The Heart Center Research and Innovation

Carl Backes Jr MD

Patent Ductus Arteriosus Closure: Which Patients and When?

New review cites need for randomized clinical trials comparing conservative management, surgery, and catheter-based closure.

NICU nurse with baby

When is Palliative Care Right for Families of Children With Single Ventricle Congenital Heart Defects?

Practitioners suggest involving a palliative care team early after diagnosis.

Heart Function

Cheaper, Generic Drug Just as Effective in Preserving Heart Function in Duchenne Muscular Dystrophy

A new clinical trial found a cheaper generic drug is effective in protecting the heart in boys with Duchenne muscular dystrophy.

Heart beating inside the chest

New Model Provides Novel View of Congenital Heart Disease

The small animal model helps researchers to interpret genomic findings.

Heart beating inside the chest

Variation in Functional Measurements of the Left Ventricle

Data from The Pediatric Heart Network Normal Echocardiogram Database show interobserver variability, especially in younger and smaller patients.

Regular Physical Activities Tied to Improved Quality of Life in Adults With Fontan Circulation

Starting regular exercise in childhood can help lay the groundwork for greater health and quality of life, pediatric cardiologists suggest.

Linda H. Cripe, MD

Use of Cardiac MRI to Monitor Medical Treatment of Rhabdomyoma

A new case study shows success of using cardiac MRI – rather than electrocardiogram – to monitor tumor regression of rhabdomyoma in a newborn with an mTOR inhibitor.

Additional Research

The Heart in Neuromuscular Disease

Heart problems have been reported in nearly all the neuromuscular disorders. They are particularly common and serious in Duchenne and Becker muscular dystrophies.

Adult Congenital Heart Disease Research

Faculty at Nationwide Children’s Hospital are focused on evaluating and customizing treatments for adults with congenital heart disease in order to improve clinical outcomes for these patients.

Cardiovascular Development Research

Investigators at Nationwide Children’s Hospital are focused on understanding the molecular pathways that regulate normal and abnormal heart development.

Genetics of Congenital Heart Disease Research

Faculty members at Nationwide Children’s Hospital are working to understand the genetic basis of congenital heart disease and are investigating how genetic and environmental factors play a role in the development of heart defects in children.

Surgical Palliation and Device-Based Therapies Research

The Heart Center faculty members continue to investigate new surgical treatment options and ways to improve surgical outcomes.