Susan E. Ingraham, MD, PhD

Susan E. Ingraham, MD, PhD, is an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is an attending physician in the Division of Pediatric Nephrology at Nationwide Children’s Hospital and is a NIH-funded principal investigator in the Center for Clinical and Translational Research. Dr. Ingraham’s research focus is the investigation of the changes that occur in the kidneys as a result of inborn defects in the urinary outflow tract. Her clinical interests span all aspects of pediatric nephrology.

Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• The leading cause of chronic kidney disease in children is congenital obstructive nephropathy – injury and altered development in the kidneys that results from inborn obstructions of normal urine flow. The long-term objectives of my research are to improve the care of pediatric patients with congenital obstructive nephropathy by identifying effective early biomarkers for the diagnosis and prognosis of congenital obstructive nephropathy, as well as elucidating novel therapeutic targets for this devastating condition. The main focus of my current research tests the hypothesis that microRNAs (miRNAs) play critical roles in the renal response to congenital urinary obstruction, and that miRNAs therefore represent a novel class of potential biomarkers and therapeutic targets in congenital obstructive nephropathy. For these studies, my lab is using the megabladder (mgb) mouse – a unique genetic model that develops chronic and end-stage kidney disease secondary to a functional lower urinary tract obstruction – as a model system for the discovery of potential biomarkers and the testing of novel therapies. With the knowledge we gain from this animal model, we then translate our efforts into the clinical realm, investigating the potential biomarkers we identify in samples from children with and without kidney disease.

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2005

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2007

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2011

Medical School

• Ohio State University
  Date Completed: 08/30/2011

Department:

• Pediatrics

Section:

• Nephrology

Speciality:

• Pediatric Nephrology
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 08/15/2011