Susan E Ingraham, MD, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Susan E. Ingraham, MD, PhD

Susan E. Ingraham, MD, PhD

Contact Information

Nephrology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4360
FX: (614) 722-6482

Biography

Susan E. Ingraham, MD, PhD, is an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is an attending physician in the Division of Pediatric Nephrology at Nationwide Children’s Hospital and is a NIH-funded principal investigator in the Center for Clinical and Translational Research. Dr. Ingraham’s research focus is the investigation of the changes that occur in the kidneys as a result of inborn defects in the urinary outflow tract. Her clinical interests span all aspects of pediatric nephrology.

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • The leading cause of chronic kidney disease in children is congenital obstructive nephropathy – injury and altered development in the kidneys that results from inborn obstructions of normal urine flow. The long-term objectives of my research are to improve the care of pediatric patients with congenital obstructive nephropathy by identifying effective early biomarkers for the diagnosis and prognosis of congenital obstructive nephropathy, as well as elucidating novel therapeutic targets for this devastating condition. The main focus of my current research tests the hypothesis that microRNAs (miRNAs) play critical roles in the renal response to congenital urinary obstruction, and that miRNAs therefore represent a novel class of potential biomarkers and therapeutic targets in congenital obstructive nephropathy. For these studies, my lab is using the megabladder (mgb) mouse – a unique genetic model that develops chronic and end-stage kidney disease secondary to a functional lower urinary tract obstruction – as a model system for the discovery of potential biomarkers and the testing of novel therapies. With the knowledge we gain from this animal model, we then translate our efforts into the clinical realm, investigating the potential biomarkers we identify in samples from children with and without kidney disease.

Education and Training

Medical School

  • University of Cincinnati College of Medicine
    Date Completed: 06/11/2004

Internship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2005

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2007

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2011

Department:

  • Pediatrics

Section:

  • Nephrology

Specialty:

  • Pediatric Nephrology
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 08/15/2011

