William C. Ray, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

William C. Ray, Ph.D.

William C. Ray, Ph.D.

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
Assistant: (614) 355-5645
FX: (614) 355.2728
E-mail Me

Biography

View CV »

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • New technologies and improved techniques for the collection of biological data are invented almost daily. One of the compounded effects of these new and improved methods is the exponential growth of biological databases, and the super-exponential growth of correlative inferences that could be drawn from the data, if it could be mined effectively. Such improvements in our ability to process this data tend to come evolutionarily, leaving researchers further and further behind every day. Fortunately, much of the disparity between the rates of data collection and data comprehension, is often rooted in the application, and continued development of sub-optimal tools, rather than in any fundamental feature of the system. My laboratory focuses on understanding the disconnect between complex biological systems and currently applied data analysis techniques, and on developing new techniques that are more appropriate to the data and to the end-researcher needs.

Education and Training

Undergraduate School

  • The Ohio State University
    Date Completed: 06/30/1990

Graduate School

  • The Ohio State University
    Date Completed: 06/30/1993

Post Doctoral

  • The Ohio State University
    Date Completed: 06/30/2000

Professional Experience

2008–present

  • Research Assistant Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital

2002–2008

  • Research Scientist; Co-Director, Advanced Computing Core; Adj. Aux. Assistant Professor of Pediatrics. The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

2000–2002

  • Postdoctoral Fellow. Children's Research Institute, Columbus, Ohio. Laboratory of Robert S. Munson Jr., Ph.D.

1998–2000

  • Research Assistant, The Ohio State University, Columbus, Ohio. College of Biological Sciences. Laboratory of Charles J. Daniels, Ph.D.

1994–1998

  • Research Assistant.  System Administrator, Acting Manager. The Ohio State University, Columbus, Ohio. College of Biological Sciences. College Computational Biology Facility.

1989–1994

  • Senior Programming Analyst.  Online Computer Library Center, Dublin, Ohio.  Office of Research.

1985–1991

  • Undergraduate Research Assistant/Volunteer.  The Ohio State University, Columbus, Ohio. College of Mathematical and Physical Sciences, Department of Physics. Laboratory of Carl Neilsen, Ph.D., Solar Ponds Research Group.

