Louis G. Chicoine, MD

Louis G. Chicoine, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. As a principal investigator in the Center for Gene Therapy at The Research Institute at Nationwide Children’s Hospital, Dr. Chicoine’s research interests are focused on the study of normal and abnormal lung and lung vascular development. Several ongoing studies using models ranging from cell culture to isolated lung, and techniques ranging from siRNA interference to physiological studies are directed at answering questions relating to NOS expression and NO production, and their affect on pulmonary artery tone during development. Gene therapy using NOS directed at the lung might be expected to decrease pulmonary vascular resistance and arrest pulmonary vascular remodeling associated with PPHN, and be more efficacious than inhaled NO therapy. Dr. Chicoine is currently utilizing a rat model of PPHN to study the effects and potential toxicities of gene therapy with NOS. These studies are the first step in providing more effective and safer treatment to babies born with PPHN cared for in the Neonatal Intensive Care Unit.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Gene Therapy

Areas of Interest:

• Our lab is focused on the study of normal and abnormal lung and lung vascular development. Successful transition from the high resistance fetal pulmonary circulation to the low resistance postnatal pulmonary circulation involves a shift in the balance between vasoconstriction and vasodilation. Pulmonary endothelial nitric oxide synthase (eNOS) is an important source of the endogenous vasodilator nitric oxide (NO). Changes in eNOS may activity be an important contributor to the decrease in pulmonary vascular resistance normally seen after birth. Several ongoing studies using models ranging from cell culture to isolated lung, and techniques ranging from RNA interference to physiological studies are directed at answering questions relating eNOS expression and NO production, and their affect on pulmonary artery tone during development. Under certain conditions this normal progression from the high resistance pulmonary arteries of the fetus to the low resistance pulmonary arteries of the neonate fails, causing persistent pulmonary hypertension of the newborn (PPHN). PPHN continues to have high morbidity and mortality despite advances in neonatal intensive care. The hallmark of PPHN is abnormally constricted and thickened pulmonary arteries. Several poorly understood mechanisms are likely responsible for these changes that include smooth muscle cell migration, proliferation, and hypertrophy. Current treatment modalities are often of limited value and are associated with high degrees of morbidity. With its anti-mitogenic and vasodilatory properties, alterations in pulmonary NO production are key in the pathogenesis of PPHN. Clinical trials using inhaled NO for the treatment of PPHN demonstrated limited efficacy with a failure rate of between 40 and 50%. Gene therapy using inducible NO synthase (iNOS) directed at the lung might be expected to decrease pulmonary vascular resistance and arrest pulmonary vascular remodeling associated with PPHN, and be safer and more efficacious than inhaled NO therapy. Therefore, we are currently utilizing a neonatal rat model of pulmonary hypertension to study the effects of gene therapy with iNOS on pulmonary vascular reactivity and remodeling, as well as any potential toxicities of iNOS gene therapy. These studies are the first step in providing more effective and safer treatment to babies born with PPHN cared for in the neonatal intensive care unit.

Research Funding*:

• Diverse Strategies to Correct the Dystrophin Gene Using Vascular Delivery, National Institutes of Health
• Cationic amino acid transporters and lung NO production, National Institutes of Health, HLBI
• Pulmonary Vascular Targeting of Gene Delivery Using Directed Evolution of AAV, National Heart, Lung and Blood Institute
• The Role of Endogenous Nitric Oxide Synthase Inhibitors in Neonatal Pulmonary Hypertension, The Research Institute at Nationwide Children’s Hospital/OSU

Medical School

• University of Texas Medical Branch at Galveston
  Date Completed: 05/26/1990

Internship

• Stanford University
  Date Completed: 06/30/1991

Residency

• Stanford University
  Date Completed: 06/30/1993

Fellowship

• University of Colorado Health Sciences Center
  Date Completed: 06/30/1996

Department:

• Pediatrics

Section:

• Neonatology

Specialty:

• Neonatal-Perinatal Medicine
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 03/26/2004

