Trent E. Tipple, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Trent E. Tipple, MD

Trent E. Tipple, MD

Center for Perinatal Research
Principal Investigator

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4530
FX: (614) 722-4541
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722.2700

Biography

Trent E. Tipple, MD, is an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital, a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of Dr. Tipple’s laboratory is the evaluation of the role of the thioredoxin (Trx) redox system in oxidative and developmental lung injury. Ongoing projects include the analysis of alterations of developmental expression of the Trx system by exposure to sublethal hyperoxia in a murine model of bronchopulmonary dysplasia, characterization of the protective effects of transgenic over expression of thioredoxin-1 (Trx1) in hyperoxic lung injury in neonatal and adult mice, and development of methods to accurately quantify the extent of sulfhydryl oxidation of the Trx system in complex tissue homogenates. The ultimate goal of this research is to elucidate the role of the Trx system in the pathogenesis of developmental and oxidative lung injury allowing translation of these findings into meaningful human therapies.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • The main focus of Dr. Tipple’s lab is the investigation of the role of the thioredoxin redox system in the pathogenesis of bronchopulmonary dysplasia (BPD). BPD, characterized by impaired alveolar and vascular growth resulting in alveolar simplification and a reduction in the size of the pulmonary capillary bed, is caused in part by exposure to hyperoxia. The dramatic shift in oxygen homeostasis that occurs with premature birth disrupts oxygen-mediated regulatory events that are critical for proper lung development. Vascular endothelial growth factor (VEGF) is required for normal vascular and alveolar development and VEGF levels are reduced in the lungs of human patients with BPD and in animal models of BPD. Thioredoxin-1 (Trx1), which regulates VEGF expression and angiogenesis in solid tumors, is correlated with VEGF levels and is inversely correlated with Txnip levels. Our preliminary data indicate that hyperoxia inhibits the normal developmental decrease in lung Txnip protein expression and inhibits the normal developmental increase in VEGF protein expression in a newborn mouse model of BPD. Furthermore, lung VEGF and Txnip levels are inversely correlated. Utilizing the newborn mouse model of BPD, our studies are focused on elucidating the mechanism(s) by which hyperoxia alters Txnip expression in the developing murine lung and determining the role of Txnip in lung alveolar and vascular development with a specific emphasis on alterations in VEGF expression.

