Nationwide Children's Research News
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Feb 15, 2024
Midwest Pediatric Device Consortium Launches to Accelerate Innovation in Pediatrics
Columbus, OH—February 15, 2024 —Today, the Midwest Pediatric Device Consortium (MPDC), a new consortium led by Nationwide Children’s Hospital, The Ohio State University, Cincinnati Children’s, and Cleveland Clinic Children’s launched to utilize the resources of the
Feb 12, 2024
Study Finds Adolescents with Concussion May Benefit from More Activity Earlier
Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, activity type matters. In a study published today in British Journal of Sports Medicine, researchers found that limiting screen time and returning to school early following a concussion may speed up recovery.
Jan 22, 2024
New Study Finds Liquid Laundry Detergent Packet Exposure Burden among Young Children Remains; Increase in Exposures among Older Children, Teens, and Adults
A new study conducted by researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital and the Central Ohio Poison Center investigated trends in calls to poison centers across the country for exposures to liquid laundry detergent packets. The study investigators identified declines in the number, rate and severity of liquid laundry detergent packet exposures among children younger than 6 years. However, the exposure burden remained high. Additionally, exposures have increased among older children, teens and adults.
Jan 18, 2024
Jerry Mendell, MD, Announced as King Faisal Prize Laureate in Medicine
Jerry Mendell, MD, senior advisor in the Center for Gene Therapy in the Abigail Wexner Research Institute at Nationwide Children’s Hospital, is this year’s recipient of the King Faisal Prize for Medicine for his contributions toward the screening, diagnosis and treatment of neuromuscular diseases, including spinal muscular atrophy (SMA), Duchenne muscular dystrophy (DMD) and limb girdle muscular dystrophy.
Dec 11, 2023
Nationwide Children’s Hospital Becomes Authorized Treatment Center for Sickle Cell Gene Therapy
Nationwide Children’s Hospital has been designated an authorized treatment center for CASGEVY™ (exagamglogene autotemcel (exa-cel)), a gene therapy for the treatment of sickle cell disease.
Nov 28, 2023
How Can Health Care Systems Research Improve Health Equity?
In the United States, health care inequities based on racial and ethnic sociodemographics are pervasive and persistent. Research has shown the systems that deliver health care have both contributed to and maintain these disparities. Quality improvement programs and health policy innovations have led to modest improvements in equity, but research on which approaches work best and how to scale promising programs is limited.
Nov 16, 2023
Study Shows Amount and Days of Opioids Prescribed at Discharge Decreased After 2017 Ohio Prescription Opioid Cap Law
In a new study, published in PLOS One, researchers at the Center for Injury Research and Policy, Center for Pediatric Trauma Research, Department of Pediatric Surgery, Department of Pediatrics, Department of Orthopedics, and Department of Anesthesiology and Pain Medicine at Nationwide Children’s Hospital compared the amount of opioid analgesics prescribed to children following enactment of the Ohio Opioid Cap Law with historical controls.
Oct 23, 2023
Probiotics Delivered in Biofilm State Protect the Intestines and Brain in NEC Model
Researchers at Nationwide Children’s have been working on a novel solution to prevent NEC. They have developed a novel probiotic system that harnesses the durability of biofilms to improve the administration of probiotics to patients. It has been licensed to Scioto Biosciences. Their latest study, published in Nature Scientific Reports, describes the use of a biofilm formulation of Limosilactobacillus reuteri (Lr) to prevent NEC in a piglet model.
Oct 18, 2023
Nationwide Children's Hospital to Expand Mental and Behavioral Health Research
Nationwide Children's Hospital has created a new Institute for Mental and Behavioral Health Research, significantly expanding opportunities to seek a better understanding of mental and behavioral health in children and to develop better diagnostics, treatment and preventative strategies. Leading this new institute will be Eric Youngstrom, PhD, a nationally renowned psychologist specializing in the relationship of mood and psychopathology, and the clinical assessment of children and families.
Oct 09, 2023
Study Finds GERD Less Likely Cause of Fussiness in Irritable Infants
In a new study published in The Journal of Pediatrics, researchers in the Abigail Wexner Research Institute at Nationwide Children’s Hospital have found that high-risk infants who express irritability and arching of their backs likely are not suffering from gastroesophageal reflux disease (GERD).
Sep 18, 2023
Study Shows Nearly 300% Increase in ADHD Medication Errors
In a new study, published today in Pediatrics, researchers at the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital investigated the characteristics and trends of out-of-hospital ADHD medication errors among people younger than 20 years old reported to U.S. poison centers from 2000 through 2021.
Sep 13, 2023
Nationwide Children’s, Ohio State Receive $17.7 Million to Study Children’s Health
A research team at Nationwide Children’s Hospital and The Ohio State University Wexner Medical Center was recently awarded $17.7 million from the National Institutes of Health (NIH) to join a national consortium to study how childhood environments and experiences influence the health of children as they grow and develop.
Sep 11, 2023
$6.95 Million FDA Grant to Help Create Medical Devices Just for Children
The Food and Drug Administration (FDA) announced a $6.95 million grant to be distributed over five years to create a new consortium led by investigators from Nationwide Children’s Hospital, The Ohio State University, Cleveland Clinic Children’s, and Cincinnati Children’s to help increase the number of pediatric medical devices across the nation.
Aug 08, 2023
From Bench to Bedside: Patient with Duchenne Muscular Dystrophy Receives First Dose of Gene Therapy Developed at Nationwide Children’s Hospital
In a landmark moment for the Abigail Wexner Research Institute at Nationwide Children’s, a 5-year-old from Bellefontaine, Ohio, received the first dose of a recently approved gene therapy for Duchenne muscular dystrophy at Nationwide Children’s Hospital, where the therapy was invented and initially tested.
Jun 22, 2023
FDA Approves First Gene Therapy Treatment for Duchenne Muscular Dystrophy Developed at the Abigail Wexner Research Institute at Nationwide Children’s Hospital
Today, the Abigail Wexner Research Institute at Nationwide Children’s Hospital praised the Food and Drug Administration (FDA) for its accelerated approval of SRP-9001/ELEVIDYS for Duchenne muscular dystrophy (DMD) following decades of research in its Center for Gene Therapy to help patients with neuromuscular diseases.
Jun 13, 2023
Mapping the 3D Structure of Rhabdomyosarcoma Chromatin
In a paper published in Nucleic Acids Research Cancer (NAR Cancer), researchers from the Center for Childhood Cancer Research at Nationwide Children’s and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of rhabdomyosarcoma (RMS).
Apr 25, 2023
Nationwide Children's Hospital Names First Chief Data Sciences Officer
Peter White, PhD, has been named the inaugural Chief Data Sciences Officer (CDSO) of the Abigail Wexner Research Institute (AWRI) at Nationwide Children's Hospital. The CDSO will lead biomedical data science initiatives to support Nationwide Children's mission as a leader in pediatric health care innovation.
Apr 06, 2023
Using Machine Learning in the Electronic Medical Record to Save Lives
In a report published in Pediatric Critical Care Medicine, a team from Nationwide Children's Hospital describes a machine learning tool for timely identification of hospitalized children at risk for deterioration – a worsening clinical condition with increased risk of morbidity and mortality. The tool, which is trained on disease-specific groups, promisingly outperformed the existing situational awareness program in identifying at-risk children.
Feb 27, 2023
Dr. Patrick Gallagher of Yale University Named Director of Perinatal Research Center at Nationwide Children's Hospital
Patrick Gallagher, MD, from Yale University has been named the new director of the Center for Perinatal Research in the Abigail Wexner Research Institute at Nationwide Children's Hospital.
Jan 20, 2023
New Insights into the Role of the NOTCH1 Gene in Congenital Heart Defects
A new study published in Circulation Research provides novel insights into how mutations in the NOTCH1 gene may lead to abnormal differentiation and proliferation of cardiomyocytes and contribute to ventricular hypoplasia and other structural anomalies found in congenital heart defects in humans.
Jan 19, 2023
Cynthia Gerhardt, PhD, Named Chief Clinical Research Officer at Nationwide Children's Hospital
Cynthia A. Gerhardt, PhD, director, Center for Biobehavioral Health in the Abigail Wexner Research Institute at Nationwide Children's Hospital, has been appointed Chief Clinical Research Officer (CCRO) at Nationwide Children's.
Jan 18, 2023
Genomic Medicine, Physician Dedication Give Family Answers About Teen’s Rare Disease
Through whole exome sequencing performed in 2020 at the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s, one family was finally able to put a real name to their adolescent's rare disease.
Nov 03, 2022
“The Ripple Effect” New Study Illustrates Vast Influence Children’s Mental Health Concerns have on Workforce Challenges in America
“The Ripple Effect” study from On Our Sleeves found that the mental health of their children remains a concern for the large majority of working parents, with almost half of all parents reporting that in the past year their child's mental health has been somewhat or extremely disruptive to their ability to work on most days.
Oct 26, 2022
Saliva, Genomic Analysis Used to Identify Promising Biomarkers for Persistent Post-Concussive Symptoms in Children
In a study published in Frontiers in Public Health, researchers with the Center for Injury Research and Policy, Division of Sports Medicine, and the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital have demonstrated a method by which increased risk of persistent post-concussive symptoms (PPCS) in children with concussion can be identified. This could allow families and their care teams to better assess recovery time of children with concussion.
Aug 29, 2022
New Study Finds Battery-Related Injuries in Children More than Doubled in Recent Decade
Pediatric battery-related emergency department (ED) visits have increased considerably in the last decade, particularly among children 5 years old and under, according to a new study published today in Pediatrics by a team of researchers from Safe Kids Worldwide and Nationwide Children’s Hospital.
Aug 18, 2022
New Disorder of Copper Metabolism Identified, Caused by Variants in CTR1 Gene
Copper is essential for many cellular functions, including cellular respiration, antioxidant defense, neurotransmitter biosynthesis and neuropeptide amidation, among others. Until recently, only two inborn errors of copper metabolism were well established. Both are rare. Wilson's disease and Menkes disease result from mutations in the copper-transporting P-type ATPases; ATP7B and ATP7A, respectively.
Aug 09, 2022
New Center at Nationwide Children's Hospital Receives Significant NIH Funding
Researchers at Nationwide Children's Hospital recently received coveted P50 Center grant funding from the National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), to support a new center focused on suicide prevention.
Jul 27, 2022
St. Baldrick's Foundation Funds $8.9 Million in Grants to Support the Most Promising Childhood Cancer Research
No hospital has a monopoly on good ideas. This is why the St. Baldrick's Foundation funds the most promising research — no matter where it takes place – from your backyard institution to other cutting edge research facilities treating childhood cancers around the globe. Since 2005, this philosophy has translated to more than 1,674 grants in 31 countries, totaling more than $322 million. Thanks to the tremendous efforts of volunteers, donors, partners and advocates across the country this past year, St. Baldrick's is proud to announce $8.9 million has been awarded in new grants.
Jul 26, 2022
Researchers Receive Funding Award Aimed at Improving Early Childhood Preventive Care Outcomes
Researchers at Nationwide Children’s Hospital, in partnership with researchers at Seattle Children’s Hospital, have been approved for a $5 million research funding award from the Patient-Centered Outcomes Research Institute (PCORI) for an innovative project that will test a community navigator model to improve the delivery of preventive care for young children and has a special focus on improving outcomes for Black children and their families.
Mar 23, 2022
Nationwide Children’s Hospital Selected as Clinical Coordinating Center in Large National Clinical Trial Sponsored by National Heart Lung and Blood Institute (NHLBI)
The National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH) has announced that Nationwide Children’s Hospital has been selected for funding as the Clinical Coordinating Center for the multicenter randomized trial: “Percutaneous intervention versus observational trial of arterial ductus in lower gestational age infants (PIVOTAL)”.
