Robert S. Munson, Ph.D.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Microbial Pathogenesis

Areas of Interest:

• Nontypeable Haemophilus influenzae (NTHi) is an important cause of otitis media in children, and a major cause of lower respiratory disease in children in the developing world. The organism is also associated with exacerbations of chronic bronchitis, and pneumonia in elderly and immunocompromised patients. Haemophilus ducreyi is the causative agent of chancroid, a sexually transmitted disease. Chancroid ulcers facilitate the transmission of HIV. My laboratory is employing a number of genetic and immunological approaches in order to assess the role of outer membrane proteins, toxins and adhesins in the pathogenesis of Haemophilus disease.

Undergraduate

• University of Connecticut
  Date Completed: 06/30/1968

Post Doctoral

• University of Connecticut School of Medicine
  Date Completed: 06/30/1976

Fellowship

• Washington University School of Medicine
  Date Completed: 06/30/1980

1999–present

• Professor of Microbiology.  The Ohio State University.

1997–present

• Director, Core DNA Sequencing Facility, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio. 

1994–present

• Professor of Pediatrics, The Ohio State University, School of Medicine

1994–present

• Professor of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, College of Medicine

1989–1994

• Associate Professor of Molecular Microbiology, Washington University, School of Medicine

1989–1994

• Associate Professor of Pediatrics, Washington University, School of Medicine

1987–1988

• Assistant Professor of Molecular Microbiology, Washington University, School of Medicine

1982–1988

• Assistant Professor of Pediatrics, Washington University, School of Medicine

1980–1982

• Research Assistant Professor of Pediatrics, Washington University, School of Medicine, St. Louis, MO.