Education and Training

Medical School

  • Indiana University School of Medicine
    Date Completed: 05/14/2000

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2003

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2006

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2006

Publications

  • Velten M, Britt RD, Heyob KM, Tipple TE, Rogers LK. 2014. Maternal Dietary Docosahexaenoic Acid (DHA) Supplementation Prevents Fetal Growth Restriction and Pulmonary Injury in a Newborn Murine Model of Perinatal Inflammation.  Journal of Nutrition. Vol. 144, no. 3. (March): 258-66.
  • Velten,Markus; Britt,Rodney,D; Heyob,Kathryn,M; Tipple,Trent,E; Rogers,Lynette,K. 2014. Maternal dietary docosahexaenoic Acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation.  journal of nutrition. Vol. 144, no. 3. (March): 258-266.
  • Raffay TM, Locy ML, Hill CL, Jindal NS, Rogers LK, Welty SE, Tipple TE. 2013. Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1.  Biomedical Research International. Vol. 2013, no. September: e408485.
  • Chen,Bernadette; Nelin,Viktoria,E; Locy,Morgan,L; Jin,Yi; Tipple,Trent,E. 2013. Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation.  American journal of physiology. Lung cellular and molecular physiology. Vol. 305, no. 5. (September): L389-95.
  • Britt,Rodney,D; Velten,Markus; Tipple,Trent,E; Nelin,Leif,D; Rogers,Lynette,K. 2013. Cyclooxygenase-2 in newborn hyperoxic lung injury.  FREE RADICAL BIOLOGY AND MEDICINE. Vol. 61, no. August: 502-511.
  • Velten,Markus; Britt,Rodney,D; Heyob,Kathryn,M; Tipple,Trent,E; Rogers,Lynette,K. 2013. Maternal dietary Docosahexaenoic acid (DHA) supplementation prevents fetal growth restriction and pulmonary fibrosis caused by perinatal inflammation. In Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
  • Jin,Yi; Tipple,Trent,E; Chicoine,Louis,G; Nelin,Leif,D; Chen,Bernadette. 2013. Thioredoxin-1 is necessary for hypoxia-induced cell proliferation in human pulmonary artery smooth muscle cells. In Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB)
  • Locy,Morgan,L; Rogers,Lynette,K; Prigge,Justin,R; Schmidt,Edward,E; Arner,Elias,SJ; Tipple,Trent,E. 2012. Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury.  ANTIOXIDANTS & REDOX SIGNALING. Vol. 17, no. 10. (November): 1407-1416.
  • Britt,Rodney,D; Locy,Morgan,L; Rogers,Lynette,K; Tipple,Trent,E. 2012. Aurothioglucose Enhances Lung Glutathione Levels and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.  FREE RADICAL BIOLOGY AND MEDICINE. Vol. 53, no. November: S60-S60.
  • Locy ML, Rogers LK, Prigge JR, Schmidt EE, Arner ES, Tipple TE. 2012. Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Carla cells:implications for oxidant-induced lung injury.  Antioxid Redox Signal. Vol. 17, no. 10. (November): 1407-16.
  • Britt,Rodney,D; Locy,Morgan,L; Rogers,Lynette,K; Tipple,Trent,E. 2012. Aurothioglucose Enhances Lung Glutathione Levels and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome. In 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM)
  • Rogers,Lynette,K; Velten,Markus; Tipple,Trent,E; Britt,Rodney,D. 2012. Inhibition of Cox-2 Decreases Macrophage Infiltration in Newborn Hyperoxic Lung Injury. In 19th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM)
  • Rogers LK, YOung CM, Pennell ML, Tipple TE, Leonhart KL, Welty SE. 2012. Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.  Acta Paediatr. Vol. 101, no. 8. (August): e321-6.
  • Velten M, Britt RD Jr, Heyob KM, Welty SE, Eiberger B, Tipple TE, Rogers LK. 2012. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice.  Am J PHysiol Regul Intergr Comp Physiol. Vol. 1, no. 303. (August): R279-90.
  • Velten,Markus; Britt,Rodney,D; Heyob,Kathryn,M; Welty,Stephen,E; Eiberger,Britta; Tipple,Trent,E; Rogers,Lynette,K. 2012. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice.  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. Vol. 303, no. 3. (August): R279-R290.
  • Rogers,Lynette,K; Young,Christine,M; Pennell,Michael,L; Tipple,Trent,E; Leonhart,Karen,L; Welty,Stephen,E. 2012. Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.  ACTA PAEDIATRICA. Vol. 101, no. 8. (August): e321-e326.
  • Velten,Markus; Heyob,Kathryn,M; Britt,Rodney,D; Valentine,Christina,J; Tipple,Trent,E; Rogers,Lynette,K. 2012. Maternal DHA Supplementation Improves Lung Growth and Function in Offspring Exposed to LPS and Hyperoxia. In Experimental Biology Meeting 2012
  • Tipple,Trent,E; Nelin,Viktoria; Gin,Yi; Rogers,Lynette; Nelin,Leif. 2012. Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation. In Experimental Biology Meeting 2012
