Researchers at Nationwide Children’s Hospital complete a first-of-its-kind project to evaluate a large-scale genomic data management system on the scale of up to one million genomes. The influx of genomics data resulting from the increasing affordability of whole exome/genome sequencing and President Obama’s requires a novel technological solution to data storage, communication with other clinical decision support systems and the Health Information Exchange. Any solutions must also enable the use of the data in secondary research studies.
Some children with Duchenne muscular dystrophy (DMD) have not engaged in a habitual exercise routine in their entire childhood lives to date. A team at Nationwide Children's designed an experience in which the adolescent users would participate in a bicycling exercise routine, by turning the act of exercise into an interactive video game. This project was made possible as a result of research conducted by the team of Jerry Mendell, MD, director of the Center for Gene Therapy at The Research Institute and collaboration with the Biomedical Engineering team at Nationwide Children's.
KinectTM-Based Virtual Reality Game as a Clinical Outcomes Tool for Patients with Spinal Muscular Atrophy
In February 2015, Cure SMA, an organization dedicated to the treatment and cure of spinal muscular atrophy (SMA), the number one genetic cause of death for infants, awarded an $80,000 research grant to Linda Lowes, PT, PhD, at Nationwide Children's Hospital. The grant was for the "Development of an Innovative Outcome Measure to Define Disease Progression in SMA Type I for Use in the Home or Clinic," and Dr. Lowes and her co-investigator, Lindsay Alfano, PT, DPT, collaborated on this project along with physicians and researchers in the Center for Gene Therapy at The Research Institute at Nationwide Children's and RISI.
Researchers at Nationwide Children's Hospital, in collaboration with RISI and the Office of Technology Commercialization at Nationwide Children's, developed a way to measure upper extremity movement in patients with muscular dystrophy using Ability Captured Through Interactive Video Evaluation, or ACTIVE-seated technology. Previously, patients with diseases like muscular dystrophy who have lost mobility and use wheelchairs were excluded from clinical trials due to the lack of an easy, affordable and comprehensive way to measure their muscular function.