Robert E Pyatt, PhD :: Nationwide Children's Hospital, Columbus, Ohio

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Robert E Pyatt, PhD

Robert E Pyatt, PhD

Clinical Pathology
Associate Director, Cytogenetics/ Molecular Genetics Laboratory

Pathology and Laboratory Medicine
Clinical Pathology Team

Pathology Fellowship
Faculty

Contact Information

Laboratory Medicine/ Anatomic Pathology
700 Children's Dr.
Columbus, OH 43205 [ map ]
PH: (614) 722-2870
E-mail Me

Biography

Dr. Pyatt is an Assistant Director of the Cytogenetics & Molecular Genetics Laboratories.

Gender:

  • Male

Languages Spoken:

  • English

Education and Training

Fellowship

  • The Ohio State University
    Date Completed: 07/01/2008

Section:

  • Clinical Pathology

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2008

Publications

  • Rosales,Xiomara,Q; Malik,Vinod; Sneh,Amita; Chen,Lei; Lewis,Sarah; Kota,Janaiah; Gastier-Foster,Julie,M; Astbury,Caroline; Pyatt,Rob; Reshmi,Shalini; Rodino-Klapac,Louise,R; Clark,K,Reed; Mendell,Jerry,R; Sahenk,Zarife. 2013. Impaired regeneration in LGMD2A supported by increased PAX7-positive satellite cell content and muscle-specific microrna dysregulation.  MUSCLE & NERVE. Vol. 47, no. 5. (May): 731-739.
  • Beunders,Gea; Voorhoeve,Els; Golzio,Christelle; Pardo,Luba,M; Rosenfeld,Jill,A; Talkowski,Michael,E; Simonic,Ingrid; Lionel,Anath,C; Vergult,Sarah; Pyatt,Robert,E; van de Kamp,Jiddeke; Nieuwint,Aggie; Weiss,Marjan,M; Rizzu,Patrizia; Verwer,Lucilla,ENI; van Spaendonk,Rosalina,ML; Shen,YiPing; Wu,Bai-Lin; Yu,Tingting; Yu,Yongguo; Chiang,Colby; Gusella,James,F; Lindgren,Amelia,M; Morton,Cynthia,C; van Binsbergen,Ellen; Bulk,Saskia; Van Rossem,Els; Vanakker,Olivier; Armstrong,Ruth; Park,Soo-Mi; Greenhalgh,Lynn; Maye,Una; Neill,Nicholas,J; Abbott,Kristin,M; Sell,Susan; Ladda,Roger; Farber,Darren,M; Bader,Patricia,I; Cushing,Tom; Drautz,Joanne,M; Konczal,Laura; Nash,Patricia; de los Reyes,Emily; Carter,Melissa,T; Hopkins,Elizabeth; Marshall,Christian,R; Osborne,Lucy,R; Gripp,Karen,W; Thrush,Devon,Lamb; Hashimoto,Sayaka; Gastier-Foster,Julie,M; Astbury,Caroline; Ylstra,Bauke; Meijers-Heijboer,Hanne; Posthuma,Danielle; Menten,Bjoern; Mortier,Geert; Scherer,Stephen,W; Eichler,Evan,E; Girirajan,Santhosh; Katsanis,Nicholas; Groffen,Alexander,J; Sistermans,Erik,A. 2013. Exonic Deletions in AUTS2 Cause a Syndromic Form of Intellectual Disability and Suggest a Critical Role for the C Terminus.  AMERICAN JOURNAL OF HUMAN GENETICS. Vol. 92, no. 2. (February): 210-220.
  • Alyaqoub,Fadel; Pyatt,Robert,E; Bailes,Andrea; Brock,Amanda; Deeg,Carol; McKinney,Aimee; Astbury,Caroline; Reshmi,Shalini; Shane,Kate,P; Thrush,Devon,Lamb; Sommer,Annemarie; Gastier-Foster,Julie,M. 2012. 12q14 microdeletion associated with HMGA2 gene disruption and growth restriction.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 158A, no. 11. (November): 2925-2930.
  • La Madrid,Andres,Morales; Volchenboum,Samuel; Gastier-Foster,Julie,M; Pyatt,Robert; Liu,Don; Pytel,Peter; Lavarino,Cinzia; Rodriguez,Eva; Cohn,Susan,L. 2012. Locoregional MYCN-amplified neuroblastoma.  PEDIATRIC BLOOD & CANCER. Vol. 59, no. 4. (October): 736-738.
  • Repnikova,Elena,A; Astbury,Caroline; Reshmi,Shalini,C; Ramsey,Sarah,N; Atkin,Joan,F; Thrush,Devon,Lamb; Mitchell,Anna,L; Pyatt,Robert,E; Reber,Kristina; Slavin,Thomas; Gastier-Foster,Julie,M. 2012. Microarray comparative genomic hybridization and cytogenetic characterization of tissue-specific mosaicism in three patients.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 158A, no. 8. (August): 1924-1933.