• Chicoine LG, Montgomery CL, Bremer WG, Shontz KM, Griffin DA, Heller KN, Lewis S, Malik V, Grose WE, Shilling CJ, Campbell KJ, Preston TJ, Coley BD, Martin PT, Walker CM, Clark KR, Sahenk Z, Mendell JR, Rodino-Klapac LR. 2013. Plasmapheresis eliminates the negative impact of AAV antibodies on micro-dystrophin gene expression following vascular delivery.  Mol Ther. 2013. Vol. 10.1038/mt, no. October: e244.
• Chicoine LG, Rodino-Klapac LR, Shao G, Xu R, Bremer WG, Camboni M, Golden B, Montgomery CL, Shontz K, Heller KN, Griffin DA, Lewis S, Coley BD, Walker CM, Clark KR, Sahenk Z, Mendell JR, Martin PT. 2013. Vascular delivery of rAAVrh74.MCK.GALGT2 to the gastrocnemius muscle of the rhesus macaque stimulates the expression of dystrophin and laminin a2 surrogates.  Mol Ther. 2013. Vol. 10.1038/mt, no. October: e246.
• Hayes D Jr, Nicol KK, Tobias JD, Chicoine LG, Duffy VL, Mansour HM, Preston TJ. 2013. Identification of the nodose ganglia and TRPV1 in swine.  Lung. 2013. Vol. 191, no. 5. (October): 445-7.
• Jin Y, Chen B, Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2013. Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.  Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine. Vol. 304, no. 2. (January): 195-205.
• Jin Y, Chen B, Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2012. Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.  Am J Physiol Heart Circ Physiol. Vol. 15, no. 304(2). (October): H195-205.
• Hongmei Cui, Bernadette Chen, Louis G Chicone, Leif D Nelin. 2011. Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.  Clin Exp Pharmacol Physiol. Vol. 38, no. September: 796-803.
• Bevan AK, Duque S, Foust KD, Morales PR, Braun L, Schmelzer L, Chan CM, McCrate M, Chicoine LG, Coley BD, Porensky PN, Kolb SJ, Mendell JR, Burges AH, Kaspar BK. 2011. Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric Disorders.  Molecular Therapy. Vol. 0, no. Mol Ther. 2011 Aug 2. doi: 10.1038/mt.2011.157. [Epub ahead of print]. (August): ee.
• Cua CL, Rogers LK, Chicoine LG, Augustine M, Jin Y, Nash PL, Nelin LD. 2011. Down Syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.  Eur J Pediatrics. Vol. 170, no. 7. (July): 859-863.
• Louis Chicoine, Michael Stenger, Hongmei Cui, Andrea Calvert, Rebecca Evans, Boyce English, Yusen Liu, and Leif Nelin. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine stimulated pulmonary endothelial cells.  American Journal of Physiology - Lung Cellular and Molecular Physiology. Vol. 300, no. 4. (April): L596-604.
• L Nelin, H Cui, B Chen, L Chicoine, Y Liu. 2011. L-arginine uptake is necessary for lipopolysaccharide/tumor necrosis factor-{alpha}-induced apoptotic cell death in pulmonary endothelial cells. In Federation of American Societies for Experimental Biology
• Z Han, L Druhan, A Cardounel, L Chicoine. 2011. Regulation of Endothelial Nitric Oxide Production By Protein Methyltransferase's. In Federation of American Societies for Experimental Biology
• Louise R Rodino-Klapac, Chrystal L Montgomery, Jerry R Mendell, Louis G Chicoine. 2011. AAV Mediated Gene Therapy to the Isolated Limb in Rhesus Macaques. In Muscle Gene Therapy-Methods Mol Biol. Edited by Dongsheng Duan. Columbus, OH: Humana Press.
• Rodino-Klapac LR, Montgomery CL, Mendell JR, Chicoine LG. 2011. AAV-Mediated gene therapy to the isolated limb in rhesus macaques.  Methods Mol Biol. Vol. 709, no. January: 287-298.
