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Laboratory Test Directory

Amniotic Fluid 5-Cell Chromosome Analysis

Components

Name Method Department Units
Amniotic Fluid 5-Cell Chromosome Analysis Cytogenetics

Specimen Requirements

Amniotic fluid

Container Type Container Size Specimen Volume
Preferred

Sterile container

N/A 20 mL-35 mL
Stability

Room temperature - 24 hour(s)

Specimen Preparation

  • Do not freeze
  • Keep at room temperature
  • Do not refrigerate
  • Do not centrifuge
  • Do not add fixative

Reasons for Rejection

  • Delayed or improper handling
  • Frozen specimen
  • Not received within specified time frame
  • Fixed specimen

Comments

Submission of a completed Prenatal Genetic Test Requisition Form is required. To request a requisition form, please call (614) 722-5321 and ask to speak with a laboratory genetic counselor.

In this study, cells in amniotic fluid specimen will be cultured, and the number of chromosomes will be evaluated in 5 cultured cells and the full karyotype analysis will be performed on 1 of the 5 cells. This test is available to confirm the results of previous cytogenetic testing performed in patient's current pregnancy, such as patients who had chromosome analysis and/or microarray analysis on chorionic villus sampling (CVS) specimen.

PLEASE NOTE: Due to the limited number of cells evaluated by this study for chromosome analysis, mosaicism for chromosomal abnormality may not be detected by this study. If mosaicism is suspected, an alternate testing "Amniotic Fluid Chromosome Analysis (test code: AFST)" that evaluates 15 colonies is available, with an option for "Mosaicism Study" that evaluates additional number of colonies.

CPT Code

  • 88235
  • 88261