Publications

  • Michael R. Goode, Soo Yeon Cheong, Ning Li, William C. Ray and Christopher W. Bartlett. 2014. Collection and Extraction of Saliva DNA for Next Generation Sequencing.  Journal of Visualized Experiments. Vol. 0, no. 90. (August): ee51697.
  • William C. Ray, R. Wolfgang Rumpf, Brandon Sullivan, Nicholas Callahan, Thomas Magliery, Raghu Machiraju, Bang Wong, Martin Krzywinski and Christopher W. Bartlett. 2014. Understanding the Sequence Requirements of Pro- tein Families : Insights from the BioVis 2013 Contests.  Proceedings of the 3rd Annual Symposium on Biological Data Visualization: Data Analysis and Redesign Contests. Vol. 8, no. s2. (August): eS1.
  • William C. Ray, Samuel L. Wolock, Nicholas W.Callahan, Min Dong, Q. Quinn Li, Chun Liang, Thomas Magliery and Christopher W. Bartlett. 2014. Addressing the unmet need for visualizing Conditional Random Fields in Biological Data.  BMC Bioinformatics. Vol. 15, no. July: e202.
  • A. Vulin; N. Wein; D.M. Strandjord; E.K. Johnson; A.R. Findlay; B. Maiti; M.T. Howard; Y.J. Kaminoh; L.E. Taylor; W.C. Ray; F. Montanaro; J.M. Ervasti; K.M. Flanigan. 2013. The ZZ domain of dystrophin in DMD: making sense of missense mutations.  Human Mutation. Vol. 35, no. 2. (December): 257-264.
  • William C. Ray; Samuel L. Wolock; Ning Li; Christopher W. Bartlett. 2013. "StickWRLD: Interactive Visualization of massive parallel contingency data for Personalized Analysis to facilitate Precision Medicine".
  • McLellan Jason S, Ray William C, Peeples Mark E. 2013. Structure and function of respiratory syncytial virus surface glycoproteins.  Current Top Microbiology Immunology. Vol. 372, no. January: 83-104.
  • William C. Ray; Samuel L. Wolock; Ning Li; Christopher W. Bartlett. 2012. StickWRLD: Interactive Visualization of massive parallel contingency data for Personalized Analysis to facilitate Precision Medicine.  Proceedings of 2013 AMIA Workshop on Visual Analytics in Health Care. Vol. 3, no. November: 68-71.
  • Justice,Sheryl,S; Li,Birong; Downey,Jennifer,S; Dabdoub,Shareef,M; Brockson,M,Elizabeth; Probst,G,Duane; Ray,William,C; Goodman,Steven,D. 2012. Aberrant Community Architecture and Attenuated Persistence of Uropathogenic Escherichia coli in the Absence of Individual IHF Subunits.  PLOS ONE. Vol. 7, no. 10. (October): ee48349.
  • Ryo Sakai, Christopher Bartlett, Dusan Popovic, William C. Ray, and Jan Aerts. 2012. Aracari – exploration of eQTL data through visualization.  IEEE Transaction on Biological Data Visualization. Vol. 1, no. October: e33.
  • Chalkidis G, Tremmel G, Ray W, Bartlett CW, Miyano S, Nagasaki M. 2012. Reverse Engineering Complex Disease Networks by Information Flow Analysis in eQTL Datasets.  Proceedings of the 2012 IEEE Transactions on Biomedical Engineering. Vol. 1, no. June: 1-4.
  • John Ray and William C. Ray. 2012. SAMS Teach Yourself Xcode in 24 Hours. 1st ed. Edited by Greg Wiegand. Indianapolis, IN: SAMS Publishing.
  • Bartlett,Christopher,W; Cheong,Soo,Yeon; Hou,Liping; Paquette,Jesse; Lum,Pek,Yee; Jaeger,Guenter; Battke,Florian; Vehlow,Corinna; Heinrich,Julian; Nieselt,Kay; Sakai,Ryo; Aerts,Jan; Ray,William,C. 2012. An eQTL biological data visualization challenge and approaches from the visualization community.  BMC BIOINFORMATICS. Vol. 13, no. May: eS8.
  • Heather M. Costello, William C. Ray, Supranee Chaiwatpongsakorn, and Mark E. Peeples. 2012. Targeting RSV with Vaccines and Small Molecule Drugs.  Infectious Disorders. Vol. vol 12, no. April: pp 110-128.
  • Shareef Dabdoub, Brian Vanderbrink, Sheryl Justice and William C. Ray. 2011. Quantitating Pathogenic Biofilm Architecture in Biopsied Tissue.  Proceedings of the Workshop on Visual Analytics in Healthcare: Understanding the Physician Perspective. Vol. 1, no. October: pp 49-52.
  • Eddie Worbis, Raghu Machiraju, Christopher Bartlett, and William C. Ray. 2011. Visual Interactive Quality Assurance of Personalized Medicine Data and Treatment Subtype Assignment.  Proceedings of the Workshop on Visual Analytics in Healthcare: Understanding the Physician Perspective. Vol. 1, no. October: pp 33-36.
  • William C. Ray and Christopher Bartlett. 2011. The BioVis Contest : Open letter from the BioVis Contest Organizers.  Proceedings of the 1st Annual IEEE Symposium on Biological Data Visualization. Vol. 1, no. October: exvi.