  • Velten,Markus; Britt,Rodney,D; Heyob,Kathryn,M; Welty,Stephen,E; Tipple,Trent,E; Rogers,Lynette,K. 2012. Perinatal Inflammation and Decreases in miR29b-1 Expression are Associated with Structural and Functional Pulmonary Deficits in Adult Mice. In Experimental Biology Meeting 2012
  • Britt RD Jr, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lippopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells.  Cell Physiol Biochem. Vol. 29, no. 1-2. (March): 213-22.
  • Britt RD, Locy ML, Tipple TE, Nelin LD, Rogers LK. 2012. Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Mouse Transformed Clara Cells.  Cell Physiol and Biochem. Vol. 29, no. 1-2. (March): 213-22.
  • Rogers LK, Valentine CJ, Pennell M, Velten M, Britt RD, Dingess K, Zhao X, Welty SE, Tipple TE. 2012. Maternal doxosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed mewborn mice.  J Nutr. Vol. 141, no. 2. (February): 214-22.
  • Tipple TE, Rogers LK. 2012. Methods for the determination of plasma or tissue glutathione levels.  Methods Mol Biol. Vol. 889, no. January: 315-24.
  • Tipple,Trent,E; Rogers,Lynette,K. 2012. Methods for the determination of plasma or tissue glutathione levels.  Methods in molecular biology (Clifton, N.J.). Vol. 889, no. January: 315-324.
  • Trent E. Tipple and Lynette K. Rogers. 2012. Methods for the Determination of Plasma or Tissue Glutathione Levels. In Methods in Molecular Biology – Developmental Toxicology. Edited by Craig Harris and Jason Hansen. London: Humana Press.
  • Robbins,Mary; Locy,Morgan; Hill,Cynthia; Hansen,Jason; Rogers,Lynette; Tipple,Trent. 2011. Altered Lung Glutathione Redox Status in Glutathione Reductase Knockout Mice: Implications for Alveolar Epithelial Cell Differentiation. In 18th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM)
  • Hill,Cynthia; Nelin,Viktoria; Gin,Yi; Rogers,Lynette; Nelin,Leif; Tipple,Trent. 2011. Knockdown of Thioredoxin-1 Attenuates Hypoxia-induced Pulmonary Artery Smooth Muscle Cell Proliferation. In 18th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM)
  • Locy,Morgan,L; Rogers,Lynette,K; Nelin,Leif,D; Prigge,Justin,R; Schmidt,Edward,E; Arner,Elias,SJ; Tipple,Trent,E. 2011. Thioredoxin Reductase Inhibition Induces Nrf2-mediated Antioxidant Responses in Murine Transformed Clara Cells. In 18th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine (SFRBM)
  • Heyob KM; Rogers LK; Tipple TE; Welty SE. 2011. Riboflavin Supplementation Does Not Attenuate Hyperoxic LungInjury in Transgenic spc-mt hGR Mice.  Experimental Lung Research. Vol. 3, no. 37. (April): 155-161.
  • Rogers, LK; Valentine, CJ; Pennell, M; Velten, M; Britt, RD; Dingess, K; Zhao, XL; Welty, SE; Tipple, TE. 2011. Maternal Docosahexaenoic Acid Supplementation Decreases Lung Inflammation in Hyperoxia-Exposed Newborn Mice.  JOURNAL OF NUTRITION. Vol. 141, no. 2. (February): 214-222.
  • Velten,M; Heyob,K,M; Britt,R,D; Tipple,T,E; Welty,S,E; Roger,L,K. 2011. Perinatal Inflammation Contributes To Adult Pulmonary Fibrosis.
  • Farrell,Michael,R; Rogers,Lynette,K; Liu,Yusen; Welty,Stephen,E; Tipple,Trent,E. 2010. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.  FREE RADICAL BIOLOGY AND MEDICINE. Vol. 49, no. 9. (November): 1361-1367.
  • Rogers, LK; Tipple, TE; Britt, RD; Welty, SE. 2010. Hyperoxia Exposure Alters Hepatic Eicosanoid Metabolism in Newborn Mice.  PEDIATRIC RESEARCH. Vol. 67, no. 2. (February): 144-149.
  • Luchsinger,Joseph; Rogers,Lynette,K; Locy,Morgan,L; Hill,Cynthia,L; Velten,Markus; Nelin,Leif,D; Tipple,Trent,E. 2010. Glutathione Reductase Deficiency Alters Lung Development in Newborn Mice. In 17th Annual Meeting of the Society-for-Free-Radical-Biology-Medicine /15th Biennial Meeting of the Society-for-Free-Radical-Research-International
  • Rogers,Lynette,K; Tipple,Trent,E; Heyob,Kathtyn,M; Velten,Markus. 2010. Maternal Inflammation and Neonatal Hyperoxia Results in Adult Pulmonary Fibrosis. In 17th Annual Meeting of the Society-for-Free-Radical-Biology-Medicine /15th Biennial Meeting of the Society-for-Free-Radical-Research-International
  • Tipple,Trent,E; Welty,Stephen,E; Nelin,Leif,D; Hansen,Jason,M; Rogers,Lynette,K. 2009. Alterations of the Thioredoxin System by Hyperoxia Implications for Alveolar Development.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 41, no. 5. (November): 612-619.
  • Rogers,L,K; Tipple,T,E; Zhao,X; Welty,S,E. 2009. Maternal DHA Supplementation Decreases Inflammatory Responses in the Lungs of Newborn Mouse Pups Exposed to Hyperoxia.
  • Rogers, LK; Tipple, TE; Nelin, LD; Welty, SE. 2009. Differential Responses in the Lungs of Newborn Mouse Pups Exposed to 85% or > 95% Oxygen.  PEDIATRIC RESEARCH. Vol. 65, no. 1. (January): 33-38.
