W. Joshua Frazier, MD

W. Joshua Frazier, MD, is an attending physician in the Pediatric Intensive Care Unit at Nationwide Children’s Hospital, an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics, Division of Critical Care Medicine at The Ohio State University College of Medicine. He received his medical degree from Marshall University School of Medicine in Huntington, West Virginia before coming to Nationwide Children’s Hospital for his residency in pediatrics in 2001. He was chief resident in 2004. Dr. Frazier also completed his fellowship in pediatric critical care medicine at Nationwide Children’s Hospital where he was awarded the Outstanding Fellow Award in 2006 and 2008. Dr. Frazier’s primary research interest is the regulation of inflammatory responses in the innate immune system by the mitogen-activated protein kinase (MAPK) system. Dr. Frazier studies the actions of MAPK Phosphatase-1, a critical regulator of inflammation, with a particular interest in the molecular pathogenesis of septic shock.

Gender:

• Male

Languages Spoken:

• English

Areas of Interest:

• Dr. Frazier focuses on regulation of inflammation in the innate immune system. For patients suffering from serious infections, survival depends on the proper coordination of immune functions, including both a competent proinflammatory response and compensatory counter-inflammation. The most severe manifestations of infection, severe sepsis and septic shock, are characterized by a harmful overproduction of proinflammatory cytokines by the innate immune system. Using a murine model of live Gram-negative sepsis, Dr. Frazier studies the actions of Mitogen Activated Protein Kinase Phosphatase-1 (or Mkp-1) which is a critical regulator of the host inflammatory response and serves to down-regulate the production of proinflammatory cytokines such as TNF-? and IL-6. Elucidating the importance of this key molecule will allow for greater understanding of the pathophysiology of septic shock on the cellular and sub-cellular levels and will potentially identify novel therapeutic targets for this disease.

Undergraduate School

• West Virginia Wesleyan College
  Date Completed: 06/30/1997

Medical School

• Marshall University School of Medicine
  Date Completed: 05/05/2001

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2002

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2004

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2008

Department:

• Pediatrics

Section:

• Critical Care

Speciality:

• Pediatric Critical Care
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 08/27/2004

2008–present

• Nationwide Children's Hospital, Assistant Professor of Pediatrics, Investigator, Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Columbus, Ohio

• Frazier,W,Joshua; Xue,Jianjing; Luce,Wendy,A; Liu,Yusen. 2012. MAPK Signaling Drives Inflammation in LPS-Stimulated Cardiomyocytes: The Route of Crosstalk to G-Protein-Coupled Receptors.  PLOS ONE. Vol. 7, no. 11. (November): ee50071.
• Matta,Ranyia; Barnard,John,A; Wancket,Lyn,M; Yan,Jing; Xue,Jianjing; Grieves,Jessica; Frazier,W,Joshua; Nelin,Leif; Cato,Andrew,CB; Liu,Yusen. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. Vol. 302, no. 11. (June): G1322-G1335.
• Dewhirst, E., Frazier, W. J., Leder, M., Fraser, D. D., Tobias, J. D. 2012. Cardiac Arrest Following Ketamine Administration for Rapid Sequence Intubation.  J Intensive Care Med. Vol. *, no. May: e*.
• Wancket,Lyn,M; Frazier,W,Joshua; Liu,Yusen. 2012. Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease.  LIFE SCIENCES. Vol. 90, no. 7-8. (February): 237-248.
• Frazier, W. Joshua. 2011. Immunity, inflammation and sepsis: new insights and persistent questions.  Critical Care. Vol. 15, no. 1. (February): e124.
• Frazier,W,Joshua. 2011. Immunity, inflammation and sepsis: new insights and persistent questions.  CRITICAL CARE. Vol. 15, no. 1. (January): e124.
• Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology. Vol. 183, no. 11. (December): 7411-7419.
• Frazier WJ; Hall MW. 2008. Immunoparalysis and adverse outcomes from critical illness.  Pediatric Clinics Of North America. Vol. 55, no. 3. (June): e647.
• Frazier,W,Joshua; Hall,Mark,W. 2008. Immunoparalysis and adverse outcomes from critical illness.  PEDIATRIC CLINICS OF NORTH AMERICA. Vol. 55, no. 3. (June): 647-668.