Mar 09, 2022
Early Phase Gene Therapy Study for SMARD1/CMT2S Disease Now Enrolling
Nationwide Children's Hospital has launched a new Phase I/IIa gene replacement clinical study to evaluate the safety of a gene therapy for IGHMBP2-related diseases, specifically spinal muscular atrophy with respiratory distress type 1 (SMARD1) and Charcot Marie Tooth disease type 2S (CMT2S). SMARD1 and CMT2S are rare inherited conditions that are both caused by mutations in the IGHMBP2 gene, of which more than 60 have been found to date. SMARD1 is the most severe form of these diseases and causes muscle weakness and respiratory failure in infancy.
Feb 25, 2022
Dennis Durbin, MD, MSCE, Named President of the Abigail Wexner Research Institute at Nationwide Children’s Hospital
Beginning March 1, 2022, Dennis Durbin, MD, MSCE, will become the third president of the Abigail Wexner Research Institute at Nationwide Children's Hospital. Dr. Durbin joined Nationwide Children's in 2018 as its first chief scientific officer.
Feb 10, 2022
Epilepsy Centers in United States Expand in Size and Specialized Testing Services with Accreditation
New research from the Abigail Wexner Research Institute at Nationwide Children’s Hospital has found that as a result of the increased number of accredited epilepsy centers in the United States, drug-resistant epilepsy (DRE) patients have easier access to specialized testing and services. The report, which describes level 3 and level 4 epilepsy centers that were accredited by the National Association of Epilepsy Centers (NAEC) from 2012 to 2019, published this week in Neurology.
Feb 03, 2022
New Study Finds High-Powered Magnets Lead to Hospitalizations and Life-Threatening Injuries in Children
A recent study led by researchers at the Center for Injury Research and Policy and Emergency Medicine at Nationwide Children’s Hospital along with 24 other children’s hospitals across the country looked at nearly 600 cases of high-powered magnet-related injuries in the three years after high-powered magnets re-entered the US market (2017 to 2019).
Feb 01, 2022
Study supports virotherapy as a potential treatment for brain tumors
A new study provides additional evidence of the efficacy of virotherapy for glioblastoma, the most deadly type of brain tumor. The research findings, published Feb. 1, 2022, in Clinical Cancer Research, indicate that an oncolytic herpes simplex virus, G207, appears to boost immune response and that this is associated with better overall survival for patients with glioblastoma.
Dec 28, 2021
Right Care, Right Place, Right Time? Frequency and Duration of Boarding for Pediatric Mental Health Conditions at Acute Care Hospitals
According to the results of a national survey conducted, in part by a researcher at Nationwide Children’s Hospital, mental health boarding in emergency departments (ED) and/or hospital inpatient settings is common with a median of 4 patients daily and associated with median durations of 48 hours – 10 times longer than standards established by the Joint Commission. In addition, in these acute care settings, youths received minimal mental health services during their lengthy boarding. Unfortunately, these patients are getting the wrong care, in the wrong place and at the wrong time. The study was published in the Journal of the American Medical Association.
Dec 23, 2021
Study Finds High Mortality Rates of Youths Previously Incarcerated in the Juvenile Legal System
New research from the Abigail Wexner Research Institute at Nationwide Children’s Hospital finds that youth aged 11 to 21 years, who have been previously incarcerated in the juvenile legal system, are 5.9 times more likely than the general population to experience early mortality. The report, which describes a cohort study of 3645 previously incarcerated youths in Ohio’s juvenile legal system, appears this week in JAMA Network Open.
Dec 14, 2021
Creating a Physician Workforce that Reflects the Patients and Families We Serve
Workforce disparities persist within health care institutions and medical training. While individuals who identify as Black/African American, Latinx/Hispanic, Native American, and Pacific Islander comprise roughly 30% of the U.S. population, they are less than 15% of physicians, making them underrepresented in medicine – or URM. In fact, as the U.S. population grows more diverse, the racial and ethnic demographic gap between patients and physicians, including pediatricians, is worsening. In a bold effort to bridge that gap, a team of physicians (medical educators, advocates, and researchers) at Nationwide Children’s Hospital developed a plan. The plan and its results are now published in Pediatrics.
Dec 13, 2021
Human MicroRNA Inhibits Expression of Pathogenic Gene Underlying Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is caused by aberrant expression of the DUX4 gene in skeletal muscles. Researchers at Nationwide Children’s Hospital have recently demonstrated that an endogenous human microRNA, miR-675, inhibits DUX4 expression and protects muscles from DUX4-mediated cell death in a mouse model when administered via gene therapy. They also showed that the small molecule-based treatments that upregulate miR-675 inhibited DUX4 mRNA and DUX4-associated biomarkers in myotubes derived from patients with FSHD.
Sep 09, 2021
Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two times more likely to die by suicide than their White counterparts. However, the literature investigating Black youth suicide is extremely limited. For the first time, researchers have examined the trends and precipitating circumstances of suicide in Black youth only by age group and sex.
Aug 26, 2021
Every 46 Minutes a Child is Treated in a U.S. Emergency Department for an Injury from a Furniture or TV Tip-Over
Furniture and TV tip-overs are an important source of injury, especially for children younger than 6 years old. A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital found that an estimated 560,200 children younger than 18 years old were treated in U.S. emergency departments for furniture or TV tip-over injuries from 1990 through 2019. In 2019, there were 11,521 injured children, which is an average of one child every 46 minutes.
Aug 20, 2021
When Dismantling Bacterial Biofilms, the First Line of Defense Comes From Within
Researchers identified the mechanism behind the anti-biofilm properties of a protein found in all vertebrates. Too little of this protein allows disease-causing bacteria protected by biofilms to spread, while too much can lead to septic shock. Could a molecule of this protein be engineered to destroy biofilms without negative effects on the body?
Aug 06, 2021
An Alarming Connection Between Justice System Involvement and Child Health
A new study conducted at Nationwide Children’s Hospital’s Abigail Wexner Research Institute and published in the journal Health & Justice, appears to be the first to use electronic medical records and link children’s personal or family involvement in the correctional system to diagnoses – and the authors say the findings are so alarming they should be a call to action for pediatric providers.
Jul 29, 2021
New Study Finds Hands-free Cellphone Laws Associated with Fewer Driver Deaths
A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital looked at drivers, non-drivers (passengers, pedestrians, bicyclists, motorcyclists), and total deaths involved in passenger vehicle crashes from 1999 through 2016 in 50 U.S. states, along with the presence and characteristics of cellphone use laws.
Jul 27, 2021
Mental Health Concerns and Traumatic Events Are Common Among Young Children Who Die By Suicide
A study published today by Nationwide Children’s Hospital researchers found that although the circumstances around any suicide death are complex, there are often shared characteristics and experiences among young children who die by suicide.
Jun 28, 2021
Understanding Black Youth Suicide: Steps Toward Prevention
In a statement published in JAMA Pediatrics, researchers at the Nationwide Children’s Hospital, the University of North Carolina at Chapel Hill and the nonprofit research institute RTI International responded to a call from the National Institute of Mental Health (NIMH) requesting information on how to prevent Black youth suicide. The researchers emphasize the need for research and action of suicide prevention among Black youth must start from the ground up.
Jun 21, 2021
Virtual Reality as Pain Relief: Reducing Dressing Change Pain in Pediatric Burn Patients
Although opioids relieve burn injury-related pain, they have serious adverse side effects. Prior studies have investigated alternative approaches to pain reduction in burn injury patients that focus on distraction, such as music, hypnosis, toys, and virtual reality (VR). In a study published today in JAMA Network Open, Henry Xiang, MD, MPH, PhD, MBA, and his research team reported the use of smartphone-based VR games during dressing changes in pediatric patients with burn injuries.
Mar 15, 2021
Calls to Poison Centers about High-Powered Magnets Increased by 444% after Ban Lifted
A recent study led by researchers at the Center for Injury Research and Policy, Emergency Medicine, and the Central Ohio Poison Center at Nationwide Children’s Hospital along with the Children’s Hospital at Montefiore (CHAM) analyzed calls to U.S. poison centers for magnet exposures in children age 19 years and younger from 2008 through October 2019 to determine the impact of the CPSC rule and the subsequent lift of the ban.
Mar 09, 2021
New Study Looks at Effect of COVID-19-Related Social Distancing Policies on Motor Vehicle Crashes and Traffic Volume in Ohio
A new study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital estimated associations between COVID-19-related social-distancing policies, traffic volume, and motor vehicle crash-related outcomes in Ohio.
Mar 08, 2021
No More Sitting in the Dark?
A new study by researchers at the Center for Injury Research and Policy, Sports Medicine, and Emergency Medicine at Nationwide Children’s Hospital investigated objectively measured, self-paced physical and cognitive activity across the first week post-concussion.
Dec 16, 2020
Despite Decrease in Recent Years, Rate of Sledding-Related Injuries Still Concerning
A new study conducted by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital found that 220,488 patients were treated in U.S. emergency departments for injuries related to sledding from 2008 through 2017. Nearly 70% of these patients were children age 19 years and younger. Compared to adults, children were almost seven times as likely to be treated in an emergency department for a sledding-related injury.
Dec 02, 2020
New Study Finds Association Between Types of Cellphone Laws and How Often Teens Talk on the Phone While Driving
A new study conducted by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital analyzed the association between cellphone laws and the prevalence of talking on a phone while driving among teen drivers by using data from the Youth Risk Behavior Surveys from 2013 through 2019.
Nov 23, 2020
Andelyn Biosciences Breaks Ground for New Commercial-Scale Gene Therapy Manufacturing Facility
Andelyn Biosciences, an affiliate company of Nationwide Children’s Hospital that manufactures gene therapy products for the biotechnology and pharmaceutical industries, has broken ground on its new site located at 1250 Arthur E. Adams Dr. in The Ohio State University’s Innovation District. Opening in 2022, it will be central Ohio’s first commercial-scale Good Manufacturing Practices (cGMP) production facility devoted to gene therapies.
Oct 12, 2020
Sound the Alarm: Researchers Determine More Effective Ways to Awaken Children and Their Families During a House Fire
When residential fires happen at night while families are sleeping, deaths are more likely to occur. Smoke alarms are important for preventing these deaths, yet research has shown that many pre-teenage children don’t wake up to traditional high-frequency tone alarms. Researchers from the Center for Injury Research and Policy and the Sleep Disorders Center at Nationwide Children’s Hospital conducted a series of studies to identify smoke alarm signals that would more effectively awaken children and other members of the household in the event of a fire.
Aug 27, 2020
Patient-Centered, Age-Appropriate Contraception Counseling Helps Health Care Providers Educate Adolescents About Contraceptive Methods
Preventing unplanned pregnancies in adolescents with effective and easy-to-use contraception is key to ensuring that adolescents do not become parents before they are ready. Adolescents view their health care providers as trusted sources of medical information. Thus, providers are tasked with providing adolescent patients with comprehensive, age-appropriate and nonjudgmental contraception counseling.
Aug 10, 2020
Despite Decreases in Recent Years, New Study Finds ATV-Related Head and Neck Injuries Among Youth Continue to Remain High
A new study conducted by researchers at the Center for Injury Research and Policy and the Department of Otolaryngology-Head and Neck Surgery at Nationwide Children’s Hospital analyzed data regarding ATV-related head and neck injuries treated in U.S. emergency departments from 1990 through 2014 involving patients younger than 18 years of age, and found an average of more than 11,000 children and teens treated for nonfatal ATV-related head and neck injuries annually – that’s approximately 31 children and teens injured each day.
Jul 27, 2020
Study Finds Significant Increase in Number and Severity of Suicide-Related Calls to U.S. Poison Control Centers Involving Over-the-Counter Pain Relievers
In a new study, researchers at the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital analyzed the 549,807 calls made to Poison Control Centers (PCCs) in the US for suicide-related cases involving OTC analgesics from 2000 through 2018 and found that both the overall number and rate of these cases increased significantly by 57% and 34%, respectively, during this period.