• Preston, Thomas J. BS CCP, Ratliff, Todd M.AS RN, Gomez, Daniel BS CCP,Olshove, Vincent F. Jr.BS CCP, FPP, Nicol, Kathleen K. MD, Sargel, Cheryl L. PharmD, Chicoine, Louis G. MD. 2010. Modified surface coatings and their effect on drug adsorption within the extracorporeal life support circuit.  J Extra Corpor Technol. Vol. 42, no. 3. (September): 199-202.
• Stenger MR, Rose MJ, Joshi MS, Rogers LK, Chicoine LG, Bauer JA, Nelin LD. 2010. Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen.  Lung. Vol. 188, no. 3. (June): 217-227.
• A Calvert, L Chicoine, B Chen. 2010. Resveratrol Prevents Hypoxia-Induced Arginase II Expression and Proliferation of Human Pulmonary Artery Smooth Muscle Cells. In E-PAS
• Yi Jin, Thomas Calvert, Bernadette Chen, Louis Chicoine, Mandar Joshi, John Bauer, Yusen Liu, and Leif Nelin. 2010. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  Am J Physiol Heart Circ Physiol.. Vol. 298, no. 5. (May): H1518-1528.
• IT Toby, Y Jin, B Chen, BK English, L Chicoine, L Nelin. 2010. Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Activity Prevents Chronic Hypoxia-Induced Pulmonary Hypertension in Mice. In Pediatric Academic Society
• Y Jin, B Chen, S Welty, BK English, L Chicoine. 2010. L-arginine Increases Hemodynamically Relevant Nitric oxide Production in Isolated Perfused Lungs from Chronically Hypoxic Rats. In Pediatric Academic Society
• Inimary T Toby, Louis G Chicoine, Hongmei Cui, Bernadette Chen, Leif D Nelin. H. 2010. Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.  Am J Physiol Lung Cell Mol Physiol.. Vol. 298, no. 4. (April): L600-606.
• Louise R. Rodino-Klapac, Chrystal L Montgomery, William G Bremer, Vinod Malik, Kimberly M Shontz, Nancy Davis, Spencer Sprinkle, Katherine J Campbell, Zarife Sahenk, K Reed Clark, Chirstopher M Walker, Jerry R Mendell, Louis G Chicoine. 2010. Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.  Molecular Therapy. Vol. 18, no. 1. (January): 109-117.
• Chicoine LG, Stewart JA Jr, Lucchesi PA. 2009. Is Resveratrol the Magic Bullet for Pulmonary Hypertension?.  Hypertension. Vol. 54, no. 3. (September): 473-474.
• H Cui, LG Chicoine, B Chen, LD Nelin. 2009. Over-Expression of Catationic Amino Acid Transporter-1 in Human Pulmonary Microvascular Endothelial Cells Increases NO Production in Hypoxia. In Pediatric Academic Society 2009
• JL Slutzky, EK Natale, SL Sprinle, Z Han, LG Chicoine. 2009. Resveratrol Prevents RV/T Changes in a Neonatal Model of Hypoxia-Induced Pulmonary Hypertension. In Pediatric Academic Society 2009
• DT Malleske, LG Chicoine, LD Nelin. 2009. A pro-proliferative endothelial cell phenotype occurs late in the course of inflammation. In Federation of American Societies for Experimental Biology
• DT Malleske, LG Chicoine, LD Nelin. 2009. Inflammatory Stimuli Induce a Pro-Proliferative Phenotype in Pulmonary Vascular Endothelial Cells. In Pediatric Academic Society 2009
• Y Jin, T Calvert, L Chicoine, L Nelin. 2009. Chronic hypoxia decreases arterial compliance in rat lungs.  FASEB. Vol. 23, no. April: e619.3.
• EK Natale, JL Slutzky, LG Chicoine. 2009. Resveratrol reverses both thromboxane A2 receptor and non-receptor (K+) mediated pulmonary vasoconstriction. In Federation of American Societies for Experimental Biology
