The human heart is the first functional fetal organ and undergoes several stages of development before birth. However, the underlying biology that dictates proper heart development remains poorly understood.
Investigators at Nationwide Children’s Hospital are focused on understanding the molecular pathways that regulate normal and abnormal heart development. Using mouse models, they are studying heart disease at the molecular level in order to identify essential cardiac regulators of heart development. They are also interested in understanding how genetic mutations disrupt normal cardiac development. These studies could help develop new ways to prevent, diagnose and care for congenital heart disease.