  • Kevin M. Mason, Forrest K. Raffel, William C. Ray and Lauren O. Bakaletz. 2011. Heme Utilization by Nontypeable Haemophilus Influenzae is Essential and Dependent on Sap Transporter Function.  Journal of Bacteriology. Vol. 193, no. May: pp2527-2535.
  • Mason KM, Raffel FK, Ray WC and Bakaletz LO. 2011. Heme Utilization by Nontypeable Haemophilus influenzae is Essential and Dependent on Sap Transporter Function.  J Bacteriol. Vol. 193, no. May: 2527-2535.
  • Dabdoub,Shareef,M; Ray,William,C; Justice,Sheryl,S. 2011. FIND: A new software tool and development platform for enhanced multicolor flow analysis.  BMC BIOINFORMATICS. Vol. 12, no. May: e145.
  • William C. Ray. 2011. Dramatically Reduced Precision in Microarry Analysis Retains Quantitative Properties, and Provides Additional Benefits.  Software Tools and Algorithms for Biological Systems. Vol. 2011, no. January: 101-111.
  • Dabdoub,Shareef,M; Justice,Sheryl,S; Ray,William,C. 2011. A Dynamically Masked Gaussian Can Efficiently Approximate a Distance Calculation for Image Segmentation.  SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS. Vol. 696, no. January: 425-432.
  • Shareef Dabdoub and William C. Ray. 2010. Aesthetics and Understanding in Molecular Motion.  IEEE Proceedings on Information Visualization. Vol. 21, no. October: e#3.
  • Federica Montanaro, Hugh D. Allen, Jerr R. Mendell, Rita Wen Kaspar, Kevin M. Flanigan, John T. Kissel, Alan Pestronk, Robert B. Weiss, William C. Ray, and Carlos E. Alvarez. 2010. Response to Letter by Yilmaz et al Regarding Article, 'Analysis of Dystrophin Deletion Mutations Predicts Age Cardiomyopathy Onset in Becker Muscular Dystropy'.  Cardiovascular Genetics. Vol. 3, no. 2. (February): ee2.
  • Shareef Dabdoub, Sheryl S. Justice and William C. Ray. 2010. A Dynamically Masked Gaussian Can Efficiently Approximate a Distance Calculation for Image Segmentation.  In proceedings of BIOCOMP '09.
  • William C. Ray. 2010. Dramatically Reduced Precision in Microarray Analysis Retains Quantitative Properties, and Provides Additional Benefits.  In proceedings of BIOCOMP '09. Vol. 696, no. January: 101-111.
  • William C. Ray. 2010. A Visual Analytics Approach to Identifying Protein Structural Constraints.  IEEE Proceedings of Visual Analytics Science and Technology (VAST). Vol. 5, no. 1. (January): 249-250.
  • William C. Ray. 2010. A Visual Analytics Approach to Identifying Protein Structural Constraints.  Proceedings of the 5th Annual IEEE. Vol. 2010, no. January: pp 249-250.
  • William C. Ray. 2010. A Visual Analytics Approach to Identifying Protein Structural Constraints.  Proceedings of the 5th Annual IEEE. Vol. 2010, no. January: pp 249-250.
  • Kaspar RW; Allen HD; Ray WC; Alvarez CE; Kissel JT; Pestronk A; Weiss RB; Flanigan KM; Mendell JR; Montanaro F. 2009. Analysis of Dystrophin Deletion Mutations Predicts Age of Cardiomyopathy Onset in Becker Muscular Dystrophy.  Circulation. Cardiovascular Genetics. Vol. 2, no. 6. (December): 544-551.
  • William C. Ray, Hatice G. Ozer, David W. Armbruster and Charles J. Daniels. 2009. Beyond Identity- When Classical Homology Searching Fails; Why, and What You Can Do About It.  The Proceedings of the 2009 Ohio Collaborative Conference on Bioinformatics. Vol. 1, no. June: 51-56.
  • Ray,William,C; Ozer,Hatice,G; Armbruster,David,W; Daniels,Charles,J. 2009. Beyond identity - When classical homology searching fails, Why, and What you can do about it. In 4th Annual Ohio Collaborative Conference on Bioinformatics
  • Ranyia Matta, Xianxi Wang, Hui Ge, William C. Ray, Leif D. Nelin and Yusen Liu. 2009. Triptolide Induces Anti-inflammatory Cellular Responses.  Am J Transl Res. Vol. 1, no. January: 267-282.
  • Shareef Dabdoub, Abhilash Mohan and William C. Ray. 2008. Visualizing molecular uncertainty: A path to the path.  TOG. Vol. 35, no. 1. (August): e#128.
  • Ozer,Hatice,Gulcin; Ray,William,C. 2007. Informative motifs in protein family alignments. In 7th International Workshop on Algorithms in Bioinformatics (WABI 2007)
  • Ozer HG, Ray WC. 2007. Informative Motifs in Protein Family Alignments.  Lecture Notes in Bioinformatics. Vol. 4645, no. January: 161-170.
