Richard Ransom, Ph.D.

Richard F. Ransom, Ph.D., is a principal investigator in the Center for Clinical and Translational Research at The Research Institute at Nationwide Children's Hospital, and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His research program is primarily focused on the mechanism of action of glucocorticoids, with an emphasis on the kidney disease, nephrotic syndrome. His investigations involve a broad range of systems, from cell culture and molecular biology thru animal models, and includes a multi-center clinical study of children with new-onset nephrotic syndrome.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• Dr. Ransom's research is focused on the molecular mechanisms underlying both the development of and therapy for nephrotic syndrome, a common kidney disease in both adults and children. His work is based on the hypothesis that glucocorticoids, the most commonly used treatment for nephrotic syndrome, act directly on glomerular podocytes to induce changes in podocyte protein expression, changes that are partly or wholly responsible for the therapeutic action of glucocorticoids

Undergraduate

• Michigan State University
  Date Completed: 06/30/1983

Post Doctoral

• Purdue University
  Date Completed: 06/30/1991

Fellowship

• University of California, Riverside
  Date Completed: 06/30/1992

Fellowship

• Michigan State University
  Date Completed: 06/30/1996

2007–present

• Principal Investigator, Center for Clinical and Translational Research, The Research Institute, Assistant Professor, Pediatrics, The Ohio State University

2005–2007

• Research Assistant Professor, Department of Pediatrics, University of Michigan Medical School

2001–2005

• Research Investigator, Department of Pediatrics, University of Michigan Medical School

