Stephen Lessnick, MD, PhD
Stephen Lessnick, MD, PhD, is director of the Center for Childhood Cancer & Blood Diseases for The Research Institute at Nationwide Children's Hospital, a physician for the Division of Hematology and Oncology at Nationwide Children's Hospital and a professor of pediatrics at The Ohio State University College of Medicine.
Dr. Lessnick earned his bachelor's degree from Brandeis University, followed by MD and PhD degrees from the University of California, Los Angeles (UCLA), as part of the Medical Scientist Training Program (MSTP). He trained in pediatrics at Children’s Hospital, Boston, and in pediatric hematology/oncology at Dana-Farber Cancer Institute and Children’s Hospital, Boston. Dr. Lessnick was on-faculty at the University of Utah for approximately 11 years. In July 2015, Dr. Lessnick joined the faculty at The Research Institute at Nationwide Children’s Hospital as the Director of the Center for Childhood Cancer and Blood Diseases and The Ohio State University as a Professor of Pediatrics in the Division of Pediatric Hematology/Oncology/BMT.
Dr. Lessnick has spent his research career studying Ewing sarcoma and EWS/FLI. EWS/FLI is the “driver mutation” in Ewing sarcoma and functions as a master regulator of gene expression. His laboratory focuses on understanding how EWS/FLI functions with the idea that this understanding will lead to more effective treatments for patients with this highly aggressive pediatric, adolescent, and young-adult cancer.
Emily earned her BSc. in Biology at her hometown University of Wisconsin -Madison. Spurred by an interest in biological chemistry, she moved to Salt Lake City, UT for her doctoral work in Pharmaceutics and Pharmaceutical Chemistry. Her collaborative project working to discover and develop novel small molecules which target the epigenetic machinery spanned the Huntsman Cancer Institute and the College of Pharmacy. As an early career scientist she remains deeply interested in uncovering new basic priniciples of epigenetic and chromatin biology in pediatric cancer, understanding both how this biology is altered, and identifying novel therapeutic strategies based on this knowledge. She's most adept doing hardcore chromatin biology at the bench and following up with in depth "omics" analytics to bring the biochemical story to life.
Graduate Research Fellow
I am originally from West Virginia and moved to Columbus in June 2016 to begin my first year in the Biomedical Sciences Graduate Program at OSU. Our lab works on Ewing sarcoma, which is a pediatric and AYA bone- and soft-tissue-associated cancer. Although the driver mutation of this cancer (EWS/FLI) was discovered almost 30 years ago, we still lack a full understanding of how it functions to drive oncogenesis. My project in the lab focuses on elucidating the basic biology of EWS/FLI, particularly how the FLI domain contributes to disease formation. My long-term research interests are in translating basic research findings to the clinic to better patient outcomes.
Julia earned her bachelor’s and master’s degrees in Molecular Biomedicine from the University of Münster in Germany in 2007 and 2010. She is a lab manager in the Lessnick Lab and involved in Ewing Sarcoma research.
Jessed graduated from OSU with a BS in Molecular Genetics in 2016. She is currently a technician in the Lessnick lab working to support post docs and grad students in the lab.
I am a hematology/oncology/bone marrow transplant fellow. For my research years, I am investigating the role of LDS2 in Ewing Sarcoma.
Graduate Research Associate
My research focuses on elucidating the role of EWS/FLI (a fusion oncoprotein) in defining the 3D chromatin landscape that regulates the oncogenic transcriptional profile in Ewing sarcoma.