Technology Commercialization News & Announcements :: The Research Institute at Nationwide Children's Hospital, Columbus, Ohio

News and Announcements

Nationwide Children's Hospital Uses Spinoff Technology to Best Genetic Sleuthing Companies in Contest to Help Undiagnosed Patients

A team from Nationwide Children's Hospital was honored as the winner of the 2015 international CLARITY Undiagnosed Challenge. The CLARITY Challenge involved 26 leading genomics teams from seven countries who sought to interpret DNA sequences and provide information to five different families about their conditions that had eluded diagnosis despite multiple doctor visits, tests and genetic studies. The Nationwide Children's team - the only team from a pediatric hospital - was unanimously chosen by an independent panel of judges that included medical geneticists, computer scientists, bioinformaticians and clinical experts (November 16, 2015). 

>> Read more in Columbus Business First

>> Read the full news release in our News Room

Milo Biotechnology Receives 2015 Venture NEXT Award for Spinout from Rev1 Ventures

Milo Biotechnology was recognized as the most promising company based on a technology developed at one of Rev1 Ventures' Innovation Partners, The Research Institute at Nationwide Children's Hospital. Milo Biotechnology is developing a therapy that increases muscle strength or reduces the rate of muscle atrophy for treatment of muscular disorders. The company's technology, a gene therapy-based upregulation of the muscle-strengthening follistatin protein, was developed at and is exclusively licensed from Nationwide Children's Hospital (October 22, 2015).

>> Learn more about the award recipients at

Data from Ongoing Study of AVXS-101 in Spinal Muscular Atrophy Type 1 Presented at World Muscle Congress

AveXis, Inc., a clinical stage gene therapy company developing treatments for rare and life-threatening neurological genetic diseases, presented data from its ongoing Phase 1/2 trial of AVXS-101, the company's initial product candidate for the treatment of spinal muscular atrophy (SMA) Type 1, at the International Congress of the World Muscle Society in Brighton, United Kingdom. Jerry Mendell, MD, director of the Center for Gene Therapy at The Research Institute at Nationwide Children's Hospital and lead investigator in the study, reported preliminary observations from the ongoing study (October 5, 2015).

>> Read more in the AveXis press release

AveXis, Gene Therapy Company, Secures $65 Million in Financing

AveXis, Inc., a leaeding gene therapy company developing treatments for rare and life-threatening neurological genetic diseases such as spinal muscular atrophy (SMA), completed a $65 million Class D common stock financing. These proceeds will be used to advance the company's ongoing SMA clinical program and expand key operational capabilities (September 8, 2015). 

>> Read more in the AveXis press release

GenomeNext, Powered by Amazon Web Services and Intel, Achieves Unprecendented Throughput of 1,000 Genomes Analyzed per Day, Enabling Population-Scale Genomics

GenomeNext, LLC, a leader in genomic data management and integrated analysis, has benchmarked whole genome sequencing analysis at an unprecedented 1,000 genomes per day, through the “Intel Heads In The Clouds Challenge on Amazon Web Services (AWS)” with support from JHC Technology, and in conjunction with Nationwide Children’s HospitalGenomeNext and Nationwide Children’s were challenged to perform analysis of the complete 1000 Genomes Consortium’s sequencing dataset in one week. This dataset consists of raw genomic sequence data from 2,504 individuals sampled across 26 different populations,and results of the analysis will be published in the coming months by Peter White, PhD, director of the Biomedical Genomics Core, and his team (March 17, 2015).

>> Read more in our News Room

New Company, Lattice Biotech, and Nationwide Children's Join Forces to Attack Chronic Bacterial Infections

Lattice Biotech is leveraging a discovery that disrupts bacterial biofilms, creating a more effective environment for antibiotics to eradicate chronic infections. The research comes from Lauren Bakaletz, PhD, director of the Center for Microbial Pathogenesis in The Research Institute at Nationwide Children's, and Steve Goodman, PhD, principal investigator in the center. Biofilm infections, such as pneumonia in cystic fibrosis patients, chronic wound infections, chronic draining ear infections and infections caused by inadequately sterilized medical equipment, affect millions of children and adults throughout the world each year (March 11, 2015).

>> Read more in our News Room

Nationwide Children's Hospital Joins Nationwide to Develop New Make Safe Happen App for Parents and Caregivers

Rev1 Ventures Announces Landmark Investment in Nationwide Children's Hospital Spinout

Rev1 Ventures and Nationwide Children's Hospital have combined forces to help a promising life science spinout deliver a new gene-based therapy to treat muscular dystrophy and various other muscle disorders to improve the lives of patients with neuromuscular diseases. Rev1 will invest in Milo Biotechnology, the exclusive licensee of patented therapy deveoped at Nationwide Children's by Brian Kaspar, PhD and Milo co-founder, and Jerry Mendell, MD, director of the Center for Gene Therapy at The Research Institute at Nationwide Children's (January 19, 2015).

>> Read more in the Rev1 Ventures blog post

Video Game Technology Helps Upper Extremity Movement in Patients with Muscular Dystrophy

Linda Lowes, clinical therapies research coordinator for the neuromuscular program, and Lindsay Alfano, physical therapist at Nationwide Children's, are part of a research team responsible for developing a way to measure upper extremity movement in patients with muscular dystrophy using interactive video game technology. Their hope is to expand inclusion criteria for clinical trials to incorporate patients using wheelchairs (January 12, 2015).

>> Read more in our News Room

Ohio State, Nationwide Children's Hospital Partner with ENTvantage Diagnostics to Bring Rapid Sinusitis Diagnostic Test to Physicians

The first-of-its-kind diagnostic kit for in-office, rapid diagnosing of bacterial sinusitis was developed as a result of the research collaboration between Subinoy Das, MD, former director of The Ohio State University Sinus and Allergy Center and now adjunct Assistant Professor at The Ohio State University, and Lauren O. Bakaletz, PhD, director of the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children's Hospital and professor in the Departments of Pediatrics and Otolaryngology at The Ohio State University College of Medicine. The jointly-created technology will be the foundation for ENTvantage Diagnostics, Inc. to develop a diagnostic kit to better equip physicians with additional information when making a bacterial sinusitis diagnosis (August 21, 2014).

>> Read more in our News Room

Nanofiber Solutions Receives Award from Ohio Third Frontier to Further Develop Tissue Engineered Intestine Technology

Nanofiber Solutions, LLC, in collaboration with Gail E. Besner, MD, chief of Pediatric Surgery, program director of the Residency in Pediatric Surgery and co-director of the Burn Program all at Nationwide Children’s Hospital, recently was honored with the Ohio Third Frontier Technology Validation and Start-up Fund award. Earlier this month, Nanofiber Solutions, an Ohio-based start-up company housed in the TechColumbus incubator, received a $100,000 grant to further develop the tissue engineered intestine technology developed in the lab of Dr. Besner, who also is principal investigator in the Center for Perinatal Research in The Research Institute at Nationwide Children’s (July 1, 2013). 

>> Read more in our News Room

Research Informatics Core Honored at 2012 TechColumbus Innovation Awards

The Research Informatics Core at The Research Institute at Nationwide Children’s received the 2012 Outstanding Service (+250 Employees) Award at the 2012 TechColumbus Innovation Awards announced February 7, 2013.

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Nationwide Children’s Hospital Partners with Silicon Valley to Market High-End Diagnostic and Medical Research Software

Nationwide Children’s and Transformatix Technologies, Inc. have partnered to create BioLinQ, a new biomedical informatics company designed to supply advanced software solutions for disease diagnosis and medical research (October 29, 2012).

>> Read more in our News Room

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