May 27, 2020
How a Network of Hospitals Reduced Average Age at Cerebral Palsy Diagnosis to 9.5 Months
Five hospital systems in the United States have become the first in the world to successfully implement, in clinical practice, international CP diagnosis guidelines that were released in 2017. Their efforts, which resulted in an average decrease of 10 months in time-to-diagnosis, demonstrate the practicality and effectiveness of the guidelines for improving age at diagnosis — a key requirement for early interventions, which can improve CP-related developmental outcomes substantially
May 01, 2020
Nationwide Children’s Hospital Names CEO of Andelyn Biosciences
Nationwide Children's Hospital is pleased to announce Mayo Pujols as CEO of Andelyn Biosciences, an affiliate company that will manufacture gene therapy products for the biotechnology and pharmaceutical industries.
Mar 31, 2020
Head-to-Head Comparison Finds Three Anti-Seizure Drugs Equally Effective for Severe Form of Epilepsy
(COLUMBUS, Ohio) – There are three treatment options commonly used by doctors in the emergency room to treat patients with refractory status epilepticus, severe seizures that continue even after benzodiazepine medications, which are effective in controlling seizures in more than two-thirds of
Mar 06, 2020
Study Shows Promising Approach for the Prevention and Cure of Gonorrhea in Women
(COLUMBUS, Ohio) – In research recently published in mBio, researchers from the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital and Griffith University’s Institute for Glycomics have discovered non-antibiotic (host-targeted) therapies for the effective
Feb 28, 2020
Nationwide Children's Hospital Celebrates Opening of the Big Lots Behavioral Health Pavilion
Nationwide Children’s Hospital held a Community Dedication Celebration of the Big Lots Behavioral Health Pavilion today. At nine stories tall, it is America’s largest and most comprehensive center dedicated exclusively to child and adolescent behavioral and mental health on a pediatric medical campus in the United States.
Dec 12, 2019
Triple Medication Combination Could be Life-changing for Majority of Patients with Cystic Fibrosis
(COLUMBUS, Ohio) – A Phase III clinical trial shows that elexacaftor added to ivacaftor and tezacaftor improves lung function and quality of life in cystic fibrosis patients with the most common genetic mutation, F508del.
Dec 09, 2019
Study Shows Three-Day Intensive Crisis Intervention is Associated with Reduced Suicidality in Adolescents
When an adolescent is acutely suicidal and cannot safely remain in the community, inpatient psychiatric hospitalization is the traditional intervention. But a lack of appropriate facilities across the United States, combined with an increasing demand for inpatient psychiatric services, means many young people who are at critical risk often cannot get the help they need.
Dec 09, 2019
While Study Finds Decrease in Eye Exposures Associated with Household Cleaning Products, Experts Still Urge Proper Storage
A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital analyzed data regarding eye exposures associated with household cleaning products from 2000 through 2016 and found a decrease in the number of exposures during this period. However, the number of these exposures among young children remains high.
Dec 04, 2019
Redirecting the Natural Immune Response to Disrupt Bacterial Biofilms
(COLUMBUS, Ohio) – Most bacterial species prefer to live in biofilms, where they are protected from antibiotic treatments and can lead to chronic and recurrent diseases in humans.
Nov 26, 2019
Study Finds Increase in Calls to U.S. Poison Control Centers for Natural Psychoactive Substances, Driven by Increase in Marijuana Exposures
A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found there were more than 67,300 calls to U.S. Poison Control Centers regarding exposures to natural psychoactive substances. The study looked at calls from January 2000 through December 2017, which totaled an average of 3,743 exposures each year, or approximately 10 calls every day.
Nov 25, 2019
Study Finds Increase in Pediatric Eye Injuries from Nonpowder Firearms
A new study conducted by researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital investigated nonpowder firearm injuries treated in U.S. emergency departments (EDs) among children younger than 18 years from 1990 through 2016. It found an overall decrease in the rate of nonpowder firearm injuries during the study period, but an increasing rate of eye injuries related to nonpowder firearms.
Nov 19, 2019
Study Identifies Barriers High Schools Face When Implementing and Enforcing State Concussion Laws
A new study conducted by researchers at the Center for Injury Research and Policy in the Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital investigated the barriers high schools across the country face when implementing state concussion laws.
Nov 01, 2019
Study Shows Media Overlook Best Practices when Reporting a Celebrity Suicide Death
A study published today in JAMA Network Open by researchers at Nationwide Children’s Hospital examined suicide reporting guideline adherence by the media for the suicide deaths of Kate Spade and Anthony Bourdain. The study found that some media coverage of the Spade and Bourdain deaths did not adhere to several of the suicide reporting guidelines.
Oct 14, 2019
Study Finds Black Youth are Attempting Suicide More Often than All Other Racial and Ethnic Groups
(COLUMBUS, Ohio) – According to the Centers for Disease Control and Prevention, suicide is the second leading cause of death in youth 12-18 years old in the United States, and in 2017 alone, suicide accounted for more than 2,200 deaths among this age group.
Oct 07, 2019
Study Shows Over-The-Counter Medications Most Commonly Used in Cases of Attempted Suicide by Self-Poisoning in Youth, Adolescents
A new study from Nationwide Children’s Hospital and the Central Ohio Poison Center found rates of suicide attempts by self-poisoning among youth and adolescents are higher in rural communities, higher during the academic school year and involve common medications found in many households.
Sep 30, 2019
Childhood Cancer Research Team at Nationwide Children’s Hospital Awarded $10.2 Million Moonshot Grant
The National Cancer Institute at the National Institutes of Health announced it has awarded one of its Cancer Moonshot grants to Timothy Cripe, MD, PhD, chief of the division of Hematology, Oncology & Blood and Marrow Transplant and Elaine Mardis, PhD, co-executive director of the Steve and Cindy Rasmussen Institute for Genomic Medicine at Nationwide Children’s Hospital.
Sep 05, 2019
Stopping Progression of Tissue Injury after Button Battery Ingestion
Button battery injuries in children have been increasingly severe, resulting in devastating injuries and even death. Button batteries damage esophageal tissue through isothermic hydrolysis reactions, resulting in alkaline caustic injury, which leads to tissue necrosis. Prompt removal of the battery is critical to minimizing damage. However, when children swallow a button battery, the injury can progress even after it is removed.
Aug 15, 2019
Screening for Cervical Spine Risk Factors Could Reduce CT Scans by Half
Study finds identifiable risk factors ED staff can use for evaluation, avoiding over 100,000 unnecessary scans annually.
Jul 11, 2019
Study Finds No Correlation Between Brain Function and Head Impacts After Two Seasons of Youth Tackle Football
To date, most studies that have attempted to understand connections between neurocognitive function and sub-concussive head impacts have been retrospective – and inconclusive.
Jul 08, 2019
Nationwide Children’s Hospital Receives $2.8 Million Grant to Participate in Federally-Funded Pediatric Research
The Emergency Medicine department at Nationwide Children’s Hospital recently received a four-year, $2.8 million grant to continue leading one of the six U.S. Research Node Centers for the Pediatric Emergency Care Applied Research Network (PECARN), the first federally-funded pediatric emergency medicine research network.
Jun 17, 2019
Hidden in Plain Sight: New Study Finds Personal Care Products Send a Young Child to the Emergency Room Every Two Hours
A new study conducted by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital found that 64,686 children younger than five years of age were treated in U.S. emergency departments for injuries related to personal care products from 2002 through 2016 – that is the equivalent of about one child every two hours.
Jun 06, 2019
Study Shows Increase in Ingestions of Marijuana by Children in U.S.
In a study published online in Pediatric Emergency Care, researchers at the Central Ohio Poison Center at Nationwide Children’s Hospital examined the relationship between state marijuana legalization and the rates of unintentional ingestions of marijuana in children under six years old.
Jun 03, 2019
Despite Safety Standard, Laundry Packet Exposures Increase in Older Children, Adults; Decrease in Young Children
A new study conducted by researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital and the Central Ohio Poison Center found a modest decrease in calls for children younger than 6 years of age following adoption of a 2015 product safety standard but an increase in calls for older children and adults.
May 24, 2019
FDA Approves First Gene Therapy Treatment for SMA Developed at the Abigail Wexner Research Institute at Nationwide Children’s Hospital
Today, the Abigail Wexner Research Institute at Nationwide Children’s Hospital praised the Food and Drug Administration (FDA) for its approval of Zolgensma® for spinal muscular atrophy (SMA) following decades of research in its Center for Gene Therapy to help patients with neuromuscular diseases.
May 21, 2019
Nationwide Children’s Hospital Dedicates Abigail Wexner Research Institute at Nationwide Children’s Hospital
Nationwide Children’s Hospital dedicated the hospital’s Research Institute as the Abigail Wexner Research Institute at Nationwide Children’s Hospital. This naming recognizes Mrs. Wexner, whose ongoing, passionate advocacy has ushered in a period of unprecedented transformation at the hospital.
May 20, 2019
MEDIA ADVISORY: Dedication of the Abigail Wexner Research Institute at Nationwide Children’s Hospital
WHAT: The dedication of the Abigail Wexner Research Institute at Nationwide Children’s Hospital and announcement of the Allen Distinguished Scholar in Pediatric Research WHEN: Tuesday, May 21, 2019 10:30 a.m. – Media Tour of the Abigail Wexner Research Institute 11:30 a.m.
May 20, 2019
Pinterest Homemade Sunscreens: A Recipe for Sunburn
A new study conducted by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital and the Brooks College of Health at University of North Florida examined how homemade sunscreens were portrayed on Pinterest.
May 17, 2019
Study Finds Narrowing Gender Gap in Youth Suicides
New research from Nationwide Children’s Hospital finds a disproportionate increase in youth suicide rates for females relative to males, particularly in younger youth aged 10-14 years.
May 16, 2019
Weight-Loss Surgery in Teens with Severe Obesity Offers Greater Benefits Than Waiting Until Adulthood
A study from the New England Journal of Medicine has revealed that adolescents who underwent gastric bypass were more likely to experience a complete remission of diabetes and hypertension by 5 years after surgery compared to adults — who also had severe obesity as adolescents — who underwent the procedure.
May 08, 2019
Nationwide Children’s Hospital is Now Recognized as a Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies
Designation as a Jeffrey Modell Diagnostic and Research Center is an honor and testament to the one team, comprehensive approach that Nationwide Children’s provides in diagnosing and caring for patients with primary immunodeficiency disorders.
May 01, 2019
Suicide Attempts by Self-Poisoning Have More Than Doubled in Teens, Young Adults
A new study from Nationwide Children’s Hospital and the Central Ohio Poison Center found rates of suicide attempts by self-poisoning among adolescents have more than doubled in the last decade in the U.S., and more than tripled for girls and young women.
Apr 29, 2019
Suicide Rates Spike Nationally Among Youth After “13 Reasons Why” Release
A recent study revealed approximately 195 more youth suicide deaths than expected were associated with the television series “13 Reasons Why” in the nine months immediately following the series release.
Apr 01, 2019
Anne M. Connolly, MD, Named Division Chief of Neurology at Nationwide Children’s Hospital
Anne M. Connolly, MD, has joined Nationwide Children’s Hospital as division chief of Neurology and a member of the Center for Gene Therapy.
Mar 13, 2019
National Survey of Emergency Department Management of Self-Harm Highlights Successes, Room for Improvement
In a study published today in JAMA Psychiatry, researchers at Nationwide Children’s Hospital describe the results of a national survey to evaluate how frequently evidence-based management practices are used in EDs when treating patients who present for self-harm.
Feb 21, 2019
New Study Finds Dramatic Increase in Calls to U.S. Poison Control Centers for Kratom Exposure
A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that there were more than 1,800 calls to U.S. Poison Control Centers regarding exposures to kratom from January 2011 through December 2017.
