Peter J. Giannone, MD

Peter J. Giannone, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Clinical Pediatrics at The Ohio State University College of Medicine. His research interests are in the areas of inflammation and how it relates to diseases and consequences associated with preterm birth. These interests include necrotizing enterocolitis (NEC) and the effects of prenatal inflammation on downstream cardiac and vascular development and function. Dr. Giannone’s NEC research focuses on the effects of prenatal inflammation on intestinal development and the role of poly (ADP-ribose) polymerase-1 (PARP-1) plays in the cell death pathways triggered in the intestinal epithelium during NEC. He also aims to determine the developmental regulation and activation of the innate immune system of the small intestine upstream from PAPRP activation, specifically the Toll-like receptors (TRLs). Dr. Giannone currently is working with human intestinal specimens from infants who have had surgery for NEC, rat and human intestinal cell lines, as well as mouse and rat NEC models to help examine the role PARP and innate immune system plays in NEC. Dr. Giannone’s laboratory is also working to elicit the effects prenatal inflammation has on postnatal cardiac development and function. Dr. Giannone continues to publish neonatal outcome’s research in the area of neonatal cardiovascular adaptation.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Research Funding*:

• Fetal Imprinting of Cardiac Inflammatory Response, American Heart Association of Ohio

Medical School

• State University of New York - Syracuse
  Date Completed: 05/15/1996

Internship

• Children's Hospital of the King's Daughters Hospit
  Date Completed: 06/30/1997

Residency

• Children's Hospital of the King's Daughters Hospit
  Date Completed: 06/30/1999

