W. Joshua Frazier, MD

W. Joshua Frazier, MD, is an attending physician in the Pediatric Intensive Care Unit at Nationwide Children’s Hospital, an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics, Division of Critical Care Medicine at The Ohio State University College of Medicine. He received his medical degree from Marshall University School of Medicine in Huntington, West Virginia before coming to Nationwide Children’s Hospital for his residency in pediatrics in 2001. He was chief resident in 2004. Dr. Frazier also completed his fellowship in pediatric critical care medicine at Nationwide Children’s Hospital where he was awarded the Outstanding Fellow Award in 2006 and 2008. Dr. Frazier’s primary research interest is the regulation of inflammatory responses in the innate immune system by the mitogen-activated protein kinase (MAPK) system. Dr. Frazier studies the actions of MAPK Phosphatase-1, a critical regulator of inflammation, with a particular interest in the molecular pathogenesis of septic shock.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Areas of Interest:

• Dr. Frazier focuses on regulation of inflammation in the innate immune system. For patients suffering from serious infections, survival depends on the proper coordination of immune functions, including both a competent proinflammatory response and compensatory counter-inflammation. The most severe manifestations of infection, severe sepsis and septic shock, are characterized by a harmful overproduction of proinflammatory cytokines by the innate immune system. Using a murine model of live Gram-negative sepsis, Dr. Frazier studies the actions of Mitogen Activated Protein Kinase Phosphatase-1 (or Mkp-1) which is a critical regulator of the host inflammatory response and serves to down-regulate the production of proinflammatory cytokines such as TNF-? and IL-6. Elucidating the importance of this key molecule will allow for greater understanding of the pathophysiology of septic shock on the cellular and sub-cellular levels and will potentially identify novel therapeutic targets for this disease.

Undergraduate

• West Virginia Wesleyan College
  Date Completed: 06/30/1997

Undergraduate

• West Virginia Wesleyan College
  Date Completed: 06/30/1997

Medical School

• Marshall University School of Medicine
  Date Completed: 05/05/2001

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2002

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2004

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2008

Department:

• Pediatrics

Section:

• Critical Care

Speciality:

• Pediatric Critical Care, Certified
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 08/27/2004

2008–present

• Nationwide Children's Hospital, Assistant Professor of Pediatrics, Investigator, Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Columbus, Ohio

• W. Joshua Frazier. 2011. Immunity, inflammation and sepsis: new insights and persistent questions.  Critical Care. Vol. 15, no. 1. (February 24): 124. (IF: 4.93)
• Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 183, no. 11. (December 1): 7411. (IF: 5.7)
• Frazier WJ, Hall MW. 2008. Immunoparalysis and adverse outcomes from critical illness. Pediatr Clin North Am.. Vol. 55, no. 3. (June): 647-668, xi.
• Frazier WJ; Hall MW. 2008. Immunoparalysis and adverse outcomes from critical illness.  Pediatric Clinics Of North America. Vol. 55, no. 3. (June 1): 647. (IF: 2.2)
• Frazier WJ, Wang X, Kuhlman J, Liu Y., Poster Presenter. 2008. Regulation of inflammation by Mitogen Activated Protein Kinase Phosphatase (MKP)-1 in Gram-negative infection. Presented at 2008 Society of Critical Care Medicine Annual Congress. [Peer Reviewed]
• Frazier WJ, Wang X, Kuhlman J, Liu Y., Poster Presenter. 2007. MKP-1, a critical regulator of the innate immune response to gram-negative bacterial infection. Presented at 2007 American Association of Immunologists Annual Meeting. [Peer Reviewed]
• Marquardt DF, Frazier WJ, Yates AR, Muszynski JA, Hoffman TM, Hall MW, Poster Presenter. 2007. Anterior pituitary function acutely following cardiopulmonary bypass in children. Presented at 2007 Society of Critical Care Medicine Annual Congress. [Peer Reviewed]
• Marquardt DJ, Frazier WJ, Hall MW, Yates AR, Hoffman TM, Muszynski JA, Poster Presenter. 2007. Anterior Pituitary (AP) Function Acutely Following Cardiopulmonary Bypass (CPB) in Children. Presented at 2007 Society of Critical Care Medicine Annual Congress. [Peer Reviewed]
• Frazier WJ, Wang X, Meng X, Nelin LD, Liu Y, Poster Presenter. 2008. The function of MAP kinase phosphatase-1 in Gram-negative sepsis. Presented at 2008 Society for Leukocyte Biology Annual Meeting. [Peer Reviewed]
• Frazier WJ, Coley BD, Hall MW, Poster Presenter. 2005. Catheter-directed thrombolysis during extracorporeal membrane oxygenation in a child with massive pulmonary embolus. Critical Care Medicine. December 2004; 32(12):A179. Presented at 2005 Society of Critical Care Medicine Annual Congress. [Peer Reviewed]
• Marquardt DJ, Frazier WJ, Yates AR, Muszynski JA, Muszynski JA, Hoffman TM, Hall MW, Poster Presenter. 2007. Anterior pituitary function acutely following cardiopulmonary bypass in children. Presented at 2007 Pediatric Academic Societies' Annual Meeting. [Peer Reviewed]
• Frazier WJ, Wang X, Kuhlman J, Liu Y, Poster Presenter. 2008. Regulation of inflammation by Mitogen Activicated Protein Kinase Phosphatase (MKP)-1 in Gram-negative infection. Presented at 2008 The Research Institute at Nationwide Children's Hospital Annual Retreat. [Peer Reviewed]
• Frazier WJ, Wang X, Kuhlman J, Liu Y, Poster Presenter. 2009. MKP-1, a critical regulator of the innate immune response to gram-negative bacterial infection. Presented at 2007 The Research Institute at Nationwide Children's Hospital Annual Retreat. [Peer Reviewed]
• Frazier WJ, Poster Presenter. 1999. A Shotgun Cloning Approach for Identifying Genes Localized to a Bacterial Artificial Chromosome (BAC) on Mouse Chromosome 10. Presented at Marshall University School of Medicine Annual Research Conference. (March) [Peer Reviewed]