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Laboratory Test Directory

Chromosome Analysis, 5-Cell Confirmation in Tissue


Name Method Department Units
Tissue, Chromosome Analysis, 5-Cell Confirmation Chromosomal analysis

Specimen Requirements

Tissue (Fresh)

Container Type Container Size Specimen Volume

Tissue culture transport media

N/A 10 mm cube

Sterile container with saline

N/A 10 mm cube

Ringer's lactate solution in sterile container

N/A 10 mm cube

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not add fixative
  • Do not formalin fix the sample
  • Do not freeze
  • Keep at room temperature
  • Transport to laboratory as soon as possible

Reasons for Rejection

  • Fixed specimen
  • Formalin Fixed Tissue
  • Frozen specimen
  • Delayed or improper handling


Submission of a completed Genetics Test Requisition Form is required. When submitting tissue from products of conception (POC), such as placenta, umbilcal cord, and/or fetal tissue sample completed POC Requistiion Form is required - to obtain the form, pleaes call the Cytognetics Lab at (614) 722-5321. When submitting a postnatally obtained tissue sample, such as from skin biopsy and surgical specimen, submission of Genetic Test Requisition Form is required.

This test is intended for patients who have previously had abnormal chromosome results in the prenatal period (e.g. CVS, amniotic fluid, or PUBS chromosome analysis) or had abnormal chromosome result on postnatal blood sample and confirmation of previous result is desired on the tissue sample. This test will evaluate chromosomes in 5 cells in cultured tissue sample. Please note - this test should not be ordered if mosaicism is suspected. If complete tissue chromosome analysis (20 cell evaluation) is desired, order test code: TCS.

Fresh tissue sample is needed for this test. Collected tissue sample should be placed in a sterile container containng tissue transport media or sterile saline, and tissue should be completely immersed in the media/saline. DO NOT expose to formalin or other fixatives and DO NOT freeze. Transport the specimen to the laboratory as soon as possible at room temperature. If additional in-house or send-out testing on cultured fibroblasts is desired, please clearly indicate the desired testing on the lab order and call the Cytogenetics lab tp speak to a laboratory genetic counselor to coordinate additonal testing.

CPT Code

  • 88233
  • 88261