Robert P. Hoffman, MD

Robert P. Hoffman, MD, is a member of the Section of Endocrinology and Metabolism at Nationwide Children’s Hospital and an Associate Professor of Pediatrics at The Ohio State University College of Medicine. He received his medical degree from The Ohio State University in 1981, followed by pediatric internship and residency at Children’s Hospital Medical Center of Akron, Ohio, and a pediatric endocrine fellowship at Children’s Hospital of Pittsburgh in Pennsylvania. He is board certified by the American Board of Pediatrics (ABP) and ABP Sub-board of Pediatric Endocrinology. Dr. Hoffman’s research interests include hypoglycemia in Type 1 diabetes, insulin resistance, endothelial function and puberty. His teaching activities include education on Type 1 diabetes in children and adolescents, hypoglycemia in infants and children and growth disorders, regionally and internationally. Administratively, he is the director for the fellowship program and the coordinator for the attending, consultation and physician schedules for the division.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Hospital-Based Research Faculty

Research Funding*:

• Oral Insulin TrialNet - George Washington University
• Major Affiliates to Support Research Activities (TrialNet), TrialNet - George Wasington University/Nationals Institute of Health

Medical School

• Ohio State University College of Medicine and Publ
  Date Completed: 06/12/1981

Internship

• Akron Children's Hospital
  Date Completed: 06/30/1982

Residency

• Akron Children's Hospital
  Date Completed: 06/30/1984

Fellowship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/1987

Department:

• Pediatrics

Section:

• Endocrinology/Metabolism/Diabetes

Speciality:

• Pediatric Endocrinology
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 03/30/2001

2006–present

• Program Director Nationwide Children's Hospital Pediatric Endocrine Fellowship
   

2001–present

• Associate Professor, The Ohio State University College of Medicine, Department of Pediatrics

1996–2000

• Associate Professor, University of Iowa College of Medicine, Department of Pediatrics

1990–1996

• Assistant Professor, University of Iowa College of Medicine, Department of Pediatrics

1989–1990

• Associate in Pediatrics, University of Iowa College of Medicine, Department of Pediatrics
  

1987–1989

• Assistant Professor & Division Chief, Pediatric Endocrinology, University of Florida Health Science Center

