March 2018

Are High-Amplitude Background Slow Waves Normal in Young Children?

Sometimes considered a sign of infantile spasm-related hypsarhythmia – or just an indication that patients need to be followed – high-amplitude posterior waves are common in young children.

Boys With Congenital Adrenal Hyperplasia Miss Out on Valuable Screening

New research suggests fertility discussions and updated screening methods for male patients who have CAH are long overdue.

How to Reduce Cast Complications in Orthopedics

A quality improvement project resulted in an almost total elimination of cast complications in a busy pediatric department.

Mitigating Treatment-Related Toxicity in Leukemia

The multicenter Supportive Care Committee seeks to help children with relapsed or refractory leukemia avoid infections and other toxicity-related complications.

A Potential Biomarker for Lung Disease in Cystic Fibrosis

A microRNA cluster is elevated in cystic fibrosis sputum and associated with pulmonary exacerbations.

An Under-Recognized, and Under-Treated, Complication of Nephrotic Syndrome

Dyslipidemia causes renal injury and is implicated in higher rates of atherosclerosis with nephrotic syndrome, but it is still not well understood, particularly in children.

February 2018

Differences Between Pediatric and Adult Guidelines for Classifying Left Ventricular Dilation

More than half of adolescent and young adult echocardiograms classified as abnormal by adult standards would be considered normal by pediatric standards.

What Is a Posterior Tongue Tie, and Is It a Reason to Perform a Tongue Clip?

Jonathan Grischkan, MD, otolaryngologist at Nationwide Children’s Hospital and assistant professor at The Ohio State College of Medicine, answers this common question from primary care providers.

Pancreatitis Patients Go Home Sooner When They Direct Nutrition Decisions

Children with acute pancreatitis who led the decision to eat again had shorter hospital stays and earlier food reintroduction compared to those who awaited clinician approval.

January 2018

A Better Non-Invasive Method To Monitor Liver Disease in Short Bowel Syndrome?

A pilot study suggests ultrasound elastography can be useful in determining degree of liver fibrosis in children with SBS.

Does Feed Fortification or Blood Transfusion Quickly Lead to NEC?

A first-of-its-kind neonatal intensive care study evaluates whether feeding advances or packed red blood cell transfusions have a short-term effect on the odds of developing necrotizing enterocolitis

How to Accurately Determine Testicular Volume Without Ultrasound

The most commonly used clinical methods can overestimate volumes by 250 percent, but a new calculator gives providers much more reliable values.

Robotic Bladder Reconstruction Surgery for Children

Benefits of robotic surgery include improved cosmesis, decreased blood loss and recovery time, and shorter hospital stays.

Successful Early Surgical Intervention for a Wrist Deformity

Vickers ligament release is a safe and effective technique to prevent Madelung’s deformity from worsening.

Surprisingly High Hospital Utilization for UTIs and Other Infections in Diabetes

The first known national study quantifying infection-related emergency department visits, hospital admissions, and healthcare costs for children with diabetes reveals the top infections affecting this population.

Vagus Nerve Stimulation Therapy Significantly Reduces Unplanned Hospitalizations in Children

A first-of-its-kind case series, using data from a pediatric accountable care organization, shows children with epilepsy had less health care utilization after VNS implantation.

December 2017

Which GERD Symptoms in NICU Babies Actually Need Treatment?

Researchers gain further insight into which gastroesophageal reflux disease symptoms merit the use of proton pump inhibitors and follow-up in NICU babies with dysphagia.

November 2017

Is Central Adrenal Insufficiency Over-diagnosed in Prader-Willi Syndrome?

A first-of-its-kind study shows poor agreement between two testing methods for central adrenal insufficiency– suggesting one of the tests may be preferred to avoid over-diagnosis and treatment in this patient population.

Developing Better Clinical Trials in Pediatric Nephrology

Researchers, drug companies and others have formed the Therapeutics Development Committee through the American Society of Pediatric Nephology – and are learning how to work together to bring therapies to patients.

Indomethacin Prophylaxis Associated With Substantially Improved Survival in Extremely Preterm Babies

While influential studies conducted in the 1990s showed no mortality benefit, a more contemporary cohort demonstrates the relative risk of death was 48 percent less for babies who received prophylaxis.

Predicting Esophageal Eosinophilia Using Serum IgE Antibody Results

Researchers can predict the presence of esophageal eosinophils — even in children with nonspecific gastrointestinal symptoms — using food-specific IgE test results and a simple new algorithm.

October 2017

DHA to Prevent Preterm Birth: The ADORE Trial

This Phase III trial will be the first study to evaluate high-dose docosahexaenoic acid with reduction of earliest preterm birth as a primary outcome.

Examining the Modern Balloon Aortic Valvuloplasty

While safe and effective for many patients with congenital aortic stenosis, some appear to be at higher risk for complications.

Sacral Nerve Stimulation Proves an Effective and Long-lasting Treatment for Children With Constipation and Fecal Incontinence

A recent study indicates that the therapy is a viable alternative for children with defecation disorders.

September 2017

A Pioneering Spine Biomechanics Lab for Children

Discovering the forces on the pediatric spine could change approaches to scoliosis surgery and other treatments.

New Targets for Nephrotic Syndrome Treatment?

Discoveries about the mechanisms of podocyte injury may lead to treatments not previously considered.

The First Consensus Guidelines for Evaluation of Pediatric Pancreatitis

An increasing incidence of these conditions in children has driven the creation of a first-of-its kind consensus from an international group of pediatric gastroenterologists.

Systemic Gene Therapy Holds Promise for Treating Certain Muscular Dystrophies

After success in animal studies with individual muscle therapy, researchers find that delivering the gene to the whole body may be effective as well.

Transfer of Patients With Testicular Torsion Associated With Worse Outcomes

If possible, urologists should correct torsion at the presenting institution instead of transferring to tertiary care hospitals.

August 2017

Severe BPD Ventilator Strategies: A Quick Guide

A chart, adapted from the Bronchopulmonary Dysplasia Consortium, shows the differences in strategies between the first week of life, when prevention is the goal, and later, when severe BPD has been established.

The Long-Term Benefit of Behavioral Intervention for Rumination Syndrome

A number of publications demonstrate that behavioral treatment strategies for adolescents with rumination syndrome have short-term success.

July 2017

Managing Depression, Anxiety and Similar Issues in Primary Care

One in five children will struggle with a mental health illness by the age of 12, but a recent survey by the American Academy of Pediatrics revealed that only 47 percent of primary care physicians feel comfortable screening for and diagnosing mental illness.

Promising Results Using a Modified Procedure for Severe Hypospadias

A first-of-its-kind study shows poor agreement between two testing methods for central adrenal insufficiency– suggesting one of the tests may be preferred to avoid over-diagnosis and treatment in this patient population.

Sleep-Disordered Breathing and Cardiovascular Issues in Children

Sleep-disordered breathing affects the heart, but cardiovascular complications can also affect sleep.

May 2017

Finding Better Markers of Cardiovascular Risk in Pediatric Type 1 Diabetes

Children and adolescents with type 1 diabetes are at risk for cardiovascular disease. Are there ways to determine who is at greatest risk, and who benefits most from early intervention?