Bronchopulmonary dysplasia (BPD) is a life-threatening lung disease that follows preterm birth and is characterized by progressive pulmonary vascular endothelial dysfunction and smooth muscle cell proliferation. There are 14,000 new cases of BPD diagnosed each year in the United States. Pulmonary hypertension (PH) complicates the clinical course in 25-40% of BPD patients and is the greatest contributor to morbidity and mortality in BPD. Patients with BPD-PH are at 4.6 times greater risk of mortality compared to BPD patients.
Currently, there are no available predictive biomarkers or curative therapies for BPD-PH. The Trittman Lab has discovered genetic and biochemical markers for BPD-PH including: single polymorphisms in arginase-1 (ARG1), dimethylarginine dimethylaminohydrolase-1 (DDAH1), dual specificity phosphatase-1&5 (DUSP1&5), and plasma levels of asymmetric dimethylarginine (ADMA). Its team is interested in developing ADMA and DDAH1 as clinical biomarkers, examining their mechanism of action as it relates to BPD-PH pathogenesis, to precisely target treatment to improve outcomes for neonatal patients with BPD-PH.
The Trittman Lab has also developed a co-culture of human pulmonary vascular endothelial and smooth muscle cells to study ADMA and DDAH1 cellular mechanism in vitro and an endothelial-DDAH1 knockout mouse model for studies after intrauterine inflammation (LPS) and post-natal hyperoxia exposure to study PH endpoints in vivo.
Biomarker studies are completed in collaboration with the Ohio Perinatal Research Network and research repository at the Abigail Wexner Research Institute at Nationwide Children’s Hospital.
Jennifer Trittman, MD, MPH
Dr. Trittman is a principal investigator in the Center for Perinatal Research and an assistant professor of Pediatrics at The Ohio State University College of Medicine.
Senior Research Associate
Hanadi's responsibilities include conducting independent research studies and laboratory analysis, assisting the principal investigator in the preparation of research papers and and presentations at national conferences, and training undergraduate and graduate students and clinical fellow trainees and coordinate laboratory activities and work assignments in accordance with the principal investigator.