Antibody biomarkers for the presymptomatic screening and diagnosis of bacterial sinusitis. Can be used with traditional balloon sinoplasty devices to offer a minimally invasive, patient specific way to rapidly diagnosis sinusitis in the outpatient clinic.
World-renowned epidemiologist and injury research expert, Dr. Dawn Comstock has developed a novel neck strength monitoring system that includes all the components necessary to effectively measure neck strength in a reliable and cost effective manner. Comprised of a strength meter with both video and written instructions, the neck strength scale is an easy to use device that effectively measures a full range of neck motions (extension, flexion, right and left lateral).
Researchers at Nationwide Children’s Hospital have developed a mathematical framework and optimized algorithms that can be used to analyze genetic/genomic data for enhanced patient diagnosis, gene biomarker selection, and genetic research.
The present technology is a medical line organizer that prevents accidental entanglement, suffocation, and strangulation of hospitalized individuals. It is a first in class device that decreases the incidence of both fatal and nonfatal asphyxiation that results from the entanglement of medical tubing/cords around the neck of patients.
A novel tracheostomy collar that minimizes collar-related neck abrasions, provides greater neck security and exhibits enhanced durability compared to currently available tracheostomy collars.
A double lumen, needle injection system that allows both aspiration and sclerosant administration to performed following a single injection.
Necrotizing entercolitis (NEC) is the most common gastrointestinal disease of infancy. It is characterized by infection and inflammation that leads to destruction of the intestine. In severe cases, NEC can cause profound impairments of multiple organs. NEC afflicts 5 to 10% of all infants of a birth weight equal or less than 1,500 grams (3 lbs, 5 oz.) or those that are less than 30 weeks gestational age. NEC is the most common and serious gastrointestinal disorder among hospitalized preterm infants. Currently there is no medical treatment for NEC. Only supportive care is available, which includes intravenous fluids, feeding pumps, antibiotic administration, and in some cases surgical intervention. Additionally, NEC has 30 – 40% mortality and high morbidity in the survivors.
The subject technology is an antimicrobial mask, used to help prevent the spread of germs (viruses and bacteria) from one person to another with an additional securing strap between the two ear straps. Typical antimicrobial masks have straps that fit over each of the ears, holding the mask against the face. The additional strap would decrease the ability of the wearer from pulling off the mask during normal use.
The technology is a web-based software application that facilitates the monitoring of medication adherence, side effects, and patient symptoms. Pharmacy Safety Tracking System (PhaST) is an interactive voice response (IVR) call system that screens and evaluates for adverse medication events or exacerbations of symptoms. If PhaST detects a possible event, such as a suicidal thought in a patient taking antidepressants, it will alert a staff person to call the patient for a live telephone interview. In the interview, the staff person will triage the risk to the patient, provide counseling to the patient or family, and when necessary contact the prescribing clinician. PhaST generates electronic reports that document these patient interactions.
The technology is a medical device that provides clinician improved foreign body retrieval within anatomical structures such as the gastrointestinal and respiratory tracts. The result of using this device is a minimally invasive procedure with decreased tissue trauma and patient discomfort. The device comes in two designs that capture the foreign body within the cavity of the device’s opening, allowing complete retrieval using one insertion.
The subject technology has identified specific protein expression levels in patients that have greater susceptibility to urinary tract infections. A number of genes have been described or implicated by looking at the DNA copy number variations. These genetic variations have led to the development of an antibody based diagnostic assay to detect protein levels that highly correlate with clinical recurrence of UTIs.
The invention is a potential therapy for Limb Girdle Muscular Dystrophy (LGMD) Type 1A. For this invention, Dr. Harper’s group designed microRNAs that specifically knock down Myotilin expression, showing that targeting it maybe a potential therapeutic for Limb Girdle Muscular Dystrophy (LGMD) Type 1A. This RNAi strategy can also be adapted to broadly impact a large class of dominant muscle disorders.
A new mouse model for Duchenne muscular dystrophy (DMD) has been created at the Research Institute by Dr. Paul T. Martin. A double knock-out mouse strain was generated that better mimics the human disease than the current standard model and thus provides a model for DMD where translational research will be more relevant to issues affecting humans with the disease.
A collaborative team of researchers and engineers from Nationwide Children’s Hospital and The Ohio State University have designed a two stage trigger system with its intent to prevent accidental operation of a spray bottle containing household or other chemical and dangerous solutions. The design restricts the ability of young children to trigger spray bottles in at least two ways. First, young children lack the development capability to perform the correct sequence of pressing down and keeping down the safety level first and then squeezing the trigger. Second, the size and strength of a child’s hand are not sufficient to active the mechanism.
Researchers at the Research Institute at Nationwide Children’s Hospital have developed a polyclonal antibody directed against human Anoctamin 5 (ANO5). Defects in ANO5 are the causative agent of limb-girdle muscular dystrophy type 2L (LGMD 2L), an autosomal recessive degenerative myopathy. This antibody can be used as a diagnostic and for research applications.
The self catheterization drainage aide is a device that helps in the draining of urine directly from the user’s bladder, when using an intermittent catheter. The device attaches to a commode or urinal to secure the catheter tubing, allowing the patient to focus on inserting the catheter into their bladder and draining thereof.
The technology is a clinical monitoring system that measures the functionality or healthiness of the optic nerve system. The researchers at The Research Institute at Nationwide Children’s Hospital has developed a near infrared spectroscopy (NIRS) system to measure the hemodynamic response or changing levels of deoxygenated hemoglobin in the optic cortex to flash or checkerboard stimuli. By exploiting the blood oxygen level dependent effect, the system will detect the development of ischemia through the decreased hemodynamic levels in the visual cortex. If the system would detect the decrease in hemodynamic levels, the anesthesiologist would still have time to correct or minimize the effects that is causing the decreased levels.
The technology is a user friendly PDA based application that facilitates the monitoring and intervention of dehydration or electrolyte abnormalities after intestinal injury. Early, Adequate, and Timely (E.A.T.) is an interactive PDA based software application that screens, evaluates, and intervenes for adverse outcomes after an intestinal injury and initial treatment has occurred. If the application detects a possible event, such as low urine output, it will alert a clinician to make contact with the patient or on-site caregiver to provide assistance with the proper medical intervention. The application will generate an electronic report that documents the patient interactions.