryonic heart development and congenital heart disease.

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Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Cardiovascular and Pulmonary Research

Areas of Interest:

• My laboratory focuses on understanding the molecular mechanisms that regulate normal heart formation in the embryo and identifying developmental origins of adult cardiovascular disease. Development of the heart is a complex process involving multiple molecular pathways that modulate cardiac morphogenesis. Alterations in these genetic networks during embryogenesis frequently lead to structural cardiac defects, malfunction and congenital heart disease (CHD) in approximately 1% of all live births. Despite the clinical significance, the regulatory pathways required for heart formation, and the genetic contributions of CHD are largely unknown. Understanding the structure-function relationship of genes important during embryonic cardiogenesis will provide insights into genetic causes of CHD associated with structural defects and dysfunction.
  To understand this, my laboratory has established sophisticated in vivo tools to manipulate target gene function during cardiogenesis and examine heart structure and function in adult mutant mice. In addition, we have developed elegant in vitro tools that allow us to manipulate signaling pathways in primary cardiac cells.
  

Research Funding*:

• 08/01/2008-05/31/2013 NIH R01 (R01HL091878), PI-Lincoln Annual Direct costs: $250,000; Indirect costs $132,500; Total costs $382,500 40% effort “Molecular regulation of heart valve development and disease” Scleraxis regulation and function during heart valve development
• 08/01/2009-07/31/2011 NIH ARRA (R01HL091878S1), PI-Lincoln Annual Direct costs: $52,000; Indirect costs $27,560; Total costs $79,560 Scleraxis regulation by microRNAs
• 07/01/2010-06/30/2012 American Heart Association, Predoctoral fellowship (10PRE4360052) Sponsor-Lincoln, PI-Ge Tao Total annual costs: $21,770 “The role of Snail in heart valve development” Understanding the regulatory mechanisms of Snail function in embryonic and adult heart valve connective tissue

Undergraduate School

• University of Durham, UK
  Date Completed: 06/01/1998

Certification Program

• University of Durham, UK
  Date Completed: 06/01/1999

Doctorate

• University of Durham, UK
  Date Completed: 06/01/2002

2011–present

• Principal Investigator, Associate Professor, Center of Cardiovascular and Pulmonary Research The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University

2006–2011

• Tenure Track Assistant Professor, Department of Molecular and Cellular Pharmacology, Department of Medicine, University of Miami, Leonard M. Miller School of Medicine

2002–2006

• Postdoctoral Research Fellow Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, Mentor: Katherine E. Yutzey, PhD

