Bernadette Chen, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Bernadette Chen, MD

Bernadette Chen, MD

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4530
FX: (614) 722-4541
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355.3618

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Gender:

  • Female

Languages Spoken:

  • English
  • Chinese

Research Interests

Research Center:

Areas of Interest:

  • Bernadette Chen, M.D. is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at the Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase- cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Education and Training

Undergraduate School

  • Youngstown State University
    Date Completed: 06/30/1997

Medical School

  • Northeastern Ohio Universities College of Medicine
    Date Completed: 05/31/2001

Residency

  • Advocate Chirst Hospital and Medical Center - Oakl
    Date Completed: 06/30/2004

Fellowship

  • Childrens Memorial Hospital (Chicago)
    Date Completed: 06/30/2007

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 09/01/2007

Professional Experience

2007–present

  • Pediatric Academic Association/The Ohio State University, Assistant Professor

1998

  • NEOUCOM, Gross anatomy. Prosector

1997

  • NEOUCOM, Academic Services, Problem Based Learning training simulation for faculty

Publications

  • Chen,Bernadette; Nelin,Viktoria,E; Locy,Morgan,L; Jin,Yi; Tipple,Trent,E. 2013. Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 305, no. 5. (September): L389-L395.
  • Jin,Yi; Chen,Bernadette; Calvert,Thomas,J; Chicoine,Louis,G; Liu,Yusen; Nelin,Leif,D. 2013. Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 304, no. 2. (January): H195-H205.
  • Chen,Bernadette; Calvert,Andrea,E; Meng,Xiaomei; Nelin,Leif,D. 2012. Pharmacologic Agents Elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 47, no. 2. (August): 218-226.
  • Yan, J, Meng, X, Wancket, LM, Lintner, K, Nelin, LD, Chen, B, Francis, KP, Smith, CV, Rogers, LK, Liu, Y. 2012. Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.  J Immunol. Vol. 188, no. 5. (March): 2316-27.
  • Cui,Hongmei; Chen,Bernadette; Chicoine,Louis,G; Nelin,Leif,D. 2011. Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. Vol. 38, no. 12. (December): 796-803.
  • Jin Y, Calvert TJ, Chen B, Chicoine LG, Joshi MS, Bauer JA, Liu Y, Nelin LD. 2010. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  Am J Physiol Heart Circ Physiol.. Vol. 298, no. 5. (May): H1518-H1528.
  • Toby IT, Chicoine LG, Cui H, Chen B, Nelin LD. 2010. Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 298, no. 4. (April): eL600.
  • Chen B, Lakshminrusimha S, Czech L, Groh BS, Gugino SF, Russell JA, Farrow KN, Steinhorn RH. 2009. Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep.  Pediatric Research. Vol. 66, no. 6. (December): e682.
  • Chen B, Calvert AE, Cui H, Nelin LD. 2009. Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.  Am J Physiol Lung Cell Mol Physiol.. Vol. 297, no. 6. (January): L1151-L1159.
  • Lakshminrusimha S, Porta NF, Farrow KN, Chen B, Gugino SF, Kumar VH, Russell JA, Steinhorn RH. 2009. Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn.  Pediatric Critical Care Medicine: A Journal Of The Society Of Critical Care Medicine And The World Federation Of Pediatric Intensive And Critical Care Societies. Vol. 10, no. 1. (January): e106.
  • Chen, B, Calvert, AE, Meng, X, Nelin, LD. 0. Pharmacologic agents elevating cAMP Prevent Arginase II Expression and Proliferation of Pulmonary Artery Smooth Muscle Cells.  Am J Respir Cell Mol Biol.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000