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Kim L. McBride, MD, MS, is an Investigator in the Center for Cardiovascular and Pulmonary Research at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University College of Medicine.
Dr. McBride is also a Clinical and Biochemical Geneticist with an interest in translational research for lysosomal storage diseases and other inborn errors of metabolism. He participates in both industry and investigator led clinical trials, including contributions to the Sanfilippo gene therapy team at NCH. He is the director of the Cardiovascular Genetics Clinic, providing care for families with a variety of cardiovascular disorders that have a genetic basis.
The McBride lab is interested in the cause of congenital heart defects, with a focus on malformations involving the left side of the heart. Dr. McBride and his lab have previously used traditional human genetic approaches to map disease loci and find disease-gene associations. More recently, they have established an NIH funded multiple investigator group to use whole exome and whole genome sequencing approaches to discover disease-causing variants. Cell based assays and in vivo systems are then used to assess the functional consequences of these variants. The McBride lab has also begun to use their large cohort of families to study treatment outcomes, with the goal of identifying genetic variants that may suggest novel treatment targets or may predict response, thus providing personalized medical management. Dr. McBride and his lab continue to recruit new families with congenital heart defects for study.