Peter J. Giannone, MD

Peter J. Giannone, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Clinical Pediatrics at The Ohio State University College of Medicine. His research interests are in the areas of inflammation and how it relates to diseases and consequences associated with preterm birth. These interests include necrotizing enterocolitis (NEC) and the effects of prenatal inflammation on downstream cardiac and vascular development and function. Dr. Giannone’s NEC research focuses on the effects of prenatal inflammation on intestinal development and the role of poly (ADP-ribose) polymerase-1 (PARP-1) plays in the cell death pathways triggered in the intestinal epithelium during NEC. He also aims to determine the developmental regulation and activation of the innate immune system of the small intestine upstream from PAPRP activation, specifically the Toll-like receptors (TRLs). Dr. Giannone currently is working with human intestinal specimens from infants who have had surgery for NEC, rat and human intestinal cell lines, as well as mouse and rat NEC models to help examine the role PARP and innate immune system plays in NEC. Dr. Giannone’s laboratory is also working to elicit the effects prenatal inflammation has on postnatal cardiac development and function. Dr. Giannone continues to publish neonatal outcome’s research in the area of neonatal cardiovascular adaptation.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Research Funding*:

• Fetal Imprinting of Cardiac Inflammatory Response, American Heart Association of Ohio

Medical School

• State University of New York - Syracuse
  Date Completed: 05/15/1996

Internship

• Children's Hospital of the King's Daughters Hospit
  Date Completed: 06/30/1997

Residency

• Children's Hospital of the King's Daughters Hospit
  Date Completed: 06/30/1999

Fellowship

• Women and Infants Hospital
  Date Completed: 06/30/2002

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine, Certified
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 09/27/2002