• Spinola SM; Fortney KR; Baker B; Janowicz DM; Zwickl B; Katz BP; Blick RJ; Munson RS Jr. 2010. Activation of the CpxRA system by deletion of cpxA impairs the ability of Haemophilus ducreyi to infect humans.  Infection And Immunity. Vol. 78, no. 9. : 3898.
• Tracy E, Ye F, Baker BD, Munson RS Jr. 2008. Efficient construction of non-polar mutants in Haemophilus influenzae using FLP recombinase technology. BMC Mol Biol. Vol. 9, no. 1. (November 11): 101. (IF: 3.371)
• Tracy E; Ye F; Baker BD; Munson RS Jr. 2008. Construction of non-polar mutants in Haemophilus influenzae using FLP recombinase technology.  BMC Molecular Biology. Vol. 9. (November 11): 101.
• Banks KE, Fortney KR, Baker B, Billings SD, Katz BP, Munson RS Jr, Spinola SM. 2008. The enterobacterial common antigen-like gene cluster of Haemophilus ducreyicontributes to virulence in humans. J Infect Dis. Vol. 197, no. 11. (June 1): 1531-1536. (IF: 6.035)
• Bauer ME, Fortney KR, Harrison A, Janowicz DM, Munson RS Jr, Spinola SM. 2008. Identification of Haemophilus ducreyi genes expressed during human infection. Microbiology. Vol. 154, no. Pt 4. (April): 1152-1160. (IF: 0.597)
• Novotny LA, Partida-Sánchez S, Munson RS Jr, Bakaletz LO. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells. Infect Immun. Vol. 76, no. 3. (March): 967-977. (IF: 3.996)
• Harrison A; Ray WC; Baker BD; Armbruster DW; Bakaletz LO; Munson RS Jr. 2007. The OxyR regulon in nontypeable Haemophilus influenzae.  Journal Of Bacteriology. Vol. 189, no. 3. (February 1): 1004.
• Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO and Munson RS Jr.  "The OxyR regulon in nontypeable Haemophilus influenze", J Bacteriol 2007; 189(3):1004-12.
• Johnston JW, Zaleski A, Allen S, Mootz JM, Armbruster D, Gibson BW, Apicella MA, and Munson RS Jr.  "Regulation of sialic acid transport and catabolism in Haemophilus influenzae", Molecular Microbiology 2007; 66(1):26-39.
• Post DM, Munson RS Jr., Baker BD, Zhong H, Bozue JA, and Gibson BW. "Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class Haemophilus ducreyi, Infect. Immun 2007; 75(1):113-21.
• Post DM, Munson RS Jr, Baker B, Zhong H, Bozue JA, Gibson BW. 2007. Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class of Haemophilus ducreyi.  Infection and Immunity. Vol. 75, no. 1. : 113-121.
• Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO, Munson RS Jr. 2007. The OxyR regulon in nontypeable Haemophilus influenzae.  The Journal of Bacteriology. Vol. 189, no. 3. : 1004-1012.
• Johnston JW, Zaleski A, Allen S, Mootz JM, Armbruster D, Gibson BW, Apicella MA, Munson RS Jr. 2007. Regulation of sialic acid transport and catabolism in Haemophilus influenzae. Molecular Microbiology. Vol. 66, no. 1: 26-39.
• McGillivary G, Ray WC, Bevins CL, Munson RS Jr, Bakaletz LO. 2007. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Molecular Immunology. Vol. 44, no. 9: 2446-2458.
• Juhas M, Power PM, Harding RM, Ferguson DJ, Dimopoulou ID, Elamin AR, Mohd-Zain Z, Hood DW, Adegbola R, Erwin A, Smith A, Munson RS Jr, Harrison A, Mansfield L, Bentley S, Crook DW. 2007. Sequence and functional analyses of Haemophilus spp. genomic islands. Genome Biology. Vol. 8, no. 11: R237.
• Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO and Munson RS Jr.  "Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: Comparative study with H. influenzae serotype d, strain KW20", J Bacteriol 2005; 187(13):4627-36.
• Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO. 2007. The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract. Molecular Microbiology. Vol. 65, no. 5: 1288-1299.
• Mason KM; Bruggeman ME; Munson RS; Bakaletz LO. 2006. The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition.  Molecular Microbiology. Vol. 62, no. 5. (December 1): 1357-72.
• Post DM; Mungur R; Gibson BW; Munson RS Jr. 2005. Identification of a novel sialic acid transporter in Haemophilus ducreyi.  Infection And Immunity. Vol. 73, no. 10. (October 1): 6727-35.
• Harrison A; Dyer DW; Gillaspy A; Ray WC; Mungur R; Carson MB; Zhong H; Gipson J; Gipson M; Johnson LS; Lewis L; Bakaletz LO; Munson RS Jr. 2005. Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.  Journal Of Bacteriology. Vol. 187, no. 13. (July 1): 4627-36.
• Bakaletz LO; Baker BD; Jurcisek JA; Harrison A; Novotny LA; Bookwalter JE; Mungur R; Munson RS Jr. 2005. Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.  Infection And Immunity. Vol. 73, no. 3. (March 1): 1635-43.
• Post DM, Mungur R, Gibson BW and Munson RS Jr., "Identification of a novel sialic acid transporter in Haemophilus ducreyi", Infect Immun. 2005; 73(10):6727-35.
• Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R and Munson RS Jr,. “Demonstration of type IV pilus expression and a twitching phenotype by Haemophilus influenzae”, Infect Immun 2005; 73(3):1635-43.
• Mason KM; Munson RS Jr; Bakaletz LO. 2005. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.  Infection And Immunity. Vol. 73, no. 1. (January 1): 599.
• Harris RH; Wilk D; Bevins CL; Munson RS Jr; Bakaletz LO. 2004. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.  The Journal Of Biological Chemistry. Vol. 279, no. 19. (May 7): 20250-20256.
• Munson RS Jr; Harrison A; Gillaspy A; Ray WC; Carson M; Armbruster D; Gipson J; Gipson M; Johnson L; Lewis L; Dyer DW; Bakaletz LO. 2004. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.  Infection And Immunity. Vol. 72, no. 5. (May 1): 3002-3010.
• Kolker E; Makarova KS; Shabalina S; Picone AF; Purvine S; Holzman T; Cherny T; Armbruster D; Munson RS Jr; Kolesov G; Frishman D; Galperin MY. 2004. Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae.  Nucleic Acids Research. Vol. 32, no. 8. (April 30): 2353-2361.
• Munson RS Jr; Zhong H; Mungur R; Ray WC; Shea RJ; Mahairas GG; Mulks MH. 2004. Haemophilus ducreyi strain ATCC 27722 contains a genetic element with homology to the vibrio RS1 element that can replicate as a plasmid and confer NAD independence on haemophilus influenzae.  Infection And Immunity. Vol. 72, no. 2. (February 1): 1143-1146.