  • McGillivary G, Ray WC, Bevins CL, Munson RS Jr, Bakaletz LO. 2007. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.  Molecular Immunology. Vol. 44, no. 9. (January): 2446-2458.
  • Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO, Munson RS Jr. 2007. The OxyR regulon in nontypeable Haemophilus influenzae.  The Journal of Bacteriology. Vol. 189, no. 3. (January): 1004-1012.
  • Daniel Schreiber and William C. Ray. 2006. Tea 43.  Proceedings of ACM SIGGRAPH 2006. Vol. 33, no. 1. (August): e#43.
  • William C. Ray, Abhilash Mohan, and Jeffrey Bartlett. 2006. Using Flow-Visualization for Studying Sub-Molecular Motions.  Proceedings of ACM SIGGRAPH 2006. Vol. 33, no. 1. (August): e#30.
  • Daniel Schreiber and William C. Ray. 2006. Perfectly Rendered.  Proceedings of ACM SIGGRAPH 2006. Vol. 33, no. 1. (August): e#42.
  • Ozer HG; Ray WC. 2006. MAVL/StickWRLD: analyzing structural constraints using interpositional dependencies in biomolecular sequence alignments.  Nucleic Acids Research. Vol. 34, no. Web Server issue. (July): eW133.
  • John Ray, William C. Ray and Joan Ray. 2005. Mac OS X Tiger Unleashed. Indianapolis: SAMS Publishing.
  • William C. Ray and Hatice Gulcin Ozer. 2005. Discovering biostructure constraints using VRML visualization.  Proceeings of ACM SIGGRAPH 2005. Vol. 32, no. July: e#133.
  • Harrison A; Dyer DW; Gillaspy A; Ray WC; Mungur R; Carson MB; Zhong H; Gipson J; Gipson M; Johnson LS; Lewis L; Bakaletz LO; Munson RS Jr. 2005. Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.  Journal Of Bacteriology. Vol. 187, no. 13. (July): e4627.
  • Robert S. Munson Jr, Alistair Harrison, David W. Dyer, Allison Gillaspy, William C. Ray, Rachna Mungur, Matt Carson, Huachun Zhong, Jenny Gipson, Mandy Gipson, Linda S. Johnson, Lisa Lewis, and Lauren O. Bakaletz. 2005. Haemophilus influenze strain 86-028NP.  GenBank Accession. Vol. 2005, no. July: eNC_007146.
  • William C. Ray and Joseph A. Jurcisek. 2005. Modeling the fluffy lens: construction of the virtual chinchilla.  Proceedings of ACM SIGGRAPH 2005. Vol. 32, no. 1. (July): e#135.
  • Ray WC. 2005. MAVL/StickWRLD for protein: visualizing protein sequence families to detect non-consensus features.  Nucleic Acids Research. Vol. 33, no. Web Server issue. (July): eW315.
  • William C. Ray and Robert S. Munson Jr. 2004. Microbial-pathogenesis.org, an Experimental System for Simultaneous Genomics Research and Data Sharing: Preliminary Report.  WSEAS Transactions on Computers. Vol. 3, no. 5. (November): pp 1264-1267.
  • Ray, W,C. 2004. MAVL and StickWRLD: visually exploring relationships in nucleic acid sequence alignments.  Nucleic Acids Research. Vol. 32, no. Web Server issue. (July): eW59.
  • Selnur Erdal, Ozgur Ozturk, Dave Armbruster, Hakan Ferhatosmanoglu, and William C. Ray. 2004. A Novel Approach to Time Series Analysis of Microarray Data.  Transactions of the IEEE Fourth International Symposium on Bioinformatics and Bioengineering. Vol. 4, no. May: 366-378.
  • Munson RS Jr; Harrison A; Gillaspy A; Ray WC; Carson M; Armbruster D; Gipson J; Gipson M; Johnson L; Lewis L; Dyer DW; Bakaletz LO. 2004. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.  Infection And Immunity. Vol. 72, no. 5. (May): 3002-3010.
  • Munson RS Jr; Zhong H; Mungur R; Ray WC; Shea RJ; Mahairas GG; Mulks MH. 2004. Haemophilus ducreyi strain ATCC 27722 contains a genetic element with homology to the vibrio RS1 element that can replicate as a plasmid and confer NAD independence on haemophilus influenzae.  Infection And Immunity. Vol. 72, no. 2. (February): e1143.
  • Erdal,S; Ozturk,O; Armbruster,D; Ferhatosmanoglu,H; Ray,W,C. 2004. A time series analysis of microarray data. In 4TH IEEE Symposium on Bioinformatics and Bioengineering (BIBE 2004)
  • John Ray, William C. Ray and Joan Ray. 2003. Mac OS X Panther Unleashed. Indianapolis: SAMS Publishing.
  • Scheffler NK; Falick AM; Hall SC; Ray WC; Post DM; Munson RS Jr; Gibson BW. 2003. Proteome of Haemophilus ducreyi by 2-D SDS-PAGE and mass spectrometry: strain variation, virulence, and carbohydrate expression.  Journal Of Proteome Research. Vol. 2, no. 5. (September): e523.
  • John Ray, William C. Ray and Joan Ray. 2003. Maximum Mac OS X Security. Indianapolis: SAMS Publishing.
  • Ray WC; Daniels CJ. 2003. PACRAT: a database and analysis system for archaeal and bacterial intergenic sequence features.  Nucleic Acids Research. Vol. 31, no. 1. (January): e109.
