Susan E. Ingraham, MD, PhD

Susan E. Ingraham, MD, PhD, is an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is an attending physician in the Division of Pediatric Nephrology at Nationwide Children’s Hospital and is a NIH-funded principal investigator in the Center for Clinical and Translational Research. Dr. Ingraham’s research focus is the investigation of the changes that occur in the kidneys as a result of inborn defects in the urinary outflow tract. Her clinical interests span all aspects of pediatric nephrology.

Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• The leading cause of chronic kidney disease in children is congenital obstructive nephropathy – injury and altered development in the kidneys that results from inborn obstructions of normal urine flow. The long-term objectives of my research are to improve the care of pediatric patients with congenital obstructive nephropathy by identifying effective early biomarkers for the diagnosis and prognosis of congenital obstructive nephropathy, as well as elucidating novel therapeutic targets for this devastating condition. The main focus of my current research tests the hypothesis that microRNAs (miRNAs) play critical roles in the renal response to congenital urinary obstruction, and that miRNAs therefore represent a novel class of potential biomarkers and therapeutic targets in congenital obstructive nephropathy. For these studies, my lab is using the megabladder (mgb) mouse – a unique genetic model that develops chronic and end-stage kidney disease secondary to a functional lower urinary tract obstruction – as a model system for the discovery of potential biomarkers and the testing of novel therapies. With the knowledge we gain from this animal model, we then translate our efforts into the clinical realm, investigating the potential biomarkers we identify in samples from children with and without kidney disease.

Medical School

• University of Cincinnati College of Medicine
  Date Completed: 06/11/2004

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2005

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/2007

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2011

Department:

• Pediatrics

Section:

• Nephrology

Speciality:

• Pediatric Nephrology
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 08/15/2011

• Becknell B, Carpenter AR, Bolon B, Asplin JR, Ingraham SE, Hains DS, Schwaderer AL, McHugh KM. 2013. Struvite Urolithiasis and Chronic Urinary Tract Infection in a Murine Model of Urinary Diversion.  Urology. Vol. S0090-4295(13, no. March: 00164-7.
• Ingraham, SE and McHugh, KM. 2012. Congenital Obstructive Nephropathy: Clinical Perspectives and Animal Models. In Novel Insights on Chronic Kidney Disease, Acute Kidney Injury, and Polycystic Kidney Disease. Edited by Vijayakumar, S. Rijeka, Croatia: Intech Europe.
• Carpenter AR, Becknell B, Ingraham SE, McHugh KM. 2012. Ultrasound Imaging of the Murine Kidney.  Methods Mol Biol. Vol. 886, no. January: 403-10.
• Ingraham,Susan,E; McHugh,Kirk,M. 2011. Current perspectives on congenital obstructive nephropathy.  PEDIATRIC NEPHROLOGY. Vol. 26, no. 9. (September): 1453-1461.
• Ingraham,Susan,E; Saha,Monalee; Carpenter,Ashley,R; Robinson,Melissa; Ismail,Ihab; Singh,Sunita; Hains,David; Robinson,Michael,L; Hirselj,Daniel,A; Koff,Stephen,A; Bates,Carlton,M; McHugh,Kirk,M. 2010. Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.  PEDIATRIC RESEARCH. Vol. 68, no. 6. (December): 500-507.
• Ingraham SE, Patel HP. 2010. Evaluation of Renal Function in the Pediatric Patient. In Clinician's Manual of Pediatric Nephrology. Edited by Chand D, Valentini RP. Hackensack, NJ: World Scientific Publishing Co.
• Saha,Monalee; Ingraham,Susan,E; Carpenter,Ashley; Robinson,Melissa; McHugh,Kelsey,E; Singh,Sunita; Robinson,Michael,L; McHugh,Kirk,M. 2009. Identification of Distinct Myocardin Splice Variants in the Bladder.  JOURNAL OF UROLOGY. Vol. 182, no. 2. (August): 766-775.
• Hains,David,S; Bates,Carlton,M; Ingraham,Susan; Schwaderer,Andrew,L. 2009. Management and etiology of the unilateral multicystic dysplastic kidney: a review.  PEDIATRIC NEPHROLOGY. Vol. 24, no. 2. (February): 233-241.