• PJ, Richter JM, Schanbacher BS, Nankervis CA, Besner GA and Bauer JA. 2010. Poly(ADP-ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis.  Am J Path. (First submission)
• Carrol PD, Nankervis CA, Giannone PJ, Cordero L. 2010. Use of Polyethylene Bags in ELBW Infant Resuscitation for the Prevention of Hypothermia.  J Reprod Med.. Vol. Jan-Feb. 55, no. 1-2: 9-13.
• Cordero L; Nankervis CA; Oshaughnessy RW; Koff SA; Giannone PJ. 2009. Postnatal follow-up of antenatal hydronephrosis: a health-care challenge.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 29, no. 5 (May 1): 382.
• Giannone PJ, Nakervis CA, Schanbacher BS, Richter JM, Reber KM. 2009. Prenatal Lipopolysaccharide Increases Intestinal Injury via iNOS in Neonatal Rats. J Pediatr Gastroenterol Nutr. Vol. 48, no. 3. (March): 276-282.
• Han, B.; Huang, H.; Schambacher, B.; Luce, W. A.; Bauer, J. A.; Giannone, P. J. 2009. Effects Of Prenatal Inflammation On Cardiac Function And Redox Status In Adulthood.  Pediatric Research. Vol. 66, no. 4: 474.
• Giannone PJ, Luce WA, Nankervis CA, and Bauer JA. Congential Heart Disease and Necrotizing Enterocolits. In Heart Disease in Children. Edited by Columbus F. Hauppauge, NY: Nova Science Publishers, Inc. (In press)
• Luce WA, Schwartz R, Beauseau W, Giannone PJ, Hashiguchi B, Cheatham JP, Galantowicz M,Cua CL. Necrotizing Enterocolitis in Neonates Undergoing the Hybrid Approach to Complex Congenital Heart Disease.  Pediatr Crit Care. (In press)
• Nowicki, P. T.; Dunaway, D. J.; Nankervis, C. A.; Giannone, P. J.; Reber, K. M.; Hammond, S. B.; Besner, G. E.; Caniano, D. A. 2009. Endothelin-1 in Human Intestine Resected for Necrotizing Entercolitis (vol 146, pg 805, 2005).  Journal of Pediatrics. Vol. 155, no. 4: 602.
• Han B, Baliga R, Huang H, Giannone PJ, Bauer JA. 2009. Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic ventricular performance deficits.  Am J Physiol Heart Circ Physiol. Vol. Aug;297, no. 2: H829-H835.
• Giannone PJ and Richter JM. Retinopathy of Prematurity. In e-Essential Evidence. Edited by Ebell MH, Ferenchick G, Smith M, Barry H, Slawson D, Shaughnessy A, Forsch R, Li S, Wilkes M, Usatine R,. Hoboken, NJ: John Wiley and Sons. (In press)
• Alcamo AM, Schanbacher BL, Nankervis CA, Cordero L, Bauer JA, Giannone PJ. 2009. Increased Cytokine Production Induced by Cyclic Strain in Immature Intestinal Epithelial Cells [Abstract]: E-PAS2009:4333.171 [Peer Reviewed] (Published)
• Bing H, Huang H, Schanbacher BL, Bauer JA, Giannone PJ. 2009. The effects of prenatal lipopolysaccharide on cardiac function [Abstract]: FASEB 2009 [Peer Reviewed] (Published)
• Cordero L, Nankervis CA, Coley B, Giannone PJ. 2009. Orogastric Tube Placement in Extremely Low Birth Weight Infants.  J Neonat and Perinat Med, no. 2: 253-259.
• Richter JM, Schanbacher BL, Mofleh MM, Giannone PJ, Bauer JA. 2009. Lipopolysaccharide (LPS) and Necrotic Cell Debris Attenuate Wound Healing of Immature Intestinal Epithelium [Abstract]: E-PAS2009:4333.167 [Peer Reviewed] (Published)
• Giannone PJ, Richter JM, and Bauer JA. Low Birth Weight is a Significant Risk Factor for Cardiovascular Disease. In Cardiovascular Complications in Pregnancy. Edited by Columbus F. Hauppauge, NY: Nova Science Publishers, Inc. (In press)
• Cordero L, Giannone PJ, Valentine CA, Coley B, Nankervis CA. Pnuematosis Coli: A Resurgence of a Benign Form of Necrotizing Enterocolitis.  Neonatology. (In press)
• Nuthakki S, Giannone PJ, Lynette K. Rogers LK, Nelin LD. 2009. Lipopolysaccharide Increases Production of Both Nitric Oxide and Urea in Fetal Intestinal Cells [Abstract]: E-PAS2009:2839.375 [Peer Reviewed] (Published)
• Cordero L, Coley BD, Giannone PJ, Nankervis CA. 2009. Orogastric Tube Insertion Length in Extremely Low Birth Weight Infants [Abstract]: E-PAS2009:5505.81 [Peer Reviewed] (Published)
• Cordero L, Nankervis CA, Coley B, Giannone PJ. 2009. A Novel Formula for Orogastric Tube Placement in Extremely Low Birth Weight Infants.  Neonatology. (First submission)
• Han B, Huang, H, Bauer JA and Giannone PJ. 2009. Prenatal Lipopolysaccharide Exposure Exacerbates Murine Cardiac Function [Abstract]: E-PAS2009:4339.201 [Peer Reviewed] (Published)
• Backes CH, Schanbacher BL, Alcamo AM, Ackerman WE, Wold LE, Giannone PJ. 2009. Particulate Matter (PM 2.5) Exposure on Placental Cell Viability in a Trophoblast Cell Line [Abstract]: E-PAS2009:2838.363 [Peer Reviewed] (Published)
• Carrol PD, Nankervis CA, Giannone PJ, Cordero L. 2009. Use of Polyethylene Bags in ELBW Infant Resuscitation for the Prevention of Hypothermia. J Perinatol. (Revised submission)
• Cordero L, Nankervis CA, O?Shaunesy R, Knoff S, Giannone PJ. 2009. Postnatal Follow-up of Antenatal Hydronephrosis: A Health Care Challenge.  J Perinatol, no. May29: 382-387.
• Zhang, H., Huang, H., Schanbacher, B., Giannone, PJ, Bauer, JA. 2009. Prenatal Imprinting of Adult Cardiac Dysfunction: Impact of Maternal High-Fat Deit in Mice [Abstract]: Heart Association Meeting The Scientific Basis of Heart Failure in Children [Peer Reviewed] (Published)