• Chittiprol S, Chen P, Petrovic-Djergovic D, Eichler T, Ransom RF. 2011. Marker expression, behaviors, and responses vary in different lines of conditionally-immortalized cultured podocytes.  American Journal of Physiology-Renal Physiology. no. Epub ahead of print. (June 1) (IF: 3.731)
• Pengal R, Guess AJ, Agrawal S, Manley J, Ransom RF, Mourey RJ, Benndorf R, Smoyer WE. 2011. Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.  American Journal of Physiology-Renal Physiology. no. Epub ahead of print. (May 25) (IF: 3.731)
• Petrovic-Djergovic D, Chittiprol S, Chen P, Eichler T, Ransom RF and The MWPNC. 2011. TIF2/SRC2 expression in blood leukocytes is a determinant of steroid response in pediatric idiopathic nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study [Abstract]. Philadelphia: American Society of Nephrology [Peer Reviewed] (Unspecified)
• Guess A; Agrawal S; Wei CC; Ransom RF; Benndorf R; Smoyer WE. 2010. Dose- and time-dependent glucocorticoid receptor signaling in podocytes.  American Journal Of Physiology. Renal Physiology. Vol. 299, no. 4. (October 1): F845. (IF: 3.731)
• Petrovic-Djergovic D, Chittiprol S, Ransom RF. 2010. Immunomodulation of puromycin aminonucleoside-induced nephrotic syndrome in rats [Abstract]. Bristol, England: International Podocyte Conference [Peer Reviewed] (Unspecified)
• Eichler, TE, Petrovic-Djergovic D, Chittiprol S, Ransom RF. 2010. Glucocorticoid action in experimental nephrotic syndrome is modulated by P-glycoprotein and can induce increased P-glycoprotein activity [Abstract]. Bristol, England: International Podocyte Conference [Peer Reviewed] (Published)
• Ransom, Richard F. 2010. Differential expression of markers and responses to podocyte toxins and glucocorticoids in conditionally-immortalized cultured podocytes [Abstract]. Bristol, England: International Podocyte Conference [Peer Reviewed] (Unspecified)
• Ransom, Richard F. 2009. Comparative Podocytomics: Analyses of Conditionally-Immortalized Lines of Cultured Podocytes [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Reddy GR, Kotlyarevska K, Ransom RF, Menon RK. 2008. The podocyte and diabetes mellitus: is the podocyte the key to the origins of diabetic nephropathy? Review.  Current Opinion in Nephrology and Hypertension. Vol. 17, no. 1. (January): 32-36. (IF: 3.961)
• Ransom, Richard F.; Eichler, Tad E. 2007. B-Crystallin and Hsp25 Modulate the Protective Effects of Glucocorticoids on Podocytes [Abstract]. Toronto, Canada: Pediatric Academic Societies [Peer Reviewed] (Published)
• Reddy GR, Pushpanathan MJ, Ransom RF, Holzman LB, Brosius FC 3rd, Diakonova M, Mathieson P, Saleen MA, List EO, Kopchick JJ, Frank SJ, Menon RK. 2007. Identification of the glomerular podocyte as a target for growth hormone action.  Endocrinology. Vol. 148, no. 5. : 2045-2055. (IF: 4.752)
• Ransom, Richard F.; Eicher, Tad; Holthofer, Harry; Kuusniemi, Arvi-Matti; Jalanko, Hannu; Mundel, Peter; Smoyer, William E. 2007. Glomerular Hsp27 Induction Represents a Generalized Podocyte Stress Response in Both Humans and Animal Models of Nephrotic Syndrome [Abstract]. Toronto, Canada: Pediatric Academic Societies [Peer Reviewed] (Published)
• Ransom RF, Thornton A, Jia Y, Smoyer WE. 2006. Hsp27 interacts with both ArpC1a and ArpC1b in podocytes [Abstract]. Helsinki, Finland: International Podocyte Congress [Peer Reviewed] (Unspecified)
• Ransom RF, Eicher TE, Holthöfer H, Kuusniemi A-M, Jalanko H, Mundel P, Shirato I, Smoyer WE. 2006. Induction of glomerular Hsp27 represents a generalized podocyte stress response in both humans and animal models of nephrotic syndrome [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Thornton A, Ransom RF, Jia Y, Smoyer WE. 2006. Interaction of Hsp27 with Arp2/3 actin initiation complex homologs ArpC1a and ArpC1b in podocytes [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Eichler, Tad; Ma, Qing; Kelly, Caitlin; Mishra, Jaya; Parikh, Samir; Ransom, Richard F.; Devarajan, Prasad; Smoyer, William E. 2006. Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway.  Toxicological Sciences. Vol. 90, no. 2. : 392-399. (IF: 4.814)
