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Laboratory Test Directory

Parental FISH Analysis

Components

Name Method Department Units
Parental FISH Fluorescence in situ hybridization (FISH)
Cytogenetics

Specimen Requirements

Whole blood

Container Type Container Size Specimen Volume
Preferred

Green tube (Sodium heparin), No Gel

6 mL 3 mL-6 mL
Stability

Room temperature - 24 hour(s)
Refrigerated - 72 hour(s)

Specimen Preparation

  • Do not centrifuge
  • Do not freeze
  • Keep at room temperature

Reasons for Rejection

  • Wrong collection tube
  • Wrong type of specimen
  • Serum sample
  • Clotted specimen
  • Frozen specimen
  • Centrifuged specimen

Comments

Please click on the Lab Form Link in the Forms Section to print and complete the Genetic Test Requisition Form. Completed Genetic Test Requisition required. When ordering this test, please provide following information on the test requisition form: 1) previously tested Proband's Name, 2) Proband's Date of Birth and/or Proband's Test Accession Number.

Please collect whole blood in Sodium Heparin tube (green-top tube without gel separator). DO NOT use Lithium Heparin or other types of heparin tubes; check tube for proper heparin type. 

This test is available for biological parents (mother and father) of a proband who previously had cytogenetic abnormality detected by Nationwide Children's laboratory (e.g. proband has a balanced or unbalanced chromosome abnormality detected by chromosome analysis or FISH analysis, or a genomic gain or loss detected by microarray analysis). If the proband's cytogenetic abnormality was detected by an outside laboratory or if the patient to be tested is a family member of, but not biological parents of, the proband (e.g. grandparent, sibling, aunt/uncle, cousin, etc), then please order a test called "FISH Analysis Only (test code: FISHON)" in place of this test.

Depending on the chromosome loci to be tested, special FISH probes may need to be ordered, which may result in longer result turn-around-time.

PLEASE NOTE: Small cytogenetic abnormalities below certain size may not be detectable by FISH analysis. If uncertain whether the proband's cytogenetic abnormality is detectable by FISH analysis or not, please call the Cytogenetic Laboratory (614) 722-5321 and ask to speak with a laboratory genetic counselor.

Forms

Lab Form

CPT Code

  • 88230
  • 88271
  • 88273