W. Joshua Frazier, MD :: Nationwide Children's Hospital, Columbus, Ohio

W. Joshua Frazier, MD

W. Joshua Frazier, MD Best Doctors 2011-2012

Contact Information

Critical Care
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3435
FX: (614) 722-3443

Location Information for Patients

Main Campus


W. Joshua Frazier, MD, is an attending physician in the Pediatric Intensive Care Unit and Medical Director of the Pediatric ECMO Program at Nationwide Children’s Hospital. He is an Assistant Professor of Pediatrics, Division of Critical Care Medicine at The Ohio State University College of Medicine. He received his medical degree from Marshall University School of Medicine in Huntington, West Virginia before coming to Nationwide Children’s Hospital for his residency in pediatrics in 2001. He was chief resident in 2004. Dr. Frazier also completed his fellowship in pediatric critical care medicine at Nationwide Children’s Hospital where he was awarded the Outstanding Fellow Award in 2006 and 2008. Dr. Frazier’s primary research interest is the regulation of inflammatory responses in the innate immune system by the mitogen-activated protein kinase (MAPK) system. Dr. Frazier studies the actions of MAPK Phosphatase-1, a critical regulator of inflammation, with a particular interest in the molecular pathogenesis of septic shock.


  • Male

Languages Spoken:

  • English

Education and Training

Undergraduate School

  • West Virginia Wesleyan College
    Date Completed: 06/30/1997

Medical School

  • Marshall University School of Medicine
    Date Completed: 05/05/2001


  • Nationwide Children's Hospital
    Date Completed: 06/30/2002


  • Nationwide Children's Hospital
    Date Completed: 06/30/2004


  • Nationwide Children's Hospital
    Date Completed: 06/30/2008


  • Pediatrics


  • Critical Care


  • Pediatric Critical Care
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 08/27/2004


  • Frazier, WJ; Brilli, RJ. 2014. Closer to understanding the value proposition for medical emergency teams.  Pediatrics. Vol. 134, no. 2. (August): 375-376. PubMed ID: 25070316
  • Muszynski, JA, Frazier, WJ, Hall, MW. 2014. Pro-inflammatory and Anti-inflammatory Mediators in Critical Illness and Injury. In Pediatric Critical Care Medicine. 2nd ed. Edited by Wheeler, DS, Wong, HR, Shanley, TP. London: Springer.
  • Dewhirst, E, Frazier, WJ, Leder, M, Fraser, DD, Tobias, JD. 2013. Cardiac Arrest Following Ketamine Administration for Rapid Sequence Intubation.  J Intensive Care Med. Vol. 28, no. 6. (December): 375-379. PubMed ID: 22644454
  • Suttle, M; Frazier, WJ; Muszynski, J. 2013. Aggressive Fluid Resuscitation in Two Pediatric Patients with DKA and Shock. In 43rd Annual Critical Care Congress
  • Yan, J; Ralston, MM; Meng, X; Bongiovanni, KD; Jones, AL; Benndorf, R; Nelin, LD; Frazier, WJ; Rogers, LK; Smith, CV; Liu, Y. 2013. Glutathione reductase is essential for host defense against bacterial infection.  FREE RADICAL BIOLOGY AND MEDICINE. Vol. 61, no. August: 320-332. PubMed ID: 23623936
  • Liu, Y; Xue, J; Wancket, L; Shakibi, Y; Nelin, L; Frazier, W. 2013. Regulation of the expression of MKP-1 and MKP-2 by ERK MAP kinases in macrophages following LPS stimulation. In 100th Annual Meeting of the American Association of Immunologists
  • Liu, Y; Xue, J; Shakibi, Y; Xu, P; Wancket, LM; Nelin, LD; Frazier, WJ. 2013. ERK MAP Kinases Are Critical for the Expression of MKP-1 and MKP-2 in Macrophages Following LPS Stimulation. In Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
  • Frazier, WJ; Xue, J; Luce, WA; Liu,Y. 2012. MAPK Signaling Drives Inflammation in LPS-Stimulated Cardiomyocytes: The Route of Crosstalk to G-Protein-Coupled Receptors.  PLOS ONE. Vol. 7, no. 11. (November): ee50071. PubMed ID: 23226236
  • Matta, R; Barnard, JA; Wancket, LM; Yan, J; Xue, J; Grieves, J; Frazier, WJ; Nelin, L; Cato, ACB; Liu, Y. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 302, no. 11. (June): G1322-G1335. PubMed ID: 22461024
  • Liu, Y; Matta, R; Barnard, J; Wancket, L; Yan, J; Grieves, J; Frazier, WJ; Nelin, L; Cato, A. 2012. Knockout of mitogen-activated protein kinase phosphatase (Mkp)-1 exacerbates colitis development in interleukin-10-deficient mice. In 99th Annual Meeting of the American Association of Immunologists
  • Wancket, LM; Frazier, WJ; Liu, Y. 2012. Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease.  LIFE SCIENCES. Vol. 90, no. 7-8. (February): 237-248. PubMed ID: 22197448
  • Frazier, WJ. 2011. Immunity, inflammation and sepsis: new insights and persistent questions.  CRITICAL CARE. Vol. 15, no. 1. (January): e124.
  • Frazier, W; Wang, X; Wancket, L; Liu, Y. 2009. IL-10 INHIBITS BACTERIAL KILLING IN MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE (MKP)-1 DEFICIENT MICE. In 39th Critical Care Congress of the Society of Critical Care Medicine
  • Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology. Vol. 183, no. 11. (December): 7411-7419. PubMed ID: 19890037
  • Wang, X; Frazier, WJ; Meng, X; Nelin, LD; Liu, Y. 2009. The function of MAP kinase phosphatase-1 in Gram-negative sepsis.
  • Frazier, WJ; Hall, MW. 2008. Immunoparalysis and adverse outcomes from critical illness.  Pediatric Clinics of North America. Vol. 55, no. 3. (June): 647-668. PubMed ID: 18501759
  • Frazier, WJ; Wang, X; Kuhlman, J; Liu, Y. 2007. Regulation of inflammation by mitogen activated protein kinase phosphatase (MKP)-1 in gram-negative infection. In 37th Critical Care Congress of the Society of Critical Care Medicine
  • Hoffman, TM; Muszynski, JA; Marquardt, DJ; Yates, AR; Frazier, WJ; Hall, MW. 2007. Increased pulsatility of thyroid stimulating hormone (TSH) release is associated with immunodepression acutely after pediatric cardiopulmonary bypass (CPB). In 37th Critical Care Congress of the Society of Critical Care Medicine
  • Marquardt, DJ; Frazier, WJ; Hall, MW; Yates, AR; Hoffman, TM; Muszynski, JA. 2006. Anterior pituitary (AP) function acutely following cardiopulmonary bypass (CPB) in children. In 36th Critical Care Congress of the Society of Critical Care Medicine
  • Frazier WJ, Coley BD, Hall MW. 2004. Catheter-Directed Thrombolysis During Extra-Corporeal Membrane Oxygenation (ECMO) in a Child With Massive Pulmonary Embolus (PE): 638. In Society of Critical Care Medicine 34th Critical Care Congress
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700 Children's Drive Columbus, Ohio 43205 614.722.2000