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Laboratory Test Directory

Renin Activity, Plasma


Name Method Department Units
Renin Activity Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Send Out ng/mL/h

Specimen Requirements

Plasma Spun

Container Type Container Size Specimen Volume

Purple tube (EDTA)

6 mL 2 mL

Frozen - 14 day(s)

Specimen Preparation

  • Cool tube in ice before collection
  • Centrifuge within 30 minutes, separate supernatant, and freeze
  • Keep frozen
  • Transport to laboratory as soon as possible

Reasons for Rejection

  • Gross hemolysis
  • Wrong collection tube
  • Thawed frozen specimen


Draw blood in a chilled syringe or directly into a chilled, lavender top (EDTA) tube, from a patient in a seated position; and mix. Immediately place EDTA tube in ice. The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone (Aldactone). Spironolactone should be discontinued for 4 to 6 weeks before testing.

CPT Code

  • 84244