• Alcamo AM, Schanbacher BL, Nankervis CA, Cordero L, Bauer JA, Giannone PJ. 2009. Altered Cell Density Induced by Cyclic Strain in Immature Intestinal Epithelial Cells [Abstract]: E-PAS2009:4334.172 [Peer Reviewed] (Published)
• Johnson D, Schanbacher BL, Alcamo AM, Mofleh MM, Bauer JA, Giannone PJ. 2009. Extracellular Mitochondria as Mediators of Cell Death and Injury [Abstract]: E-PAS2009:4333.164 (Published)
• Cordero L, Backes CH, Coley BD, Giannone PJ, Nankervis CA. 2009. Needle Aspiration and Chest Tube Insertion for Pneumothorax in ELBW Infants [Abstract]: E-PAS2009:4346.287 [Peer Reviewed] (Published)
• Nankervis CA, Giannone PJ, Reber KM. 2008. The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis. Review. Semin Perinatol.. Vol. 32, no. 2. (April): 83-91. (IF: 2.477)
• Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. 2008. Necrotizing enterocolitis in neonates with congenital heart disease. Life Sci.. Vol. 82, no. 7-8. (February): 341-347. (IF: 2.257)
• Richter JM, Schanbacher BS, Alcamo AM, Bauer JA, Giannone PJ. 2008. Novel Effectors of Wound Healing in Immature Intestinal Epithelium. [Abstract]: E-PAS2008:4453.18 [Peer Reviewed] (Published)
• Cordero L, Nankervis CA, Coley BD, Giannone PJ. 2008. Orogastric Tube (OGt) Placement in Extremely Low Birth Weight (ELBW) Infants. [Abstract]: E-PAS2008:5840.11. [Peer Reviewed] (Published)
• Carroll P, Cordero L, Giannone PJ. 2008. Early Experience with Plastic Bags During Resuscitation of Extremely Low Birth Weight (ELBW) Infants Receiving Surfactant in the Delivery Room. [Abstract]: E-PAS2008:5819.5. [Peer Reviewed] (Published)
• Han B, Bauer JA and Giannone PJ. 2008. Evaluation of Cocaine Induced Acute and Chronic Toxicity in the Cardiovascular System. [Abstract]: AAPS 2008 [Peer Reviewed] (Published)
• Giannone PJ, Richter JM, Alcamo AM, Luce WA, Nankervis CA, Schanbacher BL, Bauer JA. 2008. Nicotinamide Attenuates Intestinal Injury in an Animal Model of Necrotizing Enterocolitis (NEC). [Abstract]: E-PAS2008:3055.6 [Peer Reviewed] (Published)
• Cordero L; Nankervis CA; Delooze D; Giannone PJ. 2007. Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 27, no. 3 (March 1): 158.
• Giannone PJ; Bauer JA; Schanbacher BL; Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry: Official Publication Of The Biological Stain Commission. Vol. 82, no. 1 (February 1): 17.
• Giannone PJ, Bauer JA, Schanbacher BL, Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development. Biotechnic & Histochemistry. Vol. 82, no. 1: 17-22.
• Cordero L, Nankervis CA, Delooze D, Giannone PJ. 2007. Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?. Journal of Perinatology. Vol. 27, no. 3: 158-163.
• Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, Nankervis CA. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis. Journal of Pediatrics. Vol. 150, no. 1: 5-6.
• Giannone, P. J.; Bauer, J. A.; Schanbacher, B. L.; Reber, K. M. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry. Vol. 82, no. 1: 17-22.
• Giannone, P. J.; Richter, J. M.; Schanbacher, B. S.; Luce, W. A.; Nankervis, C. A.; Bauer, J. A. 2007. Novel therapuetic targets in necrotizing enterocolitis.  Pediatric Research. Vol. 62, no. 4: 516.
• Cordero L; Nankervis CA; Gardner D; Giannone PJ. 2007. The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 27, no. 1 (January 1): 22.
• Luce, W. A.; Huang, H.; Baliga, R.; Giannone, P. J.; Liu, Y.; Bauer, J. A. 2007. Deficiency of mitogen activated protein kinase phosphatase-1 (mkp-1) causes enhanced impairment of cardiac function after endotoxin exposure.  Pediatric Research. Vol. 62, no. 4: 517.
• Richter, J. M.; Schanbacher, B. L.; Reber, K. M.; Bauer, J. A.; Giannone, P. J. 2007. Novel effectors of wound healing on immature intestinal epithelium.  Pediatric Research. Vol. 62, no. 4: 517.
• Cordero L, Nankervis CA, Gardner D, Giannone PJ. 2007. The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants. Journal of Perinatology. Vol. 27, no. 1: 22-27.
• Mangino, J. E.; Taylor, D.; Giannone, P.; Covdero, L.; Bannerman, T.; Panchoi, P. 2007. Control of an Outbreak of Methicillin-resistant Staphylococcus aureus (mrsa) Bacteremia in a Neonatal Intensive Care Unit (nicu).  Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. Vol. 47: 333.
• Karlowicz MG; Giannone PJ; Pestian J; Morrow AL; Shults J. 2000. Does candidemia predict threshold retinopathy of prematurity in extremely low birth weight (.  Pediatrics. Vol. 105, no. 5 (May 1): 1036.
• Giannone, P. J.; Pestian, J.; Karlowicz, M. G. 1999. Does candidemia predict threshold retinopathy of prematurity in extremely low birth weight (less than 1000g) neonates?.  Journal of Investigative Medicine. Vol. 47, no. 2: 152A.

• 2007 Finalist – March of Dimes Health Leadership Award for Academic Physician
• MWSPR Travel Award for Trainee Juli M. Richter, MD, PharmD