• Eichler TE, Streetman DS, Smoyer WE, Ransom RF. 2006. Inhibition of multiple drug resistance pump (ABCB1) in podocytes enhances the protective effects of glucocorticoids [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Ransom RF, Eichler TE, Smoyer WE. 2006. Increases in expression of hsp25 and ?B-crystallin are associated with dexamethasone-induced protection of glomerular podocytes from puromycin aminonucleoside injury [Abstract]. San Francisco, CA: Pediatric Academic Societies [Peer Reviewed] (Published)
• Richard F. Ransom, creator. 2006. Richard F. Ransom's Laboratory Website. website. University of Michigan Health System. Last Update (2009) http://sitemaker.umich.edu/ransom.lab/about_me.
• Eichler TE, Streetman DS, Smoyer WE, Ransom RF. 2006. Inhibition of multiple drug resistance protein (ABCB1) in podocytes results in enhancement of protective effect of glucocorticoids [Abstract]. Helsinki, Finland: International Podocyte Congress [Peer Reviewed] (Unspecified)
• Vega-Warner V, Eichler TE, Ransom RF, Jia Y, Smoyer WE. 2005. Hic-5 regulates podocyte focal adhesion dynamics in two murine podocyte cell lines [Abstract]. Philadelphia, PA: American Society of Nephrology [Peer Reviewed] (Published)
• Eichler, Tad E.; Ransom, Richard F.; Smoyer, William E. 2005. Differential induction of podocyte heat shock proteins by prolonged single and combination toxic metal exposure.  Toxicological Sciences. Vol. 84, no. 1. : 120-128. (IF: 4.814)
• Hirano, Sahoko; Sun, Xiankui; DeGuzman, Cheryl A.; Ransom, Richard F.; McLeish, Kenneth R.; Smoyer, William E.; Shelden, Eric A.; Welsh, Michael J.; Benndorf, Rainer. 2005. p38 Mapk/hsp25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli.  American Journal of Physiology - Renal Physiology. Vol. 288, no. 6. : F1133-F1143. (IF: 3.731)
• Eichler TE, Ransom RF, Smoyer WE. 2005. Role of metallothionein in toxic metal-induced injury to cultured podocytes [Abstract]. Washington, DC: Pediatric Academic Societies [Peer Reviewed] (Published)
• Ransom, Richard F.; Vega-Warner, Virginia; Smoyer, William E.; Klein, Jon. 2005. Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes.  Kidney International. Vol. 67, no. 4. : 1275-1285. (IF: 6.193)
• Ransom, Richard F.; Lam, Nancy G.; Hallett, Mark A.; Atkinson, Simon J.; Smoyer, William E. 2005. Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization.  Kidney International. Vol. 68, no. 6. : 2473-2483. (IF: 6.193)
• Vega-Warner V, Eichler TE, Ransom RF, Jia Y, Smoyer WE. 2005. Regulation of podocyte focal adhesion dynamics and actin polymerization by hic-5 in cultured murine podocytes [Abstract]. Washington, DC: Pediatric Academic Societies [Peer Reviewed] (Published)
• Ransom, Richard F. 2004. Podocyte Proteomics. In Proteomics in Nephrology. Edited by Thongboonkerd, V., Klein J.B. Basel: S. Karger AG.
• Ransom RF, Vega-Warner V, Klein J, Smoyer WE. 2004. Increased hsp27 expression mimics the protection from injury and actin filament disruption caused by dexamethasone [Abstract]. St. Louis, MO: American Society of Nephrology [Peer Reviewed] (Published)
• Eichler T, Ma Q, Kelly C, Mishra J, Parikh S, Ransom RF, Devarajan P, Smoyer WE. 2004. Environmental toxic metals induce apoptosis in cultured murine podocytes via the Fas-Fadd caspase 8 pathway [Abstract]. San Francisco, CA: Pediatric Academic Societies [Peer Reviewed] (Published)
• Ransom RF, Vega-Warner V, Smoyer WE, Klein J. 2004. Identification of proteins in cultured murine podocytes whose expression is altered by glucocorticoids [Abstract]. Seattle, WA: International Podocyte Symposium [Peer Reviewed] (Unspecified)
• Vega-Warner, Virginia; Ransom, Richard F.; Vincent, Andrea M.; Brosius, Frank C.; Smoyer, William E. 2004. Induction of antioxidant enzymes in murine podocytes precedes injury by puromycin aminonucleoside.  Kidney International. Vol. 66, no. 5. : 1881-1889. (IF: 6.193)
• Ransom RF, Smoyer WE, Klein J. 2003. Proteomic analysis of protein expression altered by glucocorticoids in cultured murine podocytes [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Li X, Ransom RF, Jia Y, Welsh MJ, Smoyer WE. 2003. Functional identification of the hsp27 binding protein sop2p [Abstract]. San Diego, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Vega-Warner V, Ransom RF, Brosius FC, Smoyer WE. 2003. Podocyte antioxidant enzyme activity induction in an in vitro model of podocyte injury [Abstract]. San Diego, CA: FASEB Meeting [Peer Reviewed] (Published)