Fellowship

• Women and Infants Hospital
  Date Completed: 06/30/2002

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 09/27/2002

• Alcamo AA, Schanbacher BS, Nankervis CA, Bauer JA, Giannone PJ. 2012. Cellular Strain amplifies LPS-induced stress signaling in immature enterocytes; potential implications for preterm infant nasal CPAP.  Pediatric Research. Vol. 71, no. June: edoi:10.1038.
• Stenger MR, Reber KM, Giannone PG, Nankervis CA. 2011. Probiotics and the Prevention of Necrotizing Enterocolitis.  Current Infectious Disease Reports. Vol. 13, no. December: 13-20.
• Backes CH Jr., Markham K, Nankervis CA, Giannone PJ. 2011. Transition of Neonatal Methadone Patients from the Inpatient to Outpatient Setting.  Journal of Perinatology. Vol. Epub ahead of print, no. August: eEpub.
• Backes CH, Backes CR, Gardner D, Nankervis CA, Giannone PJ, Cordero L. 2011. Neonatal abstinence syndrome: transitioning methadone-treated infants from an inpatient to an outpatient setting.  Journal of Perinatology. Vol. 8, no. August: e10.
• Giannone,Peter,J; Alcamo,Alicia,A; Schanbacher,Brandon,L; Nankervis,Craig,A; Besner,Gail,E; Bauer,John,A. 2011. Poly(ADP-Ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis.  PEDIATRIC RESEARCH. Vol. 70, no. 1. (July): 67-71.
• Cordero L, Nankervis CA, Coley B, Giannone PJ. 2011. A Novel Formula for Orogastric Tube Placement in Extremely Low Birth Weight Infants.  Journal of Neonatal-Perinatal Medicine. Vol. 4, no. April: 9-13.
• Cordero L, Nankervis CA, Valentine CA, Coley B, Giannone PJ. 2011. Pneumatosis Coli: A Resurgence of a Benign Form of Necrotizing Enterocolitis.  Journal Neonatal-Perinatal Medicine. Vol. 3, no. March: e4.
• Stenger,Michael,R; Reber,Kristina,M; Giannone,Peter,J; Nankervis,Craig,A. 2011. Probiotics and prebiotics for the prevention of necrotizing enterocolitis.  Current infectious disease reports. Vol. 13, no. 1. (February): 13-20.
• Backes,Carl,H; Markham,Kara; Moorehead,Pamela; Cordero,Leandro; Nankervis,Craig,A; Giannone,Peter,J. 2011. Maternal preeclampsia and neonatal outcomes.  Journal of pregnancy. Vol. 2011, no. January: 214365-?.
• PJ, Richter JM, Schanbacher BS, Nankervis CA, Besner GA and Bauer JA. Poly(ADP-ribose) Polymerase-1: A Novel Therapeutic Target in Necrotizing Enterocolitis.  Am J Path.
• Carrol PD, Nankervis CA, Giannone PJ, Cordero L. 2010. Use of Polyethylene Bags in ELBW Infant Resuscitation for the Prevention of Hypothermia.  J Reprod Med.. Vol. Jan-Feb. 55, no. 1-2. (January): 9-13.
• Nowicki,P,T; Dunaway,D,J; Nankervis,C,A; Giannone,P,J; Reber,K,M; Hammond,S,B; Besner,G,E; Caniano,D,A. 2009. Endothelin-1 in Human Intestine Resected for Necrotizing Entercolitis (vol 146, pg 805, 2005).  JOURNAL OF PEDIATRICS. Vol. 155, no. 4. (October): 602-602.
• Cordero L; Nankervis CA; Oshaughnessy RW; Koff SA; Giannone PJ. 2009. Postnatal follow-up of antenatal hydronephrosis: a health-care challenge.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 29, no. 5. (May): e382.
• Cordero L, Nankervis CA, O-Shaunesy R, Knoff S, Giannone PJ. 2009. Postnatal Follow-up of Antenatal Hydronephrosis: A Health Care Challenge.  Journal of Perinatology. Vol. 29, no. May: 382-387.
• Giannone,Peter,J; Nankervis,Tcraio,A; Richter,Juli,M; Schanbacher,Brandon,L; Reber,Kristina,M. 2009. Prenatal Lipopolysaccharide Increases Postnatal Intestinal Injury in a Rat Model of Necrotizing Enterocolitis.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 48, no. 3. (March): 276-282.
• Giannone PJ, Nakervis CA, Schanbacher BS, Richter JM, Reber KM. 2009. Prenatal Lipopolysaccharide Increases Intestinal Injury via iNOS in Neonatal Rats.  J Pediatr Gastroenterol Nutr. Vol. 48, no. 3. (March): 276-282.
• Carrol PD, Nankervis CA, Giannone PJ, Cordero L. Use of Polyethylene Bags in ELBW Infant Resuscitation for the Prevention of Hypothermia.  J Perinatol.
• Giannone PJ, Luce WA, Nankervis CA, and Bauer JA. Congential Heart Disease and Necrotizing Enterocolits. In Heart Disease in Children. Edited by Columbus F.
• Giannone PJ and Richter JM. Retinopathy of Prematurity. In e-Essential Evidence. Edited by Ebell MH, Ferenchick G, Smith M, Barry H, Slawson D, Shaughnessy A, Forsch R, Li S, Wilkes M, Usatine R,.
• Cordero L, Nankervis CA, Coley B, Giannone PJ. 2009. Orogastric Tube Placement in Extremely Low Birth Weight Infants.  J Neonat and Perinat Med. Vol. 1, no. 2. (January): 253-259.
• Cordero L, Giannone PJ, Valentine CA, Coley B, Nankervis CA. Pnuematosis Coli: A Resurgence of a Benign Form of Necrotizing Enterocolitis.  Neonatology.
• Cordero L, Nankervis CA, O’Shaunesy R, Knoff S, Giannone PJ. 2009. Postnatal Follow-up of Antenatal Hydronephrosis: A Health Care Challenge.  J Perinatol. Vol. 1, no. May29. (January): 382-387.
• Han B, Baliga R, Huang H, Giannone PJ, Bauer JA. 2009. Decreased cardiac expression of vascular endothelial growth factor and redox imbalance in murine diabetic ventricular performance deficits.  Am J Physiol Heart Circ Physiol. Vol. Aug;297, no. 2. (January): H829-H835.
• Cordero L, Nankervis CA, Coley B, Giannone PJ. A Novel Formula for Orogastric Tube Placement in Extremely Low Birth Weight Infants.  Neonatology.
