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Laboratory Test Directory

Aneuploidy Screen by FISH, Amniotic Fluid (Prenatal) (Updated)

Components

Name Method Department Units
Prenatal Aneuploidy FISH Fluorescence in situ hybridization (FISH)
Cytogenetics

Specimen Requirements

Amniotic fluid

Container Type Container Size Specimen Volume
Preferred

Sterile container

N/A 5 mL-10 mL
Stability

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not add fixative
  • Do not centrifuge
  • Do not freeze
  • Keep at room temperature
  • Transport to laboratory as soon as possible

Reasons for Rejection

  • Fixed specimen
  • Frozen specimen
  • Minimum volume/concentration not submitted
  • Delayed or improper handling

Comments

Submission of a completed Prenatal Genetic Test Requisition Form is required. To request for the form, please call Cytogenetics Lab at (614) 722-5321.

This test evaluates for numerical abnormalities of chromosomes 13,18, X, and Y and is used to screen for common numerical chromosome abnormalities such as trisomy 13, trisomy 18, trisomy 21, monosomy X (Turner syndrome), triploidy and tetraploidy. This test is done by fluorsecence in situ hybridization (FISH) analysis performed on direct (uncultured) amniotic fluid specimen. Because this test is a screening test, this test CANNOT be ordered as a stand-alone test; this test MUST be performed along with other diagnostic cytogenetic test(s), such as amniotic fluid chromosome analysis (test code: AFST) and/or amniotic fluid/prenatal microarray analysis.

To perform this test, please submit 5 mL amniotic fluid in addition to the amniotic fluid volume required for other testing requested on the sample (e.g. additional 15-20 mL required for chromosome analysis or microarray analysis). Amniotic fluid should be collected in a non-toxic, sterile container and transported at room temperature. 

CPT Code

  • 88275
  • 88271 (x5)