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Laboratory Test Directory

Sickle Screen


Name Method Department Units
Sickle Screen Hemoglobin reduction by sodium hydrosulfite
Core Lab, Special Hematology Negative or Positive

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume

Purple tube (EDTA)

3 mL 3 mL

Purple tube (EDTA)

Micro sample tube 0.5 mL

Refrigerated - 14 day(s)
Room temperature - 8 hour(s)

Specimen Preparation

  • Do not centrifuge
  • Mix by gentle inversion immediately after collection
  • Keep at room temperature or refrigerate

Reasons for Rejection

  • Not received within specified time frame
  • Clotted specimen
  • Wrong collection tube
  • Frozen whole blood


See InLab Processing section for important information about testing location. STATS are available, 24/7. A positive result will typically prompt reflexive testing that will include Hemoglobin Electrophoresis (CPT 83020). If sample volume permits, a CBC (CPT 80525) and pathologist's consult (billed from Pediatric Pathology Associates (PPAC)) will be ordered and charged if Hemoglobin Electrophoresis yields results that are abnormal, and do not present as sickle cell trait (Hb A and S present). A negative result for the sickle screen on a patient less than 6 months of age will prompt Hemoglobin Electrophoresis (CPT 83020, LIS code: HGBE) as a reflexive test to rule out interference by fetal hemoglobin. Sickle Screen result may be affected if the patient has been transfused with red blood cells within the past 3-4 months. Patients enrolled in patient screening program (e.g. Head Start) will not have reflexive testing performed.

CPT Code

  • 85660