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W. Joshua Frazier, MD, is an attending physician in the Pediatric Intensive Care Unit at Nationwide Children’s Hospital, an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics, Division of Critical Care Medicine at The Ohio State University College of Medicine. He received his medical degree from Marshall University School of Medicine in Huntington, West Virginia before coming to Nationwide Children’s Hospital for his residency in pediatrics in 2001. He was chief resident in 2004. Dr. Frazier also completed his fellowship in pediatric critical care medicine at Nationwide Children’s Hospital where he was awarded the Outstanding Fellow Award in 2006 and 2008. Dr. Frazier’s primary research interest is the regulation of inflammatory responses in the innate immune system by the mitogen-activated protein kinase (MAPK) system. Dr. Frazier studies the actions of MAPK Phosphatase-1, a critical regulator of inflammation, with a particular interest in the molecular pathogenesis of septic shock.