Louis G. Chicoine, MD, is a member of the Section of Neonatology at Nationwide Children's Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. As a principal investigator in the Center for Gene Therapy at The Research Institute at Nationwide Children's Hospital, Dr. Chicoine's research interests are focused on the study of normal and abnormal lung and lung vascular development. Several ongoing studies using models ranging from cell culture to isolated lung, and techniques ranging from siRNA interference to physiological studies are directed at answering questions relating to NOS expression and NO production, and their affect on pulmonary artery tone during development. Gene therapy using NOS directed at the lung might be expected to decrease pulmonary vascular resistance and arrest pulmonary vascular remodeling associated with PPHN, and be more efficacious than inhaled NO therapy. Dr. Chicoine is currently utilizing a rat model of PPHN to study the effects and potential toxicities of gene therapy with NOS. These studies are the first step in providing more effective and safer treatment to babies born with PPHN cared for in the Neonatal Intensive Care Unit.
Date of Appointment at Nationwide Children’s Hospital: 03/26/2004
- Neonatal-Perinatal Medicine
|Fellowship||University of Colorado Health Sciences Center||Date Completed: 06/30/1996|
|Residency||Stanford University||Date Completed: 06/30/1993|
|Internship||Stanford University||Date Completed: 06/30/1991|
|Medical School||University of Texas Medical Branch at Galveston||Date Completed: 05/26/1990|