Publications

  • Becknell,Brian; Carpenter,Ashley,R; Allen,Jordan,L; Wilhide,Michael,E; Ingraham,Susan,E; Hains,David,S; McHugh,Kirk,M. 2013. Molecular Basis of Renal Adaptation in a Murine Model of Congenital Obstructive Nephropathy.  PLOS ONE. Vol. 8, no. 9. (September): ee72762.
  • Becknell B, Carpenter AR, Bolon B, Asplin JR, Ingraham SE, Hains DS, Schwaderer AL, McHugh KM. 2013. Struvite Urolithiasis and Chronic Urinary Tract Infection in a Murine Model of Urinary Diversion.  Urology. Vol. S0090-4295(13, no. March: 00164-7.
  • Ingraham, SE and McHugh, KM. 2012. Congenital Obstructive Nephropathy: Clinical Perspectives and Animal Models. In Novel Insights on Chronic Kidney Disease, Acute Kidney Injury, and Polycystic Kidney Disease. Edited by Vijayakumar, S. Rijeka, Croatia: Intech Europe.
  • Ingraham SE, McHugh KM. 2012. Congenital Obstructive Nephropathy: Clinical Perspectives and Animal Models. In Novel Insights on Chronic Kidney Disease, Acute Kidney Injury and Polycystic Kidney Disease. Edited by Vijayakumar, S. Rijeka: InTech.
  • Carpenter AR, Becknell B, Ingraham SE, McHugh KM. 2012. Ultrasound Imaging of the Murine Kidney.  Methods Mol Biol. Vol. 886, no. January: 403-10.
  • Ingraham,Susan,E; McHugh,Kirk,M. 2011. Current perspectives on congenital obstructive nephropathy.  PEDIATRIC NEPHROLOGY. Vol. 26, no. 9. (September): 1453-1461.
  • Ingraham,Susan,E; Saha,Monalee; Carpenter,Ashley,R; Robinson,Melissa; Ismail,Ihab; Singh,Sunita; Hains,David; Robinson,Michael,L; Hirselj,Daniel,A; Koff,Stephen,A; Bates,Carlton,M; McHugh,Kirk,M. 2010. Pathogenesis of Renal Injury in the Megabladder Mouse: A Genetic Model of Congenital Obstructive Nephropathy.  PEDIATRIC RESEARCH. Vol. 68, no. 6. (December): 500-507.
  • Ingraham SE, Patel HP. 2010. Evaluation of Renal Function in the Pediatric Patient. In Clinician's Manual of Pediatric Nephrology. Edited by Chand D, Valentini RP. Hackensack, NJ: World Scientific Publishing Co.
  • Saha,Monalee; Ingraham,Susan,E; Carpenter,Ashley; Robinson,Melissa; McHugh,Kelsey,E; Singh,Sunita; Robinson,Michael,L; McHugh,Kirk,M. 2009. Identification of Distinct Myocardin Splice Variants in the Bladder.  JOURNAL OF UROLOGY. Vol. 182, no. 2. (August): 766-775.
  • Hains,David,S; Bates,Carlton,M; Ingraham,Susan; Schwaderer,Andrew,L. 2009. Management and etiology of the unilateral multicystic dysplastic kidney: a review.  PEDIATRIC NEPHROLOGY. Vol. 24, no. 2. (February): 233-241.
  • Ingraham SE, Lynch RA, Surti U, Rutter JL, Buckler AJ, Khan SA, Menon AG, Lepont P. 2006. Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma.  Mutat Res. Vol. 602, no. 1-2. (December): 43-53.
  • Lee AH, Ingraham SE, Kopp M, Foraida MI, Jazieh AR. 2006. The incidence of potential interactions between dietary supplements and prescription medications in cancer patients at a Veterans Administration Hospital.  Am J Clin Oncol. Vol. 29, no. 2. (April): 178-182.
  • Ingraham SE, Lynch RA, Kathiresan S, Buckler AJ, Menon AG. 1999. hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma.  Cancer Genet Cytogenet. Vol. 115, no. 1. (November): 56-61.
  • DiDonato CJ, Ingraham SE, Mendell JR, Prior TW, Lenard S, Moxley RT, 3rd, Florence J, Burghes AH. 1997. Deletion and conversion in spinal muscular atrophy patients: is there a relationship to severity?.  Ann Neurol. Vol. 41, no. 2. (February): 230-237.
  • Thompson TG, DiDonato CJ, Simard LR, Ingraham SE, Burghes AH, Crawford TO, Rochette C, Mendell JR, Wasmuth JJ. 1995. A novel cDNA detects homozygous microdeletions in greater than 50% of type I spinal muscular atrophy patients.  Nat Genet. Vol. 9, no. 1. (January): 56-62.
  • DiDonato CJ, Morgan K, Carpten JD, Fuerst P, Ingraham SE, Prescott G, McPherson JD, Wirth B, Zerres K, Hurko O, Wasmuth, JJ, Mendell JR, Burghes AHM. 1994. Association between Ag1-CA alleles and severity of autosomal recessive proximal spinal muscular atrophy.  Am J Hum Genet. Vol. 55, no. 6. (December): 1218-1229.
  • Carpten JD, DiDonato CJ, Ingraham SE, Wagner-McPherson C, Nieuwenhuijsen BW, Wasmuth JJ, Burghes AH. 1994. A YAC contig of the region containing the spinal muscular atrophy gene (SMA): identification of an unstable region.  Genomics. Vol. 24, no. 2. (November): 351-356.
  • Burghes AH, Ingraham SE, McLean M, Thompson TG, McPherson JD, Kote-Jarai Z, Carpten JD, DiDonato CJ, Ikeda JE, Surh L, Wirth B, Sargent CA, Ferguson-Smith MA, Fuerst P, Moyzis RK, Grady DL, Zerres K, Korneluk R, MacKenzie A, Wasmuth JJ. 1994. A multicopy dinucleotide marker that maps close to the spinal muscular atrophy gene.  Genomics. Vol. 21, no. 2. (May): 394-402.
  • Burghes,A,HM; Ingraham,S,E; KOTEJARAI,Z; Rosenfeld,S; HERTA,N; Nadkarni,N; DiDonato,C,J; Carpten,J; Hurko,O; Florence,J; Moxley,R,T; Cobben,J,M; Mendell,J,R. 1994. LINKAGE MAPPING OF THE SPINAL MUSCULAR-ATROPHY GENE.  HUMAN GENETICS. Vol. 93, no. 3. (March): 305-312.
  • Wilhide M, Mohamed A, Becknell B, Ingraham SE. ). miR-205 Expression Correlates with Disease Severity in a Mouse Model of Congenital Obstructive Nephropathy.  ????.
  • Kusumi K, Ayoob A, Bowden S, Ingrham SE, Mahan JD. Beneficial Effects of Intravenous Pamidronate Treatment in Children with Osteogenesis Imperfecta Under 24 Months of Age.  J Bone Miner Metab.
  • Becknell B, Mohamed, A,Wilhide M, Li B, Ingraham S. Spontaneous Pyelonephritis and Struvite Urolithiasis in the Megabladder Mouse Model.  N/A.
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700 Children's Drive Columbus, Ohio 43205 614.722.2000