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Trent E. Tipple, MD, is an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital, a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of Dr. Tipple’s laboratory is the evaluation of the role of the thioredoxin (Trx) redox system in oxidative and developmental lung injury. Ongoing projects include the analysis of alterations of developmental expression of the Trx system by exposure to sublethal hyperoxia in a murine model of bronchopulmonary dysplasia, characterization of the protective effects of transgenic over expression of thioredoxin-1 (Trx1) in hyperoxic lung injury in neonatal and adult mice, and development of methods to accurately quantify the extent of sulfhydryl oxidation of the Trx system in complex tissue homogenates. The ultimate goal of this research is to elucidate the role of the Trx system in the pathogenesis of developmental and oxidative lung injury allowing translation of these findings into meaningful human therapies.