Feb 18, 2019
Study provides new clinical guidance that avoids painful tests for infants with fever
A national research team led by UC Davis Health clinicians and researchers from the University of Michigan, Nationwide Children’s Hospital and Columbia University, has derived and validated a new protocol for emergency departments that can determine which infant patients with fevers, age 60 days or younger, are at low risk of significant bacterial infections.
Feb 11, 2019
Poison Control Centers Receive 10 Calls Every Hour for Eye Exposures
A new study published recently by Ophthalmic Epidemiology and conducted by researchers at the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that from 2000 through 2016 there were nearly 1.5 million calls to US poison centers for eye exposures associated with pharmaceutical and non-pharmaceutical substances.
Jan 25, 2019
Nationwide Children’s Hospital Announces Plans to Dedicate the Abigail Wexner Research Institute
Ms. Wexner’s partnership with her fellow board members, Chief Executive Officer Steve Allen, MD, and the Nationwide Children’s executive team made this evolution possible. In recognition of Dr. Allen’s role, Nationwide Children’s will also establish the Allen Distinguished Scholar in Pediatric Research.
Jan 23, 2019
Suicide Deaths Among Incarcerated Youth
According to a U.S. Department of Justice survey, from 2000 to 2014, suicide rates were two to three times higher for youth in custody than those in the general population. In a new study published in the Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP), researchers from Nationwide Children's Hospital looked at circumstances preceding suicide to understand better why this disparity in suicide rate exists.
Dec 21, 2018
Nationwide Children’s Hospital Researchers Review Influences of Maternal Diabetes on Fetal Heart Development
In a comprehensive review recently published in Birth Defects Research, Vidu Garg, MD, and Madhumita Basu, PhD, offer a “state of the science” look at the impact of maternal diabetes, and potential gene-environmental influences in that context, on fetal heart development.
Dec 04, 2018
Prenatal Magnesium Sulfate May Not Reduce Cerebral Palsy Severity as Once Believed
A new study from Nationwide Children’s Hospital and The Ohio State University Wexner Medical Center calls into question whether these labor-intensive magnesium administrations have an effect outside of the controlled environment of a trial.
Nov 13, 2018
Wishes Help Keep Pediatric Patients Out of the Hospital
Cimone Stills, 15, has a medical condition that has caused her to have multiple seizures a day for most of her life. Specifically, she has treatment-resistant generalized epilepsy because of a genetic variation. Like many patients with such a serious illness, it affects her daily life and as a result, she was diagnosed with clinical depression. But Cimone’s outlook on life completely changed for the better after her wish of going to Paris.
Nov 05, 2018
Youth TBI Laws Promote Head Injury Evaluation in Emergency Department
To help reduce the effects of TBIs in youth sports, all 50 states and the District of Columbia enacted state youth TBI laws between 2009 and 2014. A new study from researchers in the Center for Injury Research and Policy at Nationwide Children’s Hospital examined the effectiveness of these laws by looking at sports and recreation mild TBI (mTBI)-related emergency department (ED) visits for children ages 5 to 18 years before and after TBI legislation was enacted in each state. Specifically, researchers looked at ED visits from 2006 through 2014 for diagnosis of mTBI and compared them with diagnoses of moderate to severe TBI, minor head injury, and long bone fracture.
Oct 25, 2018
Smoke Alarms Using Mother’s Voice Wake Children Better than High-Pitch Tone Alarms
(COLUMBUS, Ohio) – When residential fires happen at night while people are sleeping, deaths are more likely to occur. Smoke alarms are important for preventing these deaths, yet many young children don’t wake up to traditional high-pitch tone alarms.
Oct 23, 2018
Omega Fatty Acid Supplement for Toddlers Born Preterm
Premature birth can affect children’s early brain development, such that children born preterm sometimes struggle in school or with behavior problems. Docosahexaenoic acid (DHA) is an omega-3 fatty act that plays important roles in early brain development.
Oct 15, 2018
Cumulative Sub-concussive Impacts in a Single Season of Youth Football
COLUMBUS, Ohio – In an investigation of head impact burden and change in neurocognitive function during a season of youth football, researchers find that sub-concussive impacts are not correlated with worsening performance in neurocognitive function.
Aug 03, 2018
Housing for Health
In a recent publication in the journal Pediatrics, researchers from Nationwide Children’s Hospital present a case study for treating a neighborhood as a patient.
Jul 19, 2018
St. Baldrick’s Foundation Announces $19.1 Million in Grants to Fund Lifesaving Childhood Cancer Research
Physician scientists in The Research Institute at Nationwide Children’s Hospital are St. Baldrick’s Foundation grant recipients
Jul 11, 2018
A Better Way to Administer Probiotics?
Researchers have designed a delivery system to treat premature infants with necrotizing enterocolitis that may have applications beyond the NICU
Jun 25, 2018
Bicycle-related Injuries Send 25 Children to Emergency Departments Every Hour
A new study conducted by researchers in the Center for Injury Research and Policy of the Research Institute at Nationwide Children’s Hospital, published online in Accident Analysis & Prevention, found that from January 2006 through December 2015, more than 2.2 million children age 5-17 years were treated in US hospital emergency departments for bicycle-related injuries. This averages 608 cases per day or 25 every hour.
Jun 25, 2018
A Medication Used to Treat Opioid Dependence Can Cause Serious Health Consequences for Exposed Children
A new study published online today by Pediatrics and conducted by researchers at the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that from January 2007 through December 2016 there were more than 11,000 calls to US Poison Centers for pediatric exposures to buprenorphine – a prescription opioid medication used to treat opioid use disorder.
Jun 11, 2018
Ingesting Honey After Swallowing Button Battery Reduces Injury and Improves Outcomes
A team of ear, nose, and throat (ENT) specialists has demonstrated that eating honey after swallowing a button battery has the potential to reduce serious injuries in small children.
Jun 08, 2018
Study Finds Why Obese Women Have More Surgical Infections After Cesarean Delivery
COLUMBUS, Ohio – Even though all pregnant woman typically undergo a standardized antiseptic preparation before a cesarean delivery, obese women are twice as likely to develop a surgical site infection after the procedure as women with a normal body mass index.
Jun 01, 2018
Nationwide Foundation Pediatric Innovation Fund Making Significant Patient Impact at the Institute For Genomic Medicine at Nationwide Children's Hospital
The Nationwide Foundation today announced a new $10 million gift for the Nationwide Foundation Pediatric Innovation Fund at Nationwide Children's Hospital to help accelerate the most promising research and clinical discoveries at Nationwide Children's.
May 21, 2018
U.S. Poison Control Centers Receive 29 Calls Per Day About Children Exposed to ADHD Medications
(COLUMBUS, Ohio) – A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that there were more than 156,000 calls to US Poison Control Centers regarding exposures to attention-deficit hyperactivity
May 16, 2018
Cannabidiol is effective in children with Lennox-Gastaut syndrome
Children with Lennox-Gastaut syndrome can have hundreds of brief seizures every day. This complex form of epilepsy often does not respond to conventional epilepsy medication, leaving children at serious risk of injury from their seizures, or confined to wheelchairs and beds.
May 08, 2018
A Novel Approach to Patient Safety Proactively Addresses Common Health Care System Successes
Clinical researchers at Nationwide Children’s Hospital have published one of the first health care studies to examine how behavior aligned with Safety II concepts impacts patient safety. Safety II is a novel approach to patient safety that focuses on why processes perform correctly in high-performing units, as opposed to its predecessor, Safety I, which focuses on why processes fail.
May 07, 2018
Children Hospitalized for Injuries Have Increased Mental Health Needs
A study, published in The Journal of Pediatrics, looked at children ages 0-18 years who were hospitalized for unintentional injuries from June 2005 through May 2015. Researchers found that children hospitalized for an injury had on average a 63% increase in mental health diagnoses and a 155% increase in medications prescribed to treat a mental illness.
Apr 24, 2018
Nationwide Children’s Researcher Wins Distinguished Clinical Research Achievement Award
The Clinical Research (CR) Forum, a non-profit membership association of top clinical research experts and thought leaders from the nation’s leading academic health centers, presented the Distinguished Clinical Research Achievement Award to two outstanding studies at the Top Ten Clinical Research Achievement Awards on April 18th at the National Press Club in Washington, D.C.
Mar 27, 2018
Nationwide Children's Hospital Study Named Among Top Ten Clinical Research Achievement Awards by the Clinical Research Forum
The first clinical trial to test the functional replacement of the mutated gene responsible for SMA1 will be recognized at the 2018 Top Ten Clinical Research Achievement Awards at the National Press Club in Washington, D.C., on April 18, 2018.
Mar 01, 2018
Small Trial of Omega Fatty Acid Supplementation in Toddlers Born Preterm Shows Promising Results: Larger Scale Trial Indicated
Researchers from Nationwide Children’s Hospital have shown that omega fatty acid supplements may improve autism spectrum disorder symptoms in toddlers who were born very preterm (more than 11 weeks early). The study was published online recently by The Journal of Nutrition.
Feb 21, 2018
Laws Banning Hand-Held Cellphone Calls More Effective than Texting Bans for Teen Drivers
A new study led by the Center for Injury Research and Policy at Nationwide Children’s Hospital used data from a national survey to examine the effectiveness of state-level cellphone laws in decreasing teens’ use of cellphones while driving.
Feb 20, 2018
Biospecimen Core Resource Wins NIH Contract to Further Cancer Research
The Biospecimen Core Resource (BCR) in The Research Institute at Nationwide Children’s Hospital has received a new $4.5 million federal contract — with the potential of reaching more than $49.9 million over five years — to accept, process, ensure quality, and distribute tumor
Jan 08, 2018
Adolescents Show Decreased Risk for Cardiovascular Disease Later in Life After Bariatric Surgery
Adolescents with severe obesity who had bariatric surgery showed significant improvements in cardiovascular disease risk factors, according to the most recent “Teen Longitudinal Assessment of Bariatric Surgery” (Teen-LABS) study, published online today by Pediatrics.
Jan 08, 2018
New Study Finds Large Increase in Non-Powder Gun-Related Eye Injuries
A new study conducted by researchers in the Center for Injury Research and Policy of the Research Institute at Nationwide Children’s Hospital investigated sports- and recreation-related eye injuries during a 23-year period and found a slight decrease in eye injuries overall; however, the rate
Dec 11, 2017
Injuries from Window Blinds Send Two Children to the Emergency Department Every Day
Most homes have them. They help keep our rooms warm or cold and even add a pop of color to tie the décor together. But window blinds can cause serious injuries or even death to young children.
Nov 01, 2017
Phase 1 Study Shows Encouraging Data for Gene Replacement Therapy for Spinal Muscular Atrophy Type 1
A one-time intravenous infusion of the high dose of gene therapy extended the survival of patients with spinal muscular atrophy type 1 (SMA1) in a Phase 1 clinical trial, according to a study published today in the New England Journal of Medicine. The study was conducted by Researchers from Nationwide Children’s Hospital in collaboration with AveXis, Inc. and The Ohio State University College of Medicine.
Sep 28, 2017
Hyundai Hope On Wheels Awards $250,000 Research Grant To Nationwide Children's Hospital In Honor Of National Childhood Cancer Awareness Month
Hyundai Hope On Wheels® will today present Nationwide Children's Hospital with a $250,000 Hyundai Scholar Hope Grant. The grant funds will support the research of Timothy Cripe, MD, PhD, principal investigator and division chief of Hematology/Oncology and BMT. Dr.
Sep 15, 2017
A New Paradigm for Treating Transcription Factor-Driven Cancers
In the current issue of Proceedings of the National Academy of Sciences, researchers from Nationwide Children’s Hospital describe a new paradigm for treating transcription factor-driven cancers.