  • Cottrell CE, Mendell J, Hart-Kothari M, Ell D, Thrush DL, Astbury C, Pastore M, Gastier-Foster JM, Pyatt RE. 2012. Maternal uniparental disomy of chromosome 4 in a patient with limb-girdle muscular dystrophy 2E confirmed by SNP array technology.  CLINICAL GENETICS. Vol. 81, no. 6. (June): 578-583.
  • Pyatt RE, Astbury C. 2011. Interpretation of Copy Number Alterations Identified Through Clinical Microarray-Comparative Genomic Hybridization.  CLINICS IN LABORATORY MEDICINE. Vol. 31, no. 4. (December): 565-?.
  • Talkowski,Michael,E; Mullegama,Sureni,V; Rosenfeld,Jill,A; van Bon,W,M; Shen,YiPing; Repnikova,Elena,A; Gastier-Foster,Julie; Thrush,Devon,Lamb; Kathiresan,Sekar; Ruderfer,Douglas,M; Chiang,Colby; Hanscom,Carrie; Ernst,Carl; Lindgren,Amelia,M; Morton,Cynthia,C; An,Yu; Astbury,Caroline; Brueton,Louise,A; Lichtenbelt,Klaske,D; Ades,Lesley,C; Fichera,Marco; Romano,Corrado; Innis,Jeffrey,W; Williams,Charles,A; Bartholomew,Dennis; Van Allen,Margot,I; Parikh,Aditi; Zhang,Lilei; Wu,Bai-Lin; Pyatt,Robert,E; Schwartz,Stuart; Shaffer,Lisa,G; de Vries,Bert,BA; Gusella,James,F; Elsea,Sarah,H. 2011. Assessment of 2q23.1 Microdeletion Syndrome Implicates MBD5 as a Single Causal Locus of Intellectual Disability, Epilepsy, and Autism Spectrum Disorder.  AMERICAN JOURNAL OF HUMAN GENETICS. Vol. 89, no. 4. (October): 551-563.
  • Kalman L; Leonard J; Gerry N; Tarleton J; Bridges C; Gastier-Foster JM; Pyatt RE; Stonerock E; Johnson MA; Richards CS; Schrijver I; Ma T; Miller VR; Adadevoh Y; Furlong P; Beiswanger C; Toji L. 2011. Quality assurance for Duchenne and Becker muscular dystrophy genetic testing: development of a genomic DNA reference material panel.  The Journal Of Molecular Diagnostics: JMD. Vol. 13, no. 2. (March): e167.
  • Cottrell C, Mendell J, Hart-Kothari M, Ell D, Thrush D, Astbury C, Pastore M, Gastier-Foster J, Pyatt RE. 2011. Maternal uniparental disomy of chromosome 4 in a patient with limb-girdle muscular dystrophy 2E confirmed by SNP array technology.  Clin Genet (Epub ahead of print).
  • Prior TW; Snyder PJ; Rink BD; Pearl DK; Pyatt RE; Mihal DC; Conlan T; Schmalz B; Montgomery L; Ziegler K; Noonan C; Hashimoto S; Garner S. 2010. Newborn and carrier screening for spinal muscular atrophy.  American Journal Of Medical Genetics. Part A. Vol. 152A, no. 7. (July): e1608.
  • Ballif BC; Theisen A; Rosenfeld JA; Traylor RN; Gastier-Foster J; Thrush DL; Astbury C; Bartholomew D; McBride KL; Pyatt RE; Shane K; Smith WE; Banks V; Gallentine WB; Brock P; Rudd MK; Adam MP; Keene JA; Phillips JA 3rd; Pfotenhauer JP; Gowans GC; Stankiewicz P; Bejjani BA; Shaffer LG. 2010. Identification of a recurrent microdeletion at 17q23.1q23.2 flanked by segmental duplications associated with heart defects and limb abnormalities.  American Journal Of Human Genetics. Vol. 86, no. 3. (March): e454.
  • Cottrell CE, Prior TW, Pyatt R, Astbury C, Reshmi S, Bartholomew D, Atkin J, Manickam K, Thrush DL, Pastore M, Mendell J, Tsao CY, Al-Dahhak R. Newmeyer A, Gastier-Foster JM. 2010. Unexpected detection of dystrophin gene deletions by array comparative genomic hybridization.  Am J Med Genet A. Vol. 152A, no. January: 2301-2307.
  • Rosales XQ, Gastier-Foster JM, Lewis S, Vinod M, Lamb Thrush D, Astbury C, Pyatt R, Reshmi S, Sahenk Z, Mendell JR. 2010. Novel diagnostic features of Dysferlinopathies.  Muscle Nerve. Vol. 42, no. January: 14-21.