• Z Han, AJ Pope, A Cardounel, L Nelin, L Chicoine. 2009. Increased ADMA/protein methylation modulates nitric oxide generation in hypoxic human lung Microvascular endothelial cells. In Federation of American Societies for Experimental Biology
• JL Slutzky, EK Natale, SL Sprinkle, LG Chicoine. 2009. Resveratrol prevents RV/T changes in a neonatal model of hypoxia induced pulmonary hypertension. In Federation of American Societies for Experimental Biology
• Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine L, Clark KR, Sahenk Z, Mendell JR, Janssen PM. 2009. Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.  Am J Physiol Cell Physiol.. Vol. 296, no. 3. (March): C476-488.
• Cua Clifford L, Chicoine LG, Nelin LD, and Mullen Mary. 2009. Pulmonary Hypertension in the Down Syndrome Population. In Cardiology Research and Clinical Developments Series. New York, NY: Nova Science Publishers.
• Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. 2008. Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity.  Am J Physiol Lung Cell Mol Physiol.. Vol. 295, no. 4. (October): L688-L697.
• L Rodino-Klapac, C Montgomery, N. Walton, J Kota, B Coley, K Reed Clark, J Mendell, L Chicoine. 2008. Gastrocnemius Targeted Vascular Delivery of AAV8 in Non-Human Primates. In Pediatric Academic Society 2008
• Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2008. Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.  Am J Physiol Heart Circ Physiol.. Vol. 294, no. 4. (April): H1621-H1629.
• IT Toby, LG Chicoine, H Cui, LD Nelin. 2008. Hypoxia-Induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth receptor (EGFR) tyrosine kinase activty.  FASEB. Vol. 22, no. April: e1178.21.
• Chicoine LG, Paffett ML, Girton MR, Metropolulus MJ, Joshi MS, Bauer Ja, Nelin LD, Resta TC, Walker BR. 2007. Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats.  Am J Physiol Lung Cell Mol Physiol.. Vol. 293, no. 5. (November): L1261-1270.
• Nelin LD, DT Malleske, MR Stenger, and LG Chicoine. 2007. Vascular arginase and hypertension.  Current Hypertension Reviews. Vol. 3, no. 4. (November): 242-249.
• Pope AJ, Druhan L, Guzman JE, Forbes SP, Murugesan V, Lu D, Xia Y, Chicoine LG, Parinandi NL, Cardounel AJ. 2007. Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.  Am J Physiol Cell Physiol.. Vol. 293, no. 5. (November): C1679-1686.
• Rodino-Klapac LR, Janssen PM, Montgomery CL, Coley BD, Chicoine LG, Clark KR, Mendell JR. 2007. A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy.  Journal of Translational Medicine. Vol. 5, no. September: e45.
• Rodino-Klapac LR, Chicoine LG, Kaspar BK, Mendell JR. 2007. Gene therapy for duchenne muscular dystrophy: expectations and challenges.  Archives of Neurology. Vol. 64, no. 9. (September): 1236-1241.
• Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y. 2007. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.  Am J Physiol Cell Physiol.. Vol. 293, no. 2. (August): C632-640.
• Chicome,Louis,G; Girton,Mark,R; Nelin,Leif,D; Cardounel,A,J. 2007. Developmental differences in pulmonary nitric oxide (NO) production and endogenous nitric oxide synthase inhibitors in the neonatal rat.  FASEB JOURNAL. Vol. 21, no. 6. (April): A1440-A1440.
