Medical Professional Publications

Research Now: Molecule May Suppress Dangerous Inflammation Associated with Septic Shock

Dr. W. Joshua Frazier is studying the ways in which the innate immune system responds during the early stages of septic shock

W. Joshua Frazier, MD, principal investigator in the Center for Perinatal Research and his lab are studying the ways in which the innate system responds during the early stages of septic shock, an illness which is characterized by an early inflammatory surge. The lab studies the molecule Mkp-1 and its ability to down-regulate the inflammatory cascade. After establishing the importance of Mkp-1 in animal models, the lab is now investigating the way the molecule in regulated.

Select citations:
Matta R, Barnard JA, Wancket LM, Yan J, Xue J, Grieves J, Frazier WJ, Nelin LD, Cato AC, Liu Y.  Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  American Journal of Physiology: Gastrointestinal and Liver Physiology. June 1, 2012 302:(11) G1322-G1335

Frazier WJ, Wang X, Wancket LM, Li X, Meng X, Nelin LD, Cato ACB, Liu Y.  Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice.  J Immunol.  2009; 183: 7411-9

Contact: Joshua Frazier, MD

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