Estradiol vaginal ring (Estring)
What is this medicine?
ESTRADIOL (es tra DYE ole) vaginal ring is an insert that contains a female hormone. This medicine helps relieve symptoms of vaginal irritation and dryness that occurs in some women during menopause.
How should I use this medicine?
This medicine may be inserted by you or your physician. Follow the directions that are included with your prescription. If you are unsure how to insert the ring, contact your doctor or health care professional. The vaginal ring should remain in place for 90 days. After 90 days you should replace your old ring and insert a new one. Do not stop using except on the advice of your doctor or health care professional.
Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.
A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breast tissue changes or discharge
signs and symptoms of a blood clot such as breathing problems; changes in vision; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg
signs and symptoms of infection like fever or chills; vomiting; diarrhea; muscle pain; dizziness; or a red, sunburn-like rash on face and body
signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
symptoms of bowel blockage like constipation, abdominal swelling, abdominal pain, inability to pass gas or have a bowel movement
symptoms of vaginal infection like itching, irritation or unusual discharge
unusual or increased vaginal bleeding
vaginal pain or soreness, redness, swelling
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this medicine?
Do not take this medicine with any of the following medications:
aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone, vorozole
This medicine may also interact with the following medications:
certain antibiotics used to treat infections
certain barbiturates used for inducing sleep or treating seizures
medicines for fungus infections like itraconazole and ketoconazole
raloxifene or tamoxifen
rifabutin, rifampin, or rifapentine
St. John's Wort
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Throw away any unused medicine after the expiration date.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
abnormal vaginal bleeding
blood vessel disease or blood clots
breast, cervical, endometrial, ovarian, liver, or uterine cancer
heart disease or recent heart attack
high blood pressure
high level of calcium in the blood
protein C deficiency
protein S deficiency
systemic lupus erythematosus (SLE)
an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.
This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.
If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.
Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.
This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.
If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.
You may bathe or participate in other activities while using this medicine. You do not need to remove the vaginal ring during sexual or other activities unless you are more comfortable doing so. Within the 90-day dosage period, you may remove the vaginal ring, rinse it with clean lukewarm (not hot or boiling) water, and re-insert the ring as needed.
Online Medical Reviewer:
Date Last Reviewed: Unavailable
NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
- About Clinical Trials: Information from the National Cancer Institute
- Alendronate; Cholecalciferol tablets
- Alendronate effervescent oral tablets
- Alendronate oral solution
- Alendronate tablets
- Alendronate weekly tablets
- Anastrozole tablets
- Belladonna Alkaloids; Ergotamine; Phenobarbital tablets
- Bicalutamide tablets
- Black Cohosh, Cimicifuga racemosa oral dosage forms
- Calcitonin injection
- Calcitonin nasal spray
- Calcium Carbonate; Risedronate tablets
- Calcium; Vitamin D chewable tablet
- Calcium; Vitamin D oral tablets
- Capecitabine tablets
- Conjugated Estrogens injection
- Conjugated Estrogens; Medroxyprogesterone tablets
- Conjugated Estrogens tablets
- Conjugated Estrogens vaginal cream
- Cyclophosphamide injection
- Cyclophosphamide tablets or Capsules
- Docetaxel injection
- Doxorubicin injection
- Drospirenone; Estradiol oral tablet
- Epirubicin injection
- Esterified Estrogens; Methyltestosterone tablets
- Esterified Estrogens tablets
- Estradiol acetate vaginal ring (Femring)
- Estradiol injection
- Estradiol; Levonorgestrel skin patches
- Estradiol; Norethindrone Acetate tablets
- Estradiol; Norethindrone skin patches
- Estradiol; Norgestimate tablets
- Estradiol skin patches
- Estradiol tablets
- Estradiol topical emulsion
- Estradiol topical gel
- Estradiol topical spray
- Estradiol vaginal cream
- Estradiol vaginal tablets
- Estramustine capsules
- Estropipate tablets
- Ethinyl Estradiol; Desogestrel tablets
- Ethinyl Estradiol; Levonorgestrel emergency contraceptive kit
- Ethinyl Estradiol; Levonorgestrel tablets
- Ethinyl Estradiol; Norethindrone acetate chew tab; EE tab; Iron tab
- Ethinyl Estradiol; Norethindrone Acetate (estrogen replacement)
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate chew tabs (contraception)
- Ethinyl Estradiol; Norethindrone Acetate tablets (contraception)
- Ethinyl Estradiol, Norethindrone Chewable tablet, Ferrous Fumarate Chewable tablet
- Ethinyl Estradiol; Norethindrone tablets
- Etidronate injection
- Etidronate tablets
- Exemestane tablets
- Fluorouracil, 5-FU injection
- Fluorouracil, 5-FU skin cream or solution
- Flutamide capsules
- Follitropin, r-FSH injection (Follistim(TM))
- Follitropin, r-FSH injection (Gonal-F(R))
- Fulvestrant injection
- Goserelin injection
- Histrelin implant (Supprelin LA)
- Histrelin implant (Vantas)
- Human Chorionic Gonadotropin, HCG injection
- Ibandronate injection
- Ibandronate monthly tablets
- Ibandronate tablets
- Ifosfamide injection
- Letrozole tablets
- Leuprolide depot injection
- Leuprolide injection
- Megestrol oral suspension
- Megestrol tablets
- Methotrexate injection
- Methotrexate subcutaneous injection
- Methotrexate tablets
- Methyltestosterone tablets or capsules
- Mitoxantrone injection
- Nanoparticle Albumin-Bound Paclitaxel injection
- Nilutamide tablets
- Paclitaxel injection
- Pamidronate injection
- Raloxifene tablets
- Risedronate delayed-release weekly tablets (Atelvia)
- Risedronate tablets
- Risedronate weekly tablets (Actonel)
- Soy Isoflavones oral dosage forms
- Synthetic Conjugated Estrogens (A) oral tablet
- Synthetic Conjugated Estrogens (B) oral tablet
- Tamoxifen oral solution
- Tamoxifen oral tablet
- Teriparatide injection
- Testolactone tablets
- Testosterone buccal system
- Testosterone injection
- Testosterone skin gel
- Testosterone skin patches
- Testosterone subcutaneous pellets
- Testosterone topical solution
- Thiotepa injection
- Toremifene tablets
- Trastuzumab injection for infusion
- Triptorelin injection
- Vinblastine injection
- Vincristine injection