• Hoffman,Robert,P; Dye,Amanda,S; Bauer,John,A. 2012. Ascorbic acid blocks hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.  PEDIATRIC DIABETES. Vol. 13, no. 8. (December): 607-610.
• Kingery SE. Wu YL, Zhou B, Hoffman RP, Yu CY. 2012. Gene Copy-Number Variations (CNVs) and Protein Levels of Complement C4A and C4B as Novel Biomarkers for Partial Disease Remissions in New-Onset Type 1 Diabetes Patients.  Pediatric Diabetes. Vol. 13, no. April: 408-412.
• Dye,Amanda,S; Huang,Hong; Bauer,John,A; Hoffman,Robert,P. 2012. Hyperglycemia Increases Muscle Blood Flow and Alters Endothelial Function in Adolescents with Type 1 Diabetes.  EXPERIMENTAL DIABETES RESEARCH. Vol. 2012, no. January: e170380.
• Meyer,Stacy,L; Hoffman,Robert,P. 2011. Retrospective Chart Review of Children With Type 2 Diabetes Mellitus Evaluating the Efficacy of Metformin vs. Insulin vs. Combination Insulin/Metformin.  SOUTHERN MEDICAL JOURNAL. Vol. 104, no. 10. (October): 684-688.
• Lanyi X, Hoffman RP, Veng-Pedersen P:. 2010. Population analysis of race and first-phase insulin release.  Diabetes Research and Clinical Practice. Vol. 89, no. Epub. (May): 243-249.
• Xie L; Hoffman RP; Veng-Pedersen P. 2009. Noncompartmental pharmacokinetics analysis of glucose-stimulated insulin response in African-American and Caucasian youths.  Biopharmaceutics & Drug Disposition. Vol. 30, no. 3. (April): e117.
• Hoffman, RP. 2009. Metabolic Syndrome Racial Differences in Adolescents.  Current Diabetes Rev. Vol. 5, no. January: 259-265.
• Bowden SA; Duck MM; Hoffman RP. 2008. Young children (12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor.  Pediatric Diabetes. Vol. 9, no. 3 Pt 1. (June): e197.
• Hoffman RP. 2008. Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents.  Pediatric Diabetes. Vol. 9, no. 3 Pt 2. (June): e57.
• Hoffman RP. 2008. Growth hormone (GH) treatment does not restore endothelial function in children with GH deficiency.  Journal Of Pediatric Endocrinology & Metabolism: JPEM. Vol. 21, no. 4. (April): e323.
• Bowden SA, Hoffman RP. 2008. Triple diabetes: Coexistence of Type 1 Diabetes Mellitus and MODY3 Caused by a Novel Mutation of Hepatocyte Nuclear Factor-1 α Gene in an Overweight Adolescent.  Pediatric Diabetes. Vol. 9, no. 2. (April): 162-164.
• Bowden SA; Hoffman RP. 2008. Triple diabetes: coexistence of type 1 diabetes mellitus and a novel mutation in the gene responsible for MODY3 in an overweight adolescent.  Pediatric Diabetes. Vol. 9, no. 2. (April): e162.
• Hoffman RP. 2007. Sympathetic mechanisms of hypoglycemic counterregulation.  Current Diabetes Reviews. Vol. 3, no. 3. (August): e185.
• Duck MM; Hoffman RP. 2007. Impaired endothelial function in healthy African-American adolescents compared with Caucasians.  The Journal Of Pediatrics. Vol. 150, no. 4. (April): e400.
• Gupta N; Hoffman RP; Veng-Pedersen P. 2006. Pharmacokinetic/pharmacodynamic insulin-glucose analysis for differentiation of beta-cell function: an 18 month follow-up study in pre-pubertal lean and obese children.  Biopharmaceutics & Drug Disposition. Vol. 27, no. 6. (September): e257.
• Hoffman RP. 2006. Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents.  Diabetes Care. Vol. 29, no. 6. (June): e1402.
• Hoffman RP. 2006. Antecedent hypoglycemia does not alter increased epinephrine-induced lipolysis in type 1 diabetes mellitus.  Metabolism: Clinical And Experimental. Vol. 55, no. 3. (March): e371.
• Gupta N; Hoffman RP; Veng-Pedersen P. 2005. Pharmacokinetic/pharmacodynamic differentiation of pancreatic responsiveness in obese and lean children.  Biopharmaceutics & Drug Disposition. Vol. 26, no. 7. (October): e287.
• Hoffman RP. 2005. Controling Diabetes.  Virtual Mentor. Available at: HTTP://www.ama-ssn.org/ama/pub/category/15622.html. Vol. 2005, no. 1. (January): http://virtualmentor.ama-assn.org/2005/11/ccas1.
• Hoffman RP; Vicini P; Cobelli C. 2004. Pubertal changes in HOMA and QUICKI: relationship to hepatic and peripheral insulin sensitivity.  Pediatric Diabetes. Vol. 5, no. 3. (September): e122.
• Hoffman RP. 2004. Practical management of type 1 diabetes mellitus in adolescent patients: challenges and goals.  Treatments In Endocrinology. Vol. 3, no. 1. (January): e27.
• Hoffman RP. 2003. Juvenile diabetes: avoiding problems during therapy.  Clinical Advisor.
• Hoffman RP. 2003. Thyroid stimulating hormone screening is more sensitive for detecting thyroid abnormalities in children and adolescents with type 1 diabetes.  Diabetes Care. Vol. 26, no. 1. (January): e255.
