|Prenatal Aneuploidy FISH||
Fluorescence in situ hybridization (FISH)
|Container Type||Container Size||Specimen Volume|
|N/A||5 mL-10 mL|
Room temperature - 24 hour(s)
- Do not add fixative
- Do not centrifuge
- Do not freeze
- Keep at room temperature
- Transport to laboratory as soon as possible
Reasons for Rejection
- Fixed specimen
- Frozen specimen
- Minimum volume/concentration not submitted
- Delayed or improper handling
Submission of a completed Prenatal Genetic Test Requisition Form is required. To request for the form, please call Cytogenetics Lab at (614) 722-5321.
This test evaluates for numerical abnormalities of chromosomes 13,18, X, and Y and is used to screen for common numerical chromosome abnormalities such as trisomy 13, trisomy 18, trisomy 21, monosomy X (Turner syndrome), triploidy and tetraploidy. This test is done by fluorsecence in situ hybridization (FISH) analysis performed on direct (uncultured) amniotic fluid specimen. Because this test is a screening test, this test CANNOT be ordered as a stand-alone test; this test MUST be performed along with other diagnostic cytogenetic test(s), such as amniotic fluid chromosome analysis (test code: AFST) and/or amniotic fluid/prenatal microarray analysis.
To perform this test, please submit 5 mL amniotic fluid in addition to the amniotic fluid volume required for other testing requested on the sample (e.g. additional 15-20 mL required for chromosome analysis or microarray analysis). Amniotic fluid should be collected in a non-toxic, sterile container and transported at room temperature.
- 88271 (x5)