  • John Ray, William C. Ray and Joan Ray. 2002. Mac OS X Unleashed, Second Edition. Indianapolis: SAMS Publishing.
  • Ray WC; Munson RS Jr; Daniels CJ. 2001. Tricross : using dot-plots in sequence-id space to detect uncataloged intergenic features.  Bioinformatics (Oxford, England). Vol. 17, no. 12. (December): e1105.
  • William C. Ray. 2001. VMD Visual Molecular Dynamics.  HMS Beagle division of BioMedNet. Vol. 1, no. October: e1.
  • John Ray and William C. Ray. 2001. Mac OS X Unleashed. Indianapolis: SAMS Publishing.
  • William C. Ray. 2001. The StarOffice suite.  HMS Beagle division of BioMedNet. Vol. 1, no. March: e1.
  • William C. Ray. 2001. The GCG software suite.  HMS Beagle division of BioMedNet. Vol. 1, no. February: e1.
  • Ray WC; Daniels CJ. 2001. The PACRAT system: an extensible WWW-based system for correlated sequence retrieval, storage and analysis.  Bioinformatics (Oxford, England). Vol. 17, no. 1. (January): e100.
  • Joan Ray and Will Ray. 1999. SAMS Teach Yourself UNIX System Administration in Twenty One Days. Indianapolis: Macmillan Computer Publishing.
  • Will Ray. 1999. SAMS Teach Yourself UNIX in Ten Minutes. Indianapolis: Macmillan Computer Publishing.
  • Ron Yagel and William C. Ray. 1996. Visibility Computation for Efficient Walk-through of Complex Environments.  Presence : Special Issue on Virtual Environments. Vol. 5, no. 1. (January): pp 45-60.
  • Stuart Weibel, Mark Bendig and Will C. Ray. 1992. The CORE Project: Formatting Chemistry Information for Screen Display in HyperCard.  Macintoshed Libraries. Vol. 5, no. March: pp 78-84.
  • William C. Ray. Tea 43.  SIGGRAPH 2006 Program.
  • William C. Ray. StickWRLD Figure.  CCRI Art in Science Competition.
  • William C. Ray. Folding Beauty.  Science Art Gallery http://australianbioinformatics.net.
  • William C. Ray. One Ugly MoFlow.  Science Art Gallery http://australianbioinformatics.net.
  • William C. Ray. Architectural Installation.  NCH RBIII 4th floor collaboration space.
  • R.S. Munson Jr, W.C. Ray, G Mahairas, P. Sabo, R. Mungur, L. Johnson, D. Nguyen, J. Wang, C. Forst, and L. Hood. Haemophilus ducreyi strain 35000HP.  GenBank Accesion.
  • R. Wolfgang Rumpf, Sam Wolock, and William C. Ray. 0. StickWRLD as an interactive visual pre-filter for canceromics-centric eQTL data.  Cancer Informatics.
  • William C. Ray. Proteins as the Downfall of RSV.  NCH Research.
  • William C. Ray. Nucleic Acids Research.  Webserver Issue 2004.
  • William C. Ray. Conference/Meeting Space Art.  NCH RBIII.
  • William C. Ray. The Art of Medicine.  The Columbus Dispatch.
  • William C. Ray, Ning Li and Christopher W. Bartlett. Defining the genetic architecture of human developmental language impairment.  Elsevier Life Sciences.
  • William C. Ray. And they built fences to hide themselves.  The Broad Institute.
  • William C. Ray. A Virus in Motion.  Art in Science.
  • William C. Ray. A Virus in Motion.  Nationwide Children's Hospital.
  • A. Vulin, N. Wein, D.M. Strandjord, E.K. Johnson, A. R. Findlay, B. Maiti, M.T. Howard, Y.J. Kaminoh, L.E. Taylor, W.C. Ray, F. Montanaro, J.M. Ervasti, and K.M. Flanigan. The ZZ domain of dystrophin in DMD: making sense of missense mutations.  Human Mutation.
  • William C. Ray. Nationwide Children's Hospial "New Campus".  Grand Opening Signage.
  • William C. Ray. Perfectly Rendered.  SIGGRAPH Juried Exhibit.
  • Goode, M.C., Cheon, S. Y., Li, N., Ray, W.C., and Bartlett, C.W. Collection and Extraction of Saliva DNA for Next Generation Sequencing.  JOVE.
  • William C. Ray. Scientific Visualization Wallpapers.  OSU/Wexner Medical Center.
  • William C. Ray. Discovering Relationships in Biosequences.  Science Art Gallery http://australianbioinformatics.net.
  • William C. Ray. Page Art and Backgrounds.  The Ohio Supercomputer Center 2006 Annual Report.
  • William C. Ray. Genome Map for H. influenzae.  McGraw-Hill Biology Rave/Mason et al. 8th edition.
  • Abhilash Mohan, William C. Ray and Jeffrey Bartlett. Acidified AAV2 Undergoes Persistent Conformational Change.  Empower.
  • William C. Ray. IEEE BioVis Symposium Sponsor Prospectus.  IEEE VisWeek/BioVis Prospectus.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000