• Hoffman RP; Vicini P; Cobelli C. 2002. Comparison of insulin sensitivity and glucose effectiveness determined by the one- and two-compartment-labeled minimal model in late prepubertal children and early adolescents.  Metabolism: Clinical And Experimental. Vol. 51, no. 12. (December): e1582.
• Hoffman RP; Sinkey CA; Dopp JM; Phillips BG. 2002. Lack of effect of alpha- and beta-adrenergic inhibition on forearm glucose uptake despite differences in forearm blood flow in healthy humans.  Metabolism: Clinical And Experimental. Vol. 51, no. 11. (November): e1506.
• Hoffman RP. 2002. Adolescent adherence in type 1 diabetes.  Comprehensive Therapy. Vol. 28, no. 2. (June): e128.
• Hoffman RP; Sinkey CA; Dopp JM; Phillips BG. 2002. Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects.  Diabetes. Vol. 51, no. 3. (March): e734.
• McCarthy AM; Richman LC; Hoffman RP; Rubenstein L. 2001. Psychological screening of children for participation in nontherapeutic invasive research.  Archives Of Pediatrics & Adolescent Medicine. Vol. 155, no. 11. (November): e1197.
• Hoffman RP. 2001. Eating disorders in adolescents with type 1 diabetes. A closer look at a complicated condition.  Postgraduate Medicine. Vol. 109, no. 4. (April): e67.
• Hoffman RP. 2001. Thyroiditis.  www.emedicine.com.
• Hoffman RP. 2001. Panhypopituitarism.  Arlan L Rosenbloom, MD, Robert Konop, Lynne Lipton Levitsky, MD, Merrily Poth, MD George P Chrousos, MD eds Pediatrics.
• Hoffman RP. 2001. Hypoglycemia.  www.emedicine.com.
• Hoffman RP; Vicini P; Sivitz WI; Cobelli C. 2000. Pubertal adolescent male-female differences in insulin sensitivity and glucose effectiveness determined by the one compartment minimal model.  Pediatric Research. Vol. 48, no. 3. (September): e384.
• Hoffman RP. 2000. Latex hypersensitivity in a child with diabetes.  Archives Of Pediatrics & Adolescent Medicine. Vol. 154, no. 3. (March): e281.
• Hoffman RP; Sinkey CA; Tsalikian E. 1999. Effect of local sympathetic blockade on forearm blood flow and glucose uptake during hypoglycemia.  Metabolism: Clinical And Experimental. Vol. 48, no. 12. (December): e1575.
• Hoffman RP; Hausberg M; Sinkey CA; Anderson EA. 1999. Hyperglycemia without hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.  Journal Of Diabetes And Its Complications. Vol. 13, no. 1. (January): e17.
• Van De Borne P; Hausberg M; Hoffman RP; Mark AL; Anderson EA. 1999. Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects.  The American Journal Of Physiology. Vol. 276, no. 1 Pt 2. (January): eR178.
• Hoffman RP; Sinkey CA; Anderson EA. 1998. Microneurographically determined muscle sympathetic nerve activity levels are reproducible in insulin-dependent diabetes mellitus.  Journal Of Diabetes And Its Complications. Vol. 12, no. 6. (November): e307.
• Hausberg M; Sinkey CA; Mark AL; Hoffman RP; Anderson EA. 1998. Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents.  American Journal Of Hypertension. Vol. 11, no. 11 Pt 1. (November): e1312.
• Hausberg M; Hoffman RP; Somers VK; Sinkey CA; Mark AL; Anderson EA. 1997. Contrasting autonomic and hemodynamic effects of insulin in healthy elderly versus young subjects.  Hypertension. Vol. 29, no. 3. (March): e700.
• Hoffman RP; Sinkey CA; Anderson EA. 1997. Hypoglycemic symptom variation is related to epinephrine and not peripheral muscle sympathetic nerve response.  Journal Of Diabetes And Its Complications. Vol. 11, no. 1. (January): e15.
• Hoffman RP; Kienzle MG. 1996. Circadian control of heart rate in young insulin-dependent diabetes mellitus patients.  Journal Of Diabetes And Its Complications. Vol. 10, no. 4. (July): e220.
• Hoffman RP; Armstrong PT. 1996. Glucose effectiveness, peripheral and hepatic insulin sensitivity, in obese and lean prepubertal children.  International Journal Of Obesity And Related Metabolic Disorders: Journal Of The International Association For The Study Of Obesity. Vol. 20, no. 6. (June): e521.
• Hoffman RP. 1996. Management of diabetic ketoacidosis in children. In Clinical Practice of Emergency Medicine. 2nd ed. Edited by Harwood-Nuss A, Linden L, Luten RC, Sternbach G, Wolfson AB,. Philladelphia, PA: JB Lippincott Company,.
• Hausberg M; Mark AL; Hoffman RP; Sinkey CA; Anderson EA. 1995. Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels.  Journal Of Hypertension. Vol. 13, no. 9. (September): e1015.