• Smoyer, William E.; Ransom, Richard F. 2002. Hsp27 regulates podocyte cytoskeletal changes in an in vitro model of podocyte process retraction.  FASEB Journal. Vol. 16, no. 3. : 315-326. (IF: 6.401)
• Siu B, Ransom RF, Vega-Warner V, Smoyer WE, Brosius FC. 2002. High glucose causes podocyte apoptosis within 12 hours. American Society of Nephrology [Abstract]. Philadephia, PA: American Society of Nephrology [Peer Reviewed] (Published)
• Ransom RF, Li Y, Lam N, Smoyer WE. 2002. Glucocorticoids protect and enhance recovery of podocytes from PAN-induced injury via an hsp27-dependent mechanism [Abstract]. Baltimore, MD: Pediatric Academic Societies [Peer Reviewed] (Published)
• Vega-Warner V, Ransom RF, Brosius FC, Smoyer WE. 2002. Induction of antioxidant enzyme activities in podocytes precedes injury in an in vitro PAN model [Abstract]. Philadelphia, PA: American Society of Nephrology [Peer Reviewed] (Published)
• Ransom RF, Li Y, Lam N, Smoyer WE. 2002. Glucocorticoids stabilize podocyte microfilaments protect and enhance recovery from PAN-induced injury [Abstract]. Philadelphia, PA: American Society of Nephrology [Peer Reviewed] (Published)
• Ransom RF, Li Y, Lam NG, Smoyer WE. 2001. Dexamethasone induces hsp27-dependent protection against and enhances recovery from PAN-induced podocyte injury [Abstract]. San Francisco, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Jia, Yifeng; Ransom, Richard F.; Shibanuma, Motoko; Liu, Chenghua; Welsh, Michael J.; Smoyer, William E. 2001. Identification and characterization of hic-5/ara55 as an hsp27 binding protein.  Journal of Biological Chemistry. Vol. 276, no. 43. : 39911-39918. (IF: 5.44)
• Smoyer WE, Ransom RF. 2001. Hsp27 protects against PAN-induced cellular injury in an in vitro model of podocyte spreading and retraction [Abstract]. Minneapolis, MN: Pediatric Academic Societies [Peer Reviewed] (Published)
• Li Y, Ransom RF, Smoyer WE. 2001. Effect of toxic metals and metal mixtures on hsp27 expression and phosphorylation in cultured murine podocytes [Abstract]. San Francisco, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Smoyer WE, Ransom RF. 2001. Hsp27-dependent dexamethasone protection against and enhanced recovery from PAN-induced podocyte injury [Abstract]. Heidelberg, Germany: International Symposium on Podocyte Biology [Peer Reviewed] (Unspecified)
• Jia Y, Ransom RF, Welsh MJ, Smoyer WE. 2001. The glomerular hsp27-binding protein, hic-5, regulates hsp27-mediated actin polymerization [Abstract]. San Francisco, CA: American Society of Nephrology [Peer Reviewed] (Published)
• Jia Y, Welsh MJ, Ransom RF, Liu C, Smoyer WE. 2000. Identification, characterization, and functional analysis of hic-5 as a new glomerular hsp27 binding protein [Abstract]. Toronto, Canada: American Society of Nephrology [Peer Reviewed] (Published)
• Smoyer WE, Ransom RF. 2000. Hsp27 protects against PAN-induced cellular injury in an in vitro model of podocyte spreading and retraction [Abstract]. Baltimore, MD: Society for Pediatric Research [Peer Reviewed] (Published)
• Ransom RF, Shelden EA, Smoyer WE. 2000. Protamine sulfate induces in vitro podocyte spreading and actin disruption reversible by heparin [Abstract]. Toronto, Canada: American Society of Nephrology [Peer Reviewed] (Published)
• Smoyer, William E.; Ransom, Richard; Harris, Raymond C.; Welsh, Michael J.; Lutsch, Gudrun; Benndorf, Rainer. 2000. Ischemic acute renal failure induces differential expression of small heat shock proteins.  Journal of the American Society of Nephrology. Vol. 11, no. 2. : 211-221. (IF: 7.689)
• Ransom RF, Smoyer WE. 2000. Hsp27 regulates paxillin expression and distribution after PAN in cultured podocytes [Abstract]. Toronto, Canada: American Society of Nephrology [Peer Reviewed] (Published)
• Smoyer WE, Ransom RF. 2000. Altered hsp27 expression regulates PAN-induced cellular injury in an in vitro model of podocyte spreading and retraction [Abstract]. Toronto, Canada: American Society of Nephrology [Peer Reviewed] (Published)
• Ransom RF, Shelden EA, Smoyer WE. 1999. Intracellular redistribution of hsp25 and actin in cultured podocytes after protamine sulfate and oxidant stress [Abstract]. Miami Beach, FL: American Society of Nephrology [Peer Reviewed] (Published)
