RISI Featured Projects :: The Research Institute at Nationwide Children's Hospital, Columbus, Ohio

Featured Projects at Nationwide Children's

Solving the Problem of Managing Big Genomic Data

Researchers at Nationwide Children’s Hospital complete a first-of-its kind project to evaluate a large-scale genomic data management system on the scale of up to one million genomes.

>>For more information, please visit the GACS website.


Interactive Bike Game Engages Patients with Duchenne Muscular Dystrophy

Due to limitations as a result of their health condition and the availability of accessible equipment, many children with Duchenne muscular dystrophy (DMD) have not engaged in a habitual exercise routine in their entire childhood lives. The RISI User Experience Team (UET) designed an interactive patient experience in which adolescents with DMD could participate in a bicycling exercise routine, transforming the act of exercise into an interactive video game.

>> For more information, please visit the Bike Game website


KinectTM-Based Virtual Reality Game as a Clinical Outcomes Tool for Patients with Spinal Muscular Atrophy

In February 2015, Cure SMA, an organization dedicated to the treatment and cure of spinal muscular atrophy (SMA), the number one genetic cause of death for infants, awarded an $80,000 research grant to Linda Lowes, PT, PhD, at Nationwide Children's Hospital. The grant was for the "Development of an Innovative Outcome Measure to Define Disease Progression in SMA Type I for Use in the Home or Clinic," and Dr. Lowes and her co-investigator, Lindsay Alfano, PT, DPT, collaborated on this project along with physicians and researchers in the Center for Gene Therapy at The Research Institute at Nationwide Children's and RISI.

The project team utilized Microsoft KinectTM to record the movement of infants with SMA type 1, and investigators visited homes to instruct families on how to use their system, teaching them to record the baby's movement, once a month for 12 months. The technology is a video-based, affordable and entertaining physical therapy assessment tool that measures movement abilities. It can be used as a clinical outcome measure not only for SMA, but other neuromuscular diseases, stroke, head injury or other conditions in which the functional abilities of the arms and legs are being investigated.

>> For more information on the grant, Dr. Lowes' research and the project, visit the Cure SMA website.


Video Game Technology Helps Measure Upper Extremity Movement in Patients with Muscular Dystrophy

  Researchers at Nationwide Children's Hospital, in collaboration with RISI and the Office of Technology Commercialization at Nationwide Children's, developed a way to measure upper extremity movement in patients with muscular dystrophy using Ability Captured Through Interactive Video Evaluation, or ACTIVE-seated technology. Previously, patients with diseases like muscular dystrophy who have lost mobility and use wheelchairs were excluded from clinical trials due to the lack of an easy, affordable and comprehensive way to measure their muscular function.

ACTIVE-seated technology utilizes the aforementioned Kinect gaming camera, found in Xbox consoles, to measure how far and how long boys with muscular dystrophy are able to reach. The game has a patient-requested zombie team and requires the boys to reach with their arms in various directions to push forward a force field, and measuring change over time is a primary goal. The development of the game relied almost entirely on patients.

>> For more information on the interactive video game technology, view the news release in our Nationwide Children's Hospital News Room.