Sep 05, 2017
Nationwide Childrens Hospital First To Implement New International Cerebral Palsy Guidelines
While diagnosis of cerebral palsy typically occurs when children are 2 years of age or older, Nationwide Children’s has decreased the average age of diagnosis to 13 months, allowing for earlier therapy.
Jul 12, 2017
Study Finds Rate of Medication Errors Resulting in Serious Medical Outcomes Rising
About every two minutes someone in the United States calls Poison Control because of a medication error. A new study from the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital analyzed calls to Poison Control Centers across the country
Jun 19, 2017
Combining Immunotherapies Effective Against Mouse Model of Cancer
Rhabdomyosarcoma, a cancer made up of cells that normally develop into skeletal muscles, is the most common soft tissue cancer in children. If it is detected early and localized in certain areas, rhabdomyosarcoma is usually curable with traditional therapies like surgery, radiation and
Jun 12, 2017
Immune Profiling Leads to Implications for Immunotherapy for NF1-Associated Tumors
Neurofibromatosis type 1 (NF1) — an autosomal dominant disorder affecting approximately one in every 3,500 people — results in dysfunctional neurofibromin, a protein expressed throughout the body and involved in the RAS signaling pathway.
Jun 08, 2017
MEDIA ADVISORY: Fifth Annual International Central Nervous System Germ Cell Tumor Conference
MEDIA ADVISORY WHAT: Fifth Annual International Central Nervous System Germ Cell Tumor Conference hosted by Nationwide Children’s Hospital. Germ cells are a specific cell that grows during the development of a fetus. These cells go on to become sperm in the testicles or eggs in the ovaries.
May 30, 2017
Mardis Receives Prestigious Luminary Award
The Precision Medicine World Conference has awarded Elaine R. Mardis, PhD, with a 2017 Luminary Award, recognizing her for her role in shaping health care through her leading work in genome sequencing and therapeutic application development.
May 30, 2017
Nationwide Foundation Pediatric Innovation Fund Accelerating Lifesaving Progress at Newly-Formed Institute For Genomic Medicine at Nationwide Childrens Hospital
The Nationwide Foundation today announced a new $10 million gift for the Nationwide Foundation Pediatric Innovation Fund at Nationwide Children’s Hospital to help accelerate the most promising research and clinical discoveries at Nationwide Children’s.
May 24, 2017
Nationwide Childrens Hospital Research Partnership Receives 2017 Distinguished International Engagement Award
In 2004, Nationwide Children’s Hospital began an international program in partnership with collaborators in the U.S. and China, with a specific research focus on pediatric violence and injury prevention.
Mar 16, 2017
Article Highlights Needs of Rural Children, Families with Mental, Behavioral and Developmental Disorders
In the latest of a series of reports on child mental health, the Center for Disease Control and Prevention documents that rural children from small communities have more mental, behavioral and developmental disorders (MBDDs) than those living in cities and suburbs.
Mar 07, 2017
Heart Drug Improves or Stabilizes Heart Function in Duchenne Muscular Dystrophy
Researchers at The Ohio State University Ross Heart Hospital and Nationwide Children’s Hospital have shown early treatment with the heart failure medication eplerenone can improve heart function in young boys with Duchenne muscular dystrophy (DMD) and stabilize heart function in older boys
Feb 06, 2017
Can Childhood Cancer Treatments Affect Survivors' Sex Lives in Adulthood?
A recent analysis showed that although adult survivors of childhood cancer did not differ overall from their peers in terms of their satisfaction with their sex lives and romantic relationships, those who received cancer treatments that were especially toxic to the nervous system were least likely
Jan 05, 2017
NIH-Sponsored Expert Panel Issues Clinical Guidelines to Prevent Peanut Allergy
An expert panel sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, issued clinical guidelines today to aid health care providers in early introduction of peanut-containing foods to infants to prevent the development of peanut
Dec 16, 2016
Hormonal Contraception Safer Than Expected For Women With Diabetes
Strokes and heart attacks are rare for women with diabetes who use hormonal contraception, with the safest options being intrauterine devices (IUDs) and under-the-skin implants, new research published in Diabetes Care shows.
Dec 12, 2016
New Study Finds Handheld Phone Ban May Reduce Drive-time Conversations
Distracted driving is a prevalent safety hazard for everyone, but especially for drivers in their first several years behind the wheel. A new study from the Center for Injury Research and Policy at The Research Institute at Nationwide Children’s Hospital shows that universal handheld phone
Dec 06, 2016
Covelli Enterprises Opens First Panera Bread Location at Nationwide Children's Hospital
Covelli Enterprises, the largest franchisee of Panera Bread, is proud to announce the Grand Opening of its newest Panera Bread location at Nationwide Children’s Hospital (NCH) on Tuesday, December 13 at 6:00 a.m. The new bakery-café will be located at 611 E.
Nov 10, 2016
New Study Points to a Possible Cause of Many Preterm Births
Most spontaneous preterm births do not have causes that are easy to identify. Physicians frequently have not known why uterine contractions begin weeks earlier than they should, in one major form of preterm birth; or why a mother’s water breaks well before the fetus is fully developed, in
Oct 04, 2016
Perky Jerky® to Support Nationwide Childrens Hospital Beginning in October
Nationwide Children’s Hospital and Perky Jerky® announced today that from October through December, customers at 16 participating Kroger stores will have an opportunity to donate to Nationwide Children’s by purchasing Perky Jerky®.
Oct 03, 2016
Becker's Hospital Review Names 50 Hospitals with Innovation Programs
NOTE TO EDITOR: The Center for Innovation in Pediatric Practice in The Research Institute at Nationwide Children’s Hospital is one of the 50 programs listed CHICAGO (October 3, 2016, 10 a.m.
Oct 03, 2016
New Study Finds Exercise Treadmills Significant Cause of Hand Burns in Children
In recent years, home exercise equipment has become increasingly common, and treadmills have continued to be the largest selling exercise category by a large margin.
Sep 20, 2016
Nationwide Childrens Hospital Leads Effort for Gene Therapy Treatment for Duchenne Muscular Dystrophy
Sarepta Therapeutics announced yesterday that the FDA has granted accelerated approval for eteplirsen for the treatment of Duchenne muscular dystrophy (DMD). Nationwide Children's Hospital was the sole original site for the clinical study that resulted in this approval, led by Dr.
Sep 19, 2016
Researchers Find Relationship, Behavioral Differences between Children and Early Adolescents Who Die by Suicide
According to the Centers for Disease Control and Prevention (CDC), suicide was the 10th leading cause of death for children ages 5 to 11 in 2014. This was the first time suicide had shown up in the CDC’s top ten leading causes of death for children in this age group.
Aug 25, 2016
New Study Finds Low Transfer Rates of Pediatric Burn Patients in the U.S.
According to a new study from researchers in the Center for Pediatric Trauma Research and the Center for Injury Research and Policy at Nationwide Children’s Hospital, nearly 127,000 kids in the U.S had burn injuries in 2012.
Aug 23, 2016
Specialized test detects bacterial infections in youngest infants with fever
Physicians from Children’s Hospital of Michigan, UC Davis Medical Center and Nationwide Children's Hospital, in collaboration with 19 other pediatric emergency departments around the country, have established a “proof of principle” for measuring patterns of ribonucleic acid
Aug 18, 2016
Study Finds Average of Two Injuries Every Hour in the U.S. from Strollers and Carriers
Although strollers and carriers are typically used to safely transport children, injuries do occur while using these products. A study conducted by the Center for Injury Research and Policy of the Research Institute at Nationwide Children’s Hospital found that, over a 21-year period from 1990
Jul 20, 2016
AveXis Receives U.S. FDA Breakthrough Therapy Designation for AVXS-101 Gene Replacement Therapy for Spinal Muscular Atrophy Type 1
AveXis, Inc., (Nasdaq:AVXS) a clinical-stage gene therapy company developing treatments for patients suffering from rare and life-threatening neurological genetic diseases, today announced the U.S.
May 09, 2016
New Study Finds Child E-Cigarette Exposures up 1,500%
As the household presence of e-cigarettes and liquid nicotine has increased, so have exposures among young children. A new study conducted by the Center for Injury Research and Policy of the Research Institute and the Central Ohio Poison Center, both at Nationwide Children’s Hospital, found
Apr 28, 2016
First Implantable Hemodynamic Monitoring Device in Single Ventricle Fontan Anatomy
While the Fontan procedure has improved the short- and mid-term outcomes for patients born with single ventricle anatomy, long-term complications of Fontan circulation include heart failure.
Apr 27, 2016
Despite Safety Concerns, Nearly 1 in 4 Babies in NICUs Receive Acid Suppressing Medication Originally Formulated for Older Children, Adults
Since 2006, several published studies have associated the use of some acid suppression medications in hospitalized high-risk babies with infections, necrotizing enterocolitis and increased risk of death.
Apr 26, 2016
Biosortia Pharmaceuticals Announces Three New Oncology Research Projects Using Microalgal Compounds
Biosortia Pharmaceuticals has launched three new oncology research projects. The projects will investigate Biosortia’s unique libraries of consortia microbial compounds for potential drug discovery in pediatric cancer (neuroblastoma), liver cancer (Hepatitis C virus) and an alternative
Apr 08, 2016
New Study Finds Skateboarding Sent About 176 Youth to U.S. EDs Every Day
Skateboarding is a popular recreational sport and participation has increased the last several decades, faster than any other sport or recreation activity between 1998 and 2007.* With growing participation, has come an increasing rate of injuries from skateboarding.
Apr 07, 2016
Often Unreported, a Gray Matter Abnormality Predicts Neurodevelopmental Problems in Smaller Premature Babies
Magnetic resonance imaging of the brain is increasingly used to predict neurodevelopmental outcomes in premature infants, but the existing systems of analyzing or “scoring” those MRIs rely heavily on expert opinion.
Feb 29, 2016
Loss of MHCI in Motor Neurons Leads to ALS Astrocyte Toxicity
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a devastating progressive neurodegenerative disease that results in the death of motor neurons, the nerve cells that control muscles.
Feb 18, 2016
Novel Approach Obtains Protein Signatures from Host and Pathogen With One Small Sample
A novel study from researchers at Nationwide Children's Hospital has shown that it is possible to obtain both host and bacteria protein signatures in a sample smaller than the average human biopsy.
Jan 07, 2016
Nationwide Childrens Hospital Researchers Receive Cystic Fibrosis Foundation Grant to Study Cell Therapy
A team of physician-scientists led by Susan D. Reynolds, PhD, at Nationwide Children’s Hospital recently received a grant from the Cystic Fibrosis Foundation to study the safety and effectiveness of cell therapy for the treatment of cystic fibrosis.
Jan 05, 2016
New Nationwide Childrens Hospital Program to Help Students Learn the Real World of Science, Explore Research Careers
Looking toward the future of medical research, a team at Nationwide Children’s Hospital recently received a five-year $540,000 grant from the National Institutes of Health to support a program to help students experience science in action and encourage them to consider careers in maternal and
Dec 01, 2015
Nationwide Children's Hospital Researcher, Mark Peeples, PhD, Elected as AAAS Fellow
Mark Peeples, PhD, principal investigator in the Center for Vaccines and Immunity at Nationwide Children’s Hospital, has been elected a Fellow in the American Association for the Advancement of Science (AAAS). Dr.
Nov 06, 2015
Adolescent Bariatric Surgery Reverses Type 2 Diabetes in 95 Percent of Teens, Achieves Major Weight Loss and Improves Quality of Life
The results of a new study to be published November 6, 2015 in The New England Journal of Medicine to coincide with presentation at The Obesity Society Annual meeting in Los Angeles, California show that three years after undergoing bariatric surgery, adolescents experienced major improvements in
Oct 29, 2015
Study Update: Breast Milk Purchased Online Contains Caffeine And Tobacco, But No Illicit Drugs
In the latest update on the testing of breast milk samples purchased online, researchers found that no samples appeared to be contaminated with illicit drugs. Dr.
