Joy Lincoln, PhD

• Center for Cardiovascular Research
  Principal Investigator
• Lincoln Lab
  Principal Investigator

My laboratory focuses on understanding the molecular mechanisms that regulate normal heart formation in the embryo and identifying developmental origins of adult cardiovascular disease. Development of the heart is a complex process involving multiple molecular pathways that modulate cardiac morphogenesis. Alterations in these genetic networks during embryogenesis frequently lead to structural cardiac defects, malfunction and congenital heart disease (CHD) in approximately 1% of all live births. Despite the clinical significance, the regulatory pathways required for heart formation, and the genetic contributions of CHD are largely unknown. Understanding the structure-function relationship of genes important during embryonic cardiogenesis will provide insights into genetic causes of CHD associated with structural defects and dysfunction.

To understand this, my laboratory has established sophisticated in vivo tools to manipulate target gene function during cardiogenesis and examine heart structure and function in adult mutant mice. In addition, we have developed elegant in vitro tools that allow us to manipulate signaling pathways in primary cardiac cells.

Publications

2011 - Present Center of Cardiovascular and Pulmonary ResearchThe Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Principal Investigator, Associate Professor

2006 - 2011 Department of Molecular and Cellular Pharmacology, Department of Medicine, University of Miami, Leonard M. Miller School of Medicine, Tenure Track Assistant Professor

2002 - 2006 Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, Postdoctoral Research Fellow