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Laboratory Test Directory

Metanephrines, Fractionated, 24 Hour, Urine (Updated)


Name Method Department Units
Metanephrines, Fractionated, 24 Hour, Urine Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Send Out mcg/24 hours

Battery Members

Metanephrine, Normetanephrine, Total Metanephrine

Specimen Requirements

Urine, 24 hours

Container Type Container Size Specimen Volume

24 hour urine container

N/A 10 mL

Refrigerated - 7 day(s)
Frozen - 14 day(s)
Room temperature - 7 day(s)

Specimen Preparation

  • Refrigerate during collection
  • Transport to laboratory as soon as possible

Reasons for Rejection

  • Wrong type of specimen


Patient Preparation: Tricyclic antidepressants, labetalol, and sotalol medications may elevate levels of metanephrines producing results that cannot be interpreted. If clinically feasible, it is optimal to discontinue these medications at least 1 week before collection. For advice on assessing the risk of removing patients from these medications and alternatives, you may consider consultation with a specialist in endocrinology or hypertension.

Collect urine for 24 hours. At beginning of collection have patient void and discard this urine. Begin timing collection at this point and collect all urine until the end of the collection period. Have patient void and save urine at the final collection period. If testing is requested on a random sample order test code XMETAR to Mayo.

CPT Code

  • 83835