• Tao G, Miller LJ, Lincoln J. 2013. Snai1 is important for avian epicardial cell transformation and motility.  Dev Dyn. 2013. Vol. unknown, no. dvdy.23967. (April): e[Epub ahead of print].
• Huk DJ, Hammond HL, Kegechika H, Lincoln J. 2013. Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.  Arterioscler Thromb Vasc Biol.. Vol. 33(2), no. ATVBAHA.. Epub 2012 Nov 29. (February): 285-93.
• Kevin Bosse PhD, Chetan P. Hans PhD, Ning Zhao MS, Sara N. Koenig BA, Nianyuan Huang BS, Anuradha Guggilam PhD, Stephanie LaHaye, Ge Tao PhD, Pamela A. Lucchesi PhD, Joy Lincoln PhD, Brenda Lilly PhD and Vidu Garg MD. 2013. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.  Journal of Molecular and Cellular Cardiology. Vol. unknown, no. January: eunknown.
• Tao,Ge; Levay,Agata,K; Peacock,Jacqueline,D; Huk,Danielle,J; Both,Sarah,N; Purcell,Nicole,H; Pinto,Jose,R; Galantowicz,Maarten,L; Koch,Manuel; Lucchesi,Pamela,A; Birk,David,E; Lincoln,Joy. 2012. Collagen XIV is important for growth and structural integrity of the myocardium.  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. Vol. 53, no. 5. (November): 626-638.
• Ricci M, Panos AL, Lincoln J, Salerno TA, Warshauer L. 2012. Is aviation a good model to study human errors in health care?.  Am J Surg.. Vol. 203(6):, no. June: 798-801.
• Dillon,Lloye,M; Williams,Sion,L; Hida,Aline; Peacock,Jacqueline,D; Prolla,Tomas,A; Lincoln,Joy; Moraes,Carlos,T. 2012. Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse.  HUMAN MOLECULAR GENETICS. Vol. 21, no. 10. (May): 2288-2297.
• Ricci,Marco; Xu,Yanji; Hammond,Harriet,L; Willoughby,David,A; Nathanson,Lubov; Rodriguez,Maria,M; Vatta,Matteo; Lipshultz,Steven,E; Lincoln,Joy. 2012. Myocardial Alternative RNA Splicing and Gene Expression Profiling in Early Stage Hypoplastic Left Heart Syndrome.  PLOS ONE. Vol. 7, no. 1. (January): ee29784.
• Tao,Ge; Kotick,James,D; Lincoln,Joy. 2012. HEART VALVE DEVELOPMENT, MAINTENANCE, AND DISEASE: THE ROLE OF ENDOTHELIAL CELLS.  HEART DEVELOPMENT. Vol. 100, no. January: 203-232.
• Marco Ricci, MD, Yanji Xu, PhD, Harriet L. Hammond, MS, David A. Willoughby, PhD, Lubov Nathanson, PhD, Maria M. Rodriguez, MD, Matteo Vatta, PhD, Steven E. Lipshultz, MD and Joy Lincoln, PhD. Alternative RNA splicing and gene expression profiles in early stage Hypoplastic Left Heart Syndrome. PLoS ONE, 7(1):e29784 Epub 2012
• Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M. 2011. FGF23 induces left ventricular hypertrophy.  J Clin Invest.. Vol. 121(11):, no. November: 4393-408.
• Tao,Ge; Levay,Agata,K; Gridley,Thomas; Lincoln,Joy. 2011. Mmp15 is a direct target of Snail during endothelial to mesenchymal transformation and endocardial cushion development.  DEVELOPMENTAL BIOLOGY. Vol. 359, no. 2. (November): 209-221.
• Peacock,Jacqueline,D; Huk,Danielle,J; Ediriweera,Hasini,N; Lincoln,Joy. 2011. Sox9 Transcriptionally Represses Spp1 to Prevent Matrix Mineralization in Maturing Heart Valves and Chondrocytes.  PLOS ONE. Vol. 6, no. 10. (October): ee26769.
• Lincoln,Joy; Yutzey,Katherine,E. 2011. Molecular and Developmental Mechanisms of Congenital Heart Valve Disease.  BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. Vol. 91, no. 6. (June): 526-534.
• Peacock, J.D., Huk, D.J. Ediriweera, H. and Lincoln, J. Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS ONE, 6(10):e26769 Epub 2011
• Tao, G., Levay, AK., Gridley, T., Lincoln, J. Snai1 is required for mmp15 expression to promote endothelial to mesenchymal transformation during endocardial cushion development. Developmental Biology 359(2):209-21, 2011
• Ricci, M. and Lincoln, J. 2011. Molecular markers of cardiomyopathy in cyanotic heart disease.  Progress in Pediatric Cardiology. Vol. 32(1), no. January: 19-23.
• Faul C*, Amaral AP*, Oskouei B*, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St. John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M. Fibroblast Growth Factor 23 Induces Left Ventricular Hypertrophy. Journal of Clinical Investigation, 121(11):4393-408, 2011
• Lincoln, J. and Yutzey, K.E. Molecular and developmental mechanisms of congenital heart valve disease. Invited review: Birth Defects Research Part A Clin Mol Teratol. 91(6):526-34, 2011
• Ricci M, Panos AL, Lincoln J, Salerno TA, Warshauer L. Is aviation a good model to study human errors in health care? American Journal of Surgery, 2011 Sep 2
• Marco Ricci, MD and Joy Lincoln, PhD. Molecular markers of cardiomyopathy in cyanotic pediatric congenital heart disease. Progress in Pediatric Cardiology 32(1):19-19-23, 2011
• Ge Tao, James D. Kotick and Joy Lincoln.Heart Valve Development, Maintenance and Disease: The Role of Endothelial Cells. Current Topics In Developmental Biology, 2011. Invited Review. Accepted
• Ricci M, Mohapatra B, Urbiztondo A, Birusingh RJ, Morgado M, Rodriguez MM, Lincoln J, Vatta M. 2010. Differential changes in TGF-ß/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome.  J Card Fail.. Vol. 16(8):, no. August: 628-34.