Oct 14, 2015
Pediatric Trauma Researchers at Ohio State University and Nationwide Childrens Hospital Receive Grant to Develop New Treatment Effects Evaluation Method
Researchers in The Ohio State University College of Public Health and the Center for Pediatric Trauma Research at Nationwide Children’s Hospital were recently awarded a grant for nearly $1 million from the Agency for Healthcare Research and Quality in the U.S.
Sep 24, 2015
Vidu Garg, MD, Named Director of the Center for Cardiovascular Research at Nationwide Childrens Hospital
Vidu Garg, MD, a pediatric cardiologist and faculty member in the Department of Pediatrics at Nationwide Children’s Hospital has been named director of the Center for Cardiovascular Research in The Research Institute at Nationwide Children’s.
Sep 24, 2015
Studies Find that Delayed Umbilical Cord Clamping May Benefit Some High-Risk Newborns
Clamping and cutting of the umbilical cord happens within 10 seconds after birth in most cases, in part so members of a medical team can more quickly begin caring for a newborn.
Sep 01, 2015
Nationwide Childrens Hospital Researchers Receive $6.75 Million Grant to Develop RSV Vaccine
Mark Peeples, PhD, and Octavio Ramilo, MD, both principal investigators in the Center for Vaccines and Immunity at Nationwide Children’s Hospital were recently awarded a $6.75 million grant from the National Institute of Allergy and Infectious Diseases.
Aug 21, 2015
Study Finds Tests Used to Measure Internal Bleeding For Patients Taking Two Popular Drugs May Not Be Reliable
A recently-published study found that while internal bleeding may be uncommon as a result of taking blood thinners such as Xarelto® (rivaroxaban) and Eliquis® (apixaban), the normal coagulation tests physicians use to check for the side effect of bleeding may not be reliable.
Jun 08, 2015
National Study Finds Rising Rate of Marijuana Exposure Among Children 5 Years Old and Younger
Debates about legalizing marijuana have focused on crime rates, economic benefits, and health effects among adults. But a study published today from researchers at Nationwide Children’s Hospital shows that the risk to young children of swallowing, breathing in or otherwise being exposed to
Jun 05, 2015
Nationwide Foundation Announces Gift to Transform the Lives of Children Through Genomics Research at Nationwide Childrens Hospital
The Nationwide Foundation today announced a new $10 million gift for the Nationwide Pediatric Innovation Fund at Nationwide Children’s Hospital to help make significant progress toward important research in genomics.
May 18, 2015
Suicide Trends in School-Aged Children Reveal Racial Disparity
While overall suicide rates in children younger than 12 years have remained steady, a new study shows increasing rates in black children and decreasing rates in white children. Suicide is a leading cause of death among children younger than 12 years.
May 07, 2015
Cure SMA Provides Additional Funding for Promising Spinal Muscular Atrophy Research at Nationwide Childrens Hospital
Cure SMA, the leading organization dedicated to the treatment and cure of spinal muscular atrophy (SMA), recently provided an additional $445,000 grant toward a gene therapy for SMA at Nationwide Children’s Hospital.
Apr 27, 2015
Musculoskeletal Outcomes From Study on Adolescent Bariatric Surgery Safety
Outcomes regarding musculoskeletal disease among severely obese adolescents participating in the “Teen Longitudinal Assessment of Bariatric Surgery” (Teen-LABS) study were published this week in JAMA Pediatrics.
Apr 06, 2015
Study Finds Cow Milk Is Added to Breast Milk and Sold to Parents Online
A study published today on the safety of human breast milk bought over the Internet found that 10 percent of samples contained added cow’s milk.
Apr 03, 2015
Cure Duchenne to Host a Webinar on Duplication Research for Duchenne Muscular Dystrophy with Dr. Kevin Flanigan from Nationwide Childrens Hospital on April 6
NEWPORT BEACH, Calif. -- CureDuchenne, a nonprofit that raises awareness and funds research to find a cure for Duchenne muscular dystrophy, will host an “Update on Duplication Mutation Research for Duchenne Muscular Dystrophy” webinar with Dr.
Mar 17, 2015
GenomeNext, Powered by Amazon Web Services and Intel, Achieves Unprecedented Throughput of 1,000 Genomes Analyzed per Day, Enabling Population-Scale Genomics
GenomeNext, LLC, a leader in genomic data management and integrated analysis, announced today that, through the “Intel Heads In The Clouds Challenge on Amazon Web Services (AWS)” with support from JHC Technology, and in conjunction with Nationwide Children’s Hospital, has
Mar 11, 2015
New Company Lattice Biotech and Nationwide Childrens Hospital Join Forces to Attack Chronic Bacterial Infections
A new Columbus-based company has been formed based on research from Nationwide Children’s Hospital. Lattice Biotech is leveraging a discovery that disrupts bacterial biofilms, creating a more effective environment for antibiotics to eradicate chronic infections.
Mar 03, 2015
Study Offers Clues to Early Detection of Bipolar Disorders in High-Risk Children
New research published today in the American Journal of Psychiatry indicates a strong link between subthreshold manic episodes and likelihood of developing bipolar disorder in children of parents with bipolar disorder.
Mar 02, 2015
Standardization and Simplification is Key to Helping NICU Babies Feed and Grow
A new standardized approach for feeding infants in the neonatal intensive care unit (NICU) helps babies attain full oral feeds sooner, improves their growth and sends them home sooner.
Feb 27, 2015
Crohns Disease Not Exempt From Racial Disparities
A study published recently in the IBD Journal found significant differences in hospital readmissions, medication usage, and both medical and surgical complications of children with Crohn’s disease related to race.
Feb 24, 2015
GenomeNext Inks Agreement with Nationwide Childrens Hospital for Genomic Sequencing Analysis
GenomeNext, LLC, a leader in genomic data management and integrated analysis, announced today an agreement with Nationwide Children’s Hospital under which Nationwide Children’s will integrate GenomeNext’s genomic sequencing analysis platform for both clinical laboratory services
Feb 17, 2015
Partners for Kids, Nationwide Childrens Hospital Demonstrate Cost Savings and Quality as Pediatric ACO
A new study published in Pediatrics demonstrates the cost-saving and health care quality outcomes of the pediatric Accountable Care Organization (ACO) Partners for Kids.
Jan 13, 2015
Researcher at Nationwide Childrens Hospital Secures Grant to Develop a Standard Statistical Evidence Measure to Reduce Errors in Biomedical Research
Veronica Vieland, PhD, director of the Battelle Center for Mathematical Medicine in The Research Institute at Nationwide Children’s Hospital, was recently awarded a $500,000 grant from the W.M.
Oct 22, 2014
Study Shows Medication is Frequently, Unintentionally Given Incorrectly to Young Children
According to Nationwide Children’s Hospital researchers, 63,000 children under the age of six experienced out-of-hospital medication errors annually between 2002 and 2012.
Sep 22, 2014
New Study Finds 34% of Severely Injured Patients Undertriaged in the United States
According to the American College of Surgeons’ Committee on Trauma, patients with severe injuries should be treated at level I or level II trauma centers. Those centers have the resources to provide the best care for those patients.
Aug 11, 2014
Discovery of New Form of Dystrophin Protein Could Lead to Therapy for Some DMD Patients
Scientists have discovered a new form of dystrophin, a protein critical to normal muscle function, and identified the genetic mechanism responsible for its production. Studies of the new protein isoform, published online Aug.
Jul 24, 2014
Teen Alcohol Use Affected by Expected Enjoyment and Understanding of Health Messages, Study Finds
Teens with the best understanding of health messaging may also be the most susceptible to messages that make alcohol use look appealing and fun — like television ads for beer or liquor — according to a study published this week in the journal Patient Education and Counseling.
Jul 16, 2014
Preeclampsia May Share Cause With Disorders Such as Alzheimers
New research has identified a potential cause of and a better diagnostic method for preeclampsia, one of the most deadly and poorly understood pregnancy-related conditions in the world.
Jul 09, 2014
Immune Function Predicts Infection Risk Among Child Trauma Patients
Researchers studying critically ill children with traumatic injuries have identified an immune marker that predicts which patients are likely to develop a hospital-acquired infection.
May 20, 2014
Breastfeeding Initiation and Success is Impacted by Diabetes Status of Mother
Women diagnosed with diabetes before or during pregnancy are less likely to initiate and continue breastfeeding their newborns than women without diabetes, a new study suggests.
May 05, 2014
Childrens Oncology Drug Alliance (CODA) Formed to Facilitate Development of Treatments for Childhood Cancers
Researchers and children’s cancer advocates in Australia and the U.S. have formed a unique research and development alliance to facilitate development of treatments for children fighting neuroblastoma, the most common and fatal form of solid cancer affecting infants.
May 05, 2014
New Study Finds Number of Children Treated in U.S. Emergency Departments for Baby Gate-Related Injuries Nearly Quadrupled Since 1990
If you are a parent, chances are you have used or will use a baby gate at some point. Baby gates are designed to help protect young children from stairs and other dangers around the home. If you use these in your home, take note.
Mar 28, 2014
Esophageal Function Implicated in Life-Threatening Experiences in Infants, Study Suggests
About 1 percent of all emergency room visits are prompted by near-death experiences in infants, such as extended periods without breathing or sudden changes in skin pallor or muscle tone.
Mar 26, 2014
Study Identifies Key Player in Motor Neuron Death in Lou Gehrigs Disease
Amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease, is marked by a cascade of cellular and inflammatory events that weakens and kills vital motor neurons in the brain and spinal cord. The process is complex, involving cells that ordinarily protect the neurons from harm.
Mar 20, 2014
Parent Project Muscular Dystrophy Awards Nationwide Childrens Hospital; Names Hospital Certified Duchenne Care Center
Nationwide Children’s Hospital was named the first Certified Duchenne Care Center by Parent Project Muscular Dystrophy (PPMD), the leading advocacy organization working to end Duchenne muscular dystrophy (Duchenne).
Mar 05, 2014
Dr. Kelly Kelleher of Nationwide Childrens Hospital Appointed to Institute of Medicine Committee
Kelly Kelleher, MD, MPH, director of the Center for Innovation in Pediatric Practice in The Research Institute at Nationwide Children’s Hospital, was recently appointed to be part of an Institute of Medicine committee.
Feb 20, 2014
TechColumbus Announces Catalyst Fund
Promising startups in Ohio have a new source of seed stage capital with the announcement of the new TechColumbus Catalyst Fund. The first close for the fund of $7 million includes investments from Nationwide Children’s Hospital, Ohio Third Frontier, The Ohio State University and TechColumbus,
Jan 24, 2014
Highly Reliable Brain Imaging Protocol Identifies Delays in Premature Infants
Infants born prematurely are at elevated risk for cognitive, motor, and behavioral deficits — the severity of which was, until recently, almost impossible to accurately predict in the neonatal period with conventional brain imaging technology.
Jan 21, 2014
New Study Finds 66 Children a Day Treated in U.S. Emergency Departments for Shopping Cart-Related Injuries
Although a voluntary shopping cart safety standard was implemented in the United States in 2004, the overall number and rate of injuries to children associated with shopping carts have not decreased.
Dec 23, 2013
PDL-1 Antibody Could Help Immune System Fight Off Influenza Viral Infection, Study Suggests
An antibody that blocks a component of a key signaling pathway in the respiratory airways could help the immune system rid the body of the influenza virus, a new study suggests.
Dec 09, 2013
New Study Finds 24 Children a Day are Treated in U.S. Emergency Departments for High Chair-Related Injuries
High chairs and booster seats are commonly used to help make feeding young children easier. Although most parents assume these products are safe, millions have been recalled in recent years, and injuries associated with their use continue to occur.