• Giannone PJ, Richter JM, and Bauer JA. Low Birth Weight is a Significant Risk Factor for Cardiovascular Disease. In Cardiovascular Complications in Pregnancy. Edited by Columbus F.
• Nankervis CA, Giannone PJ, Reber KM. 2008. The neonatal intestinal vasculature: contributing factors to necrotizing enterocolitis. Review.  Semin Perinatol.. Vol. 32, no. 2. (April): 83-91.
• Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. 2008. Necrotizing Enterocolities in Neonates with Congenital Heart Disease.  Life Sciences. Vol. 82, no. 708. (February): 341-7.
• Giannone PJ, Luce WA, Nankervis CA, Hoffman TM, Wold LE. 2008. Necrotizing enterocolitis in neonates with congenital heart disease.  Life Sci.. Vol. 82, no. 7-8. (February): 341-347.
• Cordero L; Nankervis CA; Delooze D; Giannone PJ. 2007. Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 27, no. 3. (March): e158.
• Giannone PJ; Bauer JA; Schanbacher BL; Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry: Official Publication Of The Biological Stain Commission. Vol. 82, no. 1. (February): e17.
• Cordero L; Nankervis CA; Gardner D; Giannone PJ. 2007. The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 27, no. 1. (January): e22.
• Nowicki PT, Caniano DA, Hammond S, Giannone PJ, Besner GE, Reber KM, Nankervis CA. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  Journal of Pediatrics. Vol. 150, no. 1. (January): 5-6.
• Giannone PJ, Bauer JA, Schanbacher BL, Reber KM. 2007. Effects of hyperoxia on postnatal intestinal development.  Biotechnic & Histochemistry. Vol. 82, no. 1. (January): 17-22.
• Cordero L, Nankervis CA, Gardner D, Giannone PJ. 2007. The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants.  Journal of Perinatology. Vol. 27, no. 1. (January): 22-27.
• Cordero L, Nankervis CA, Delooze D, Giannone PJ. 2007. Indomethacin prophylaxis or expectant treatment of patent ductus arteriosus in extremely low birth weight infants?.  Journal of Perinatology. Vol. 27, no. 3. (January): 158-163.
• Giannone,Peter,J; Schanbacher,Brandon,L; Bauer,John,A; Reber,Kristina,M. 2006. Effects of prenatal lipopolysaccharide exposure on epithelial development and function in newborn rat intestine.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 43, no. 3. (September): 284-290.
• Norwicki PT, Reber KM, Giannone PJ, Nankervis CP, Hammond S, Besner GE, Caniano D. 2006. Intestinal Oxygen Consumption in Necrotizing Entercolitis: The Role of Nitric Oxide.  Pediatric Research. Vol. 59, no. 4 Pt 1. (April): 500-5.
• Nowicki,P,T; Reber,K,M; Giannone,P,J; Nankervis,C,A; Hammond,S; Besner,G,E; Caniano,D,A. 2006. Intestinal O-2 consumption in necrotizing enterocolitis: Role of nitric oxide.  PEDIATRIC RESEARCH. Vol. 59, no. 4. (April): 500-505.
• Cordero,Leandro; Giannone,Peter,J; Ramirez,Nilsa,C; Joy,Saju,D. 2005. Mean arterial pressure in concordant and discordant triplets during the first week of life.  Journal of perinatology : official journal of the California Perinatal Association. Vol. 25, no. 3. (March): 198-204.
• Cordero L, Giannone PJ, Ramirez N, Joy SD. 2005. Mean arterial pressure in concordant and discordant triplets during the first week of life.  Journal of Perinatology. Vol. 25, no. 3. (March): 198-204.
• Giannone,P,J; Abu Dayyeh,B,K; Bienieki,T,C; Wands,J,R; Gruppuso,P,A. 2004. Targeted hepatic overexpression of human IRS-1: postnatal effects in the developing mouse.  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. Vol. 1672, no. 2. (May): 112-119.
• Cordero,Leandro; Giannone,Peter,J; Rich,Jason,T. 2003. Mean arterial pressure in very low birth weight (801 to 1500 g) concordant and discordant twins during the first day of life.  Journal of perinatology : official journal of the California Perinatal Association. Vol. 23, no. 7. (October): 545-551.
• Karlowicz MG; Giannone PJ; Pestian J; Morrow AL; Shults J. 2000. Does candidemia predict threshold retinopathy of prematurity in extremely low birth weight (Pediatrics. Vol. 105, no. 5. (May): e1036.
• Alcamo AA, Schambacher BS, Huang H, Giannone PG. Intestinal Stretch and Neonatal Intestinal Injury.  Peds Res.
• Giannone PJ, Nankervis CA, Stenger M and Bauer JA. Role of Nitration in Nectrotizing Enterocolits. In Studies on Perinatal and Prenatal Disorders. Edited by Phyllis Dennery, Giuseppe Buonocore and Ola Saugstad.
• Cordero L, Valentine CJ, Giannone PG, Nankervis CA. Visible Blood in the Stool in a Neonatal Intensive Care Unit.  Journal of Neonatal-Perinatal Medicine.
• Alcamo AA, Schanbacher BS, Nankervis CA, Bauer JA, Giannone PJ. Cellular Strain amplifies LPS-induced stress signaling in immature enterocytes; potential implications for preterm infant nasal CPAP.  Pediatric Research.
• Cordero L, Valentine CJ, Giannone PJ, Nankervis CA. 0. Breastfeeding in Women with Severe Preeclampsia.  Breastfeeding Medicine.
• Luce WA, Schwartz R, Beauseau W, Giannone PJ, Hashiguchi B, Cheatham JP, Galantowicz M,Cua CL. Necrotizing Enterocolitis in Neonates Undergoing the Hybrid Approach to Complex Congenital Heart Disease.  Pediatr Crit Care.

• 2007 Finalist – March of Dimes Health Leadership Award for Academic Physician
• MWSPR Travel Award for Trainee Juli M. Richter, MD, PharmD