Pulmonary Medicine Annual Report :: Nationwide Children's Hospital

Pulmonary Medicine 2014-2015 Annual Report

View the Nationwide Children's Hospital 2014-2015 Annual Report.

The mission of the Division of Pulmonary Medicine at Nationwide Children’s Hospital is to provide outstanding clinical care for children and adults with congenital respiratory disorders, including asthma, cystic fibrosis (CF), sleep related breathing disorders and lung transplant, advanced lung disease care and management of chronic mechanical ventilation. The care model is multidisciplinary. Our mission also includes education of medical and allied health professional trainees and involvement in cutting-edge clinical, basic and translational research.

Pulmonary clinicians provide care at Nationwide Children’s main campus and at Westerville, Dublin and Lima Close to Home Centers. During the 2014- 2015 year, there were over 2,500 admissions and over 10,000 outpatient visits. At present, there are 13 pediatric pulmonologists and three internal medicine/ pediatric physicians; 12 are board certified in pediatric pulmonology, two are certified in adult pulmonology, three are sleep certified, and two are transplant certified. Complementing the physicians are six advanced practice nurses. Among the providers, five specialize in adult care. Additionally, our interdisciplinary staff numbers over 65 individuals, including dedicated administrative professionals, clinical pharmacists, nurses, nutritionists, psychologists, psychiatrists, respiratory therapists and social workers, who allow us to provide timely, comprehensive and family-centered care.

Several multispecialty clinics have been developed to provide seamless care to our patients:

  • Complex asthma care with allergy
  • School-based asthma care
  • CF and otolaryngology (ENT)
  • CF and endocrinology
  • CF and gastroenterology
  • Neuromuscular disorders with cardiology
  • Aerodigestive with gastroenterology and ENT
  • Sickle-cell diseases with hematology

The division also has a robust quality-improvement portfolio, conducts clinical research with a broad group of basic-science collaborators, exhibits steadily climbing research productivity, and has over 100 publications for 2014.

2014-2015 Grants Awarded


Hayes, Don
Human Susceptibility to Legionella Infection
The Ohio State University Medical Center
National Institutes of Health (NIH)
B-cell Targeted Induction to Improve Outcomes in Pediatric Lung Transplantation
Washington University
National Institutes of Health
Kopp, Benjamin
Burkholderia-mediated defective killing mechanisms in macrophages from cystic fibrosis (CF) patients
National Institute of Allergy and Infectious Diseases
Autophagy Mediated Clearance of B. Cenocepacia in CF Alveolar Macrophages
Cystic Fibrosis Foundation (CFF)
Secondhand Smoke exposure influences on growth, lung infection and inflammation in CF 
American Academy of Pediatrics
Targetting microRNA to moderate inflammation and CFTR function in Cystic Fibrosis
Ohio State University Office of Sponsored Programs
CF Dialogue Study
Verilogue, Inc
McCoy, Karen
Cystic Fibrosis Center
Cystic Fibrosis Foundation (CFF)
CF Therapeutic Development Network - Translational TDC Center
CF Therapeutics Development Network
Cystic Fibrosis Center
Cystic Fibrosis Foundation Therapeutics (CFFT)
A Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of Single and Multiple Ascending Doses of Study Drug in Health Subjects and Multiple Doses in CF Patients
Industry Sponsor
Industry Study
Industry Sponsor
A Phase 2, Multi-Center, Randomized, Placebo-Controlled Study of IV Gallium Nitrate in Patients with Cystic Fibrosis
Seattle Children's Research Institute
University of Washington
Industry Study
Industry Sponsor
Saline Hypertonic in Preschoolers
Seattle Children's Research Institute
Cystic Fibrosis Foundation (CFF)
Training Protocol
Cystic Fibrosis Foundation Therapeutics (CFFT)
A Two-Part Multicenter Prospective Longitudinal Study of CFTR-Dependent Disease Profiling in Cystic Fibrosis (PROSPECT)
Seattle Children's Research Institute
Cystic Fibrosis Foundation Therapeutics (CFFT)
Cystic Fibrosis Foundation (CFF)
Long Term Administration of Inhaled Mannitol in Cystic Fibrosis - A Safety and Efficacy Trial in Adult Cystic Fibrosis Subjects
Industry Sponsor

Pulmonary Medicine Faculty

Karen S. McCoy, MD

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Selected Pulmonary Medicine Publications

Assani K, Tazi MF, Amer AO, Kopp BT. IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. PLoS One. 2014 May;9(5):e96681.

Hayes D Jr, Whitson BA, Black SM, Preston TJ, Papadimos TJ, Tobias JD. Influence of age on survival in adult patients on extracorporeal membrane oxygenation before lung transplantation. The Journal of Heart and Lung Transplantation: The Official Publication of the International Society for Heart Transplantation. 2015 Jun;34(6):832-8.

Kirkby SE, Hayes D Jr., Parsons JP, Wisely CE, Kopp B, McCoy KS, Mastronarde JG. Eucapnic voluntary hyperventilation to detect exercise-induced bronchoconstriction in cystic fibrosis. Lung. 2015 June 3. [Epub ahead of print].

Sheikh SI, Long FR, Flucke R, Ryan-Wenger NA, Hayes D Jr, McCoy KS. Changes in pulmonary function and controlled ventilation-high resolution CT of chest after antibiotic therapy in infants and young children with cystic fibrosis. Lung. 2015 Jun;193(3):421-8.

Wainwright CE Elborn, JS, Ramsey BW, Marigowda G, Huang X, Cipolli M, Colombo C, Davies JC, DeBoeck K, Flume PA, Konstan MW, McColley SA, McCoy K, McKone EF, Munck A, Ratjen F, Rowe SM, Waltz D, Boyle MP. Lumacaftor-Ivacaftor in patients with cystic fibrosis homozygous for Phe508del CFTR. The New England Journal of Medicine. 2015 July;373(3):220-31.

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