Pulmonary Medicine Research and Innovation

Benjamin Kopp, MD

Which Patients With Cystic Fibrosis Will Respond Best to Lumacaftor/Ivacaftor?

This common drug combination is associated with changes in lipid and amino acid metabolic pathways, raising the possibility of biomarkers to predict clinical response.


Benjamin T. Kopp, MD

How Does Secondhand Smoke Exposure Harm Children With Cystic Fibrosis?

Altered immune and inflammatory responses hinder clearance of bacterial infections.

Richard Shell

FDA Approves Novel Gene Therapy for SMA

Children with SMA1, the number one genetic killer of babies under 2 years of age, fail to meet motor milestones and typically die or require permanent mechanical ventilation by age 2.

Do All Cystic Fibrosis Modulators Improve Killing of Bacteria?

Treated immune cells function properly to kill more bacteria, depending on the treatment and the bacteria.

Heart and Lungs

Current Pediatric Lung Transplant Trends

CF patients are more often requiring lung transplants later in life while there is a growing trend in children with refractory ARDS needing transplants.

Clinical Benefits Found for Pediatric Asthma Patients in a Pulmonary Rehab Program

FEV1, shortness of breath score and physical quality of life were all improved after participation in a formalized program.

Could Earlier Spirometry Get CF Inpatients Home Sooner?

Checking spirometry earlier may help reduce length of stay those with cystic fibrosis pulmonary exacerbations.

Additional Research

Asthma Research

In 1999, the Section of Pulmonary Medicine at Nationwide Children’s was designated as an American Lung Association Asthma Clinical Research Center, one of 18 selected participants, only five of which are pediatric.

Cystic Fibrosis Research

Pulmonary Medicine at Nationwide Children’s Hospital has been involved in research related to cystic fibrosis (CF) since the early 1990s.

Cystic Fibrosis team in India

Mission Work in India

According to UNICEF data, the death rate for children under the age of 5 years is 43 per 1,000 live births in India. This means that 563,752 children will die this year, many without proper diagnosis of their diseases.