  • Tipple,Trent,E; Rogers,Lynette,K; Lin,Yusen; Nelin,Leif,D; Welty,Stephen,E. 2009. Overexpression of Thioredoxin Interacting Protein Decreases Hypoxia Response Element Promoter Activity in Murine Alveolar Epithelial Cells. In 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,T,E; Rogers,L,K; Nelin,L,D; Welty,S,E. 2009. Alteration of Lung Thioredoxin Interacting Protein Expression by Hyperoxia: Implications for Alveolar Development.
  • Rogers,Lynette,K; Tipple,Trent,E; Zhao,Xuilan; Welty,Stephen,E. 2009. Maternal DHA Supplementation Decreases Inflammation and Improves Lung Growth in Hyperoxia-Exposed Newborn Mouse Pups. In 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Rogers,Lynette,K; Tipple,Trent,E; Nelin,Leif,D; Welty,Stephen,E. 2008. Oxidant Stress in the Livers of Mouse Pups Exposed to Hyperoxia. In 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,Trent,E; Rogers,Lynette,K; Nelin,Leif,D; Welty,Stephen,E. 2008. Thioredoxin Interacting Protein-Dependent Regulation of Vascular Endothelial Growth Factor Production by Alveolar Epithelial Cells. In 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Stenger,Michael,R; Tipple,Trent,E; Rogers,Lynette,K; Liu,Yusen; Nelin,Leif,D. 2008. Inhaled Nitric Oxide Prevents the Hyperoxia-Induced Activation of P38 and JNK in Neonatal Mice Lungs. In 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple TE; Welty SE; Rogers LK; Hansen TN; Choi YE; Kehrer JP; Smith CV. 2007. Thioredoxin-related mechanisms in hyperoxic lung injury in mice.  American Journal Of Respiratory Cell And Molecular Biology. Vol. 37, no. 4. (October): e405.
  • Rogers,Lynette,Kay; Nelin,Leif,D; Tipple,Trent,E; Welty,Stephen,E. 2007. Administration of GW9662, a PPARg antagonist, causes decreased inflammation and increased alveolar number in the lungs of newborn mice exposed to > 95% O-2. In 14th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,Trent,E; Welty,Stephen,E; Nelin,Leif,D; Rogers,Lynette,K. 2007. Sublethal Hyperoxia alters pulmonary thioredoxin interacting protein and vascular endothelial growth factor levels in newborn mice. In 14th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,Trent,E; Rogers,Lynette,K; Smith,Charles,V; Welty,Stephen,E. 2006. Sublethal hyperoxia alters pulmonary and hepatic thioredoxin-1 levels in neonatal mice. In 13th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,T,E; Rogers,L,K; Welty,S,E; Hansen,T,N; Smith,C,V. 2005. Thioredoxin dependent mechanisms in defense against hyperoxic lung injury in mice. In 12th Annual Meeting Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,T,E; Choi,T,E; Rogers,L,K; Hansen,T,N; Welty,S,E; Kehrer,J,P; Smith,C,V. 2004. Enhanced expression of thioredoxin-2 in mice genetically deficient in glutathione reductase. In Annual Meeting of the Pediatric-Academic-Societies
  • Tipple,T,E; Rogers,L,K; Welty,S,E; Hansen,T,N; Smith,C,V. 2004. Enhanced sensitivity to hyperoxia in aurothioglucose-treated glutathione reductase-deficient mice suggests cross-talk between thioredoxin and glutathione systems. In 11th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Tipple,T,E; Rogers,L,K; Hansen,T,N; Welty,S,E; Smith,C,V. 2003. Enhanced thioredoxin (Trx) levels as possible adaptive responses in mice genetically hypomorphic in glutathione reductase (GR) activities. In Annual Meeting of the Pediatric-Academic-Societies/Society-for-Pediatric-Research
  • Tipple, TE. The Thioredoxin System in Neonatal Lung Disease.  Antioxidants and Redox Signaling.
  • Tipple TE. The Thioredoxin System in Neonatal Lung Disease.  Antioxidants and Redox Signaling. E-pub ahead of print (Mar 2014).
  • Britt RD, Velten M, Locy ML, Rogers LK, Tipple TE. The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Attenuates Lung Injury and Improves Survival in a Murine Model of Acute Respiratory Distress Syndrome.  Antioxidants and Redox Signaling. E-pub ahead of print (Feb 2014).
  • Kehrer JP, Robertson JD, Tipple TE, Smith CV. Mechanisms: Free Radicals and Reactive Oxygen Species. In Reference Module in Biomedical Sciences. Edited by Michael Caplan.
  • Britt RD, Velten, Tipple TE, Nelin LD, Rogers LK. Cyclooxygenase-2 in Newborn Hyperoxic Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE.
  • Tipple TE, Rogers LK, Welty SE, Hansen TN, Choi Y, Kehrer JP, Smith CV. Thioredoxin-Related Mechanisms in Hyperoxic Lung Injury in Mice. American Journal of Respiratory Cell and Molecular Biology 37(4): 405-13, October 2007.
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