Trent E. Tipple, MD

Trent E. Tipple, MD, is an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital, a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of Dr. Tipple’s laboratory is the evaluation of the role of the thioredoxin (Trx) redox system in oxidative and developmental lung injury. Ongoing projects include the analysis of alterations of developmental expression of the Trx system by exposure to sublethal hyperoxia in a murine model of bronchopulmonary dysplasia, characterization of the protective effects of transgenic over expression of thioredoxin-1 (Trx1) in hyperoxic lung injury in neonatal and adult mice, and development of methods to accurately quantify the extent of sulfhydryl oxidation of the Trx system in complex tissue homogenates. The ultimate goal of this research is to elucidate the role of the Trx system in the pathogenesis of developmental and oxidative lung injury allowing translation of these findings into meaningful human therapies.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Areas of Interest:

• The main focus of Dr. Tipple’s lab is the investigation of the role of the thioredoxin redox system in the pathogenesis of bronchopulmonary dysplasia (BPD). BPD, characterized by impaired alveolar and vascular growth resulting in alveolar simplification and a reduction in the size of the pulmonary capillary bed, is caused in part by exposure to hyperoxia. The dramatic shift in oxygen homeostasis that occurs with premature birth disrupts oxygen-mediated regulatory events that are critical for proper lung development. Vascular endothelial growth factor (VEGF) is required for normal vascular and alveolar development and VEGF levels are reduced in the lungs of human patients with BPD and in animal models of BPD. Thioredoxin-1 (Trx1), which regulates VEGF expression and angiogenesis in solid tumors, is correlated with VEGF levels and is inversely correlated with Txnip levels. Our preliminary data indicate that hyperoxia inhibits the normal developmental decrease in lung Txnip protein expression and inhibits the normal developmental increase in VEGF protein expression in a newborn mouse model of BPD. Furthermore, lung VEGF and Txnip levels are inversely correlated. Utilizing the newborn mouse model of BPD, our studies are focused on elucidating the mechanism(s) by which hyperoxia alters Txnip expression in the developing murine lung and determining the role of Txnip in lung alveolar and vascular development with a specific emphasis on alterations in VEGF expression.

Medical School

• Indiana University School of Medicine
  Date Completed: 05/14/2000

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2003

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2006

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 07/01/2006

• Locy,Morgan,L; Rogers,Lynette,K; Prigge,Justin,R; Schmidt,Edward,E; Arner,Elias,SJ; Tipple,Trent,E. 2012. Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury.  ANTIOXIDANTS & REDOX SIGNALING. Vol. 17, no. 10. (November): 1407-1416.
• Locy ML, Rogers LK, Prigge JR, Schmidt EE, Arner ES, Tipple TE. 2012. Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Carla cells:implications for oxidant-induced lung injury.  Antioxid Redox Signal. Vol. 17, no. 10. (November): 1407-16.
• Rogers LK, YOung CM, Pennell ML, Tipple TE, Leonhart KL, Welty SE. 2012. Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.  Acta Paediatr. Vol. 101, no. 8. (August): e321-6.
• Velten M, Britt RD Jr, Heyob KM, Welty SE, Eiberger B, Tipple TE, Rogers LK. 2012. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice.  Am J PHysiol Regul Intergr Comp Physiol. Vol. 1, no. 303. (August): R279-90.
• Velten,Markus; Britt,Rodney,D; Heyob,Kathryn,M; Welty,Stephen,E; Eiberger,Britta; Tipple,Trent,E; Rogers,Lynette,K. 2012. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice.  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. Vol. 303, no. 3. (August): R279-R290.
• Rogers,Lynette,K; Young,Christine,M; Pennell,Michael,L; Tipple,Trent,E; Leonhart,Karen,L; Welty,Stephen,E. 2012. Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.  ACTA PAEDIATRICA. Vol. 101, no. 8. (August): e321-e326.
• Britt RD Jr, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lippopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells.  Cell Physiol Biochem. Vol. 29, no. 1-2. (March): 213-22.
• Britt RD, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells.  Cell Physiol and Biochem. Vol. 29, no. 1-2. (March): 213-22.
• Rogers LK, Valentine CJ, Pennell M, Velten M, Britt RD, Dingess K, Zhao X, Welty SE, Tipple TE. 2012. Maternal doxosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed mewborn mice.  J Nutr. Vol. 141, no. 2. (February): 214-22.
• Tipple TE, Rogers LK. 2012. Methods for the determination of plasma or tissue glutathione levels.  Methods Mol Biol. Vol. 889, no. January: 315-24.
• Trent E. Tipple and Lynette K. Rogers. 2012. Methods for the Determination of Plasma or Tissue Glutathione Levels. In Methods in Molecular Biology – Developmental Toxicology. Edited by Craig Harris and Jason Hansen. London: Humana Press.
• Heyob KM; Rogers LK; Tipple TE; Welty SE. 2011. Riboflavin Supplementation Does Not Attenuate Hyperoxic LungInjury in Transgenic spc-mt hGR Mice.  Experimental Lung Research. Vol. 3, no. 37. (April): 155-161.
• Rogers, LK; Valentine, CJ; Pennell, M; Velten, M; Britt, RD; Dingess, K; Zhao, XL; Welty, SE; Tipple, TE. 2011. Maternal Docosahexaenoic Acid Supplementation Decreases Lung Inflammation in Hyperoxia-Exposed Newborn Mice.  JOURNAL OF NUTRITION. Vol. 141, no. 2. (February): 214-222.
• Farrell,Michael,R; Rogers,Lynette,K; Liu,Yusen; Welty,Stephen,E; Tipple,Trent,E. 2010. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.  FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, no. 9. (November): 1361-1367.
• Rogers, LK; Tipple, TE; Britt, RD; Welty, SE. 2010. Hyperoxia Exposure Alters Hepatic Eicosanoid Metabolism in Newborn Mice.  PEDIATRIC RESEARCH. Vol. 67, no. 2. (February): 144-149.
• Tipple,Trent,E; Welty,Stephen,E; Nelin,Leif,D; Hansen,Jason,M; Rogers,Lynette,K. 2009. Alterations of the Thioredoxin System by Hyperoxia Implications for Alveolar Development.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 41, no. 5. (November): 612-619.
• Rogers, LK; Tipple, TE; Nelin, LD; Welty, SE. 2009. Differential Responses in the Lungs of Newborn Mouse Pups Exposed to 85% or > 95% Oxygen.  PEDIATRIC RESEARCH. Vol. 65, no. 1. (January): 33-38.
• Tipple TE; Welty SE; Rogers LK; Hansen TN; Choi YE; Kehrer JP; Smith CV. 2007. Thioredoxin-related mechanisms in hyperoxic lung injury in mice.  American Journal Of Respiratory Cell And Molecular Biology. Vol. 37, no. 4. (October): e405.
• Britt RD, Velten, Tipple TE, Nelin LD, Rogers LK. Cyclooxygenase-2 in Newborn Hyperoxic Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE.
• Tipple TE, Rogers LK, Welty SE, Hansen TN, Choi Y, Kehrer JP, Smith CV. Thioredoxin-Related Mechanisms in Hyperoxic Lung Injury in Mice. American Journal of Respiratory Cell and Molecular Biology 37(4): 405-13, October 2007.