• Hoffman RP; Sinkey CA; Anderson EA. 1995. Muscle sympathetic nerve activity is higher in intensively versus conventionally treated IDDM subjects.  Diabetes Care. Vol. 18, no. 3. (March): e287.
• Hoffman RP; Stumbo PJ; Janz KF; Nielsen DH. 1995. Altered insulin resistance is associated with increased dietary weight loss in obese children.  Hormone Research. Vol. 44, no. 1. (January): e17.
• Hoffman RP. 1995. Management of diabetic ketoacidosis in children. In Handbook of Emergency Medicine.. 2nd ed. Edited by Harwood-Nuss A, Luten RC. Philadelphia, PA: JB Lippincott Company.
• Hoffman RP. 1995. Insulin antagonistic effects of growth hormone in short children.  Hormone Research. Vol. 44, no. 5. (January): e197.
• Hoffman RP; Singer-Granick C; Drash AL; Becker DJ. 1994. Abnormal alpha cell hypoglycemic recognition in children with insulin dependent diabetes mellitus (IDDM).  The Journal Of Pediatric Endocrinology. Vol. 7, no. 3. (July): e225.
• Hoffman RP; Arslanian S; Drash AL; Becker DJ. 1994. Impaired counterregulatory hormone responses to hypoglycemia in children and adolescents with new onset IDDM.  The Journal Of Pediatric Endocrinology. Vol. 7, no. 3. (July): e235.
• Hoffman RP; Sinkey CA; Anderson EA. 1994. Hypoglycemia increases muscle sympathetic nerve activity in IDDM and control subjects.  Diabetes Care. Vol. 17, no. 7. (July): e673.
• Hoffman RP. 1994. Independent effects of youth and poor diabetes control on responses to hypoglycemia in children. Summary and Commentary.  Diabetes Spectrum. Vol. 7, no. January: 255-256.
• Hoffman,R,P; Sinkey,C,A; Kienzle,M,G; Anderson,E,A. 1993. NO REASON TO REGARD A LOW NUMBER OF BURSTS OF MUSCLE SYMPATHETIC-NERVE ACTIVITY IN IDDM AS A SIGN OF AUTONOMIC NEUROPATHY - RESPONSE.  DIABETES. Vol. 42, no. 9. (September): 1379-1380.
• Cook JS; Hoffman RP; Stene MA; Hansen JR. 1993. Effects of maturational stage on insulin sensitivity during puberty.  The Journal Of Clinical Endocrinology And Metabolism. Vol. 77, no. 3. (September): e725.
• Hoffman RP; Sinkey CA; Kienzle MG; Anderson EA. 1993. Muscle sympathetic nerve activity is reduced in IDDM before overt autonomic neuropathy.  Diabetes. Vol. 42, no. 3. (March): e375.
• Diabetes Control And Complications Trial Research Group (Usa). 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.  New England Journal of Medicine. Vol. 329, no. 14. (January): 977-986.
• Anderson EA; Balon TW; Hoffman RP; Sinkey CA; Mark AL. 1992. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans.  Hypertension. Vol. 19, no. 6 Pt 2. (June): e621.
• Cook JS; Bale JF Jr; Hoffman RP. 1992. Pubertal arrest associated with valproic acid therapy.  Pediatric Neurology. Vol. 8, no. 3. (May): e229.
• McSweeney JJ; Hoffman RP. 1991. Munchausen's syndrome by proxy mistaken for IDDM.  Diabetes Care. Vol. 14, no. 10. (October): e928.
• Anderson EA; Hoffman RP; Balon TW; Sinkey CA; Mark AL. 1991. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.  The Journal Of Clinical Investigation. Vol. 87, no. 6. (June): e2246.
• Mandoki MW; Sumner GS; Hoffman RP; Riconda DL. 1991. A review of Klinefelter's syndrome in children and adolescents.  Journal Of The American Academy Of Child And Adolescent Psychiatry. Vol. 30, no. 2. (March): e167.
• Hoffman RP; Singer-Granick C; Drash AL; Becker DJ. 1991. Plasma catecholamine responses to hypoglycemia in children and adolescents with IDDM.  Diabetes Care. Vol. 14, no. 2. (February): e81.
• Hoffman RP. 1990. Management of diabetic ketoacidosis in children. In Clinical Practice of Emergency Medicine.. 1st ed. Edited by Harwood-Nuss A, Linden L, Luten RC, Sternbach G, Wolfson AB. Philadelphia, PA: J.B. Lippincott.
• Singer-Granick C; Hoffman RP; Kerensky K; Drash AL; Becker DJ. 1988. Glucagon responses to hypoglycemia in children and adolescents with IDDM.  Diabetes Care. Vol. 11, no. 8. (September): e643.
• Hoffman RP; Steele MW; Lee PA; Brown TR; Wenger SL; Skiba PL. 1988. 46XY siblings with inadequate virilization and CNS deficiency.  Hormone Research. Vol. 29, no. 5-6. (January): e207.
• Hoffman RP; Klein RL; Glazer N; Abramo TJ. 1983. Fortuitous reduction of Bochdalek hernia with positive-pressure ventilation.  The Journal Of Pediatrics. Vol. 103, no. 6. (December): e925.
• Kingery SE, Wu YL, Zhou B, Hoffman RP, Yu CY. 0. Gene Copy-Number Variations (CNVs) and Protein Levels of Complement C4A and C4B as Novel Biomarkers for Partial Disease Remissions in New-Onset Type 1 Diabetes Patients. Pediatric Diabetes.  Pediatric Diabetes.

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