  • Pyatt, RE; Rosser, T; Powell, K. 2009. Undergraduates as Science Museum Docents Training Students To Be the Teachers Using Peer Led Team Learning.  AMERICAN BIOLOGY TEACHER. Vol. 71, no. 1. (January): 16-19.
  • Pyatt RE; Mihal DC; Prior TW. 2007. Assessment of liquid microbead arrays for the screening of newborns for spinal muscular atrophy.  Clinical Chemistry. Vol. 53, no. 11. (November): e1879.
  • Pyatt RE; Prior TW. 2006. A feasibility study for the newborn screening of spinal muscular atrophy.  Genetics In Medicine: Official Journal Of The American College Of Medical Genetics. Vol. 8, no. 7. (July): e428.
  • Pyatt RE; Pilarski R; Prior TW. 2006. Mutation screening in juvenile polyposis syndrome.  The Journal Of Molecular Diagnostics: JMD. Vol. 8, no. 1. (February): e84.
  • Holtzclaw JD, Morris L, Pyatt RE, Giver C, Hoey J, Gunn R, Eaton D, Haynes JK, and Eisen A. 2005. FIRST: A New Model for Developing Future Science Faculty.  J Coll Sci Teach. Vol. 34, no. January: 24-29.
  • Pyatt RE. 2005. Haploid Analysis (Monosomal Hybrid Technique). In Encyclopedia of Diagnostic Genomics and Proteomics. New York: Marcel Dekker.
  • Kerstann KF, Feingold E, Freeman SB, Bean LJ, Pyatt R, Meltzer M, Heffner A, Capone G, and Sherman SL. 2004. Linkage disequilibrium mapping in trisomic populations, analytical approaches and an application to congenital heart defects in Down Syndrome.  Genet Epidemiol. Vol. 27, no. January: 240-251.
  • Pyatt RE; Nakagawa H; Hampel H; Sedra M; Fuchik MB; Comeras I; de la Chapelle A; Prior TW. 2003. Identification of a deletion in the mismatch repair gene, MSH2, using mouse-human cell hybrids monosomal for chromosome 2.  Clinical Genetics. Vol. 63, no. 3. (March): e215.
  • Chadwick RB; Pyatt RE; Niemann TH; Richards SK; Johnson CK; Stevens MW; Meek JE; Hampel H; Prior TW; de la Chapelle A. 2001. Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma.  Journal Of Medical Genetics. Vol. 38, no. 7. (July): e461.
  • Adebamowo CA, Adeyi O, Pyatt R, Prior TW, Chadwick RW, and de la Chapelle A. 2000. Case Report on Hereditary Non-Polyposis Colon Cancer (HNPCC) in Nigeria.  African J Med Med Sci. Vol. 29, no. January: 71-73.
  • Pyatt RE; Jenski LL; Allen R; Cornetta K; Abonour R; Traycoff CM; Srour EF. 1999. Use of merocyanine 540 for the isolation of quiescent, primitive human bone marrow hematopoietic progenitor cells.  Journal Of Hematotherapy. Vol. 8, no. 2. (April): e189.
  • Pyatt R, Chadwick RB, Johnson CK, Adebamowo C, de la Chapelle A., and Prior TW. 1999. Polymorphic Variation at the Bat-25 and Bat-26 Loci in Individuals of African Origin: Implications for Microsatellite Instability Testing.  Am Journal Path. Vol. 155, no. January: 349-353.
  • Gothot A, Pyatt R, McMahel J, Rice S, and Srour EF. 1998. Assessment of Proliferative and Colony-Forming Capacity after Successive in vitro Divisions of Single Human CD34+ Cells Initially Isolated in G0.  Exp Hem. Vol. 26, no. January: 562-570.
  • Ladd AC, Pyatt R, Gothot A, Rice S, McMahel J, Traycoff CM, and Srour EF. 1997. Orderly Process of Sequential Cytokine Stimulation is Required for Activation and Maximal Proliferation of Primitive Human Bone Marrow CD34+ Hematopoietic Progenitor Cells Residing in G0.  Blood. Vol. 90, no. January: 658-668.
  • Gothot A, Pyatt R, McMahel J, Rice S, and Srour EF. 1997. Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0/G1 Phase of the Cell Cycle.  Blood. Vol. 90, no. January: 4384-4393.
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