New Search

Laboratory Test Directory

Aneuploidy Screen by FISH, Amniotic Fluid (Prenatal)


Name Method Department Units
Prenatal Aneuploidy FISH Fluorescence in situ hybridization (FISH)

Specimen Requirements

Amniotic fluid

Container Type Container Size Specimen Volume

Sterile container

N/A 5 mL-10 mL

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not add fixative
  • Do not centrifuge
  • Do not refrigerate
  • Do not freeze
  • Keep at room temperature

Reasons for Rejection

  • Fixed specimen
  • Frozen specimen
  • Minimum volume/concentration not submitted
  • Delayed or improper handling


Submission of completed Prenatal Genetic Test Requisition Form is required. To request the Requisition Form, please call (614) 722-5321 and ask to speak with a laboratory genetic counselor.

This test is a screening test for common aneuploidies involving chromosomes 13,18, 21, X and Y done by fluorsecence in situ hybridization (FISH) performed on direct (uncultured) amniotic fluid specimen. Because this test is a screening test, this test CANNOT be ordered as a stand-alone test; this test MUST be performed along with other diagnostic cytogenetic test(s), such as amniotic fluid chromosome analysis and/or amniotic fluid microarray analysis. To perform this test, please submit 5 mL amniotic fluid in addition to the amniotic fluid volume required for other testing requested on the sample (e.g. additional 20 mL required for chromosome analysis or microarray analysis).

CPT Code

  • 88275
  • 88271 (x5)