Innovation and Discovery

(From the July 2018 Issue of MedStat)

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Newly Formed Biostatistics Resource Supports Clinical, Lab-Based and Population Health Research

The newly formed Biostatistics Resource at Nationwide Children’s Hospital (BRANCH) merges the existing Nationwide Children’s Biostatistics Core with The Ohio State University’s Center for Biostatistics. BRANCH provides biostatistical support for Nationwide Children’s investigators and is led by Guy Brock, PhD, research associate professor in the Department of Biomedical Informatics and deputy director of the Center for Biostatistics. BRANCH consists of five PhD faculty / research scientists and six MS biostatisticians with expertise in a variety of areas including clinical trials, complex observational studies, and high-throughput statistical bioinformatics.

Questions to Ask, Signs to Look for in Young Women at Risk for von Willebrand Disease

Nearly 90 percent of girls with heavy menstrual bleeding are not screened for von Willebrand Disease, despite recommendations by the American College of Obstetricians and Gynecologists, a study led by Sarah O’Brien, MD, MSc, a pediatric hematologist at Nationwide Children’s, found. She and colleagues recommend pediatricians ask young women some specific questions about their periods during health supervision visits, look for underlying causes of anovulatory bleeding or menstrual bleeding well-controlled by hormonal contraceptives and more. The study is in Obstetrics & Gynecology.   

Learn more in this Pediatrics Nationwide article.

Guide to Lyme Disease, West Nile Virus and Other Conditions

With summer comes increased risks for tick- and mosquito-borne diseases. The number of cases of Lyme disease in Ohio continues to grow annually and West Nile virus has been found in all counties within the state and, under some conditions, seasonal epidemics occur. Laboratory Services and the Division of Infectious Diseases at Nationwide Children’s have developed a guide for primary care providers reviewing signs and symptoms, testing and diagnosis for these and other conditions.

Read more and download the guide in this PediatricsOnline article.

PEG 3350 Use Not Associated With Abnormally High Glycol Levels in Children

Recent reports of behavioral changes in children taking the laxative polyethylene glycol (PEG) 3350 laxative, commonly sold as MiraLAX, spurred the U.S. Food and Drug Administration to request research into whether the laxative contributes to neuropsychiatric events. A study in The Journal of Pediatrics, led by Kent Williams, MD, a member of the Division of Gastroenterology, Hepatology & Nutrition at Nationwide Children’s, found low levels of potentially neurotoxic glycol compounds in children taking PEG3350 and untreated children. The researchers suggest behavioral changes are more likely associated with constipation.

Read more in this PediatricsOnline article.