• Peacock,Jacqueline,D; Levay,Agata,K; Gillaspie,Devin,B; Tao,Ge; Lincoln,Joy. 2010. Reduced Sox9 Function Promotes Heart Valve Calcification Phenotypes In Vivo.  CIRCULATION RESEARCH. Vol. 106, no. 4. (March): 712-U166.
• Peacock, JD., Levay, AK., Gillaspie, D., Tao, G., Lincoln, J. Reduced sox9 function leads to calcific heart valve phenotypes in vivo. Circulation Research 106(4):712-9, 2010
• Ricci, M., Mohapatra, B., Urbiatondo, A., Birgusingh, R.J., Morgado, M., Rodriguez, M.M., Lincoln, J., Vatta, M. Differential changes in TGF-beta/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome. Journal of Cardiac Failure 16(8):628-34, 2010
• Levay,Agata,K; Peacock,Jacqueline,D; Lu,Yinhui; Koch,Manuel; Hinton,Robert,B; Kadler,Karl,E; Lincoln,Joy. 2008. Scleraxis Is Required for Cell Lineage Differentiation and Extracellular Matrix Remodeling During Murine Heart Valve Formation In Vivo.  CIRCULATION RESEARCH. Vol. 103, no. 9. (October): 948-U100.
• Peacock,Jacqueline,D; Lu,Yinhui; Koch,Manuel; Kadler,Karl,E; Lincoln,Joy. 2008. Temporal and Spatial Expression of Collagens During Murine Atrioventricular Heart Valve Development and Maintenance.  DEVELOPMENTAL DYNAMICS. Vol. 237, no. 10. (October): 3051-3058.
• Levay, A.K., Peacock, J.D., Lu, Y., Hinton, Jr., Koch, M., Hinton, R.B., Kadler, K.E., Lincoln, J. Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circulation Research 103(9): 948-56, 2008
• Peacock, J.D., Lu, Y., Koch, M., Kadler, K.E., and Lincoln, J. Temporal and Spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Developmental Dynamics (237)10;3051-8, 2008
• Lincoln,Joy; Kist,Ralf; Scherer,Gerd; Yutzey,Kathenine,E. 2007. Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.  DEVELOPMENTAL BIOLOGY. Vol. 305, no. 1. (May): 120-132.
• Lincoln, J., Kist, R., Scherer, G. Yutzey, K.E. Sox9 is required for valve precursor cell expansion and extracellular matrix organization during mouseheart valve development. Developmental Biology 305(1):120-32, 2007
• Lincoln,Joy; Florer,Jane,B; Deutsch,Gail,H; Wenstrup,Richard,J; Yutzey,Katherine,E. 2006. ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development.  DEVELOPMENTAL DYNAMICS. Vol. 235, no. 12. (December): 3295-3305.
• Lincoln,Joy; Lange,Alexander,W; Yutzey,Katherine,E. 2006. Hearts and bones: Shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development.  DEVELOPMENTAL BIOLOGY. Vol. 294, no. 2. (June): 292-302.
• Hinton,Robert,B; Lincoln,Joy; Deutsch,Gail,H; Osinska,Hanna; Manning,Peter,B; Benson,D,Woodrow; Yutzey,Katherine,E. 2006. Extracellular matrix remodeling and organization in developing and diseased aortic valves.  CIRCULATION RESEARCH. Vol. 98, no. 11. (June): 1431-1438.
• Lincoln,Joy; Alfieri,Christina,M; Yutzey,Katherine,E. 2006. BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells.  Developmental biology. Vol. 292, no. 2. (April): 292-302.
• Lincoln,J; Alfieri,C,M; Yutzey,K,E. 2006. BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells.  DEVELOPMENTAL BIOLOGY. Vol. 292, no. 2. (April): 290-302.
• Lincoln, J., Lange, A.L., Yutzey, K.E. “Hearts and Bones”: Shared regulatory mechanisms in heart valve, cartilage, tendon and bone. Review article. Developmental Biology 294; 292-302, 2006
• Lincoln, J., Florer, J.B., Deutsch, G.H., Wenstrup, R.J., Yutzey, K.E. ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. Developmental Dynamics 235(12);3295-3305, 2006
• Hinton, Jr., R.B*., Lincoln, J*., Deutsch, G., Osinska, H., Benson, W., Yutzey, K.E. Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circulation Research 98(11):1431-8, 2006 . *Both authors contributed equally. Front cover article.
• Lincoln, J., Alfieri, C.M., Yutzey, K.E. BMP and FGF regulatory pathways control cartilage- and tendon-like cell lineage differentiation ofheart valve precursor cells. Developmental Biology 292;290-302, 2006
• Lincoln,J; Alfieri,C,M; Yutzey,K,E. 2004. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.  DEVELOPMENTAL DYNAMICS. Vol. 230, no. 2. (June): 239-250.
• Lincoln, J., Alfieri, C.M., Yutzey K.E. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Developmental Dynamics 229 (4), 2004. Front cover article.
• Lako, M., Lindsay, S., Lincoln, J., Cairns, P.M., Armstrong, L., Hole, N. Charaterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation. Mechanisms of Development 103, 49-59 2001
• Lako, M., Lindsay, S., Lincoln, J., Cairns, P.M., Armstrong, L., Hole, N. 2001. Charaterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation.  Mechanisms of Development. Vol. 103, no. January: 49-59.
• Armstrong, L., Lako, M., Lincoln, J., Cairns, P.M., Hole, N. 2000. mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells.  Mechanisms of Development. Vol. 97, no. October: 109-116.
• Armstrong, L., Lako, M., Lincoln, J., Cairns, P.M., Hole, N. mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. Mechanisms of Development 97, 109-116, 2000