New Search

Laboratory Test Directory

Histone Antibody, IgG


Name Method Department Units
Histone Antibody, IgG Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Send Out Units

Specimen Requirements

Serum Spun

Container Type Container Size Specimen Volume

Red tube, (no anticoagulant), No Gel

3 mL 0.5 mL

Gold tube, (SST) with Gel

3.5 mL 0.5 mL

Red Tube (no anticoagulant) with Gel

3 mL 0.5 mL

Room temperature - 2 day(s)
Refrigerated - 2 week(s)
Frozen - 12 month(s)

Specimen Preparation

  • Avoid repeated freeze/thaw cycles
  • Centrifuge within 2 hours, separate supernatant and refrigerate

Reasons for Rejection

  • Wrong collection tube
  • Bacterial contamination
  • Lipemic specimen
  • Plasma unacceptable
  • Urine
  • Icteric specimen
  • Gross hemolysis


Histone antibodies are present in 20-55% of idiopathic systemic lupus erythematosus (SLE) and 80-95% of drug-induced SLE. They occur in less than 20% of other types of connective tissue diseases.

CPT Code

  • 83516