• Scheffler NK; Falick AM; Hall SC; Ray WC; Post DM; Munson RS Jr; Gibson BW. 2003. Proteome of Haemophilus ducreyi by 2-D SDS-PAGE and mass spectrometry: strain variation, virulence, and carbohydrate expression.  Journal Of Proteome Research. Vol. 2, no. 5. (September 1): 523-533.
• Mason KM; Munson RS Jr; Bakaletz LO. 2003. Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.  Infection And Immunity. Vol. 71, no. 6. (June 1): 3454-3462.
• Sun S; Scheffler NK; Gibson BW; Wang J; Munson RS Jr. 2002. Identification and characterization of the N-acetylglucosamine glycosyltransferase gene of Haemophilus ducreyi.  Infection And Immunity. Vol. 70, no. 10. (October 1): 5887-5892.
• Nika JR; Latimer JL; Ward CK; Blick RJ; Wagner NJ; Cope LD; Mahairas GG; Munson RS Jr; Hansen EJ. 2002. Haemophilus ducreyi requires the flp gene cluster for microcolony formation in vitro.  Infection And Immunity. Vol. 70, no. 6. (June 1): 2965-2975.
• Tullius MV; Phillips NJ; Scheffler NK; Samuels NM; Munson Jr RS Jr; Hansen EJ; Stevens-Riley M; Campagnari AA; Gibson BW. 2002. The lbgAB gene cluster of Haemophilus ducreyi encodes a beta-1,4-galactosyltransferase and an alpha-1,6-DD-heptosyltransferase involved in lipooligosaccharide biosynthesis.  Infection And Immunity. Vol. 70, no. 6. (June 1): 2853-2861.
• Jones PA; Samuels NM; Phillips NJ; Munson RS Jr; Bozue JA; Arseneau JA; Nichols WA; Zaleski A; Gibson BW; Apicella MA. 2002. Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation.  The Journal Of Biological Chemistry. Vol. 277, no. 17. (April 26): 14598-14611.
• Speaker. 2000. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at Bacteriology and Mycology Horizons for the 21st Century, A Symposium in Honor of Dr. William Branche. Bethseda, MD. (June)
• Speaker. 2007. Non-lipooligosaccharide glycoconjugates in Haemophilus ducreyi. Presented at The Haemophilus ducreyi Symposium. Seattle, WA. (July)
• Session Convener. 2004. Session on Microbial Interactions with the Rest of the World. Presented at The 11th Annual Midwest Microbial Pathogenesis Conference. East Lansing, MI. (October)
• Speaker. 2000. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at University of Wisconsin Medical School, Department of Medical Microbiology and Immunology. Madison, WI. (September)
• Speaker. 2008. Type IV Pilus Biogenesis in Nontypeable Haemophilus influenzae. Presented at International Pasteurellaceae Society. Sorrento, Italy. (October)
• Speaker. 2000. Update of the Haemophilus ducreyi Genome Project. Presented at Los Alamos Laboratory, NIH Advisory Panel on Sexually Transmitted Diseases Pathogen Genomics. Santa Fe, NM. (September)
• Speaker. 2006. Approaches to understanding the virulence of nontypeable Haemophilus influenzae. Presented at The Ohio State University, Grand Rounds, Department of Pathology. (December)
• Speaker. 2003. Approaches for the Identification of Microbial Virulence Determinants. Presented at Chemical Abstracts Service. Columbus, OH. (August)
• Speaker. 2000. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at Emory University, Department of Microbiology and Immunology. Atlanta, GA. (September)
• Speaker. 2001. The Haemophilus ducreyi Genome Project. Presented at Sixth International Symposium on Haemophilus ducreyi Pathogenesis and Chancroid. Berlin, Germany. (June)
• Speaker. 2001. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at The 8th Annual Midwest Microbial Pathogenesis Meeting. Urbana, IL. (October)
• Speaker. 2005. Haemophilus Species, Genomics and Pathogenesis. Presented at The Ohio State University, Biochemistry 850. Columbus, OH. (February)
• Session Convener. 2001. Session on Host Responses, Vaccine Development and Virulence Determinants. Presented at The 6th International Symposium on Haemophilus ducreyi Pathogenesis and Chancroid. Berlin, Germany. (June)
• Speaker. 2002. Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae. Presented at International Pasteurellaceae Society Conference. Banff, Alberta, Canada. (May)
• Session Moderator. 2007. Session on HPV Vaccines: Immunobiology and Implementation. Presented at The Haemophilus ducreyi Symposium. Seattle, WA. (July)
• Speaker. 2000. The Impact of Haemophilus ducreyi Genome Project on Our Understanding of the Virulence of H. ducreyi. Presented at Ohio Branch Meeting of The American Society for Microbiology. Oxford, OH. (April)
• Speaker. 2006. Molecular Pathogenesis of Haemophilus infections. Presented at Virginia Tech, Molecular Cell Biology and Biotechnology Program. Blacksburg, VA. (February)
• Speaker. 2007. Type IV Pili of Haemophilus influenzae: role in transformation and virulence. Presented at Dean McGee Eye Institute. Oklahoma City, OK. (October)
• Session Convener. 2005. Haemophilus ducreyi Pathogenesis and Chancroid. Presented at The 8th International Symposium on Haemophilus ducreyi Pathogenesis and Chancroid. Amsterdam, The Netherlands. (July)
• Speaker. 2003. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at The Ohio State University, Department of Medical Virology, Immunology and Medical Genetics. Columbus, OH. (September)
• Speaker. 2003. Haemophilus ducreyi: From Pathogenesis to Genome. Presented at The University of Texas Southwestern Medical Center, Department of Microbiology. Dallas, TX. (March)
• Invited Seaker. 2005. Identification and Partial Characterization of the Sialic Acid Transporter from Haemophilus ducreyi. Presented at Eighth International Symposium on Haemophilus ducreyi Pathogenesis and Chancroid. Amsterdam, The Netherlands. (July)
• Speaker. 2000. Molecular Pathogenesis of Haemophilus ducreyi Disease. Presented at UTMB at Galveston, Distinguished Lecture Series. Galveston, TX. (March)
• Speaker. 2001. Haemophilus ducreyi: From Pathogenesis to genome. Presented at University of Oklahoma Health Sciences Center, Department of Microbiology and Immunology. Oklahoma City, OK. (March)