• Smoyer WE, Ransom RF. 1999. Altered hsp25 expression regulates PAN-induced cytoskeletal changes in cultured podocytes in an in vitro model of nephrotic syndrome [Abstract]. Miami Beach, FL: American Society of Nephrology [Peer Reviewed] (Published)
• Wegener, Sigrun; Ransom, Richard F.; Walton, Jonathan D. 1999. A unique eukaryotic beta-xylosidase gene from the phytopathogenic fungus Cochliobolus carbonum.  Microbiology (Reading). Vol. 145, no. 5. : 1089-1095. (IF: 0.638)
• Benndorf, Rainer; Ransom, Richard F.; Gilmont, Robert R., Hayess, Katrin; Welsh, Michael J. 1998. Inhibition of mammalian small heat shock protein 25 (HSP25) kinase (MAPKAP kinase-2).  Expert Opinion on Therapeutic Targets. Vol. 2, no. 1. : 147-149. (IF: 3.713)
• Smoyer WE, Ransom RF, Harris RC, Welsh MJ, Lutsch G, Benndorf R. 1998. Ischemic acute renal failure in rats results in differential induction of hsp27 and ?B-crystallin [Abstract]. Evanston, IL: Midwest Stress Response and Chaperone Meeting [Peer Reviewed] (Unspecified)
• Scott-Craig, J.S., Apel-Birkhold, P.C.; Gorlach, J.M.; Nikolskaya, A.; Pitkin, J.W., Ransom, R.F.; Sposato, P.; Ahn, J-H; Tonukari, N.J.; Wegener, S.; Walton, J.D. 1997. Cell wall degrading enzymes in HST-producing fungal pathogens. In Molecular Genetics of Host-Specific Toxins in Plant Disease. Edited by Kohmoto, K., Yoder, O.C. Dordrecht, The Netherlands: Kluhwer Academic Publishers. 245-252.
• Smoyer WE, Harris RC, Ransom R, Welsh MJ, Benndorf, RC. 1997. Differential renal expression of hsp27 and ?B-crystallin in rats following acute ischemia [Abstract] [Peer Reviewed] (Published)
• Ransom, Richard F.; Walton, Jonathan D. 1997. Histone hyperacetylation in maize in response to treatment with Hc-toxin or infection by the filamentous fungus Cochliobolus carbonum.  Plant Physiology (Rockville). Vol. 115, no. 3. : 1021-1027. (IF: 6.235)
• Walton, J.D.; Ahn, J-H, Pitkin, J.W.; Cheng, Y., Nikolskaya, A.N., Ransom, R.F., Wegener, S. 1997. Enzymology, molecular genetics, and regulation of biosynthesis of the host-selective toxin HC-toxin. In Molecular Genetics of Host-Specific Toxins in Plant Disease. Edited by Kohmoto, K.; Yoder, O.C. Dordrecht, The Netherlands: Kluwer Academic Publishers. 25-34.
• Walton, Jonathan D.; Ransom, Richard F.; Pitkin, John. 1997. Northern corn leaf spot: Chemistry, enzymology, and molecular genetics of a host-selective phytotoxin. In Plant-Microbe Interactions. Edited by Stacey, G.; Keen, N. T. New York: Chapman and Hall, Inc.
• Walton JD, Ahn J-H, Akimitsu K, Pitkin JW, Ransom RF. 1997. Leaf-spot disease of maize: Chemistry, biochemistry, and molecular biology of a host-selective cyclic peptide [Abstract]. Advances in Molecular Genetics of Plant-Microbe Interactions. Vol. 3. Dordrecht, The Netherlands: Kluwer Academic Publishers: 231-237. [Peer Reviewed] (Published)
• Ransom, Richard F.; Walton, Jonathan D. 1997. Purification and characterization of extracellular beta-xylosidase and alpha-arabinosidase from the plant pathogenic fungus Cochliobolus carbonum.  Carbohydrate Research. Vol. 297, no. 4. : 357-364. (IF: 2.025)
• Scott-Craig J, Pitkin JW, Apel PC, Murphy JM, Sposato P, Ransom RF, Schaeffer HJ, and Walton JD. 1997. Cell wall degrading enzymes of fungal plant pathogens [Abstract] [Peer Reviewed] (Unspecified)
• Broschl, Gerald; Ransom, Richard F.; Lechner, Thomas; Walton, Jonathan D.; Loidl, Peter. 1995. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.  The Plant Cell. Vol. 7. : 1941-1950. (IF: 9.293)
• Ransom, Richard F.; Wilder, John; Dunkle, Larry D. 1994. Purification and distribution of pathotoxin-enhanced proteins in sorghum.  Physiological and Molecular Plant Pathology. Vol. 45, no. 5. : 385-395. (IF: 1.407)
• Ransom, Richard F.; Hipskind, John; Leite, Breno; Nicholson, Ralph L.; Dunkle, Larry D. 1992. Effect of elicitor from Colletotrichum graminicola on the response of sorghum to Periconia circinata and its pathotoxin.  Physiological and Molecular Plant Pathology. Vol. 41, no. 2. : 75-84. (IF: 1.407)
• Traylor, Elbert A.; Shore, Scott H., Ransom, Richard F.; Dunkle, Larry D. 1987. Pathotoxin effects in sorghum are also produced by mercuric chloride treatment.  Plant Physiology. Vol. 84. : 975-978. (IF: 6.235)