• Toby,Inimary; Chicoine,Louis,G; Nelin,Leif,D. 2007. EGFR stimulation promotes proliferation in human pulmonary microvascular endothelial cells.  FASEB JOURNAL. Vol. 21, no. 6. (April): A1431-A1431.
• Cui,Hongmei; English,B,Keith; Chicoine,Louis,G; Nelin,Leif,D. 2007. SRC family tyrosine kinases and cytokine-induced arginase expression in pulmonary microvascular endothelial cells.  FASEB JOURNAL. Vol. 21, no. 6. (April): A1431-A1431.
• Evans,Rebecca,J; Young,Tamara,L; Chicoine,Louis,G; Nelin,Leif,D. 2007. Cytokine-induced L-arginine metabolism depends on cationic amino acid transporter activity.  FASEB JOURNAL. Vol. 21, no. 6. (April): A1430-A1430.
• Nankervis CA, Preston TJ, Dysart KC, Wilkinson WD, Chicoine LG, Welty SE, Nelin LD. 2007. Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation.  ASAIO J.. Vol. 53, no. 1. (January): 111-114.
• Chicoine,L,G; Stenger,M,R; Metroupolus,M,J; Girton,M,R; Nelin,L,D. 2006. Maturational changes in NO sensitivity are due to increases in soluble gaunylyl cyclase in the developing rat lung.  FASEB JOURNAL. Vol. 20, no. 4. (March): A400-A400.
• Stenger,M,R; Chicoine,L,G; Liu,Y,S; Hatch,D,M; Nelin,L,D. 2006. Nitric oxide increases mortality and prevents MKP-1 expression in neonatal mice exposed to hyperoxia.  FASEB JOURNAL. Vol. 20, no. 4. (March): A406-A406.
• Nelin,L,D; Chicoine,L,G; Wang,X,X; Hatch,D,M; Young,T,L; Liu,Y,S. 2006. MKP-1 deficiency results in greater LPS-induced nitric oxide production in mice.  FASEB JOURNAL. Vol. 20, no. 5. (March): A1389-A1389.
• Stanley KP, Chicoine LG, Yount TL, Reber KM, Lyons CR, Liu Y, Nelin. 2006. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.  Am J Physiol Lung Cell Mol Physiol.. Vol. 290, no. 2. (February): L298-306.
• Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. 2005. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.  Am J Respir Cell Mol Biol.. Vol. 33, no. 4. (October): 394-401.
• Nelin,L,D; Young,T,L; English,B,K; Chicoine,L,G; Liu,Y,S. 2005. Epidermal growth factor receptor kinase is involved in cytokine-induced arginase, but not nitric oxide synthase, up-regulation in bovine pulmonary arterial endothelial cells.  FASEB JOURNAL. Vol. 19, no. 5. (March): A1275-A1275.
• Chicoine,L,G; Young,T; Nelin,L,D. 2005. Hypoxia attenuates nitric oxide production in bovine pulmonary arterial endothelial cells transfected with inducible nitric oxide synthase.  FASEB JOURNAL. Vol. 19, no. 5. (March): A1326-A1326.
• Nelin,L,D; Chicone,L,G; English,B,K; Young,T,L; Liu,Y,S. 2005. MKP-1 switches arginine metabolism from NOS to arginase in RAW264.7 cells.  FASEB JOURNAL. Vol. 19, no. 5. (March): A1223-A1223.
• Chicoine LG, Tzeng E, Bryan R, Saenz S, Paffett ML, Jones J, Lyons CR, Resta TC, Nelin LD, Walker BR. 2004. Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats.  J Appl Physiol.. Vol. 97, no. 5. (November): 1814-1822.
• Chicoine LG, Paffett ML, Young TL, and Nelin LD. 2004. Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.  Am J Physiol Lung Cell Mol Physiol.. Vol. 287, no. 1. (July): L60-68.
• Carter BW Jr, Chicoine LG, Nelin LD. 2004. L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs.  Pediatric Res. Vol. 55, no. 6. (June): 979-987.
• Young,T,L; Chicoine,L,G; Liu,Y,S; Nelin,L,D. 2004. Genistein inhibits cytokine-induced arginase expression and urea production in pulmonary arterial endothelial cells.  PEDIATRIC RESEARCH. Vol. 55, no. 4. (April): 502A-502A.
