Joy Lincoln, PhD

My laboratory focuses on understanding the molecular mechanisms that regulate normal heart formation in the embryo and identifying developmental origins of adult cardiovascular disease. Development of the heart is a complex process involving multiple molecular pathways that modulate cardiac morphogenesis. Alterations in these genetic networks during embryogenesis frequently lead to structural cardiac defects, malfunction and congenital heart disease (CHD) in approximately 1% of all live births. Despite the clinical significance, the regulatory pathways required for heart formation, and the genetic contributions of CHD are largely unknown. Understanding the structure-function relationship of genes important during embryonic cardiogenesis will provide insights into genetic causes of CHD associated with structural defects and dysfunction.

To understand this, my laboratory has established sophisticated in vivo tools to manipulate target gene function during cardiogenesis and examine heart structure and function in adult mutant mice. In addition, we have developed elegant in vitro tools that allow us to manipulate signaling pathways in primary cardiac cells.

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Publications

Joy Lincoln, PhD, is a Principal Investigator in The Center for Cardiovascular and Pulmonary Research at Nationwide Children's Hospital and Associate Professor in the Department of Pediatrics at The Ohio State University. Dr. Lincoln's funded research is focused on understanding mechanisms of embryonic heart development and congenital heart disease.

See Joy Lincoln’s Curriculum Vitae (CV)