Nov 25, 2013
Two Faculty in The Research Institute at Nationwide Childrens Hospital Named AAAS Fellows
Brian K. Kaspar, PhD, and Veronica J. Vieland, PhD, principal investigators in The Research Institute at Nationwide Children’s Hospital, have been named Fellows of the American Association for the Advancement of Science (AAAS).
Nov 22, 2013
New Study Helps Explain Why Some Ear and Respiratory Infections Become Chronic
Scientists have figured out how a bacterium that causes ear and respiratory illnesses is able to elude immune detection in the middle ear, likely contributing to chronic or recurrent infections in adults and children.
Nov 15, 2013
Pediatric Biomedical Research Bill Passes Congress
A bill eight years in the making to strengthen pediatric biomedical research is headed to President Obama’s desk to be signed into law. The legislation, known as the National Pediatric Research Network Act and strongly supported by The Research Institute at Nationwide Children’s
Nov 14, 2013
Genetic Signature Identified for RSV, the Leading Cause of Infant Hospitalizations Worldwide
Scientists have identified the genetic signature of respiratory syncytial virus (RSV), the leading cause of infant hospitalizations around the world. The work is a key step toward a better understanding of the immune response to RSV, which will aid the development of a vaccine and a tool that could
Nov 06, 2013
Findings Announced from Landmark Study on Safety of Adolescent Bariatric Surgery
Initial results of a first and largest of its kind study focusing on the safety of adolescent bariatric surgery were published this week in JAMA Pediatrics.
Nov 04, 2013
Abusive Head Trauma Injuries Linked to Socioeconomic Status, Age and Gender
A new study estimates that more than seven children under the age of five with abusive head trauma were treated each day in U.S. emergency departments between 2006 and 2009.
Oct 30, 2013
Study: Researchers Identify Way to Increase Gene Therapy Success
Scientists in The Research Institute at Nationwide Children’s Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload.
Oct 18, 2013
AveXis- BioLife Licenses Spinal Muscular Atrophy (SMA) Patent Portfolio from Nationwide Childrens Hospital and The Ohio State University
BioLife, a synthetic biology platform company soon to be renamed AveXis, has been granted exclusive rights to the spinal muscular atrophy gene therapy program developed at The Research Institute at Nationwide Children’s Hospital and The Ohio State University in Columbus, Ohio.
Oct 08, 2013
$25.4 Million Awarded to Center for Clinical and Translational Science to Continue Critical Bench to Bedside Translational Research
The National Institutes of Health has awarded a $25.4 million grant to the Center for Clinical and Translational Science (CCTS), a collaboration between The Ohio State University and Nationwide Children’s Hospital created to accelerate basic science discoveries into life-saving medical
Sep 25, 2013
Nationwide Children's Hospital Awarded $250,000 Childhood Cancer Research Grant from Hyundai Hope On Wheels
Hyundai Hope On Wheels® and Central Ohio Hyundai dealers will today award Nationwide Children’s Hospital with a $250,000 Hyundai Hope Grant for pediatric cancer research.
Sep 09, 2013
Therapy Slows Onset and Progression of Lou Gehrigs Disease, Study Finds
Studies of a therapy designed to treat amyotrophic lateral sclerosis (ALS) suggest that the treatment dramatically slows onset and progression of the deadly disease, one of the most common neuromuscular disorders in the world.
Sep 04, 2013
Study Examines Ways to Restore Immunity to Chronic Hepatitis C Infection
The hepatitis C virus hijacks the body’s immune system, leaving T cells unable to function. A new study in animal models suggests that blocking a protein that helps the virus thrive could restore immune function, allowing the body to fight infection.
Sep 03, 2013
Nationwide Children's Radiologists Train Military Physicians in Foreign Body Removal Techniques
William E. Shiels II, DO, chief of the Nationwide Children’s Hospital Department of Radiology and president of Children’s Radiological Institute, Inc., is leading a team of radiologists for the training of military physicians to remove shrapnel foreign bodies from warfighters with
Aug 26, 2013
Grand Challenge Grant Awarded to Team Led by Nationwide Childrens Researcher
The Saving Lives at Birth: A Grand Challenge for Development recently shortlisted 53 finalists from around the world from more than 400 entries. Only 22 teams were awarded grants for their bold, new ideas to save the lives of mothers and newborns in developing countries.
Aug 21, 2013
HB-EGF Protects Intestines from a Variety of Injuries, Pair of Studies Suggests
It’s not often that one treatment offers therapeutic potential for multiple conditions. However, after more than two decades of research, Gail Besner, MD, principal investigator for the Center for Perinatal Research and pediatric surgeon for the Department of Pediatric Surgery at Nationwide
Aug 09, 2013
Combined Therapy Could Repair and Prevent Damage in Duchenne Muscular Dystrophy
New research on two promising gene therapies suggests that combining them into one treatment not only repairs muscle damage caused by Duchenne muscular dystrophy, but also prevents future injury from the muscle-wasting disease.
Aug 08, 2013
New Drug Improves Walking Performance for Duchenne Muscular Dystrophy Patients
Results from a clinical trial of eteplirsen, a drug designed to treat Duchenne muscular dystrophy, suggest that the therapy allows participants to walk farther than people treated with placebo and dramatically increases production of a protein vital to muscle growth and health.
Aug 05, 2013
Chronic Illness Puts Pediatric Trauma Patients at Higher Risk
In a recent study published in the Journal of Trauma and Acute Care Surgery, researchers from the Center for Injury Research and Policy in The Research Institute at Nationwide Children’s Hospital found that pediatric trauma patients with preexisting chronic conditions have longer hospital
Aug 05, 2013
New Initiative Could Help Improve Surgical Outcomes in Children, Study Suggests
A group of pediatric surgeons at hospitals around the country have designed a system to collect and analyze data on surgical outcomes in children – the National Surgical Quality Improvement Program (NSQIP) is the first national database able to reliably compare outcomes among different
Jul 29, 2013
Parents Don't Fully Understand Biobank Research, Study Finds
Researchers who collect genetic samples from children for medical research need to explain the process more clearly to parents, according to a new study that suggests many parents don’t fully understand the finer details about how these samples will be used and stored.
Jul 29, 2013
New Study Finds Increase in Nonfatal Food-Related Choking Among Children in the U.S.
Choking is a leading cause of injury among children, especially for children 4 years of age and younger. A new study by researchers at the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital and colleagues at the Centers for Disease Control and
Jun 26, 2013
$6.3 Million Grant To Further Childhood Sarcoma Therapeutic Research
Researchers at Nationwide Children’s Hospital will use a $6.3 million grant to further their study of pediatric sarcomas, a rare form of the disease that affects bone or soft tissue and accounts for 11 percent of all childhood cancers.
Jun 18, 2013
Multidisciplinary Initiative Reduces Airway Infection in Pediatric Intensive Care Patients
An initiative that combines a multidisciplinary health care approach with a range of preventive measures could cut the rate of a common airway infection among children in intensive care by more than half, a new study suggests.
Jun 14, 2013
Global Collaborative Effort Will Study Abuse-Related Pediatric Traumatic Injury in China
Child abuse and neglect are considered a serious public health problem in modern China. A number of factors, including social and cultural traditions and a lack of public awareness regarding appropriate child discipline, have caused child abuse to remain an understudied issue.
Jun 06, 2013
Farm Safety Day Camp for Ross County Kids July 2
The Safe Play Areas for Ross County Kids (SPARK) Project in the Center for Injury Research and Policy (CIRP) at Nationwide Children’s Hospital has teamed up with the Ohio State University Extension Office and the Ohio Farm Bureau Federation to host a Farm Safety Day Camp 9 a.m.
May 30, 2013
Technique Could Identify Patients at High Risk of Stroke or Brain Hemorrhage
Measuring blood flow in the brain may be an easy, noninvasive way to predict stroke or hemorrhage in children receiving cardiac or respiratory support through a machine called ECMO, according to a new study by researchers at Nationwide Children’s Hospital.
May 21, 2013
Nationwide Children's Part of Multi-Million Dollar Research Center to Solve the Mystery of Premature Birth
Three major Ohio universities and four hospitals have joined with the March of Dimes Foundation to establish a new collaborative research program aimed exclusively at finding the unknown causes of premature birth. The March of Dimes intends to invest $10 million in the program over five years.
May 15, 2013
Study Shows Preschoolers Affected by Medication-Related Poisonings at Alarming Rate
Poisonings in young children have increased over the past decade, mainly due to medications in the home. A new study led by the Central Ohio Poison Center at Nationwide Children’s Hospital, found that medication-related poisonings in children younger than 6 increased by 33 percent during the
May 06, 2013
New Study Says Summer Brings Increase in Gasoline and Other Chemical-Related Injuries in Young Children
Hydrocarbons, a chemical compound commonly found in household items from cleaning products to gasoline, are among the top 10 causes of pediatric poisoning deaths in the United States.
May 01, 2013
New Study Finds 20 Children a Day During the Summer are Treated in U.S. Emergency Departments for Amusement Ride-Related Injuries
A new study by researchers in the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital examined injuries to children related to amusement rides, which included rides at amusement parks (fixed-site rides), rides at fairs and festivals (mobile rides)
Mar 22, 2013
Study: Research Reveals Protective Properties of Influenza Vaccines
Collaborating scientists from Nationwide Children’s Hospital, Baylor Institute for Immunology Research, and Mount Sinai School of Medicine have identified an important mechanism for stimulating protective immune responses following seasonal influenza vaccinations.
Mar 14, 2013
OSU Alum, ESPN Analyst Joey Galloway Named Honorary Chair of Woody Hayes Celebrity Classic
Legendary Ohio State football coach Woody Hayes taught those he coached to “pay forward.” Joey Galloway, former wide receiver on the 1991-94 Ohio State football team, is doing just that by accepting the honorary chairmanship of the 37th Annual Woody Hayes Celebrity Classic slated for
Mar 13, 2013
Study: Evidence Supports Blocking Immune Response to Enhance Viral Therapy against Solid Tumors
Following several years of study, investigators have found more evidence that viral therapy to treat solid tumors can be enhanced by blocking the body’s natural immune response.
Feb 18, 2013
2013 Technology Showcase Presented by The Research Institute at Nationwide Children's Hospital
The Office of Technology Commercialization in The Research Institute at Nationwide Children’s Hospital will present the “2013 Technology Showcase” Thursday, March 14, 2013 from 1 to 4 p.m.
Feb 04, 2013
New Study Finds Water Tubing-Related Injuries Up 250 Percent
Water tubing, a recreational activity in which participants ride an inner tube which is pulled behind a boat by a tow rope, has grown in popularity in recent years. Unfortunately, the number of injuries related to this activity has also increased.
Jan 31, 2013
Sophias Cure Foundation Donates $650,000 in 2012 to Nationwide Childrens Hospital
Brian Kaspar, PhD, principal investigator in the Center for Gene Therapy at The Research Institute at Nationwide Children’s Hospital, along with a team of Spinal Muscular Atrophy (SMA) researchers and clinicians, received $650,000 in grants in 2012 from Sophia’s Cure Foundation for SMA
Jan 22, 2013
New Appointments Strengthen Perinatal Programs at Nationwide Childrens Hospital and The Ohio State University
Catalin S. Buhimschi, MD, has been appointed Director of Maternal-Fetal Medicine and Vice Chair for Research in the Department of Obstetrics and Gynecology at The Ohio State University and Irina A.
Jan 18, 2013
Study: Bariatric Surgery in Extremely Obese Adolescents
This time of year many people make resolutions to live a healthier lifestyle, exercise more, lose weight and eat better. For the adolescents who are extremely obese in this country, diet and exercise alone often are not enough to get their weight down.
Jan 16, 2013
Study: Monitoring of Immune Function in Critically Ill Children with Influenza Reveals Severe Immune Suppression in Non-Survivors
Investigators from 15 children’s medical centers, including Nationwide Children’s Hospital, observed and evaluated critically ill children with influenza to evaluate the relationships between levels of systemic inflammation, immune function and likelihood to die from the illness.