• Chicoine,L,G; Paffett,M,L; Saenz,S; Nelin,L,D. 2004. Differential regulation of pulmonary vasoconstriction by nitric oxide in the developing rat.  PEDIATRIC RESEARCH. Vol. 55, no. 4. (April): 499A-499A.
• Nelin,L,D; Chicoine,L,G. 2004. L-arginine, but not D-arginine, increases nitric oxide production and vasodilates hypoxic neonatal pig lungs.  FASEB JOURNAL. Vol. 18, no. 4. (March): A327-A327.
• Chicoine,L,G; Paffett,M,L; Saenz,S; Bryan,R; Resta,T,C; Nelin,L,D; Walker,B,R. 2004. Differential regulation of pulmonary vasoconstriction by nitric oxide in the developing neonate.  FASEB JOURNAL. Vol. 18, no. 4. (March): A328-A328.
• Chicoine,L,G; Bryan,R; Saenz,S; Paffett,M; Nelin,L,D; Walker,B,R. 2003. Tracheal adenovirus-mediated iNOS gene transfection attenuates U-46619 induced pulmonary arterial constriction in isolated rat lungs.  PEDIATRIC RESEARCH. Vol. 53, no. 4. (April): 463A-463A.
• Stanley,K,P; Chicoine,L,G; Nelin,L,D. 2003. Hypoxia attenuates nitric oxide production in bovine pulmonary arterial endothelial cells transfected with inducible nitric oxide synthase.  PEDIATRIC RESEARCH. Vol. 53, no. 4. (April): 567A-567A.
• Stanley,K,P; Chang,R; Chicoine,L,G; Nelin,L,D. 2003. L-arginine uptake is not affected by iNOS transfection in bovine pulmonary arterial endothelial cells.  FASEB JOURNAL. Vol. 17, no. 4. (March): A413-A413.
• Chicoine,L,G; Bryan,R; Saenz,S; Paffett,M,L; Nelin,L,D; Walker,B,R. 2003. Intratracheal pulmonary adenoviral iNOS transfection decreases vasoconstrictor responses in rats.  FASEB JOURNAL. Vol. 17, no. 4. (March): A421-A421.
• Chicoine LG, Avitia JW, Deen C, Nelin LD, Earley S, and Walker BR. 2002. Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat.  J Appl Physiol.. Vol. 93, no. 1. (July): 311-318.
• Stanley,K,P; Chicoine,L,G; Nelin,L,D. 2002. Inducible nitric oxide synthase and arginase compete for the common substrate L-arginine in bovine pulmonary arterial endothelial cells (bPAEC).  PEDIATRIC RESEARCH. Vol. 51, no. 4. (April): 477A-478A.
• Carter,B,W; Chicoine,L,G; Nelin,L,D. 2002. Inhibiting arginine uptake decreases nitric oxide production in isolated lungs from cytokine treated neonatal pigs.  FASEB JOURNAL. Vol. 16, no. 4. (March): A76-A77.
• Earley S, Nelin LD, Chicoine LG, Walker BR. 2002. Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide.  J Appl Physiol.. Vol. 92, no. 3. (March): 1152-1158.
• Nelin LD, Krenz GS, Chicoine LG, Dawson CA, and Schapira RM. 2002. L-arginine uptake and metabolism following in vivo silica exposure in rat lungs.  Am J Resp Cell Mol Biol. Vol. 26, no. 3. (March): 348-355.
• Chang,R; North,R,M; Savard,P,M; Stanley,K,P; Chicoine,L,G; Nelin,L,D. 2002. The effect of SRC-family tyrosine kinase inhibition on urea production in cytokine stimulated bovine pulmonary arterial endothelial cells.  FASEB JOURNAL. Vol. 16, no. 4. (March): A405-A406.
• Nelin LD, Nash HE, Chicoine LG. 2001. Cytokine treatment increases arginine metabolism and uptake in bovine pulmonary arterial endothelial cells.  Am J Physiol Lung Cell Mol Physiol.. Vol. 281, no. 5. (November): L1232-1239.
• Stanley,K,P; Chicoine,L,G; Nelin,L,D. 2001. Adenovirus transfection with inducible nitric oxide synthase (iNOS) decreases arginase activity in bovine pulmonary arterial endothelial cells (bPAEC).  FASEB JOURNAL. Vol. 15, no. 4. (March): A491-A491.
