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Office Practice Information:
Peter J. Giannone, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Clinical Pediatrics at The Ohio State University College of Medicine. His research interests are in the areas of inflammation and how it relates to diseases and consequences associated with preterm birth. These interests include necrotizing enterocolitis (NEC) and the effects of prenatal inflammation on downstream cardiac and vascular development and function. Dr. Giannone’s NEC research focuses on the effects of prenatal inflammation on intestinal development and the role of poly (ADP-ribose) polymerase-1 (PARP-1) plays in the cell death pathways triggered in the intestinal epithelium during NEC. He also aims to determine the developmental regulation and activation of the innate immune system of the small intestine upstream from PAPRP activation, specifically the Toll-like receptors (TRLs). Dr. Giannone currently is working with human intestinal specimens from infants who have had surgery for NEC, rat and human intestinal cell lines, as well as mouse and rat NEC models to help examine the role PARP and innate immune system plays in NEC. Dr. Giannone’s laboratory is also working to elicit the effects prenatal inflammation has on postnatal cardiac development and function. Dr. Giannone continues to publish neonatal outcome’s research in the area of neonatal cardiovascular adaptation.