Christopher Breuer, MD
Dr. Breuer is Co-Director of the new Tissue Engineering Program at Nationwide Children's Hospital and Director of Tissue Engineering in The Ohio State University Wexner Medical Center's new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
Jenny Barker MD, PhD
Jenny earned her BS from Massachusetts Institute of Technology (MIT). She earned her MD and PhD from the University of Texas Southwestern Medical Center. She participated in the Integrated Plastic Surgery Residency at The Ohio State University. Her Breuer Lab Research Interest include mechanisms of neotissue formation for tissue engineered vascular grafts.
During my undergraduate career, I joined the laboratory of Drs. Christopher Breuer and Toshiharu Shinoka in the Vascular Biology and Therapeutics Program at the Yale School of Medicine. My work focused on the development of novel biodegradable scaffolds for vascular tissue engineering. In 2013, the lab relocated to Nationwide Children’s Hospital, where we are conducting the first FDA-approved clinical trial investigating the use of a tissue-engineered vascular graft for palliation of congenital heart defects in the pediatric population. Practicing “bench to bedside and back” research, we investigate outcomes from our trial by applying basic cellular and molecular insights from rodent experiments to evaluation in large animal models prior to translating these findings to the clinic. I am currently investigating the role of the LYST protein in tissue-engineered vascular graft remodeling as a fellow of the Biomedical Sciences Graduate Program of the Ohio State University.
Kevin received a BS and MS in biomedical engineering from Purdue University, where he studied collagen-based biomaterials. Kevin joined the MSTP at The Ohio State University in 2015 and joined the Breuer Lab in 2017. Kevin's work focuses on the role of inflammation in neotissue formation in Tissue Engineered Vascular Grafts.
Yu-Chun (Roy) Chang
Graduate Research Associate
Roy received his Bachelor's from Penn State in 2014 and a Master's from Harvard in 2018. He is currently a Ph.D. student in the Biomedical Sciences program at The Ohio State University. He joined the Breuer Lab in September of 2017 and is focused on modulating immune response in the development of tissue engineered vascular grafts.
Postdoctoral Research Fellow
I am interested in developing novel biomaterials to improve the treatment of children with congenital heart disease. My current projects focus on utilizing MRI and computational modeling to improve and predict tissue engineered graft remodeling.
I am a visiting researcher from Dr. Deling Kong's lab at Nankai University, China. As an undergraduate, I am involved in research projects focusing on tissue-engineered vascular grafts.
Gabriel received his bachelor's degree from Kent State University in 2015. He is currently a medical student at Northeast Ohio Medical University and a Ph.D. student in the Biomedical Sciences Graduate Program at The Ohio State University. He joined the lab in August 2017 and is currently investigating immune response and inflammation in tissue engineered vascular grafts.
My research is focused on studying the role of platelets in neotissue formation and stenosis in tissue engineered vascular grafts. I am also trying to determine how bone marrow-derived mononuclear cells inhibit the formation of stenosis and whether this can be attributed to surface expressed nucleotidases.
Graduate Research Associate
Jacob received his Bachelors of Science in Biomedical Engineering from the Ohio State University in 2016 and is now currently enrolled in the Biomedical Engineering PhD program at Ohio State. He is working under Dr. Christopher Breuer in the Center for Regenerative Medicine. His research involves the evaluation and optimization of arterial tissue engineered vascular grafts made of degradable polymers.
Kejal Shah, MD
Jason Zakko, MD