• Broxterman KJ, Mathew P, Chicoine L. 2000. Left brachial artery thrombus, left axillary vein thrombus, and stroke in a neonate with factor V Leiden mutation.  J Pediatr Hematol Oncol.. Vol. 22, no. 5. (October): 472-475.
• Chicoine,L,G; Avitia,J,W; Deen,C; Earley,S; Nelin,L,D; Walker,B,R. 2000. Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat.  FASEB JOURNAL. Vol. 14, no. 4. (March): A125-A125.
• Earley,S; Walker,B,R; Chicoine,L,G. 2000. Nitric oxide attenuates hypoxia-inducible factor-mediated endothelin-1 gene expression.  FASEB JOURNAL. Vol. 14, no. 4. (March): A123-A123.
• Chicoine,L,G; Resta,T,C; Earley,S; Lyons,R,C; Gerard,R,D; Walker,B,R. 1999. Adenovirus-mediated iNOS gene transfection attenuates U-46619 induced pulmonary arterial constriction in isolated rat lungs.  PEDIATRIC RESEARCH. Vol. 45, no. 4. (April): 297A-297A.
• Resta TC, Chicoine LG, Omdahl JL, and Walker BR. 1999. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia.  Am J Physiol.. Vol. 276, no. 2 Pt 2. (February): H699-708.
• Resta TC, O’Donaughy TL, Earley S, Chicoine LG, and Walker BR. 1999. Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats.  Am J Physiol.. Vol. 276, no. 1 Pt 1. (January): L122-130.
• Chicoine L, Lindsey RE, Savich R. 1998. Lung Endothelin Gene Expression does not Change with Oligohydramnios-Induced Pulmonary Hypoplasia 1626.  Pediatric Research. Vol. 43, no. April: e278.
• Chicoine,L,G; Townsend,S,F; Stenmark,K,R. 1995. INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP) PRODUCTION CHANGES DRAMATICALLY IN BOVINE PULMONARY-ARTERY SMOOTH-MUSCLE CELLS (SMC) DURING DEVELOPMENT.  PEDIATRIC RESEARCH. Vol. 37, no. 4. (April): A60-A60.
• Chicoine,L,G; Townsend,S,F; Badesch,D,B; Stenmark,K,R. 1994. INSULIN-LIKE GROWTH FACTOR-II (IGF-II) INCREASES TROPOELASTIN MESSENGER-RNA IN NEONATAL VASCULAR SMOOTH-MUSCLE CELLS (SMCS) VIA 2 DISTINCT IGF RECEPTORS.  PEDIATRIC RESEARCH. Vol. 35, no. 4. (April): A328-A328.
• Chicoine,L,G; Townsend,S,F; Stenmark,K,R. 1994. INSULIN-LIKE GROWTH FACTOR-II INCREASES TROPOELASTIN MESSENGER-RNA IN NEONATAL VASCULAR SMOOTH-MUSCLE CELLS (SMCS) VIA THE TYPE II/MANNOSE-6-PHOSPHATE RECEPTOR.  CLINICAL RESEARCH. Vol. 42, no. 1. (February): A9-A9.
• Singh P, Reubi JC, Rajakumar G, Guo YS, Prioux H, Chicoine L. 1993. In vivo mitogenic effects of estradiol on colon cancers: role of gastrin and gastrin receptors.  J Steroid Biochem Mol Biol.. Vol. 46, no. 1. (July): 49-60.
• Narayan S, Chicione L, Singh P. 1992. Characterization of gastrin binding to colonic mucosal membranes of guinea pigs.  Mol Cell Biochem.. Vol. 112, no. 2. (June): 163-171.
• Singh P, Chicoine LG, Guo Y-S, Narayan S, Rafakumar G, Parekh D, and Townsend CM Jr. 1990. Gastrointestinal Hormone Receptors and Receptor-Regulation. In Gastrointesinal Endocrinology. New York, NY: Academic Press.
• Chicone L, Narayan S, Townsend CM Jr, Singh P. 1989. The presence of a 33-40 KDa gastrin binding protein on human and mouse colon cancer.  Biochem Biophys Res Commun.. Vol. 164, no. 1. (October): 512-519.
• Chicoine,L; Townsend,C,M; THOMPSON,J,C; Singh,P. 1988. DIFFERENCES IN THE MOLECULAR-SIZE OF GASTRIN RECEPTORS (GR) ON NORMAL AND CANCEROUS GUT TISSUES FROM MICE.  GASTROENTEROLOGY. Vol. 94, no. 5. (May): A67-A67.
