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Laboratory Test Directory

Coagulation Inhibitor Titer


Name Method Department Units
Coag Inhibitor Titer Clot detection
Core Lab, Coagulation

Specimen Requirements

Platelet poor plasma

Container Type Container Size Specimen Volume

Blue plastic tube (Citrate)

2.7 mL 6 mL

Frozen - 2 week(s)

Specimen Preparation

  • Fill tubes to appropriate mark.
  • Mix by gentle inversion immediately after collection
  • Centrifuge, remove plasma/serum and freeze
  • Plasma must be platelet free

Reasons for Rejection

  • Over or under filled tube
  • Clotted specimen
  • Not received within specified time frame
  • Gross hemolysis
  • Wrong collection tube
  • Capillary specimen
  • Specimen collected in glass tube


This test is used to determine antibody production against factor concentrate by patients with hemophilia. Indicate which coagulation factor should be tested (e.g. VIII, IX) for inhibitor status. Heparin present in the sample may be a cause for rejection of the sample. Collect by venipuncture whenever possible. Requires two 2.7 mL blue top collection tubes. Centrifuge citrate tubes according to Lab policy, remove platelet-poor plasma, pool the plasma, aliquot and freeze.

CPT Code

  • 85335