Dec 13, 2012
Global Collaborative Efforts Help Delineate Pediatric Traumatic Brain Injury Causes, Characteristics and Trends in China
Traumatic brain injuries (TBIs) among children in China are a growing public health concern. Two new studies by researchers of the International Program at the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital and the Wuhan Children’s
Dec 11, 2012
Infants with Severe RSV Disease May Be Immunosuppressed
Infants with severe lower respiratory tract infection caused by respiratory syncytial virus (RSV) may have a dysfunctional innate immune response that relates to the severity of their disease.
Dec 10, 2012
Study Identifies Potential New Pathway for Drug Development
A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children’s Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a role in cell signaling that is crucial to new drug development.
Nov 19, 2012
Study: Adenotonsillectomy May Help Resolve Obstructive Sleep Apnea in Children with Prader-Willi Syndrome
Children with Prader-Willi syndrome may receive relief from sleep disorders after undergoing an adenotonsillectomy, suggests a new study from Nationwide Children’s Hospital published in the November print issue of the Archives of Otolaryngology-Head and Neck Surgery.
Nov 12, 2012
National Study led by Hasbro Childrens Hospital Shows Protective Eyewear Reduces Eye, Head, and Facial Injuries in High School Field Hockey Players
A new study conducted by researchers at Hasbro Children’s Hospital, the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital, Fairfax (VA) County Public Schools, and Boston Children’s Hospital has found that high school field hockey
Nov 12, 2012
Nationwide Childrens Hospital Biorespository Receives Accreditation from Prestigious College of American Pathologists
Biorepositories are highly complex research facilities with expert staff to process, store, characterize and secure biological specimens and their corresponding clinical information.
Nov 05, 2012
Mika Matthews, MD, Honored at AAP Section on Surgery Meeting
Mika Matthews, MD, received the Jens Rosenkrantz Resident Research Award at the recent American Academy of Pediatrics (AAP) Section on Surgery meeting held in New Orleans. Dr.
Nov 05, 2012
High Fever and Evidence of a Virus? Caution, it Still May Be Kawasaki Disease
Clinicians should take caution when diagnosing a child who has a high fever and whose tests show evidence of adenovirus, and not assume the virus is responsible for Kawasaki-like symptoms.
Oct 29, 2012
Nationwide Childrens Hospital Partners with Silicon Valley to Market High-End Diagnostic and Medical Research Software
The latest significant biomedical informatics technology is not coming from the biotech industry or a university. In fact, it’s coming from a children’s hospital.
Oct 05, 2012
Exon-Skipping Shows Promise in Duchenne Muscular Dystrophy
Results from a Phase IIb extension trial of the drug eteplirsen show an increased ability to walk in boys with Duchenne muscular dystrophy Eteplirsen, a drug that skips exon 51 of the dystrophin gene, may improve quality of life for patients with Duchenne muscular dystrophy and slow disease
Sep 27, 2012
New Intervention May Help Identify and Improve Care for Adolescents at Risk for Suicide
Investigators at Nationwide Children’s Hospital and Cincinnati Children’s Hospital Medical Center are hoping to better identify adolescents at risk for suicide and improve how these at-risk children receive follow up mental health treatment.
Sep 10, 2012
Nationwide Children's Hospital Develops Prototype for Safer, Child-Resistant Spray Bottle
Researchers at The Research Institute at Nationwide Children’s Hospital, in partnership with The Ohio State University have developed a prototype for child-resistant spray bottles for household cleaning products.
Aug 13, 2012
Center for Injury Research and Policy Awarded CDC Injury Control Research Center Designation for an Additional Five Years
The Centers for Disease Control and Prevention (CDC) has renewed the designation of the Center for Injury Research and Policy (CIRP) of The Research Institute at Nationwide Children’s Hospital as one of the agency’s Injury Control Research Centers (ICRCs).
Aug 06, 2012
New Study Examines Injuries to U.S. Workers with Disabilities
A new study conducted by researchers at the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital and The Ohio State University compared medically attended noncccupational and occupational injuries among U.S. workers with and without disabilities.
Jul 23, 2012
RNA Interference May Provide the First Therapy for Facioscapulohumeral Muscular Dystrophy
Scientists may one day be able to treat the third most common muscular dystrophy, facioscapulohumeral muscular dystrophy (FSHD), by taking advantage of a system within living cells that helps control gene activation.
Jul 18, 2012
Genomics: Colorectal cancer characterized
The genome-wide characterization of colorectal carcinoma was published online today in the journal, Nature. Nationwide Children’s Hospital was one of several institutions involved in this study.
Jul 03, 2012
New Study Finds Increase in Track-Related Injuries Among Youth in the United States
With the 2012 summer Olympic games about to take place in London, children everywhere are looking forward to watching their sports idols and role models take center stage.
Jun 21, 2012
Celebrex-Derived Drug Targets Common Childhood Bone Tumor
Jiayuh Lin, PhD, and colleagues at Nationwide Children’s Hospital have developed a drug to target the most common cancerous bone tumor in children, osteosarcoma, using a version of the FDA-approved drug, Celebrex.
Apr 30, 2012
The Antibiotic, Amoxicillin-Clavulanate, Before a Meal May Improve Small Bowel Motility
The common antibiotic, amoxicillin-clavulanate, may improve small bowel function in children experiencing motility disturbances, according to a study appearing in the June print edition of the Journal of Pediatric Gastroenterology and Nutrition from Nationwide Children’s Hospital.
Mar 12, 2012
Preemies Still Receive Inhaled Nitric Oxide Despite Lack of Supporting Evidence and Standards
Many premature infants throughout the United States continue to receive inhaled nitric oxide (iNO) during their NICU stay, despite the lack of evidence to support its use.
Mar 12, 2012
New Study Examines Stair-Related Injuries Among Children in the United States
A new study by researchers at the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital found that from 1999 through 2008, more than 93,000 children younger than 5 years of age were treated in U.S. emergency departments for stair-related injuries.
Mar 05, 2012
Concussions May Lead to Lingering Symptoms that Could Impair a Childs Daily Functioning
Children who experience mild traumatic brain injury may be more likely to show increases in symptoms over time that could impact quality of life, more so than children who experience an orthopedic injury. Injury severity could play a role.
Feb 29, 2012
Nationwide Childrens Hospital Neuromuscular Disorder Podcasts Now Available on iTunes
In 2010, the Center for Gene Therapy at Nationwide Children’s Hospital launched a monthly podcast entitled, “This Month in Muscular Dystrophy,” featuring internationally known scientists discussing the latest research in muscular dystrophy and other neuromuscular disorders.
Feb 28, 2012
Gestational Weight Gain Generally Does Not Influence Child Cognitive Development
A child’s cognitive development is not generally impacted by how much weight his or her mother gained during pregnancy, according to a study from Nationwide Children’s Hospital.
Feb 22, 2012
Study: Muscle Regeneration May Provide Ideal Environment for Rhabdomyosarcoma
Inflammation, cell division and cell differentiation that occur during skeletal muscle regeneration may provide an ideal environment for the highly malignant tumor, rhabdomyosarcoma to arise.
Feb 15, 2012
Grant Provides Funding Toward Gene Therapy Clinical Trial to Replace the DMD Gene in All of the Leg Muscles of Duchenne Patients
Investigators in the Center for Gene Therapy in The Research Institute at Nationwide Children’s Hospital are working toward an approach to replace the defective gene in Duchene muscular dystrophy (DMD) by treating all of the muscles in the leg, thanks to funding from Jesse’s Journey.
Feb 13, 2012
Study Shows Children with IBD Have Difficulty in School, Mostly due to Absences
Children with inflammatory bowel disease (IBD) may have difficulty functioning in school, particularly because their tendency to internalize problems can impact attendance.
Feb 02, 2012
Renowned Pediatric Cardiology Physician-Scientist Linda Cripe Joins Nationwide Childrens Hospital
Linda H. Cripe, MD, a distinguished pediatric cardiologist, has joined the Heart Center at Nationwide Children’s Hospital. Dr. Cripe will also be a member of the faculty at The Ohio State University College of Medicine. Dr.
Jan 31, 2012
Study: Bariatric Surgery in Adolescents Improves Obesity-related Diseases Within First Two Years
Today, about one in five children in the United States are obese. That means that in just one generation alone the number of obese kids in this country has quadrupled.
Jan 17, 2012
Childhood Cancer Research Grant Awarded to The Research Institute at Nationwide Children's Hospital
It takes life-saving research and access to clinical trials to help children with cancer. The St. Baldrick’s Foundation, a volunteer-driven charity dedicated to raising money for childhood cancer research, awarded an infrastructure grant of $47,000 to the Biopathology Center (BPC), housed in
Dec 28, 2011
Investigators to Study a New Way to Assess Heart Function in Children on Life Support
Investigators at Nationwide Children’s Hospital are evaluating a new way to assess cardiac function while children are supported by mechanical life support, thanks to a $110,000 two-year grant from the American Heart Association.
Dec 27, 2011
Bronchopulmonary Dysplasia Program at Nationwide Childrens Hospital Improves Neurodevelopmental Outcomes and Lowers Readmissions
The use of an interdisciplinary team approach has led to better outcomes for infants who suffer from bronchopulmonary dysplasia (BPD), the most common pulmonary complication of prematurity.
Nov 17, 2011
Bacteria Responsible for Middle Ear Infections, Pink Eye and Sinusitis May Protect Themselves by Stealing Immune Molecules
Bacteria responsible for middle ear infections, pink eye and sinusitis protect themselves from further immune attack by transporting molecules meant to destroy them away from their inner membrane target, according to a study from Nationwide Children’s Hospital.
Nov 16, 2011
Study: Children Experience Differing Changes One Year After a Siblings Death from Cancer
The majority of children experience personal changes and changes in relationships one year after their sibling has died from cancer; however, positive and negative changes are not universal.
Nov 10, 2011
Survey details inconsistencies in how concussions are managed in high school athletes
Concussions account for nearly 15 percent of all sport-related injuries in high school athletes, according to researchers at Children's Hospital Boston.
Nov 07, 2011
Study Finds Orally-Fed Infants Experience More Instances of Acid Reflux than Tube-Fed Infants
Infants who are fed through a tube from the nasal cavity to the stomach are not at an increased risk for acid reflux events. However, that is not the case for infants who are orally-fed; these infants having a higher risk of developing acid reflux.
Nov 02, 2011
Nationwide Children's Hospital and Ohio State Researchers Design a Viral Vector to Treat a Genetic Form of Blindness
Researchers at Ohio State University Medical Center and Nationwide Children’s Hospital have developed a viral vector designed to deliver a gene into the eyes of people born with an inherited, progressive form of blindness that affects mainly males.
Oct 11, 2011
Nationwide Childrens Hospital Clinical Trial to Use Drug to Boost Immune System Function in Critically Injured Children, May Prevent Infection
Thanks to funding from the National Institutes of Health, Nationwide Children’s Hospital will test the ability of a drug commonly used to improve immune function in pediatric cancer patients to help prevent hospital-acquired infection after severe trauma.
Oct 04, 2011
Study Finds that Childrens Asthma Care Measure Compliance is Not Associated with Reductions in Readmissions or Emergency Room Visits
One of three Children’s Asthma Care (CAC) core measures adopted by the Joint Commission shows no significant link between measure compliance and a decrease in asthma-related readmission or emergency care following an initial admission for treatment of asthma, according to a study in the
Sep 06, 2011
Neonatal and Infant Feeding Disorders Program Saves Infants from Lifetime of Feeding Tubes
An innovative approach to treating neonatal feeding problems at Nationwide Children’s Hospital has allowed infants who were struggling to feed orally to be discharged earlier and without feeding tubes, subsequently saving millions of annual healthcare charges.