• Chicoine,L; Guo,Y,S; THOMPSON,J,C; Townsend,C,M; Singh,P. 1988. REGULATION OF GASTRIN RECEPTOR AND GASTRIN-LEVELS BY GONADAL-STEROIDS INVIVO IN RODENTS.  GASTROENTEROLOGY. Vol. 94, no. 5. (May): A67-A67.
• Richman R, Chicoine LG, Collini M, Cook R, and Allis CD. 1988. Micronuclei and the cytoplasm of growing Tetrahymena contain a histone acetylase activity, which is highly specifiec for free histone H4.  Jounal of Cell Biology. Vol. 106, no. 4. (April): 1017-1026.
• Chicoine L, Singhh P. 1988. Gastrin mediated effects of gonadal steroids on the growth of mouse colon cancer cells in vivo.  29th National Student Research Forum Publication. Vol. April 1988, no. April: en/a.
• Singh,P; Chicoine,L. 1988. SPECIES-DEPENDENT DIFFERENCES IN THE MOLECULAR-SIZE OF GASTRIN RECEPTORS BY COVALENT CROSS-LINKING STUDIES.  FASEB JOURNAL. Vol. 2, no. 4. (March): A736-A736.
• Chicoine LG, Richman R, Cook R, Gorovsky M, and Allis CD. 1987. A single histone acetyltransferase from Tetrahymena macronuclei catalyzes deposition-related acetylation of free histones and transcription-related acetylation of nucleosomal histones.  Journal of Cell Biology. Vol. 105, no. 1. (July): 127-135.
• Allis D, Chicoine LG, Glover CV, White E, and Gorovsky M. 1986. Enzyme activity dot blots: a rapid and convenient assay for acetyltransferase or protein kinase activity immobilized on nitrocellulose.  Analytical Biochemistry. Vol. 159, no. 1. (November): 58-66.
• Chicoine LG, and Allis CD. 1986. Regulation of histone acetylation during macronuclear differentiation in Tetrahymena: evidence for control at the level of acetylation and deacetylation.  Developmental Biology. Vol. 116, no. 2. (August): 477-485.
• Chicoine LG, Schulman I, Richman R, Cook R, and Allis CD. 1986. Nonrandom utilization of acetylation sites in histones isolated from Tetrahymena. Evidence for functionally distinct H4 acetylation sites. 61(3): 1071-6, 1.  Journal of Biological Chemistry. Vol. 261, no. 3. (January): 1071-1076.
• Allis CD, Chicoine LG, Richman R, and Schulman I. 1985. Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 82, no. 23. (December): 8048-8052.
• Chicoine LG, Wenkert D, Richman R, Wiggins J, and Allis CD. 1985. Modulation of linker histones during development in Tetrahymena: selective elimination of linker histone during the differentiation of new macronuclei.  Developmental Biology. Vol. 109, no. 1. (May): 1-8.
• Allis CD, Allen R, Wiggins J, Chicoine LG and Richman R. 1984. Proteolytic processing of h1-like histones in chromatin: a physiologically and developmentally regulated event in Tetrahymena micronuclei.  Journal of Cell Biology. Vol. 99, no. 5. (November): 1669-1677.
• Bernadette Chen, Jianjing Xue, Xiaomei Meng, Andrea Calvert, and Louis Chicoine. Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling.  Am J Physiol Lung Cell Mol Physiol.
• Bernadette Chen, Krista Strauch, Yi Jin, Hongmei Cui, Leif Nelin, and Louis Chicoine. Asymmetric dimethyl arginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells.  Am J Physiol Lung Cell Mol Physiol.
• Esther Rieger-Fackeldey, Min Soo Par, Brandon L. Schanbacher, Mandar S Joshi, Louis G. Chicoine, Leif D. Nelin, John A. Bauer, Stephen E. Welty, Charles V. Smith. Alterations in Lung Development after Recovery of 14 Days from Exposure of Newborn Mice to Sublethal Hyperoxia.  Am J Pathol.